Testing for a Constant Mean Function using Functional Regression

jinseo cho,meng huang,halbert white 한국계량경제학회 2008 한국계량경제학회 학술대회 논문집 Vol.2009 No.-

Anatomical Variants of "Short Head of Biceps Femoris Muscle" Associated with Common Peroneal Neuropathy in Korean Populations : An MRI Based Study

Yang, Jinseo,Cho, Yongjun,Cho, Jaeho,Choi, Hyukjai,Jeon, Jinpyeong,Kang, Sukhyung The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.4

Objective : In Asians, kneeling and squatting are the postures that are most often induce common peroneal neuropathy. However, we could not identify a compatible compression site of the common peroneal nerve (CPN) during hyper-flexion of knees. To evaluate the course of the CPN at the popliteal area related with compressive neuropathy using magnetic resonance imaging (MRI) scans of healthy Koreans. Methods : 1.5-Tesla knee MRI scans were obtained from enrolled patients and were retrospectively reviewed. The normal populations were divided into two groups according to the anatomical course of the CPN. Type I included subjects with the CPN situated superficial to the lateral gastocnemius muscle (LGCM). Type II included subjects with the CPN between the short head of biceps femoris muscle (SHBFM) and the LGCM. We calculated the thickness of the SHBFM and posterior elongation of this muscle, and the LGCM at the level of femoral condyles. In type II, the length of popliteal tunnel where the CPN passes was measured. Results : The 93 normal subjects were included in this study. The CPN passed through the "popliteal tunnel" formed between the SHBFM and the LGCM in 36 subjects (38.7% type II). The thicknesses of SHBFM and posterior portions of this muscle were statistically significantly increased in type II subjects. The LGCM thickness was comparable in both groups. In 78.8% of the "popliteal tunnel", a length of 21 mm to <40 mm was measured. Conclusion : In Korean population, the course of the CPN through the "popliteal tunnel" was about 40%, which is higher than the Western results. This anatomical characteristic may be helpful for understanding the mechanism of the CPNe by posture.

구강 미생물 7종에 대한 멘톨과 불소치약의 항균 활성 비교 연구

조세희(Cho, Sehee),안태규(Ahn, Tae-Kyu),윤찬건(Yun, Chan-Gun),김지우(Kim, Jiwoo),전예담(Jeon, Yedam),황진서(Hwang, Jinseo),김지인(Kim, Jee-In),이현경(Lee, Hyeongyeong),임재환(Lim, Jae-Hwan) 한국과학영재교육학회 2020 과학영재교육 Vol.12 No.3

구강에는 600종 이상의 미생물이 존재하는 것으로 보고되고 있다. 알코올과 항생제 제품을 대체하여 천연물을 사용한 구강 위생 제제의 개발연구가 보고되고 있으나, 특정 성분들의 균주별 항균 활성 등에 관한 연구는 부족하다. 본 연구에서는 멘톨, 녹차 추출물, 불소치약, 플루오린화나트륨을 사용하여 구강 미생물 7종 -S. mutans, E. coli, B. subtilis, S. aureus, B. cereus, P. aeruginosa, L. brevis- 에 대한 항균효능을 확인하고자 하였다. 디스크 확산법을 통해 멘톨(200 mg/mL)은 구강 미생물 7종, 치약의 경우는 2종의 균주 -S. mutans, B. cereus- 에서 10.4~ 21.9 mm의 clear zone이 형성되는 것을 확인하였다. 불소치약과 멘톨의 복합 처리 시에는 구강 미생물 4종에서 증가된 항균 활성을 확인하였다. 또한 MIC 분석을 통해, 멘톨은 200~500 ㎍/mL의 농도에서 모든 균주에 대한 최소억제농도를 확인할 수 있었고 플루오린화나트륨의 경우 E. coli에서 40 ㎍/mL의 억제농도를 확인할 수 있었다. 결과적으로, 구강청결제 및 구강질환 항생물질의 대체소재로서 멘톨의 활용 가능성을 제시하고자 한다. More than 600 kinds of microorganisms exist in the oral cavity. Studies on the development of oral hygiene preparations using natural products as a substitute for alcohol and antibiotic products have been reported, but studies on the antibacterial activity of specific ingredients by strain are insufficient. In this study, menthol, green tea extract, fluoride toothpaste, and sodium fluoride were used against 7 kinds of oral microorganisms, S. mutans, E. coli, B. subtilis, S. aureus, B. cereus, P. aeruginosa, L. brevis. Using the disk diffusion method, It was confirmed that clear zones of 10.4 to 21.9 mm are formed in 7 types of oral microorganisms when menthol (200 mg/mL) is treated and 2 strains, S. mutans and B. cereus, when treated with fluoride toothpaste. When combined treatment with fluoride toothpaste and menthol, increased antibacterial activity was observed in four oral microbes. Through the MIC analysis, the minimum inhibitory concentration of menthol for all strains was confirmed at a concentration of 200-500 ㎍/mL, and the inhibitory concentration of sodium fluoride was confirmed at 40 ㎍/mL in E. coli. As a result, we suggest that the possibility of using menthol as a substitute for oral cleansers and antibiotics for oral diseases.

