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HER2 Status and Its Heterogeneity in Gastric Carcinoma of Vietnamese Patient
Dang Anh Thu Phan,Vu Thien Nguyen,Thi Ngoc Ha Hua,Quoc Dat Ngo,Thi Phuong Thao Doan,Sao Trung Nguyen,Anh Tu Thai,Van Thanh Nguyen 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.4
Background: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy with trastuzumab. Methods: We investigated 208 gastric cancer specimens using immunohistochemistry (IHC), fluorescence in situ hybridization and dual in situ hybridization (ISH). We also investigated the concordance between IHC and ISH. The correlation between HER2 status and various clinicopathological findings was also investigated. Results: In total, 15.9% (33/208) and 24.5% (51/208) of gastric cancers showed HER2 gene amplification and protein overexpression, respectively. A high level of concordance between ISH and IHC analyses (91.3%, κ = 0.76) was found. A significant correlation between HER2 status and intestinal-type (p < .05) and differentiated carcinomas (p < .05) was also noted. The HER2 heterogeneity was high in gastric cancers; we found 68.8% phenotypic heterogeneity and 57.6% genotypic heterogeneity. Heterogeneity in HER2 protein expression and gene amplification showed a close association with diffuse histologic type and IHC 2+. Conclusions: HER2 protein overexpression and gene amplification were detected in 24.5% and 15.9% of gastric cancer specimens, respectively. Intestinal-type showed a higher level of HER2 protein overexpression and gene amplification than diffuse type. HER2 status also showed a significant relationship with well- and moderately-differentiated carcinomas. The ratio of phenotypic and genotypic heterogeneity of HER2 was high in gastric carcinomas and was associated with HER2 IHC 2+ and diffuse histologic type.
Nguyen Duc Anh,Pham Van Thanh,Doan Tu Lap,Nguyen Tuan Khai,Tran Van An,Tran Duc Tan,Nguyen Huu An,Dang Nhu Dinh 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.2
Forest fires inflict great losses of human lives and serious damages to ecological systems. Hence, numerous fire detection methods have been proposed, one of which is fire detection based on sensors. However, these methods reveal several limitations when applied in large spaces like forests such as high cost, high level of false alarm, limited battery capacity, and other problems. In this research, we propose a novel forest fire detection method based on image processing and correlation coefficient. Firstly, two fire detection conditions are applied in RGB color space to distinguish between fire pixels and the background. Secondly, the image is converted from RGB to YCbCr color space with two fire detection conditions being applied in this color space. Finally, the correlation coefficient is used to distinguish between fires and objects with fire-like colors. Our proposed algorithm is tested and evaluated on eleven fire and non-fire videos collected from the internet and achieves up to 95.87% and 97.89% of F-score and accuracy respectively in performance evaluation.
Copper Tolerance of Novel Rhodotorula sp. Yeast Isolated from Gold Mining Ore in Gia Lai, Vietnam
Kim Cuc Thi Nguyen,Phuc Hung Truong,Cuong Tu Ho,Cong Tuan Le,Khoa Dang Tran,Tien Long Nguyen,Manh Tuan Nguyen,Phu Van Nguyen 한국균학회 2023 Mycobiology Vol.51 No.6
In this study, twenty-five yeast strains were isolated from soil samples collected in the goldmining ore in Gia Lai, Vietnam. Among them, one isolate named GL1T could highly tolerateCu2þ up to 10 mM, and the isolates could also grow in a wide range of pH (3–7), and temperature(10–40 �C). Dried biomass of GL1 was able to remove Cu2þ effectively up to 90.49%with a maximal biosorption capacity of 18.1 mg/g at pH 6, temperature 30 �C, and incubationtime 60 min. Sequence analysis of rDNA indicated this strain was closely related toRhodotorula mucilaginosa but with 1.53 and 3.46% nucleotide differences in the D1/D2domain of the 28S rRNA gene and the ITS1-5.8S rRNA gene-ITS2 region sequence, respectively. Based on phylogenetic tree analysis and the biochemical characteristics, the strainappears to be a novel Rhodotorula species, and the name Rhodotorula aurum sp. nov. is proposed. This study provides us with more information about heavy metal-tolerant yeasts andit may produce a new tool for environmental control and metal recovery operations.
Dieu Linh Tran,Anh Phuong Nguyen Hong,Ngoc Hoi Nguyen,Ngoc Trinh Huynh,Bao Ha Le Tran,Cam Tu Tran,Minh Dung Truong,Quan Dang Nguyen,박기동,Dai Hai Nguyen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
α-calcium sulfate hemihydrate (α-HH) was synthesized by salt solution methods to prepare a promising biomaterial for bone tissue repair and regeneration. The successful synthesis of α-HH was evaluated by field emission scanning electron microscopy (FE-SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) scanning. The sterility of α-HH before and after irradiation with gamma ray was firstly confirmed by Colonies Forming Units (CFU) counting assay, to target the surgical grade application. In vitro tetrazolium bromide (MTT) assay, crystal violet (CV) and acridine orange (AO) staining was performed to assess the initial cytotoxicity and cell attachment ability of α-HH. Further in vivo implantation into rabbit distal femoral condyles defect exhibited the ability of salt solution-synthesized α-HH to promote the localization of osteocytes and osteoblasts, which improve the bone tissue repair and regeneration. The findings suggested that α-calcium sulfate hemihydrate synthesized by salt solution method is a potential material that can be used as bone substitutes.
