Caffeine-imprinted conducting polymeric films with 2D hierarchical pore arrays prepared via colloidal mask-assisted electrochemical polymerization

Kong, Seonho,Yang, Jin Chul,Park, Jin Young Elsevier 2018 Sensors and actuators. B, Chemical Vol.260 No.-

<P><B>Abstract</B></P> <P>We developed novel caffeine-imprinted conducting polymer sensors with 2D hierarchical pore arrays. Colloidal mask-assisted electrochemical polymerization was used to design the molecularly imprinted conducting polymers (MICPs). First, 2D MICP micropore arrays were obtained by electropolymerization on 2D polystyrene (PS) colloidal arrays (<I>d</I> = 1 μm) fabricated via colloidal lithography. As a second step, each of two smaller PS colloids (<I>d</I> = 200 and 500 nm) was aligned onto the MICP pores, and second step electropolymerization was performed to fabricate hierarchical pore arrays. Relative to the single MICP pore array (<B>MICP1</B>) film, the two designed MICP films (<B>MICP1-200</B> and <B>MICP1-500</B>) showed highly enhanced sensing properties such as sensing capacity, sensitivity, and selectivity. <B>MICP1-200</B> film with nanoscale porous MICP network formed in each micropore exhibited significantly improved sensing behaviors, superior to <B>MICP1-500</B> film. This sensing improvement is attributed to well-controlled MICP pore structures increasing the recognition cavities during surface imprinting. Thus, this novel strategy can be extensively used for the development of various MICP-based sensors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel caffeine-imprinted poly(3-TAA-co-EDOT) sensors with 2D hierarchical pore arrays are developed. </LI> <LI> Colloidal mask-assisted electrochemical polymerization is used to design the molecularly imprinted conducting polymers. </LI> <LI> MICP films with the porous network in the honeycomb structure (MICP1-200) show the enhanced sensing properties. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Removal of potentioally genotoxic impurity from fluroxamine maleate crude drug by molecularly imprinted polymer

Hamid Hashemi-Moghaddam,Mohammad Shakeri 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.10

The present study describes the synthesis and preliminary testing of molecularly imprinted polymers (MIPs)as scavenger resins for removal of the genotoxic impurity (GTI) (2RS)-2-[[2-[[[(1E)-5-methoxy-1-[4(trifluoromethyl)phenyl] pentylidene] amino] oxy] ethyl] amino] butanedioic acid from active pharmaceutical ingredients (API). Tocompare the performance of this polymer, a control polymer or non-imprinted polymer (NIP) was prepared under thesame conditions without the use of template molecule. The synthesized polymers were characterized by FT-IR spectros-copy. The results of the selectivity of the molecularly imprinted polymer for absorption GTI impurity through adsorp-tion experiments reviews were compared with the adsorption of impurity by NIP. Various parameters were optimized,such as time, pH, type of eluent for elution of impurity from polymer, concentration of sample and saturation of polymer. The proposed method was applied for removal of this genotoxic impurity from Fluvoxamine maleate tablet.

Molecularly Imprinted Polymers Having Amidine and Imidazole Functional Groups As an Enzyme-Mimetic Catalyst for Ester Hydrolysis

Chen, Wen,Han, Dong-Keun,Ahn, Kwang-Duk The Polymer Society of Korea 2002 Macromolecular Research Vol.10 No.2

A molecularly imprinted polymer (MIP) having both amidine and imidazole functional groups in the active site has been prepared using p-nitrophenyl phosphate as a transition state analogue (TSA). The imprinted polymer MIP with amidine and imidazole found to have the highest hydrolysis activity compared with other MIPs with either amidine or imidazole groups only. It is postulated a cooperative effect between amidine and imidazole in the hydrolysis of p-nitrophenyl methyl carbonate (NPMC) as a substrate when both groups were arranged in proximity by molecular imprinting. The rate enhancement of the hydrolysis by MIP was 60 folds over the uncatalyzed solution reaction and two folds compared with the control non-imprinted polymer CPI having both functional groups. The enzyme-mimetic catalytic hydrolysis of p-nitrophenyl acetate by MIP was evaluated in buffer at pH 7.0 with $K_{m}$ of 1.06 mM and $k_{cat}$ of 0.137 $h^{-1}$ . . .

