Novel Directions in Adjuvant Chemotherapy for Early Stage Epithelial Ovarian Cancer

Sakarya, Derya Kilic,Yetimalar, M Hakan,Ozbasar, Demir Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Treatment of early stage ovarian cancer remains controversial despite advances in chemotherapeutic options. Over the past 30 years, molecular and clinicopathologic studies accelerated and treatment of ovarian cancer has undoubtedly improved although there is a debate as to whether this impacts outcome or not. More recently, the introduction of targeted therapy started a new era. Probably it is because early stage disease comprises a small portion of the epithelial ovarian cancer, studies have mostly ignored this group and still there is no clear consensus regarding systemic treatment of early-stage lesions. However this group of patients has the best chance of cure. In this review, we focus on current developments in the treatment of early stage ovarian cancer and query the options.

국소형 호지킨 림프종의 치료

이성은,조석구 대한내과학회 2011 대한내과학회지 Vol.81 No.5

As there has been much progress in radiation therapy, and effective chemotherapy were introduced, the survival outcome of patients with Hodgkin’s lymphoma has been significantly improved. Particularly, more than 90% of the patients with early-stage Hodgkin’s lymphoma are expected to survive for at least 5 years. This very high survival rate and increasing recognition of the long-term toxicity of treatment including second malignancies led to current studies designed to reduce or eliminate the radiotherapy and minimize the number of chemotherapy cycles. However, because patients with early-stage Hodgkin’s lymphoma are not homogeneous group recognition of risk factors in identification of unfavorable Hodgkin’s lymphoma is essential for successful therapeutic strategy. Therefore, we will review risk assessment strategies with reference to publications and discuss current standard therapy to maximize therapeutic outcomes and to minimize late, potentially fatal toxicity in early-stage Hodgkin’s lymphoma. (Korean J Med 2011;81:554-561) 조기병기 호지킨림프종 환자의 치료는 현대 종양학 분야의 성공적인 사례이고 최근 대부분의 연구에서 이들 환자들의 생존율은 90% 이상이다. 따라서, 현재 위에 관한 임상연구의 초점은 치명적인 후기 합병증을 줄이는 데 있으며, 이와 관련하여 표준 화학요법 단독치료, 최소한의 주기의 항암요법과 병변부위에만 국한된 방사선 치료와 같은 요법들이 연구되었고, 현재에도 Interim PET scan의 이용에 관한 임상연구를 비롯한 완치를 위해 요구되는 최소한의 치료 양과 개별화된 치료법 개발을 위한 임상연구가 진행되고 있다.