Thang Phan,Ha Phan Ai Nguyen,Cao Khoa Dang,Minh Tri Phan,Vu Thanh Nguyen,Van Tuan Le,Binh Thang Tran,Chinh Van Dang,Tinh Huu Ho,Minh Tu Nguyen,Thang Van Dinh,Van Trong Phan,Binh Thai Dang,Huynh Ho Ngo The Korean Society for Preventive Medicine 2023 예방의학회지 Vol.56 No.4
Objectives: The coronavirus disease 2019 (COVID-19) pandemic has increased the workload of healthcare workers (HCWs), impacting their health. This study aimed to assess sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and identify factors associated with poor sleep among HCWs in Vietnam during the COVID-19 pandemic. Methods: In this cross-sectional study, 1000 frontline HCWs were recruited from various healthcare facilities in Vietnam between October 2021 and November 2021. Data were collected using a 3-part self-administered questionnaire, which covered demographics, sleep quality, and factors related to poor sleep. Poor sleep quality was defined as a total PSQI score of 5 or higher. Results: Participants' mean age was 33.20±6.81 years (range, 20.0-61.0), and 63.0% were women. The median work experience was 8.54±6.30 years. Approximately 6.3% had chronic comorbidities, such as hypertension and diabetes mellitus. About 59.5% were directly responsible for patient care and treatment, while 7.1% worked in tracing and sampling. A total of 73.8% reported poor sleep quality. Multivariate logistic regression revealed significant associations between poor sleep quality and the presence of chronic comorbidities (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.17 to 5.24), being a frontline HCW directly involved in patient care and treatment (OR, 1.59; 95% CI, 1.16 to 2.16), increased working hours (OR, 1.84; 95% CI,1.37 to 2.48), and a higher frequency of encountering critically ill and dying patients (OR, 1.42; 95% CI, 1.03 to 1.95). Conclusions: The high prevalence of poor sleep among HCWs in Vietnam during the COVID-19 pandemic was similar to that in other countries. Working conditions should be adjusted to improve sleep quality among this population.
Nguyen, Cuong Thach,Le, Nhat-Tu,Tran, Thao Dang-Hien,Kim, Eun-Hye,Park, Sang-Sang,Luong, Truc Thanh,Chung, Kyung-Tae,Pyo, Suhkneung,Rhee, Dong-Kwon American Society for Microbiology 2014 Infection and immunity Vol.82 No.9
<P>Caseinolytic protease L (ClpL) is a member of the HSP100/Clp chaperone family, which is found mainly in Gram-positive bacteria. ClpL is highly expressed during infection for refolding of stress-induced denatured proteins, some of which are important for adherence. However, the role of ClpL in modulating pneumococcal virulence is poorly understood. Here, we show that ClpL impairs pneumococcal adherence to A549 lung cells by inducing and activating Rap1 and Rac1, thus increasing phosphorylation of cofilin (inactive form). Moreover, infection with a <I>clpL</I> mutant (Δ<I>clpL</I>) causes a greater degree of filopodium formation than D39 wild-type (WT) infection. Inhibition of Rap1 and Rac1 impairs filopodium formation and pneumococcal adherence. Therefore, ClpL can reduce pneumococcal adherence to A549 cells, likely via modulation of Rap1- and Rac1-mediated filopodium formation. These results demonstrate a potential role for ClpL in pneumococcal resistance to host cell adherence during infection. This study provides insight into further understanding the interactions between hosts and pathogens.</P>
Understanding the U.S.–Vietnam Security Relationship, 2011–2017
Dang Cam Tu,Hang Thi Thuy Nguyen 한국국방연구원 2019 The Korean Journal of Defense Analysis Vol.31 No.1
This paper seeks to explore the new dynamics of U.S.–Vietnam security relations from 2011 to 2017. It begins with a review of the attempts before 2011 to establish a foundation for a normal security relationship between the United States and Vietnam, and progresses in the scope and pace of the bilateral relationship in this field. The paper then examines the process of a deepening security relationship between the two countries from 2011 to 2017, focusing on the motivations for increased security cooperation and the developments in five main areas of cooperation, namely maritime security, high-level dialogues, search and rescue, humanitarian assistance and disaster relief, and peacekeeping operations. Finally, this paper looks at the potential and limits of the U.S.–Vietnam security relationship, analyzing the possibilities for building a more balanced and effective security relationship and the limitations of U.S.–Vietnam security cooperation. In conclusion, the authors argue that the years from 2011 to 2017 witnessed new and positive moves in the U.S.–Vietnam security relationship. This is a highly signicant development for Vietnam and the United States and an illustration of the fast geostrategic change underway in the Asia–Pacic region in the post–Cold War.
Thu Dang Anh Phan,Bao Gia Phung,Tu Thanh Duong,Vu Anh Hoang,Dat Quoc Ngo,Nguyen Dinh The Trinh,Tung Thanh Tran 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.2
Background: Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH. Methods: We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed. Results: BRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF V600E mutation rate than a single system (p = .001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression. Conclusions: In Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems.