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        Feasibility of Newly Developed Endoscopic Ultrasound with Zone Sonography Technology for Diagnosis of Pancreatic Diseases

        ( Yoshiki Hirooka ),( Akihiro Itoh ),( Hiroki Kawashima ),( Eizaburo Ohno ),( Yuya Itoh ),( Yosuke Nakamura ),( Takeshi Hiramatsu ),( Hiroyuki Sugimoto ),( Hajime Sumi ),( Daijiro Hayashi ),( Naoki Oh 대한소화기학회 2013 Gut and Liver Vol.7 No.4

        Background/Aims: To confirm the feasibility of using newly developed endoscopic ultrasound (EUS) with Zone sonographyTM technology (ZST; Fujifilm Corp.). Methods: Seventy-five patients with pancreatic disorders were enrolled: 45 with intraductal papillary mucinous neoplasm; 15 with ductal carcinoma; five with neuroendocrine tumors; three with serous cystic neoplasms; and seven with simple cysts. The endoscopes used were EG-530UR2 and EG-530UT2 (Fujifilm Corp.). Two items were evaluated: visualization depth among four frequencies and image quality after automatic adjustment of sound speed (AASS), assessed using a 5-scale Likert scale by two endosonographers blinded to disease status. Because sound speed could be manually controlled, besides AASS, image quality at sound speeds of 1,440 and 1,600 m/sec were also assessed. Results: In all cases, sufficient images were obtained in the range of 3 cm from the EUS probe. Judgments of image quality before AASS were 3.49 0.50, 3.65±0.48, respectively. After AASS, A and B scored 4.36±0.48 and 4.40±0.49 (p<0.0001). There were significant differences in the data before and after AASS and plus 60 m/sec, but no significant difference between the datasets were seen after AASS and at sound speeds manually set for minus 100 m/sec. Conclusions: EUS with ZST was shown to be feasible in this preliminary experiment. Further evaluation of this novel technology is necessary and awaited. (Gut Liver 2013; 7:486-491)

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        In-plane Anisotropy of the Magnetic and the Electric Properties of the Fe Pnictide Ba(Fe1−xCox)2As2

        Yoshiaki Kobayashi,Akihiro Ichikawa,Masayuki Toyoda,Masayuki Itoh,Masatoshi Sato 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3

        The anisotropy of the electronic and the magnetic properties within the FeAs planes of Co(2%)-doped BaFe2As2 has been investigated by using 75As nuclear magnetic resonance (NMR) measurementson the As (As0) sites with all four nearest neighbor sites occupied by Fe. Even in thetetragonal phase at temperatures above 100 K, two sets of NMR spectra with twofold symmetry ofin-plane Knight shifts and electronic nuclear quadrupole frequencies are observed. They originatefrom two domains with their symmetry axes lying at right angles to each other. The anisotropies ofthe electronic and the magnetic properties become pronounced at 140 K, below which an in-planeanisotropy is reported to appear in electrical resistivity under a pressure along one of Fe-Fe directions. 75As NMR measurements have also been carried out for the As (As1) sites surrounded byone Co and three Fe. From the data, we conclude that the spin susceptibility of As1 is ~1/3 thatof As0 and that the antiferromagnetic spin fluctuation of As1 is fairly suppressed as compared withthat of As0. We discuss these behaviors of the FeAs layer in connection with the impurity-inducedlocal orbital order model proposed by theoretical studies.

      • Correlation between Magnifying Narrow-band Imaging Endoscopy Results and Organoid Differentiation Indicated by Cancer Cell Differentiation and its Distribution in Depressed-Type Early Gastric Carcinoma

        Tatematsu, Hidezumi,Miyahara, Ryoji,Shimoyama, Yoshie,Funasaka, Kohei,Ohno, Eizaburou,Nakamura, Masanao,Kawashima, Hiroki,Itoh, Akihiro,Ohmiya, Naoki,Hirooka, Yoshiki,Watanabe, Osamu,Maeda, Osamu,Ando Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

        Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2% (16/19) and 61.1% (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7%; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2% (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.

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