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Choi, S.W.,Shin, H.K.,Yang-Yen, H.F.,Lee, M.S.,Lee, C.H.,Park, S.J.,Kim, K.J.,Lee, K.,Kim, S.H. North-Holland Pub ; Elsevier Science Ltd 2014 FEBS letters Vol.588 No.21
Translationally-controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation. Previous observations of a twofold induction of TCTP mRNA during osteoclast differentiation prompted us to investigate its involvement in osteoclast differentiation. The osteoclastogenicity of TCTP gradually expressed during osteoclast differentiation was confirmed in mouse and human cells using loss-of-function studies and TCTP heterogeneous mice and transgenic mice. Higher expression ratios of TCTP to p21 could represent TCTP-mediated phenotypic induction of osteoclast differentiation accompanied by p21 down-regulation, attenuating the proliferation of osteoclast precursor cells.
Relative Genetic Effects of Duroc and Taoyuan Breeds on the Economic Traits of Their Hybrids
Yen, N.T.,Tai, C.,Cheng, Y.S.,Huang, M.C. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.4
For determining the relative genetic effects of Duroc (D) and Taoyuan (T) breeds on the economic traits of their hybrids, 72 litters of pigs, from four mating types, namely TT (T♂$\times$T♀), DD (D♂$\times$D♀) and D-T hybrids (TD, T♂$\times$D♀ and DT, D♂$\times$T♀) were used in this study. The various crossbreeding parameters were estimated by comparisons among mating types using linear contrasts of least-square analysis. The results of reproductive traits analysis showed that T breed had contributed superior genetic effects on the total number of piglets at birth (TBN) (p<0.10) and number of live piglets at 21 days (LP21) (p<0.05) to the D-T hybrids. Estimates of maternal genetic effects showed that the T females were superior in TBN (p<0.05), but inferior in average birth weight (ABW) and average litter birth weight (LBW) (p<0.01) to the D females. Direct heterosis effects were significant for LBW, LP21 and LWT21 (p<0.01). Least-squares analysis of other economic traits showed that T breed had relative negative effects on all growth traits, withers height (WH), body type index (BTI), average backfat thickness (ABF), carcass length (LENG), loin eye area (longissimus) (LEARA), and lean percentage (LEAN) of D-T hybrids (p<0.05). Estimates of direct genetic effects showed that the D breed was superior to the T breed in all growth and carcass traits except the average backfat (BF). Estimates of maternal genetic effects showed that average body weight at 180 days (WT180) of progenies from T sows were lighter than from D sows. Progenies from D females had larger and leaner carcass than those from T females. Direct heterosis effects were significant for average daily weight gains from 150 to 180 days ($ADG_{150-180}$) (p<0.05) and for average body weights at 150 (WT150), and 180 days (WT180), average daily weight gains from birth to 150 and 180 days ($ADG_{150}$ and $ADG_{180}$, respectively), WH, body length (BL), ABF, BTI, and LENG (p<0.01). The results showed that D-T hybrids tended to have superior TBN and LP21 than D breed, and to be superior in all growth and most conformation and carcass traits to the T breed.
Hwang K.S.,Wu M.W.,Yen F.C.,Sun C.C. 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
Homogeneous microstructures of the PM compacts are difficult to attain when mixed elemental powders are used. This study examined the microstructures of pressed-and-sintered and MIM products that contain Ni and Mo.Ni-rich areas, which were lean in carbon and were soft and were found easily in regular specimens. Gaps or cracks near the Ni-rich or Mo-rich areas were also frequently observed. This problem worsened when Ni and Mo particles were large and were irregular in shape. By using ball milling treatment and ferroalloy powders, the microstructure homogeneity and mechanical properties were improved. The addition of 0.5wt%Cr further improved the distribution of Ni because Cr reduced the repulsion effect between nickel and carbon. With the elimination of Ni-rich areas, more bainites and martensites were formed and mechanical properties were significantly improved.
Gwo Giun Lee,Yen-Kuang Chen,Mattavelli, M.,Jang, E.S. IEEE 2009 IEEE transactions on circuits and systems for vide Vol.19 No.11
<P>Concurrently exploring both algorithmic and architectural optimizations is a new design paradigm. This survey paper addresses the latest research and future perspectives on the simultaneous development of video coding, processing, and computing algorithms with emerging platforms that have multiple cores and reconfigurable architecture. As the algorithms in forthcoming visual systems become increasingly complex, many applications must have different profiles with different levels of performance. Hence, with expectations that the visual experience in the future will become continuously better, it is critical that advanced platforms provide higher performance, better flexibility, and lower power consumption. To achieve these goals, algorithm and architecture co-design is significant for characterizing the algorithmic complexity used to optimize targeted architecture. This paper shows that seamless weaving of the development of previously autonomous visual computing algorithms and multicore or reconfigurable architectures will unavoidably become the leading trend in the future of video technology.</P>
Kim, T. Y.,Yen, C. J.,Al-Batran, S. E.,Ferry, D.,Gao, L.,Hsu, Y.,Cheng, R.,Orlando, M.,Ohtsu, A. Springer Science + Business Media 2018 Gastric cancer Vol.21 No.2
<P>Conclusions This exploratory analysis suggests a positive relationship between efficacy and ramucirumab exposure with manageable toxicities in East Asian patients from RAINBOW, consistent with the overall exposure-response analysis from this trial. A regimen with a higher dosage of ramucirumab warrants further consideration for East Asian patients with gastric/GEJ cancer.</P>