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- 검색키워드
- 주제어 : Pharyngeal Pumping (검색결과 5 건)
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ANK Repeat-Domain of SHN-1 Is Indispensable for In Vivo SHN-1 Function in C. elegans
Won Chan Oh,Hyun-Ok Song,Jeong Hoon Cho,박병재 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.1
Shank protein is one of the postsynaptic density (PSD) proteins which play a major role in proper localization of proteins at membranes. The shn-1, a homolog of Shank in Caenorhabditis elegans, is expressed in neurons, pharynx, intestine, vulva and sperm. We have previously reported a possible genetic interaction between Shank and IP3 receptor by examining shn-1 RNAi in IP3 receptor (itr-1) mutant background. In order to show the direct interaction of Shank and IP_3 receptor as well as to show the direct in vivo function of Shank, we have characterized two different mutant alleles of shn-1, which have different deletions in the different domains. shn-1 mutants were observed for Ca^(2+)-related behavioral defects with itr-1 mutants. We found that only shn-1 mutant defective in ANK repeatdomain showed significant defects in defecation, pharyngeal pumping and fertility. In addition, we found that shn-1 regulates defecation, pharyngeal pumping and probably male fertility with itr-1. Thus, we suggest that Shank ANK repeat-domain along with PDZ may play a crucial role in regulating Ca^(2+)-signaling with IP3 receptor.
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인후두 역류증에 대한 초치료로서 양성자 펌프 억제제4주 단기 치료의 효과
정만기,민진영,오재원,정한신,백정환,손영익 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.6
Background and Objectives:Proton pump inhibitors (PPIs) can improve the symptoms of laryngopharyngeal reflux (LPR)if used for more than 8 weeks, but little information is available on the effects of short-term PPI therapy as an initial treatmentfor LPR. We aimed to evaluate the efficacy of 4-week short-term PPI medication as an initial treatment for LPR and to identifyspecific symptoms which can predict the outcome of treatment. Subjects and Method:Among the patients complaining ofmore than 3 typical LPR symptoms for over 3 months, 62 patients with LPR symptom scores over 8 points were enrolled for thestudy. The patients were randomly subjected either to the 4 weeks of prokinetics (n=31) or PPI (n=31) medication. Changesin subjective symptoms and objective findings were assessed at first visit and 4 weeks after the medication. Results:Treatmentwith prokinetics or PPI resulted in more than 50% reduction of LPR symptom scores in 9.6% or 29% of the patientsrespectively and 25-50% reduction in 54.8% or 70.9% of them. Objective reflux findings didn’t get improved in either group.Analyses of the obtained reflux symptom scores failed to predict the treatment outcome of PPI medication. Conclusion:ShorttermPPI therapy is highly effective for the reduction of LPR symptoms in selected patients, which may validate the use of PPIas an initial treatment regimen for the patients with LPR. However, further studies are required to assess the long-term effects of4-week PPI therapy as an initial treatment regimen.
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C. elegans Behavior of Preference Choice on Bacterial Food
Emad Abd-elmoniem Abada,Hyun Sung,Meenakshi Dwivedi,박병재,이선경,안주홍 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.3
Caenorhabditis elegans is a free living soil nematode and thus in its natural habitat, C. elegans encounters many different species of soil bacteria. Although some soil bac-teria may be excellent sources of nutrition for the worm, others may be pathogenic. Thus, we undertook a study to understand how C. elegans can identify their preferred food using a simple behavioral assay. We found that there are various species of soil bacteria that C. elegans prefers in comparison to the standard laboratory E. coli strain OP50. In particular, two bacterial strains, Bacillus my-coides and Bacillus soli, were preferred strains. Interest-ingly, the sole feeding of these bacteria to wild type ani-mals results in extended lifespan through the activation of the autophagic process. Further studies will be required to understand the precise mechanism controlling the behav-ior of identification and selection of food in C. elegans.
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Human Vesicular Glutamate Transporters Functionally Complement EAT-4 in C. elegans
이덕규,Sunki Jung,Jungmin Ryu,안주홍,하일호 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.1
The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles. Three isoforms of VGLUT have been identified in humans, but their functional differences remain largely unknown. EAT-4 is the only homologue of human VGLUT in C. elegans. Here we report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.
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Human Vesicular Glutamate Transporters Functionally Complement EAT-4 in C. elegans
Lee, Dukgyu,Jung, Sunki,Ryu, Jungmin,Ahnn, Joohong,Ha, Ilho Korean Society for Molecular Biology 2008 Molecules and cells Vol.25 No.1
The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles. Three isoforms of VGLUT have been identified in humans, but their functional differences remain largely unknown. EAT-4 is the only homologue of human VGLUT in C. elegans. Here we report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.
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