Physiological influences on drug transport across human stratum corneum in vivo

( Jui Chen Tsai ),( Hamm Ming Sheu ),( Ming Kai Lin ) 한국피부장벽학회 2008 한국피부장벽학회지 Vol.10 No.2

This paper discusses the influences of physiological factors including anatomical sites and sebum secretion on drug transport across human stratum corneum (SC) in vivo by utilizing noninvasive, quantitative attenuated-total-reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) technology. 4-Cyanophenol (CP) and cimetidine (CM) were selected as two model compounds of different lipophilicity and molecular size. To investigate regional variation, saturated solutions of CP and CM were applied to the skin surface of Chinese males, at five anatomical sites, including forearm, back, thigh, leg, and abdomen, followed by sequential tape-stripping of SC. The drug concentration profiles in the tape-stripped SC were determined using ATR-FTIR spectroscopy. Thickness of the SC was estimated simultaneously using two-point measurements of transepidermal water loss before and after completion of tape stripping. Estimation of partition, diffusion and permeability coefficients was achieved by analysis of the data using the unsteady-state diffusion equation. The results demonstrated the rank order of regional variation in permeability coefficients was similar for both drugs and decreased in the order of back > forearm > thigh > leg ≥ abdomen, but the variation was more prominent for CM. Regional variation in SC transport of CP was mainly influenced by its intrinsic diffusivity across the SC, whereas variation in transport of CM could be attributed to both thermodynamic and kinetic differences among different anatomical skin sites. Similar methodology was applied to study the effects of sebum on SC drug transport. We found that sebum supplement increased the SC permeability of CM at the forearm for more than three fold, but not that of CP. The increase in SC permeability of CM was mainly attributed to the enhanced SC diffusivity. Sebum removal at the forehead has small, but significant effect on the SC permeability of CM. SC permeability of CM was linearly correlated to the frequency shift of CH2 asymmetric/symmetric stretching in the ATR-FTIR spectra of the SC due to sebum treatment. Sebum treatment increased the SC permeability of relatively hydrophilic drug and altered the barrier function of stratum corneum by disordering structures of the intercellular lipid molecules.

Applying Multi-Objective Planning in Low-Carbon Product Design

Tsai Chi Kuo,Hsiao Min Chen,Chia Yi Liu,Jui-Che Tu,Tzu-Chang Yeh 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

In low-carbon product design, product environment, as well as economic and manufacturing capabilities, should be considered simultaneously. The purpose of this paper is to improve the product carbon footprint calculation efficiency. This study not only considers cost, supplier manufacturing capacity, and transport modes of product components from the viewpoint of low-carbon product design, but it also provides information on product GHG values, design phase cost, as well as the product decisions made by enterprises. In this way, enterprise objectives about carbon footprints and product cost can be met. Based on the product life cycle and product category specifications, this study, following the actual industry process flow, collects and calculates data on GHG emissions of components within the product life cycle, cost and supplier production capacity. The aim is to determine the operational parameters and constraint equations. Multi-objective planning is used to establish a low carbon optimal evaluation model. By reviewing carbon emissions in each phase, the study further determines whether or not to modify product structure and consumption in order to improve the efficiency of product carbon footprint calculation, reduce R&D cost, and help enterprises design low-carbon products. Finally, the findings are used for a case analysis.

An Innovated Business Model with Value-Added Service for the Logistics Industry in Taiwan

Kai-Ying Chen,Pei-Fang (Jennifer) Tsai,Mei-Lin Fan,Jui-Ting Shen,Ming-Ren Chiou 대한산업공학회 2015 대한산업공학회 추계학술대회논문집 Vol.2015 No.11

The pace of globalization has been accelerated along with the surge in free trade agreements (FTA) among various nations. Facing the emergence of global value chains, companies need to integrate the flows of manufacturing goods and international trades more dynamically with other participants in the entire supply chain. The increasing growth of international transportation requires the third party logistics to provide delivery services more timely and efficiently. This case study describes how a third-party logistics company tried to develop new value-added services utilizing the free trade zone (FTZ) in Taiwan with its customer by simplifying associated shipping processes from manufacturing to retailing across multiple locations.

Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry

Wei-Yi Lei,Tso-Tsai Liu,Wei-Chuan Chang,Chih-Hsun Yi,Jui-Sheng Hung,Ming-Wun Wong,Shu-Wei Liang,Lin Lin,Chien-Lin Chen 대한소화기 기능성질환∙운동학회 2024 Journal of Neurogastroenterology and Motility (JNM Vol.30 No.1

Background/AimsThis study aims to evaluate the effects of acute codeine administration on primary and secondary esophageal peristalsis in patients with ineffective esophageal motility (IEM). MethodsEighteen IEM patients (8 women; mean age 37.8 years, range 23-64 years) were enrolled in the study. The patients underwent high-resolution manometry exams, consisting of 10 single wet swallows, multiple rapid swallows, and ten 20 mL rapid air injections to trigger secondary peristalsis. All participants completed 2 separate sessions, including acute administration of codeine (60 mg) and placebo, in a randomized order. ResultsCodeine significantly increased the distal contractile integral (566 ± 81 mmHg∙s∙cm vs 247 ± 36 mmHg∙s∙cm, P = 0.001) and shortened distal latency (5.7 ± 0.2 seconds vs 6.5 ± 0.1 seconds, P < 0.001) for primary peristalsis compared with these parameters after placebo treatment. The mean total break length decreased significantly after codeine treatment compared with the length after placebo (P = 0.003). Codeine significantly increased esophagogastric junction-contractile integral (P = 0.028) but did not change the 4-second integrated relaxation pressure (P = 0.794). Codeine significantly decreased the frequency of weak (P = 0.039) and failed contractions (P = 0.009), resulting in increased frequency of normal primary peristalsis (P < 0.136). No significant differences in the ratio of impaired multiple rapid swallows inhibition and parameters of secondary peristalsis were detected. ConclusionsIn IEM patients, acute administration of codeine increases contraction vigor and reduces distal latency of primary esophageal peristalsis, but has no effect on secondary peristalsis. Future studies are required to further elucidate clinical relevance of these findings, especially in the setting of gastroesophageal reflux disease with IEM.

Topical Glucocorticosteroid and Epidermal Permeability Barrier

( Hamm Ming Sheu ),( Jui Chen Tsai ) 한국피부장벽학회 2004 한국피부장벽학회지 Vol.6 No.1

Esophageal Bolus Domain Pressure and Peristalsis Associated With Experimental Induction of Esophagogastric Junction Outflow Obstruction

( Wei-yi Lei ),( Taher Omari ),( Tso-tsai Liu ),( Ming-wun Wong ),( Jui-sheng Hung ),( Chih-hsun Yi ),( Shu-wei Liang ),( Charles Cock ),( Chien-lin Chen ) 대한소화기기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.1

Background/Aims Intrabolus pressures are important for esophageal bolus transport and may detect obstructed bolus flow. This study measured the effect esophageal outflow obstruction experimentally induce by a leg-lift protocol. Methods Twenty-five gastroesophageal reflux disease patients referred for esophageal manometry and a normal motility diagnosis were included. Supine liquid swallows were tested. Leg-lift protocol generated esophageal outflow obstruction by increasing abdominal pressure. Esophageal pressure topography and intrabolus pressure metrics were calculated. These included, (1) mid-domain bolus distension pressure during esophageal emptying (DPE, mmHg) and (2) ramp pressure (mmHg/sec), generated by compression of the bolus between the peristaltic contraction and esophagogastric junction (EGJ). Results EGJ relaxation pressure was increased by leg-lift from 13 (11-17) to 19 (14-30) mmHg (P < 0.005) and distal contractile integral also increased from 1077 (883-1349) to 1620 (1268-2072) mmHgㆍcmㆍsec (P < 0.001) as a physiological response to obstruction. All bolus pressures were increased by leg lift; DPE increased from 17 (15-20) to 27 (19-32) mmHg (P < 0.001), and ramp pressure increased from 3 (1-4) to 5 (2-9) mmHg/sec (P < 0.05). Conclusion Measuring pressures within the intrabolus domain can quantify changes related to obstruction to outflow and may serve as adjunct measures for confirming a diagnosis EGJ outflow obstruction. (J Neurogastroenterol Motil 2022;28:62-68)

