A Comparative Experimental Study of the, In-vitro Efficiency of Hypertonic, Saline-Enhanced Hepatic Bipolar and, Monopolar Radiofrequency Ablation

Lee, Jeong Min,Han, Joon Koo,Kim, Se Hyung,Sohn, Kyu Li,Lee, Kyoung Ho,Ah, Su Kyung,Choi, Byung Ihn Korean Radiological Society 2003 Korean Journal of Radiology Vol.4 No.3

급성 A형 간염에 병발한 급성신부전 2 례

홍수민;박경식;박일권;손형래;구호석;고행일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Hepatitis A is a mild, self-limiting disease of the liver, critical complications of which, such as acute kidney injury, are rare. Two cases of patients with acute hepatitis A who had an acute renal failure complication are reported herein. The first case is that of a 30-year-old man who showed up at the author’s hospital complaining of fever and myalgia. His laboratory tests upon his admission showed 9,520 lU/L of aspartate transaminase, 5,600 lU/L of alanine transaminase, 31.9 mg/dL of blood urea nitrogen, and 5.5 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. Upon his admission, supportive treatment was started, which included fluid therapy. The laboratory tests on the next day showed 53 mg/dL of blood urea nitrogen, 9.9 mg/dL of creatinine, and lower urine output per day. Renal replacement therapy was performed only once. A renal biopsy was performed and the result was Acute Tubular Necrosis (ATN). The patient recovered from acute renal failure without sequela. In the second case, a 35-year-old man complained of fever and abdominal pain. His laboratory tests upon his admission showed 8,570 lU/L of aspartate transaminase, 4,510 lU/L of alanine transaminase, 16 mg/dL of blood urea nitrogen, and 1.19 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. He experienced acute renal failure and recovered after two-time renal replacement therapy. The result of the renal biopsy was Acute Tubular Necrosis and C1q nephropathy.

Nonalcoholic Fatty Liver Disease is Associated with Coronary Artery Calcification in Asymptomatic Individuals

( Kyoung Min Sohn ),( Younju Jeon ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Nonalcoholic fatty liver disease (NAFLD) is related closely to risk factors for coronary artery disease (CAD), but it is unclear whether NAFLD independently contributes to asymptomatic individuals. Coronary artery calcium (CAC) scanning is the predictor of coronary events. We investigated the association of coronary artery calcification with NAFLD in asymptomatic adults. Methods: This is the cross-sectional study performed in Hansol Hospital Healthcare Center. NAFLD was defined as cases with the typical ultrasonographic findings without excessive alcohol consumption, medications causing hepatic steatosis or other chronic liver diseases. CAC was evaluated using the Agatston method. Results: We enrolled 312 subjects (mean age, 46.8 ± 8.7 years; 60.7% males) without known liver disease or a history of ischemic heart disease. NAFLD was found in 27% of the enrolled 312 subjects and CAC > 100 with moderate-high risk of CAD was found in 10.3% of subjects. Male gender (odds ratios (OR), 2.857; 95% confidence intervals (CI), 1.169-6.147), diabetes mellitus (OR, 2.739; 95% CI, 1.092-5.638), increased age (OR, 1.208; 95% CI, 1.071-1.316), and NAFLD (OR, 1.862; 95% CI, 1.065-3.592) were the independent factors that increased the risk of CAC > 100 in binary logistic regression. Conclusions: NAFLD is associated with increased coronary artery calcification independent of traditional risk factors. The assessment of CAC may be useful in identifying NAFLD patients at risk of future cardiovascular events even in asymptomatic individuals.

