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- 저자 : Jesus Fernandez-Lopez (검색결과 2 건)
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HENED SAADE,RAUL GUILLERMO LOPEZ,JESUS CEPEDA GARZA,MARIA LUISA LOPEZ-QUINTANILLA,FRANCISCO ENRIQUEZ-MEDRANO,SALVADOR FERNANDEZ 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.6
Ibuprofen-loaded poly(methyl methacrylate) nanoparticles with mean diameters smaller than20 nm were prepared by a novel method. This consists in carrying out a semicontinuousheterophase polymerization, in which a solution of drug-monomer is added on a micellar solutionat an appropriate dosing rate. Scanning transmission electron microscopy (STEM) measurementsshowed number-average diameters in the range 16 – 19 nm with 1.14 – 1.15 in polydispersity,determined as the ratio of weight-average to number-average diameter. Drug contents in nano-particles close to 24% were determined by UV-Vis spectrophotometry, con¯rming the resultsobtained from a procedure that combines latex ¯ltration and quasielastic light scattering (QLS)measurements. Di®erential scanning calorimetry (CDSC) determinations suggest that at theibuprofen contents attained in this study, crystals and dispersed molecules of the drug coexistinside the nanoparticles. Based on the relative simplicity of the process it is expected that its usewill be adopted to prepare ultra¯ne nanoparticles composed of di®erent hydrophobic polymersand water insoluble drugs.
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Sebastia Sabater,Meritxell Arenas,Roberto Berenguer,Ignacio Andres,Esther Jimenez-Jimenez,Ana Martos,Jesus Fernandez-Lopez,Mar Sevillano,Angeles Rovirosa 대한암학회 2015 Cancer Research and Treatment Vol.47 No.3
Purpose Association between body mass index (BMI) and doses in organs at risk during postoperative vaginal cuff brachytherapy (VCB) treatment has not been evaluated. The aim of this study was to analyse the impact of BMI on the dose delivered to bladder and rectum during high-dose-rate VCB using computed tomography (CT) scans at every fraction. Materials and Methods A retrospective analysis of 220 planning CT sets derived from 59 patients was conducted. Every planning CT was re-segmented and re-planned under the same parameters. Rectum and bladder dose-volume histogram values (D0.1cc, D1cc, and D2cc) were extracted and evaluated. The mean values for all applications per patient were calculated and correlated with BMI, as well as other factors influencing rectal and bladder doses. Multiple regression analysis performed to model organ at risk dose-volume parameters. Results According to World Health Organization (WHO), 6.8% of patients were normal, 35.6% were overweight, and 57.6% were class I obese. Median rectal doses were 133.5%, 110.9%, and 99.3% for D0.1cc, D1cc, and D2cc, respectively. The corresponding median bladder doses were 96.2%, 80.6%, and 73.3%, respectively. BMI did not show significant association with rectal doses. However, BMI did show a significant association with evaluated bladder dose metrics (D0.1cc, r=–0.366, p=0.004; D1cc, r=–0.454, p < 0.001; D2cc, r=–0.451, p < 0.001). BMI was retained in the multivariate regression models (D0.1cc, p=0.004; D1cc, p < 0.001; D2cc, p=0.001). Conclusion In this group of Mediterranean, overweight, and moderately obese patients, BMI showed association with lower bladder dose values, but not with rectal doses.
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