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A Review of the Role of Bioreactors for iPSCs-Based Tissue-Engineered Articular Cartilage
Reina-Mahecha Alejandro,Beers Martine J.,van der Veen Hugo C.,Zuhorn Inge S.,van Kooten Theo G.,Sharma Prashant K. 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.7
BACKGROUND: Osteoarthritis (OA) is the most common degenerative joint disease without an ultimate treatment. In a search for novel approaches, tissue engineering (TE) has shown great potential to be an effective way for hyaline cartilage regeneration and repair in advanced stages of OA. Recently, induced pluripotent stem cells (iPSCs) have been appointed to be essential stem cells for degenerative disease treatment because they allow a personalized medicine approach. For clinical translation, bioreactors in combination with iPSCs-engineerd cartilage could match patients needs, serve as platform for large-scale patient specific cartilage production, and be a tool for patient OA modelling and drug screening. Furthermore, to minimize in vivo experiments and improve cell differentiation and cartilage extracellular matrix (ECM) deposition, TE combines existing approaches with bioreactors. METHODS: This review summarizes the current understanding of bioreactors and the necessary parameters when they are intended for cartilage TE, focusing on the potential use of iPSCs. RESULTS: Bioreactors intended for cartilage TE must resemble the joint cavity niche. However, recreating human synovial joints is not trivial because the interactions between various stimuli are not entirely understood. CONCLUSION: The use of mechanical and electrical stimulation to differentiate iPSCs, and maintain and test chondrocytes are key stimuli influencing hyaline cartilage homeostasis. Incorporating these stimuli to bioreactors can positively impact cartilage TE approaches and their possibility for posterior translation into the clinics.
Nuclear Data Uncertainty Propagation: Total Monte Carlo vs. Covariances
D. Rochman,A. J. Koning,S. C. van der Marck,A. Hogenbirk,D. van Veen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Two distinct methods of propagation for basic nuclear data uncertainties to large scale systems will be presented and compared. The "Total Monte Carlo" method is using a statistical ensemble of nuclear data libraries randomly generated by means of a Monte Carlo approach with the TALYS system. These libraries are then directly used in a large number of reactor calculations (for instance with MCNP) after which the exact probability distribution for the reactor parameter is obtained. The second method makes use of available covariance files and can be done in a single reactor calculation (by using the perturbation method). In this exercise, both methods are using consistent sets of data files, which implies that covariance files used in the second method are directly obtained from the randomly generated nuclear data libraries from the first method. This is a unique and straightforward comparison allowing to directly apprehend advantages and drawbacks of each method. Comparisons for different reactions and criticality-safety benchmarks from ^(19)F to actinides will be presented. We can thus conclude whether current methods for using covariance data are good enough or not.
International comparison CCQM-K116: 10 μmol mol<sup>-1</sup> water vapour in nitrogen
Brewer, P J,Gieseking, B,Feracci, V F,Ward, M,Wijk, J van,Veen, A M H van der,Lima, A A,Augusto, C R,Oh, S H,Kim, B M,Lee, S,Konopelko, L A,Kustikov, Y,Shimosaka, T,Niederhauser, B,Guillevic, M,Pascal BUREAU INTERNATIONAL DES POIDS ET MESURES 2018 METROLOGIA -BERLIN- Vol.55 No.1
Santi Devi Upadhaya,Woo Jeong Seok,Shanmugam Suresh kumar,Rudolf H. van der Veen,김인호 한국축산학회 2023 한국축산학회지 Vol.65 No.3
The aim of the present study was to evaluate the effects of dietary supplementation of Ca-Mg complex on the longevity and reproductive performance of sows. In total, seventy-two gilts ([Yorkshire × Landrace] × Duroc, average body weight 181 kg) were randomly allocated to 1 of 3 treatments during 4 successive parity in a 4 × 3 factorial arrangement. Treatments consisted of CON (basal diet), CM1 (basal diet -MgO - 0.3% limestone + 0.4% Ca-Mg complex), and CM2 (basal diet - MgO - 0.7% limestone + 0.4% Ca-Mg complex). A higher (p < 0.05) number of totals born and live piglets, and sows increased feed intake during gestation and lactation, increased backfat thickness, and increased estrus interval were observed (p < 0.05) during their third and fourth parity than during their first and second parity. Ca-Mg complex supplementation improved (p < 0.05) the number of total piglets during the first and second parity as well as live-born piglets during the first to third parity, reduction (p < 0.05) in backfat thickness during the third and fourth parity, a higher (p < 0.05) initial and final number of suckling piglets as well as higher weaning weight compared with sows fed CON diet during the first, second, and third parity. The average daily gain (ADG) was higher (p < 0.05) in piglets born to CM1 and CM2 sows regardless of parity. The treatment diets fed to sows lowered (p < 0.05) the duration of first to last piglet birth and placenta expulsion time compared with CON sows. A significant interactive effect (p = 0.042) between parities and treatment diets was observed for the first to last piglet birth. Thus, Ca-Mg complex supplementation by partially replacing limestone in the basal diet enhanced sow performance, specifically during their third and fourth parity, thereby improving sow longevity.
