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Kim, Kyung Ran,Park, Ah-Young,Moon, Hyung Ryong,Chun, Moon Woo,Jeong, Lak Shin MARCEL DEKKER INC 2007 NUCLEOSIDES NUCLEOTIDES AND NUCLEIC ACIDS Vol.26 No.8-9
<P> Novel iso D-2',3'-dideoxythianucleoside derivatives 1-3 were designed and asymmetrically synthesized to search for new anti-HIV agents. Final compounds 1-3 were evaluated against a variety of viruses including HIV-1 and 2. Only cytosine analog 3 showed a potent anti-VSV activity (EC50 = 9.43 μ g/mL). This result implies that iso 2',3'-dideoxy sugar templates might play a role of a sugar surrogate of nucleosides for the development of anti-RNA virus agent.</P>
Neural Network‐Based Analysis of Thiol Proteomics Data in Identifying Potential Selenium Targets
Lee, Jong‐,Sik,Ma, Yong‐,Beom,Choi, Kyoung‐,Soo,Park, Soo‐,Yeon,Baek, Sun‐,Hee,Park, Young‐,Mee,Zu, Ke,Zhang, Haitao,Ip, Clement,Hong Kim, Yeul,Park, Eun‐,Mi MARCEL DEKKER, INC 2006 PREPARATIVE BIOCHEMISTRY AND BIOTECHNOLOGY Vol.36 No.1
<P>Generation of a monomethylated selenium metabolite is critical for the anticancer activity of selenium. Because of its strong nucleophilicity, the metabolite can react directly with protein thiols to cause redox modification. Here, we report a neural network-based analysis to identify potential selenium targets. A reactive thiol specific reagent, BIAM, was used to monitor thiol proteome changes on 2D gel. We constructed a dynamic model and evaluated the relative importance of proteins mediating the cellular responses to selenium. Information from this study will provide new clues to unravel mechanisms of anticancer action of selenium. High impact selenium targets could also serve as biomarkers to gauge the efficacy of selenium chemoprevention.</P>
A Regularity Criterion for the Navier-Stokes Equations
Bae, Hyeong-Ohk,Choe, Hi Jun Marcel Dekker, Inc 2007 Communications in partial differential equations Vol.32 No.7
<P> We prove that a weak solution u = (u1, u2, u3) to the Navier-Stokes equations is strong, if any two components of u satisfy Prodi-Ohyama-Serrin's criterion. As a local regularity criterion, we prove u is bounded locally if any two components of the velocity lie in L6, ∞.</P>
Exposure to formaldehyde and its potential human health hazards.
Kim, Ki-Hyun,Jahan, Shamin Ara,Lee, Jong-Tae Marcel Dekker, Inc 2011 Journal of environmental science and health. Part Vol.29 No.4
<P>A widely used chemical, formaldehyde is normally present in both indoor and outdoor air. The rapid growth of formaldehyde-related industries in the past two decades reflects the result of its increased use in building materials and other commercial sectors. Consequently, formaldehyde is encountered almost every day from large segments of society due to its various sources. Many governments and agencies around the world have thus issued a series of standards to regulate its exposure in homes, office buildings, workshops, public places, and food. In light of the deleterious properties of formaldehyde, this article provides an overview of its market, regulation standards, and human health effects.</P>
Environmental exposure to lead (Pb) and variations in its susceptibility.
Kim, Jina,Lee, Youngeun,Yang, Mihi Marcel Dekker, Inc 2014 Journal of environmental science and health. Part Vol.32 No.2
<P>Based on exposure frequency and intrinsic toxicity, lead (Pb) ranks one of the highest priority toxic materials. Continuous regulation of environmental Pb exposure has contributed to dramatically diminished exposure levels of Pb, for example, blood level of Pb. However, the safety level of Pb is not established, as low-level exposure to Pb still shows severe toxicity in high susceptible population and late onset of some diseases from early exposure. In the present study, we focused on food-borne Pb exposure and found broad variations in Pb exposure levels via food among countries. In addition, there are genetic or ethnical variations in Pb-targeted and protective genes. Moreover, various epigenetic alterations were induced by Pb poisoning. Therefore, we suggest a systemic approach including governmental (public) and individual prevention from Pb exposure with continuous biological monitoring and genetic or epigenetic consideration.</P>
Enhancing proliferation and ECM expression of human ACL fibroblasts by sonic vibration.
Jiang, Yuan-Yuan,Park, Jung-Keug,Yoon, Hee-Hoon,Choi, Hynjin,Kim, Chan-Wha,Seo, Young-Kwon MARCEL DEKKER, INC 2015 PREPARATIVE BIOCHEMISTRY AND BIOTECHNOLOGY Vol.45 No.5
<P>Effects of mechanical vibration on cell activity and behavior remain controversial: There has been evidence on both positive and negative effects. Furthermore, research on the anterior cruciate ligament (ACL) has as yet been limited and the frequency-related effects remain unknown, even though ACL injury is common and an injured ACL hardly spontaneously recovers. The object of this work was to address the influence of mechanical vibration on ACL fibroblasts, to determine the effects of frequencies, and to further study this effect at the cellular level. We found that sonic vibration affected ACL fibroblasts' proliferation and metabolism in a frequency-dependent manner, and 20?Hz gave rise to the most ACL cell activity and comprehensively increased extracellular matrix (ECM) contents, including collagen type I, collagen type III, fibronectin, elastin, tenascin, glycosaminoglycan (GAG), and the cytoskeleton protein vimentin. Thus, our results indicate that sonic vibration possesses frequency-dependent effects on proliferation and productivity of ACL fibroblast with an optimal frequency of 20?Hz under the present stimulation conditions, providing further information for future research in how vibrational stimulation manipulates ACL cellular behavior.</P>
Environmental toxicants--induced epigenetic alterations and their reversers.
Kim, Minju,Bae, Minji,Na, Hyunkyung,Yang, Mihi Marcel Dekker, Inc 2012 Journal of environmental science and health. Part Vol.30 No.4
<P>Epigenetics has been emphasized in the postgenome era to clarify obscure health risks of environmental toxicants including endocrine disrupting chemicals (EDCs). In addition, mixed exposure in real life can modify health consequences of the toxicants. Particularly, some nutritional and dietary materials modify individual susceptibility through changes in the epigenome. Therefore, we focused on some environmental toxicants that induce epigenetic alterations, and introduced chemopreventive materials to reverse the toxicants-induced epigenetic alterations. Methodologically, we used global and specific DNA methylation as epigenetic end points and searched epigenetic modulators in food. We reviewed various epigenetic end points induced by environmental toxicants including alcohol, asbestos, nanomaterials, benzene, EDCs, metals, and ionizing radiation. The epigenetic end points can be summarized into global hypomethylation and specific hypermethylation at diverse tumor suppress genes. Exposure timing, dose, sex, or organ specificity should be considered to use the epigenetic end points as biomarkers for exposure to the epimutagenic toxicants. Particularly, neonatal exposure to the epimutagens can influence their future adult health because of characteristics of the epimutagens, which disrupt epigenetic regulation in imprinting, organogenesis, development, etc. Considering interaction between epimutagenic toxicants and their reversers in food, we suggest that multiple exposures to them can alleviate or mask epigenetic toxicity in real life. Our present review provides useful information to find new end points of environmental toxicants and to prevention from environment-related diseases.</P>