Outcome Analysis of External Neurolysis in Posture- Induced Compressive Peroneal Neuropathy and the Utility of Magnetic Resonance Imaging in the Treatment Process

Junmo Kim,Jinseo Yang,Yongjun Cho,Sukhyung Kang,Hyukjai Choi,Jinpyeong Jeon 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.3

Objective : We aimed to analyze the effectiveness of external neurolysis on the common peroneal nerve (CPN) in patients with posture-induced compressive peroneal neuropathy (PICPNe). Further, we aimed to examine the utility of magnetic resonance imaging (MRI) in assessing the severity of denervation status and predicting the postoperative prognosis. Methods : We included 13 patients (eight males and five females) with foot drop who underwent CPN decompression between 2018 and 2020. We designed a grading system for assessing the postoperative functional outcome. Additionally, we performed MRI to evaluate the denervation status of the affected musculature and its effect on postoperative recovery. Results : The median time to surgery was 3 months. The median preoperative ankle dorsiflexion and eversion grades were both 3, while the average functional grade was 1. Posterior crural intermuscular septum was the most common cause of nerve compression, followed by deep tendinous fascia and anterior crural intermuscular septum. There was a significant postoperative improvement in the median postoperative ankle dorsiflexion and eversion grades and average postoperative functional (4, 5, and 2.38, respectively). Preoperative ankle eversion was significantly correlated with denervation status. Additionally, the devernation status on MRI was positively correlated with the outcome favorability. However, denervation atrophy led to a less favorable outcome. Conclusion : Among patients with intractable PICPNe despite conservative management, surgical intervention could clinically improve motor function and functional ability. Additionally, MRI examination of the affected muscle could help diagnose CPNe and assess the postoperative prognosis.

Applicability of Magnetic Resonance Imaging for Early Diagnosis of Common Peroneal Neuropathy

Choi Gwang Yoon,Yang Jinseo,Cho Yongjun,최혁재,전진수,Kang Sukhyung 대한말초신경학회 2021 The Nerve Vol.7 No.2

