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Ngoc Nhon Hoang,Tri Khoi Nguyen,Tuyet Hoa Vo,Ngoc Hoi Nguyen,Dai Hai Nguyen,Dieu Linh Tran 한국고분자학회 2022 Macromolecular Research Vol.30 No.2
Fucoidan, a natural sulfated polysaccharide extracted from seaweed, has been widely used in pharmaceutical field due to its excellent biological activities including antiviral, anticancer, antioxidant, anticoagulant, etc. Therefore, investigating the new natural sources of fucoidan has been received growing attention recently. This study reported for the first time the isolation, purification, characterization, and biological activities of fucoidan from Ceratophyllum submersum (FCS). The molecular weight of obtained FCS was 9.7 kDa, composed of fucose (42.11%) and sulfate (16.38%). The FCS contained (1→3)-α-L-Fucopyranose and β-D-galactose bond in the structure. In addition, FCS showed strong antioxidant properties against 2,2-diphenyl-1-picrylhydrazyl, 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid), and reactive oxygen species radicals with inhibitory concentration 50 values were 765.48 ppm, 845.31 ppm, and 1760.00 ppm, respectively. The FCS also performed good antibacterial, antifungal, anticoagulant and anti-inflammatory activityies. Especially, it expressed a better inhibition activity on breast cancer cell line (MCF-7) than that on liver cancer cells (HepG2), lung cancer cells (NCI-H460), and cervical cancer cells (HeLa). FCS demonstrated potential utility in functional food, cosmeceutical, and pharmaceutical industries. In the trend of discovering new sources for fucoidan with outstanding bioactivities, this report would contribute a basic platform and valuable information for further studies on fucoidan from C. Submersum.
Taxus wallichiana Zucc. 현탁세포에서 Jasmonic Acid-Cellulase 복합 Elicitor가 Paclitaxel 생합성에 미치는 영향
Nguyen Ngoc Hoi,Hoang Van Luong,Nguyen Van Long,Vu Binh Duong,변상요(Sang Yo Byun) 한국생물공학회 2010 KSBB Journal Vol.25 No.2
Taxus wallichiana Zucc. 현탁세포배양에서 항암제 paclitaxel 생합성 연구를 수행하였다. 현탁세포배양에서 exponential phase의 최고 생장 속도는 0.14 day-1이었으며 배가시간이 4.96 day이었다. Paclitaxel은 배양초기에 생성되지 않고 exponential phase 말기부터 서서히 생성되어 stationary phase에서도 이어지며 declined phase에서 최고치를 나타내었다. Paclitaxel의 생산을 촉진하기 위하여 elicitor를 사용하였다. 여러 elicitor 중 jasmonic acid와 cellulase가 paclitaxel의 생성을 증가시켰다. Elicitor는 접종과 동시에 투여했을 때 가장 효과가 좋았으며, jasmonic acid와 cellulase의 combination으로 효과가 더욱 증진했는데 각각 투여할 때보다 1.8배 및 3.1배 paclitaxel 생성이 증가되었다. Cell cultures of Taxus wallichiana Zucc. were made to enhance the production of anticancer agent paclitaxel. In suspension cultures, the maximum cell growth rate in exponential growth phase was 0.14 day-1 which was correlated to 4.96 days of cell doubling time. The production of paclitaxel was non-growth associated. The paclitaxel production was started after the exponential growth phase and increased to declined phase where the maximum concentration was observed. Various elicitors were tested to enhance the production of paclitaxel. The combination of two elicitors of jasmonic acid and cellulase increased the production of paclitaxel 1.8 and 3.1 times compared to paclitaxel production by individual elicitor respectively.