The development of Taiwan Fracture Liaison Service network

Lo-Yu Chang,Keh-Sung Tsai,Jen-Kuei Peng,Chung-Hwan Chen,Gau-Tyan Lin,Chin-Hsueh Lin,Shih-Te Tu,I-Chieh Mao,Yih-Lan Gau,Hsusan-Chih Liu,Chi-Chien Niu,Min-Hong Hsieh,Jui-Teng Chien,Wei-Chieh Hung,Rong-S 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.2

Osteoporosis and its associated fragility fractures are becoming a severe burden in the healthcare system globally. In the Asian-Pacific (AP) region, the rapidly increasing in aging population is the main reason accounting for the burden. Moreover, the paucity of quality care for osteoporosis continues to be an ongoing challenge. The Fracture Liaison Service (FLS) is a program promoted by International Osteoporosis Foundation (IOF) with a goal to improve quality of postfracture care and prevention of secondary fractures. In this review article, we would like to introduce the Taiwan FLS network. The first 2 programs were initiated in 2014 at the National Taiwan University Hospital and its affiliated Bei-Hu branch. Since then, the Taiwan FLS program has continued to grow exponentially. Through FLS workshops promoted by the Taiwanese Osteoporosis Association (TOA), program mentors have been able to share their valuable knowledge and clinical experience in order to promote establishments of additional programs. With 22 FLS sites including 11 successfully accredited on the best practice map, Taiwan remains as one of the highest FLS coverage countries in the AP region, and was also granted the IOF Best Secondary Fracture Prevention Promotion award in 2017. Despite challenges faced by the TOA, we strive to promote more FLS sites in Taiwan with a main goal of ameliorating further health burden in managing osteoporotic patients.

Human sebum-from sebaceous gland to skin surface Lipid film and its effects on cutaneous permeability barrier and drug transport across the stratum corneum

( Hamm Ming Sheu ),( Yun Ting Su ),( Cheng Che. E. Lan ),( Jui Chen Tsai ) 한국피부장벽학회 2007 한국피부장벽학회지 Vol.9 No.2

Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility

Wei-Yi Lei,Shu-Wei Liang,Taher Omari,Wei-Chuan Chang,Ming-Wun Wong,Jui-Sheng Hung,Chih-Hsun Yi,Tso-Tsai Liu,Lin Lin,C Prakash Gyawali,Chien-Lin Chen 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.4

Background/Aims Straight leg raise (SLR) can be utilized to evaluate the integrity of the esophagogastric junction during high-resolution manometry (HRM). We aim to assess the value of transient hiatal separation during SLR in symptomatic reflux patients. Methods Consecutive reflux patients undergoing esophageal HRM and pH monitoring were included. Transient hiatal separation was defined by a ≥ 1 cm separation between the lower esophageal sphincter and crural diaphragm during SLR. We compared esophageal motor patterns and reflux monitoring parameters between patients with normal, transiently abnormal and consistently abnormal esophagogastric junction morphology during SLR. Results Of 85 (56.3% female, mean age: 46.7 ± 12.3 years) completed SLR, esophagogastric junction morphology was normal in 31 (36.5%), transient hiatal separation in 19 (22.3%), and consistently hiatal hernia in 35 (41.2%). The values of total acid exposure time (P = 0.016), longest acid reflux episodes (P = 0.024), and DeMeester scores (P = 0.016) were higher in hiatal hernia compared to patients with non-transient hiatal separation, but there were no differences between those with and without transient hiatal separation. Within ineffective esophageal motility, the presence of transient hiatal separation during SLR significantly associated with a higher total acid exposure time (P = 0.014), higher DeMeester scores (P = 0.019), higher total acid reflux events (P = 0.037), and higher longest acid reflux episodes (P = 0.006). Conclusion Our work suggests that SLR may have value as a provocative test during HRM, and future outcome studies are warranted to elucidate the clinical relevance of motor abnormalities depicted from SLR.