Ultrafast electron energy-loss spectroscopy in transmission electron microscopy
Pomarico, Enrico,Kim, Ye-Jin,Garcí,a de Abajo, F. Javier,Kwon, Oh-Hoon,Carbone, Fabrizio,van der Veen, Renske M. Cambridge University Press (Materials Research Soc 2018 MRS bulletin Vol.43 No.7
<▼1><B>Abstract</B><P/></▼1><▼2><P>In the quest for dynamic multimodal probing of a material’s structure and functionality, it is critical to be able to quantify the chemical state on the atomic-/nanoscale using element-specific electronic and structurally sensitive tools such as electron energy-loss spectroscopy (EELS). Ultrafast EELS, with combined energy, time, and spatial resolution in a transmission electron microscope, has recently enabled transformative studies of photoexcited nanostructure evolution and mapping of evanescent electromagnetic fields. This article aims to describe state-of-the-art experimental techniques in this emerging field and its major uses and future applications.</P></▼2>
조성보,Santi Devi Upadhaya,Woo Jeong Seok,Seyoung Mun,Haeun Lee,Rudolf H. van der Veen,한규동,김인호 한국축산학회 2023 한국축산학회지 Vol.65 No.6
Minerals is required small amounts among various nutrients, but it has a significant impact on sow longevity and reproduction performance. This study was carried out to see the beneficial effects of marine-derived Ca-Mg complex on the reproductive performance of sows during four-parity periods. Seventy-two gilts ([Yorkshire × Landrace] × Duroc), with an average body weight of 181 kg, were randomly allocated to three groups; CON (basal diet), 0.3LC (CON - MgO - 0.3% limestone + 0.4% Ca-Mg complex), and 0.7LC (CON - MgO - 0.7% limestone + 0.4% Ca-Mg complex). During parity 3 and 4, the expression level of SCD gene was lower in the umbilical cord of piglets born to 0.3LC and 0.7LC sows compared with the CON sows. During parity 2, 3 and 4, SLC2A2 and FABP4 gene expressions were higher in the umbilical cord of piglets born to 0.7LC sows and the placenta of sows from 0.3LC groups, respectively. Ca-Mg complex increased (p < 0.05) Ca and Mg concentrations in sows and their piglets’ serum as well as in colostrum regardless of parities. The serum vitamin D concentration was higher (p < 0.05) in their first parity, whereas serum prolactin and estrogen concentrations were higher (p < 0.05) during the fourth and third parity, respectively. The growth hormone concentrations were higher (p < 0.05) in the piglets born to sows during the first and second parity. The fat and immunoglobulin A (IgA) concentrations in colostrum were higher (p < 0.05) during the third and fourth parity, respectively. A reduction (p < 0.05) in salivary cortisol, epinephrine, and norepinephrine concentrations was observed in 0.3LC and 0.7LC sow groups compared with CON after farrowing regardless of parity, however before farrowing, a reduction in norepinephrine was observed. Before farrowing, the epinephrine and norepinephrine concentrations were higher (p < 0.05) during the first and second parity. After farrowing, the concentration of these hormones was higher during the second parity. Taken together, sows’ parity and dietary Ca-Mg complex supplementation influenced serum metabolites, colostrum nutrients, stress hormones as well as the gene expressions related to lipid and glucose metabolism.