Adipolysis efficacy of aged black garlic extract in 3T3-L1 adipocytes (초)

( Kyoung Min Sohn ),( Harry Jung ),( Yoon Yi Nam ),( S Karuppasamy ),( Jun Gyo Suh ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

A Case of Genotype-4 Acute Hepatitis E

( Kyoung Min Sohn ),( In-soo Choi ),( Gyu Young Jeong ),( Youn Ju Jeon ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Acute hepatitis E is an endemic disease, commonly reported in Africa, and Southeast and Central Asia. It is a self-limiting disease like other acute hepatitis except in pregnant patient. Although sporadic cases of acute hepatitis E also have been reported in developed countries, most of them are associated with travel history to HEV-endemic area. In Korea, Hepatitis E is rarely reported. Moreover, sporadic acute hepatitis E without travel history to HEV-endemic area is very rare. Methods: We experienced a sporadic cases of acute hepatitis E, without travel history. Results: A 54-year-old female presented with nausea and abdominal discomfort and elevated aminotransferase. She had not recently traveled abroad. On the 7th day of hospitalization the patient was diagnosed with acute viral hepatitis E. It was positive for IgM anti-HEV and showed no evidence of other viral infections or drug ingestion history. Phylogenetic analysis of her serum revealed genotype-4 HEV, but she denied eating any raw meat. In her comprehensive history taking, recently she had a history of eating wild plants such as acorns picked up from the mountains near Seoul. Symptoms and aminotransferase levels were normalized during hospitalization. Conclusions: This is the third case of HEV genotype 4 in Koreans who has been confirmed by phylogenetic analysis and is the first case of ingesting plants that are not wild animals. This case suggest that HEV infection occurs sporadically in Korea and should be considered as a cause of cryptogenic acute hepatitis.

Are there Beneficial Effects of Lifestyle Intervention in Non-Obese Patients with Non-Alcoholic Fatty Liver Disease?

( Kyoung Min Sohn ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Currently, the population prevalence of NAFLD in Asia is around 25%, like many Western countries. Around 8-19% of patients with non-alcoholic fatty liver disease (NAFLD) are non-obese. The benefit of weight reduction in such patients is unclear. We aim to study the efficacy of lifestyle intervention in non-obese patients with NAFLD and to identify factors that predict treatment response. Methods: A total of 50 community NAFLD patients were randomized to a 12-month lifestyle intervention program involving regular exercise, or to standard care. The primary outcome was to improve NAFLD at Month 12 by Abdominal Ultrasonography. After the program, the patients were prospectively followed until Year 3. The Asian body mass index (BMI) cut-off of 25 kg/m2 was used to define non-obese NAFLD. Results: Patients were assigned to the intervention (n=25) and control (n=25) groups. More patients in the intervention group achieved the primary outcome than the control group regardless of baseline BMI (non-obese: 64% vs. 18%, P<0.001; obese: 58% vs. 21%, P<0.001). Lifestyle intervention, lower baseline triglyceride, and reduction in body weight and waist circumference were independent factors associated with remission of NAFLD in non-obese patients. Half of the non-obese patients achieved remission of NAFLD with 3-5% weight reduction; the same could only be achieved in obese patients with 7-10% weight reduction. By Year 3, non-obese patients in the intervention group remained more likely to maintain weight reduction and alanine aminotransferase normalization than the control group. Conclusions: Lifestyle interventions are effective in improving NAFLD in both obese and non-obese patients. Moderate weight loss may be sufficient, especially in non-obese patients.

Association between Nonalcoholic Fatty Liver Disease and Metabolic Syndrome in an urban hospital (초)

( Kyoung Min Sohn ),( Yeon Ju Jeon ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

Clinical Correlation between Coronary Artery Disease and Nonalcoholic Fatty Liver Disease Using Coronary Calcium Scan

( Kyoung Min Sohn ) 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1

HCV : PE-102 ; Non-invasive estimation of significant and severe portal hypertension using contrast-enhanced ultrasonography: analysis of hepatic venous transit time and time-intensity curve

( Woo Kyoung Jeong ),( Yongsoo Kim ),( Min Yeong Kim ),( Tae Yeob Kim ),( Joo Hyun Sohn ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: To investigate parameters of hepatic perfusion study to estimate significant (HVPG >10 mmHg) and severe (>12 mmHg) portal hypertension (PH) in liver cirrhosis using contrast-enhanced ultrasonography (CEUS). Methods: This prospective study was approved by our institutional review board. After getting informed consent, healthy volunteers (n=7) and patients with chronic liver disease (n=45) who underwent hepatic venous catheterization through transjugular approach to measure hepatic venous pressure gradient (HVPG) also underwent CEUS of the liver parenchyma. Video clips were obtained using a built-in recording function on the US equipment at 8 to 10 frames/sec of frame rate for 3 minutes after contrast injection. To quantify perfused microbubblesin the liver, time-intensity curves were obtained by tracking regions of interest on cine images and subsequently analysed. Measurement of signal intensity was performed by using ‘measure stack’ function on ImageJ software. Intrahepatic transit time (IHTT), hepatic parenchymal transit time (HPTT), peak signal intensity (PSI), arrival time to PSI (TPSI), and retention rate at 3 minutes after injection (RR3min) were explored as parameters of hepatic perfusion study. Spearman’s correlation test was used to evaluate the relationship to HVPG and receiver operating characteristics (ROC) curve analysis was used for diagnostic performance of each parameter in estimating significant or severe PH. Results: HVPG was correlated best with IHTT (rho = -0.531; p <.05) and moderately with HPTT and PSI (rho = -0.329 and -0.281; p <.05), while TPSI and RR3min were not significantly correlated (rho = -0.052 and 0.212; p >.05). Areas under the ROC curves (AUROC) regarding diagnosis of significant PH (n = 39/52) were 0.812 of IHTT, 0.685 of HPTT, and 0.727 of PSI (all p <.05). In case of severe PH (n = 37/52), AUROC were 0.843 of IHTT, 0.688 of HPTT, and 0.728 of PSI (all p <.05). IHTT under 7 seconds referred to significant PH with a sensitivity of 92%. Conclusions: Hepatic perfusion study using CEUS can be useful to estimate the grade of PH and to diagnose significant and severe PH without need for catheterization.

Basic, HCC basic : PE-102 ; Non-invasive estimation of significant and severe portal hypertension using contrast-enhanced ultrasonography: analysis of hepatic venous transit time and time-intensity curve

( Woo Kyoung Jeong ),( Yongsoo Kim ),( Min Yeong Kim ),( Tae Yeob Kim ),( Joo Hyun Sohn ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: To investigate parameters of hepatic perfusion study to estimate significant (HVPG >10 mmHg) and severe (>12 mmHg) portal hypertension (PH) in liver cirrhosis using contrast-enhanced ultrasonography (CEUS). Methods: This prospective study was approved by our institutional review board. After getting informed consent, healthy volunteers (n=7) and patients with chronic liver disease (n=45) who underwent hepatic venous catheterization through transjugular approach to measure hepatic venous pressure gradient (HVPG) also underwent CEUS of the liver parenchyma. Video clips were obtained using a built-in recording function on the US equipment at 8 to 10 frames/sec of frame rate for 3 minutes after contrast injection. To quantify perfused microbubbles in the liver, time-intensity curves were obtained by tracking regions of interest on cine images and subsequently analysed. Measurement of signal intensity was performed by using ``measure stack`` function on ImageJ software. Intrahepatic transit time (IHTT), hepatic parenchymal transit time (HPTT), peak signal intensity (PSI), arrival time to PSI (TPSI), and retention rate at 3 minutes after injection (RR3min) were explored as parameters of hepatic perfusion study. Spearman`s correlation test was used to evaluate the relationship to HVPG and receiver operating characteristics (ROC) curve analysis was used for diagnostic performance of each parameter in estimating significant or severe PH. Results: HVPG was correlated best with IHTT (rho = -0.531; p <.05) and moderately with HPTT and PSI (rho = -0.329 and -0.281; p <.05), while TPSI and RR3min were not significantly correlated (rho = -0.052 and 0.212; p >.05). Areas under the ROC curves (AUROC) regarding diagnosis of significant PH (n = 39/52) were 0.812 of IHTT, 0.685 of HPTT, and 0.727 of PSI (all p <.05). In case of severe PH (n = 37/52), AUROC were 0.843 of IHTT, 0.688 of HPTT, and 0.728 of PSI (all p <.05). IHTT under 7 seconds referred to significant PH with a sensitivity of 92%. Conclusions: Hepatic perfusion study using CEUS can be useful to estimate the grade of PH and to diagnose significant and severe PH without need for catheterization.