Combined Changes of Process Conditions Improved Aromatic Properties of Vietnamese Robusta
Thi Ngoc Hoi Nguyen,변상요 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.2
The flavor and taste of coffee are affected by roasting conditions and extraction temperature. This study assessed changes in the flavors and tastes of coffee extracted from Vietnamese Robusta with different roasting times and temperatures, as well as different extraction temperatures. Vietnamese Robusta green beans were roasted for different times ranging from 5 to 20 min and at different temperatures ranging from 100 to 250oC. The roasted coffee was then extracted at five different temperatures ranging from 90 to 120oC. The coffee flavor was evaluated in terms of 5 key odorants: guaiacol; 4-ethylguaiacol; 2-ethyl-3,5-dimethylpyrazine; 2,3-diethyl-5-methylpyrazine,and 2-furfuryl. The taste of coffee was evaluated in terms of 6 main compounds that confer bitterness and sourness:caffeine, trigonelline, chlorogenic acid and citric acid, acetic acid, formic acid. The optimized roasting and extracting conditions were identified that 200 g of VN Robusta green beans, roasting at 230oC for 18 min, and then extracted with Espresso Machine at 110oC.
Dieu Linh Tran,Anh Phuong Nguyen Hong,Ngoc Hoi Nguyen,Ngoc Trinh Huynh,Bao Ha Le Tran,Cam Tu Tran,Minh Dung Truong,Quan Dang Nguyen,박기동,Dai Hai Nguyen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
α-calcium sulfate hemihydrate (α-HH) was synthesized by salt solution methods to prepare a promising biomaterial for bone tissue repair and regeneration. The successful synthesis of α-HH was evaluated by field emission scanning electron microscopy (FE-SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) scanning. The sterility of α-HH before and after irradiation with gamma ray was firstly confirmed by Colonies Forming Units (CFU) counting assay, to target the surgical grade application. In vitro tetrazolium bromide (MTT) assay, crystal violet (CV) and acridine orange (AO) staining was performed to assess the initial cytotoxicity and cell attachment ability of α-HH. Further in vivo implantation into rabbit distal femoral condyles defect exhibited the ability of salt solution-synthesized α-HH to promote the localization of osteocytes and osteoblasts, which improve the bone tissue repair and regeneration. The findings suggested that α-calcium sulfate hemihydrate synthesized by salt solution method is a potential material that can be used as bone substitutes.
The Impact of Credit on Income Inequality in Vietnam
LE, Quoc Hoi,NGUYEN, Bich Ngoc Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.5
This paper examines the impacts of credit on income inequality in Vietnam. Though it is one of the most common measures of financial development, there is a dearth of research in this area. Unlike previous studies, the paper disaggregates the impact of each type of credit on income inequality, looking at the Gini coefficient. We employ the Generalized Method of Moment (GMM) to solve the endogenous problem. The primary data set contains a panel of 60 Provincial observations, from data collected from the General Statistics Office of Vietnam from 2002 to 2016. The empirical findings show that, while commercial credit increases income inequality, policy credit contributes to reducing income inequality in Vietnam. The results also confirm the important roles of education, institutional quality and foreign direct investment in fighting against income inequality in Vietnam. However, the paper does not provide adequate evidence to support the inverted U-shaped relationship between credit and income inequality. Based on the findings, we argue that the government should direct flows of credit to real economic activities rather than speculative investment; more bank credit should be allocated to rural areas and agriculture; and favorable credit programs should be designed to promote education, especially of those living in rural areas.
Kim Won Joong,Hoi Tran Viet,Tuan La Ngoc,Trung Nguyen Ngoc 기술경영경제학회 2019 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.27 No.2
Innovation is consulted a very important activity for any firm and organization especially for business units in a transitional country. By using a binary logistic regression with Vietnam Enterprise Surveys data from World Bank project, this research finds that R&D played a vital role in encouraging innovative activities. Moreover, formal training within businesses has very strong and significant effects on all four different measures of innovation. What's more is that if a manager has experience of 5 or 15 in years in comparison with longer years of experience, marginal effects to probability of occurrence for organizational innovation likely come into being higher. Interestingly, higher obstacles for accessing to financial resources do not reduce innovative level but it does get business units have higher propensity to marketing innovation.