암 치료 초기 단계에 있는 청소년을 위한 미술치료 단일사례연구

이진,한경아 한국미술치료학회 2017 美術治療硏究 Vol.24 No.2

The aim of this study was to discover any impact of art therapy on the psychological stability and willingness to participate in medical procedures of adolescent cancer patients in the early stage of the clinical treatment process. This study was conducted with one male adolescent patient who had been diagnosed with acute lymphoblastic leukemia for two weeks prior to his participation in the study. The patient received one 50-minute art therapy session on a weekly basis for 15 weeks. The results suggest, first, that the art therapy helped relieve the patient’s stress and anxiety about his cancer treatment by providing outlets to express his negative emotions. Second, art therapy increased the patient’s self-control ability and willingness to accept his current situation, which brought more positive emotions and optimistic views about the future. Third, the results show that art therapy provided the opportunities for the patient to actively concentrate on improving the results of the cancer treatment instead of passively receiving the treatment. Therefore, this case study suggests that art therapy could help pediatric cancer patients to actively participate in their treatment at its early stage where patients tend to suffer from uncertainty and lack of confidence about their futures. 본 연구의 목적은 암 치료 초기 단계에 있는 청소년의 심리적인 안정과 의료적 치료 참여에 어떤 의미가 있는지 알아보는 데 있다. 이를 위해 급성림프모구성백혈병을 진단받은 지 2주가 된 만 16세 남자 청소년을 참여자로 선정하여 2015년 6월 26일부터 2015년 9월 30일까지 주 1회 50분간 총 15회기 미술치료를 실시하고 자료를 수집하였다. 주 보호자와의 심층 면담과 면담 녹취록, 참여자와의 미술치료 회기 진행과 회기 녹취록 그리고 작품 결과물을 수집하였으며 녹취할 수 없는 참여자의 행동 특징 및 상황은 따로 기록하였다. 수집한 자료는 비교 분석하여 정렬, 종합, 통합, 조직화하는 범주화(Categorizing) 과정을 거쳐 분석하였다. 그 결과 첫째, 미술치료는 참여자가 치료과정에서 겪는 불안, 스트레스 등 부정적인 감정을 표출하여 심리적 안정감을 느끼는데 도움이 되었다. 둘째, 미술치료는 참여자의 자기조절감과 통제감을 높여 수동적인 의료 환경 속에서 불확실했던 미래에 대한 긍정적인 상상, 희망을 통해 기대감을 높이는 계기가 되었다. 셋째, 미술치료는 참여자가 수동적으로 의료적 치료에 참여하는 것이 아니라 스스로 치료 효과를 높이고 긍정적인 결과를 얻기 위해 노력하는 기회를 제공하였다. 따라서 미술치료는 질병에 대한 불확실성과 치료과정에 대한 모호함으로 혼란스러운 암치료 초기 단계에 있는 청소년이 적극적으로 의료적 치료에 참여하는데 의미가 있음을 알 수 있었다.

Balloon Bronchoplasty for the Treatment of Bronchial Stenosis After Lung Transplantation: A Single-Center 10-Year Experience

Kim Dong Kyu,Kwon Joon Ho,Han Kichang,Kim Man-Deuk,Kim Gyoung Min,Moon Sungmo,Park Juil,Won Jong Yun,Kim Hyung Cheol,Chun Sei Hyun,Choi Seung Myeon 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.5

Objective: To assess the safety and efficacy of balloon dilatation under dual guidance using fluoroscopy and bronchoscopy for treating bronchial stenosis following lung transplantation (LT), and to elucidate the factors associated with patency after the procedure. Materials and Methods: From September, 2012, to April, 2021, 50 patients (mean age ± standard deviation, 54.4 ± 12.2 years) with bronchial stenosis among 361 recipients of LT were retrospectively analyzed. The safety of balloon dilatation was assessed by evaluating procedure-related complications. Efficacy was assessed by evaluating the technical success, primary patency, and secondary patency. Primary and secondary cumulative patency rates were calculated using the Kaplan-Meier method. The factors associated with patency after the procedure were evaluated using multivariable Cox hazard proportional regression analysis. Results: In total, 65 bronchi were treated with balloon dilatation in 50 patients. The total number of treatment sessions was 277 and the technical success rate was 99.3% (275/277 sessions). No major procedure-related complications were noted. During the mean follow-up period of 34.6 ± 30.8 months, primary patency was achieved in 12 of 65 bronchi (18.5%). However, the patency rate improved to 76.9% (50 of 65 bronchi) after repeated balloon dilatation (secondary patency). The 6-month, 1-year, 3-year, and 5-year secondary patency rates were 95.4%, 90.8%, 83.1%, and 78.5%, respectively. The presence of clinical symptoms was a significant prognostic factor associated with reduced primary patency (adjusted hazard ratio [HR], 0.465; 95% confidence interval [CI], 0.220–0.987). Early-stage treatment ≤ 6 months (adjusted HR, 3.588; 95% CI, 1.093– 11.780) and prolonged balloon dilatation > 5 min (adjusted HR, 3.285; 95% CI, 1.018–10.598) were associated with significantly higher secondary patency. Conclusion: Repeated balloon dilatation was determined to be safe and effective for treating bronchial stenosis following LT. Early-stage treatment and prolonged balloon dilatation could significantly promote long-term patency.

