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      • KCI등재

        Molecular detection and characterization of Acanthamoeba infection in dogs and its association with keratitis in Korea

        이수빈,Badriah Alkathiri,정지승,강난영,Jiyi Hwang,박상은,홍연철,박경미,이승헌 대한기생충학ㆍ열대의학회 2024 The Korean Journal of Parasitology Vol.62 No.1

        Acanthamoeba infection is associated with keratitis in humans; however, its associationwith keratitis in dogs remains unclear. To investigate this possibility, we collected 171conjunctival swab samples from dogs with eye-related diseases (65 with keratitis and106 without keratitis) at Chungbuk National University Veterinary Teaching Hospital, Korea, from August 2021 to September 2022. Polymerase chain reaction identified 9 samples (5.3%) as Acanthamoeba positive; of these, 3 were from dogs with keratitis (4.6%)and 6 were from dogs without keratitis (5.7%). Our results indicated no significant association between Acanthamoeba infection and keratitis, season, sex, or age. All Acanthamoeba organisms found in this study had the genotype T4, according to 18S ribosomal RNA analysis. Acanthamoeba infection in dogs might have only a limited association with keratitis.

      • KCI등재

        Review of ticks (families: Ixodidae and Argasidae) in the Republic of Korea

        이승헌,Badriah Alkathiri 충북대학교 동물의학연구소 2022 Journal of Biomedical and Translational Research Vol.23 No.4

        Ticks and tick-borne pathogens are among the main sources of interest in veterinary medicine and public health. This review aimed to cover published data on tick species and their geographical distribution in Korea. Over 143 articles regarding ticks were published between 1966 and 2022, and reporting at least 29 species belonging to the family Ixodidae and five belonging to the family Argasidae. Among these, Haemaphysalis longicornis, H. flava, and Ixodes nipponensis were the main genera distributed nationwide, whereas Amblyomma was mostly identified in the southern region. Conversely, only a limited number of Argasidae ticks were present, including the genera Argas and Ornithodoros. Considering the changes in tick distribution patterns due to global warming, continuous nationwide monitoring of ticks is re-quired.

      • SCIESCOPUSKCI등재

        Distribution of Gastrointestinal Parasitic Infection in Domestic Pigs in the Republic of Korea: Nationwide Survey from 2020-2021

        Lee, Subin,Alkathiri, Badriah,Kwak, Dongmi,Lee, Sang-Myeong,Lee, Wan-Kyu,Byun, Jae-Won,Lee, Seung-Hun The Korea Society for Parasitology and Tropical Me 2022 The Korean Journal of Parasitology Vol.60 No.3

        This study aimed to examine the distribution of gastrointestinal parasitic infections in domestic pigs in the Republic of Korea. From May 2020 to October 2021, 364 pig fecal samples were collected from 75 farms in 7 Provinces and microscopically examined. A total of 170 (46.7%) pigs were infected with at least one of the following parasites: Balantioides coli, strongyles, Ascaris suum, Trichuris suis, and coccidia. By parasite species, B. coli, strongyles, A. suum, T. suis, and coccidia oocysts or eggs were detected in 144 (39.6%), 24 (6.6%), 14 (3.8%), 4 (1.1%), and 1 (0.3%) samples, respectively. One hundred fifty-four, 15, and 1 cases showed single, double, and triple infections, respectively. Of the swine fecal samples from 75 farms, 69 specimens (92.0%) were infected with 1 or more parasites. All surveyed farms across the country exhibited a positive rate of over 30%, among which the highest positive rate was 65.0% in Chungcheongnamdo, and Jeollabuk-do was followed by 61.9%. Winter showed a statistically lower prevalence than other seasons. This study showed that gastrointestinal parasites are prevalent in pigs in Korea, although the diversity of parasites is low.

      • Poster Session : PS 0418 ; Infectious Disease ; Effects of Panax Ginseng Against Cutaneous Leishmaniasis Induced Oxidative Stress in Female BALB/c Mice

        ( Prof Dr Ebtesam Al Olayan ),( Badriah Alkathiri ),( Manal El Khadragy ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Cutaneous leishmaniasis a zoonotic disease caused by Leishmania parasites. (CL)is endemic in 88 different developing countries. There are an estimated 1.5 million new cases each year.The purpose of this study was to evaluate the effect of Ginseng in inhibiting a potent oxidative stress which induces cellular damage. Materials and Methods: In this study, BALB/c mice infected with (CL) were treated with the most effective dose of Ginseng in vitro and in vivo against (CL) of L. major and it was demonstrated effi cacy in the mouse model via the subcutenous route. Results: Ginseng has a better effect on reduction of size of lesion compared to control. In this study, the possible protective role of Ginseng ( 800 ug /ml ) on the free radical damage in serum of the liver and kidney caused by (CL) which produced severe injury, as demonstrated by dramatic elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and typical histopathological changes including necrosis and apoptosis. In addition, (CL) caused oxidative stress in Mice, as evidenced by a remarkable reduction in catalase (CAT) and superoxide dismutase (SOD). However, simultaneous subcutenous treatment with Ginseng signifi cantly attenuated (CL) -induced hepatotoxicity and nephrotoxicity. It ameliorated most biochemical markers tested as well as histopathological, apoptosis and necrosis features. It is therefore suggested that Ginseng can provide a defi nite protective effect against chronic injury caused by (CL) in BALB/c mice, which may mainly be associated with its antioxidative effect. Conclusions: We suggested that Ginseng was able to elevate the antioxidant defense system, clean up free radicals, lessen oxidative damages and protect the liver and the kidney against (CL),thus having a potential protective effect. The results suggest that Ginseng might be a promising approach for developing new anti-Leishmanial drugs.

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