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( Prof Dr Ebtesam Al Olayan ),( Badriah Alkathiri ),( Manal El Khadragy ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Cutaneous leishmaniasis a zoonotic disease caused by Leishmania parasites. (CL)is endemic in 88 different developing countries. There are an estimated 1.5 million new cases each year.The purpose of this study was to evaluate the effect of Ginseng in inhibiting a potent oxidative stress which induces cellular damage. Materials and Methods: In this study, BALB/c mice infected with (CL) were treated with the most effective dose of Ginseng in vitro and in vivo against (CL) of L. major and it was demonstrated effi cacy in the mouse model via the subcutenous route. Results: Ginseng has a better effect on reduction of size of lesion compared to control. In this study, the possible protective role of Ginseng ( 800 ug /ml ) on the free radical damage in serum of the liver and kidney caused by (CL) which produced severe injury, as demonstrated by dramatic elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and typical histopathological changes including necrosis and apoptosis. In addition, (CL) caused oxidative stress in Mice, as evidenced by a remarkable reduction in catalase (CAT) and superoxide dismutase (SOD). However, simultaneous subcutenous treatment with Ginseng signifi cantly attenuated (CL) -induced hepatotoxicity and nephrotoxicity. It ameliorated most biochemical markers tested as well as histopathological, apoptosis and necrosis features. It is therefore suggested that Ginseng can provide a defi nite protective effect against chronic injury caused by (CL) in BALB/c mice, which may mainly be associated with its antioxidative effect. Conclusions: We suggested that Ginseng was able to elevate the antioxidant defense system, clean up free radicals, lessen oxidative damages and protect the liver and the kidney against (CL),thus having a potential protective effect. The results suggest that Ginseng might be a promising approach for developing new anti-Leishmanial drugs.
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