Microscopic observation of frost behaviors at the early stage of frost formation on hydrophobic surfaces

Kim, Hisuk,Kim, Donghee,Jang, Hanmin,Kim, Dong Rip,Lee, Kwan-Soo Pergamon Press 2016 International journal of heat and mass transfer Vol. No.

<P><B>Abstract</B></P> <P>Microscopic seed behavior in the early stage of frost formation was experimentally observed with different fin surface contact angles from bare to superhydrophobicity under air-source heat pump operating conditions. The seed average height, radius, number, and frost density at the early stage of frost were analyzed. As the surface contact angle increased, the seed average height and number increased, while the seed radius and frost density decreased. A correlation with a Fourier number was proposed from the measured data. With the correlation, the large and small frost retardation effect regions were identified.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Frost formation in early stages is observed with different surface contact angles. </LI> <LI> The reasons of frost retardation with hydrophobic surface treatments are analyzed. </LI> <LI> Fourier number map for evaluating the effectiveness of the surface treatments is proposed. </LI> </UL> </P>

Surgery versus Locoregional Treatment in BCLC Stage 0 HCC Patients

( Jung Mi Chang ),( Soon Ho Um ),( Tae Hyung Kim ),( Han Ah Lee ),( Dae Hoe Gu ),( Jem Ma Ahn ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Yoon Tae Jeen ),( Hong Sik Lee ),( Hoon Jai Chun ),( Chang Duck K 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: The aim of this study is to compare the outcome between surgical treatment and locoregional treatment in very early stage hepatocellular carcinoma(BCLC stage 0) patients retrospectively. Methods: The survival rates of hepatocellular carcinoma patients who were newly diagnosed at Korea University Anam Hospital from March 2004 to December 2015 and whose liver function was Child-Pugh grade A and BCLC 0 (n =203) were compared according the treatment methods. In the surgical group (n=54), all patients underwent partial hepatectomy, and in the locoregional treatment group (n=149), patients who underwent TACE, RFA/PEI, and both TACE and RFA/PEI were included. Kaplan-Meier method, log-rank test and univariate multivariate Cox regression analysis were used for statistical analysis. Results: The median age of all patients was 60 years and male accounted for 70.9%. In the univariate analysis, the median survival time of the surgical group was 4345 days(95% CI 1000~7689) and the median survival time of the non-surgical group was 2923 days (95% CI 2395 ~ 3450).The survival time of the surgical group was longer than that of the non-surgical group, but the difference in survival rates between the two groups was not significant (log-rank P = 0.121). The cumulative survival rates of the surgical group in year 1, 3, 5, 7, 9 were 98%, 88.8%, 75.1%, 69.7%, and 69.7%, respectively, and the rates of the non-surgical group were 96.6%, 82.7%, 73.5%, 57.8% and 44.6%, respectively. On the other hand, age, albumin and MELD score were significantly correlated with patient survival (P<0.005) and the surgical group was younger and had higher albumin level and lower MELD score at baseline (P<0.05). The difference in survival rates between the two groups was not significant when these factors were adjusted in multivariate analysis.(P=0.738, HR 1.130, 95% CI 0.552-2.315) Conclusions: In patients with HCC of the very early stage of BCLC, there was no significant difference in survival rates statistically between the surgical and non-surgical groups.

A Model for Adaptive Decision Making of “Ablate-And-Wait” versus Transplantation in Patients with Hepatocellular Carcinoma

( Hwi Young Kim ),( Won Kim ),( Jeong-hoon Lee ),( Yoon Jun Kim ),( Jung-hwan Yoon ),( Hae Won Lee ),( Hyeyoung Kim ),( Nam-joon Yi ),( Kwang-woong Lee ),( Kyung-suk Suh ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1