Synthesis and adsorption properties of carbamazepine imprinted polymer by dispersion polymerization in supercritical carbon dioxide

Jae-Cheon Lee,Hun-Soo Byun,Chang-Ryong Kim 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.12

We synthesized molecularly imprinted polymers (MIPs) which can selectively separate carbamazepine(CMZ) as a pharmaceutically active compound by using supercritical fluid technology in supercritical carbon dioxide(scCO2), and also evaluated the adsorption properties of the prepared CMZ imprinted polymers (CMZ-IPs). CMZ-IPs is prepared with methacrylic acid (MAA) as a functional monomer, CMZ as a template, and ethylene glycol di-methacrylate (EGDMA) as a crosslinking agent. The binding characteristics of CMZ-IPs are evaluated using equilib-rium binding experiments. The adsorption ability in aqueous solution of CMZ-IPs was investigated by HPLC analysis,measuring the adsorbed amounts for the template and its structural analogue, the selectivity factor (α), and the imprinting-induced promotion of binding (IPB). The adsorption properties with the change of pH and temperature of aqueous so-lution were also examined. The results of the evaluation analysis indicate that the prepared CMZ-IPs have high selectivity(102, 94, 75 and 44 µmol/g) and separation abilities.

Polymer Catalysts by Molecular Imprinting: A Labile Covalent Bonding Approach

Kim, Jong Man,An, Gwang Deok,Alexander G. Strikovsky,Guenter Wulff Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.7

An imprinting technique with labile covalent interactions has been developed in the design of new polymer catalysts. The template monomer 2 was prepared and copolymerized with DVB or EDMA to provide the polymer with a cavity having the shape of th e transition state of the reaction as well as binding sites for the substrate and catalytic functionalities. The rate of hydrolysis of diphenyl carbonate (1) in the presence of the imprinted polymer IP-DVB-THF was found to be 120 times faster than the background uncatalyzed reaction. A Km of 32 mM and a kcat of 1.8 ${\times}$ 10-3min-1 were observed from Michaelis-Menten kinetics with the imprinted polymer IP-DVB-THF.

Magnetic molecularly imprinted polymer photocatalysts: synthesis, applications and future perspective

Komal Poonia,Pankaj Raizada,Archana Singh,Narinder Verma,Tansir Ahamad,Saad M. Alshehri,Aftab Aslam Parwaz Khan,Pardeep Singh,Chaudhery Mustansar Hussain 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.113 No.-

Effective degradation of low-concentration pollutants is a critical challenge during the water purificationprocess. The use of different chemicals can leave residue in samples that can impose potential ecotoxicologicaland adverse impacts on human health. Presently, Magnetic molecularly imprinted polymers(MMIPs) have attracted much attention as the research material comprises a non-magnetic polymerand magnetic material for selective binding for target molecule and recoverability of catalyst via magnetism,respectively. This review explains the synergistic effect of adsorption with photocatalysis tounderstand their recognition mechanism and the possible interaction between the target molecule andMIPs. Then their common imprinting polymerization processes i.e., free radical polymerization andnon-free radical polymerization are briefly discussed with their respective advantages and disadvantages. In addition, this review highlights the photocatalytic degradation mechanism of photocatalyst cumadsorbent is critically discussed by comparing it with non-imprinted polymers. Finally, the applicationsof MMIPs in the removal or degradation of refractory pollutants, sensing, and recognition have alsobeen delineated. This paper summarises progressive future challenges of the technology that need tobe exploited for the preparation of the targeted catalyst.

Selective Detection of Trace Metronidazole by Using a Magnetic Molecularly Imprinted Polymer-based Fluorescent Probe

Nai-Di Tan,Chengwu Lan,Jian-Hang Yin,Lei Meng,Na Xu 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.1

A magnetic molecularly imprinted polymer-based fluorescent (MIP-FL) probe has been synthesized by embedding glutathione-stabilized gold nanoclusters (GSH-AuNCs) and Fe3O4 nanoparticles (Fe3O4NPs) into silica composites. The Fe3O4NPs/AuNCs@MIPs are characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and UV?Vis absorption spectroscopy. The results show that the spherical Fe3O4NPs/AuNCs@MIPs contain a core-shell structure with GSH-AuNCs anchored on the surface of silica-protected Fe3O4NPs. As a fluorescence probe (excitation: 360?nm, emission: 615?nm), Fe3O4NPs/AuNCs@MIPs can selectively detect metronidazole (MNZ) among other nitroimidazoles (ronidazole, ornidazole, and tinidazole). During the detection, the fluorescence intensity of the MIP-FL probe drops gradually with increasing MNZ concentration. The sensitive linear range of the fluorescence probe is from 0 to 5 ?M, and the limit of detection is 4.2 nM. After the recognition sites interact with the template, the occurrence of charge transfer from the GSH-AuNCs to MNZ results in fluorescence quenching. Finally, a real sample test has been performed in spiked milk. Satisfactory recoveries spanning from 96% to 102% indicate that Fe3O4NPs/AuNCs@MIPs enable highly sensitive detection of MNZ based on fluorescence signal output, while the MIPs also have enrichment potential for the target from complex samples due to the magnetic properties.