International comparison CCQM-K119 liquefied petroleum gas
Brewer, P J,Downey, M L,Atkins, E,Brown, R J C,Brown, A S,Zalewska, E T,van der Veen, A M H,Smeulders, D E,McCallum, J B,Satumba, R T,Kim, Y D,Kang, N,Bae, H K,Woo, J C,Konopelko, L A,Popova, T A,Mesh IOP 2018 Metrologia Vol.55 No.-
<P></P> <P>Liquefied hydrocarbon mixtures with traceable composition are required in order to underpin measurements of the composition and other physical properties of LPG (liquefied petroleum gas), thus meeting the needs of an increasingly large industrial market.</P> <P>This comparison aims to assess the analytical capabilities of laboratories for measuring the composition of a Liquid Petroleum Gas (LPG) mixture when sampled in the liquid phase from a Constant Pressure Cylinder. Mixtures contained ethane, propane, propene, i-butane, n-butane, but-1-ene and i-pentane with nominal amount fractions of 2, 71, 9, 4, 10, 3 and 1 cmol mol<SUP>−1</SUP> respectively.</P> <H2>Main text</H2> <P> To reach the main text of this paper, click on <A HREF='https://www.bipm.org/utils/common/pdf/final_reports/QM/K119/CCQM-K119.pdf'>Final Report</A>. Note that this text is that which appears in Appendix B of the BIPM key comparison database <A HREF='http://kcdb.bipm.org/'>kcdb.bipm.org/</A>.</P> <P>The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).</P>
Santaclara, Jara G.,Olivos-Suarez, Alma I.,Gonzalez-Nelson, Adrian,Osadchii, Dmitrii,Nasalevich, Maxim A.,van der Veen, Monique A.,Kapteijn, Freek,Sheveleva, Alena M.,Veber, Sergey L.,Fedin, Matvey V. American Chemical Society 2017 Chemistry of materials Vol.29 No.21
<P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2017/cmatex.2017.29.issue-21/acs.chemmater.7b03320/production/images/medium/cm-2017-03320d_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm7b03320'>ACS Electronic Supporting Info</A></P>
CCQM-K120 (Carbon dioxide at background and urban level)
Flores, Edgar,Viallon, Joë,le,Choteau, Tiphaine,Moussay, Philippe,Idrees, Faraz,Wielgosz, Robert I,Lee, Jeongsoon,Zalewska, Ewelina,Nieuwenkamp, Gerard,Veen, Adriaan van der,Konopelko, L A,Kustiko BUREAU INTERNATIONAL DES POIDS ET MESURES 2019 METROLOGIA -BERLIN- Vol.56 No.-
<P></P> <P>CCQM-K120.a comparison involves preparing standards of carbon dioxide in air which are fit for purpose for the atmospheric monitoring community, with stringent requirements on matrix composition and measurement uncertainty of the CO<SUB>2</SUB> mole fraction. This represents an analytical challenge and is therefore considered as a Track C comparison. The comparison will underpin CMC claims for CO<SUB>2</SUB> in air for standards and calibrations services for the atmospheric monitoring community, matrix matched to real air, over the mole fraction range of 250 μmol/mol to 520 μmol/mol.</P> <P>CCQM-K120.b comparison tests core skills and competencies required in gravimetric preparation, analytical certification and purity analysis. It is considered as a Track A comparison. It will underpin CO<SUB>2</SUB> in air and nitrogen claims in a mole fraction range starting at the smallest participant's reported expanded uncertainty and ending at 500 mmol/mol. Participants successful in this comparison may use their result in the flexible scheme and underpin claims for all core mixtures</P> <P>This study has involved a comparison at the BIPM of a suite of 44 gas standards prepared by each of the participating laboratories. Fourteen laboratories took part in both comparisons (CCQM-K120.a, CCQM-K120.b) and just one solely in the CCQM-K120.b comparison.</P> <P>The standards were sent to the BIPM where the comparison measurements were performed. Two measurement methods were used to compare the standards, to ensure no measurement method dependant bias: GC-FID and FTIR spectroscopic analysis corrected for isotopic variation in the CO<SUB>2</SUB> gases, measured at the BIPM using absorption laser spectroscopy. Following the advice of the CCQM Gas Analysis Working Group, results from the FTIR method were used to calculate the key comparison reference values.</P> <P>KEY WORDS FOR SEARCH</P> <P>FTIR, CO2, GC-FID, Carbon dioxide at background level, Carbon dioxide at urban level, Delta Ray, CO2 gas standards</P> <P></P> <H2>Main text</H2> <P> To reach the main text of this paper, click on <A HREF='https://www.bipm.org/utils/common/pdf/final_reports/QM/K120/CCQM-K120.pdf'>Final Report</A>. Note that this text is that which appears in Appendix B of the BIPM key comparison database <A HREF='http://kcdb.bipm.org/'>kcdb.bipm.org/</A>.</P> <P>The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).</P>