A potentiometric non-enzymatic glucose sensor using a molecularly imprinted layer bonded on a conducting polymer

Kim, Dong-Min,Moon, Jong-Min,Lee, Won-Chul,Yoon, Jang-Hee,Choi, Cheol Soo,Shim, Yoon-Bo Elsevier Applied Science 2017 Biosensors & bioelectronics Vol. No.

<P><B>Abstract</B></P> <P>A non-enzymatic potentiometric glucose sensor for the determination of glucose in the micomolar level in saliva was developed based on a molecularly imprinted polymer (MIP) binding on a conducting polymer layer. A MIP containing acrylamide, and aminophenyl boronic acid, as a host molecule to glucose, was immobilized on benzoic acid-functionalized poly(terthiophene) (pTBA) by the amide bond formation onto a gold nanoparticles deposited-screen printed carbon electrode (pTBA/AuNPs/SPCE). Aromatic boronic acid was incorporated into the MIP layer to stably capture glucose and create a potentiometric signal through the changed pKa value of polymer film by the formation of boronate anion-glucose complex with generation of H<SUP>+</SUP> ions by the cis-diol reaction. Reversible binding and extraction of glucose on the sensor surface was observed using a quartz crystal microbalance. Each layer of the sensor probe was characterized by cyclic voltammetry, electrochemical impedance spectroscopy, X-ray photoelectron spectroscopy, and atomic force microscopy. The potentiometric response at the optimized conditions exhibited a wide linear dynamic range of 3.2×10<SUP>−7</SUP> to 1.0×10<SUP>−3</SUP> M, with a detection limit of 1.9 (±0.15)×10<SUP>−7</SUP> M. The sensor probe revealed an excellent selectivity and sensitivity for glucose compared to other saccharides. In addition, the reliability of the proposed glucose sensor was evaluated in physiological fluid samples of saliva and finger prick blood.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A non-enzymatic potentiometric glucose sensor using a MIP is successfully developed. </LI> <LI> The sensing performance of MIP is improved by its chemical bonding on a conducting polymer. </LI> <LI> The proposed sensor is successfully applied for physiological fluid samples of saliva and blood. </LI> </UL> </P>

Sensitive Detection of Morphine by Efficient Molecular Imprinted Polymers Based on Goethite Nanorods

S. Mojtaba Amininasab,Parvin Holakooei,Zahed Shami,Marjan Hassanzadeh 한국고분자학회 2018 Macromolecular Research Vol.26 No.8

We prepared new morphine molecular imprinted polymer goethite nanorods (MMIPGN) which showed excellent adsorption properties due to presence of complementary cavities on the surface of polymer. MMIPGN was synthesized by using morphine as template, fumarate-functionalized goethite nanorods (FFGN) as auxiliary monomer, methcrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross linker. The structural properties were characterized by Fourier transform infrared spectroscopy (FTIR), energy dispersive spectroscopy (EDS), field emission scanning electron microscopy (FESEM) and thermal gravimetric analysis (TGA). The adsorption behaviors of MMIPGN were monitored under various adsorption conditions such as contact time, pH, the amount of adsorbent and initial concentration of morphine. The selectivity of morphine by MMIPGN was investigated in the presence of foreign species such as epinephrine (Ep), ascorbic acid (Aa), and monoacetylmorphine (Mm) and the value of selectivity coefficients was obtained 1.19, 1.13, and 2.15, respectively. The experimental data were followed by Langmuir isotherm model and Elovich kinetic models.

Simultaneous Extraction of Organic and Inorganic Compounds Using Molecularly/Ion Imprinted Polymer

Hyeyoung Jung,Yelin Lee,Sunyoung Bae 한국분석과학회 2019 학술대회논문집 Vol.2019 No.11