Objective: This study aimed to assess the clinical applicability of magnetic resonance imaging (MRI) for the early diagnosis of common peroneal neuropathy (CPNe).Methods: Over three years, the authors have treated 58 patients with CPNe. All patients had clinical or neurophysiological confirmation of CPNe. Among them, 35 (60%) patients underwent axial knee MRI with a 1.5-Tesla scanner. These 35 patients were selected for study and were classified into three groups according to the time of examination after the occurrence of dropped foot―acute, subacute, and chronic onset groups. According to muscle appearances (normal, edematous change, and atrophy), we diagnosed them with CPNe, except for those with normal morphology. We evaluated the applicability of MRI in the diagnosis of CPNe compared to that of electromyography (EMG).Results: The 18, 11, and six cases were included in the acute, subacute, and chronic onset groups, respectively. In the acute onset group, three cases had normal muscle appearance, while 15 cases had edematous changes in the affected muscles. In the subacute onset group, eight cases had edematous changes, while three cases showed muscle atrophy. In the chronic onset group, six cases had muscle atrophy. CPNe could be diagnosed using MRI in about 91% (32/35) of all the cases. Excluding the chronologically chronic stage, diagnosis rate was approximately 89%(26/29) of all the cases. However, only in 27 cases (77%) denervation potentials were presented on EMG.Conclusion: According to our results, MRI is a helpful diagnostic modality, especially in the early stage of CPNe, and may lead to proper management.

Spectroscopic Properties of Large-volume Virtual Frisch-grid CdMnTe Detectors

김기현,박찬선,Pilsu Kim,Shin Haeng Cho,Jinseo Lee,T. K. Hong,A. Hossain,A. E. Bolotnikov,R. B. James 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.11

CdMnTe(CMT) is a promising alternative material for use as a room-temperature radiation detector. Frisch-grid detectors have a simple configuration and outstanding spectral performance compared with other single-carrier collection techniques. The energy resolution of large-volume virtual Frisch-grid CMT detectors was tested by using several isotopes such as 57Co, 22 Na , 133Ba, and 137Cs together or separately. Energy resolutions of 6.7% and 2.1% were obtained for 122-keV 57Co and 662-keV 137Cs gamma rays, respectively, without using any additional signal processing techniques. Also, a 12-mm-thick CMT detector detected the 511-keV and 1.277-MeV gamma peaks of 22Na with values of the full width at half maximum (FWHM) of 2.7% and 1.5%, respectively. In addition, multiple low- and high-energy gamma peaks of 133Ba were well separated. The mobilitylifetime product calculated from the shift of the 662-keV photo-peak vs. bias by using Hecht’s equation was 7 × 10−3 cm2/V. These results show the possibility of using CMT detectors in response to various requirements for gamma-ray detection at room-temperature.

Improving p-to-n transition and detection range of bimodal hydrogen-sensitive nanohybrids of hole-doped rGO and chemochromic Pd-decorated-MoO₃ nanoflakes

Duy, Le Thai,Lee, Gyuyeon,Kim, Jinseo,Ahn, Byungmin,Cho, In Sun,Yu, Hak Ki,Seo, Hyungtak Elsevier 2019 JOURNAL OF ALLOYS AND COMPOUNDS Vol.774 No.-

<P><B>Abstract</B></P> <P>Detection of hydrogen (H<SUB>2</SUB>) over a wide concentration range (from parts-per-million levels to 4%) is necessary for safety in using hydrogen-fuel cell systems. For this purpose, our development of H<SUB>2</SUB> sensitive nanohybrids of reduced graphene oxide (rGO) and chemochromic palladium-decorated molybdenum trioxide (Pd:MoO<SUB>3</SUB>) nanoflakes is presented. Additionally, the nanohybrids were employed as the active channel in a thin film transistor platform to invest informative characteristics for understanding their electrical properties and sensing mechanism. Through sensing measurements, (i) phenomena relating to response saturation and reversed behavior of gas sensors towards high exposure doses (i.e., p-to-n transition) and (ii) doping effects on the p-to-n transition and detection range of the hybrid materials are clarified. With combining electrical and visual output signals, the bimodal devices using the hole-doped nanohybrids can detect H<SUB>2</SUB> over a wide concentration range (from 10 ppm to over 10%) at room temperature. Our results reveal opportunities for further development and improvement of hybrid nanomaterials and chemical sensors having a large sensing capability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Our nanohybrids have two sensing capabilities towards hydrogen. </LI> <LI> Transistor sensors provide information for understanding phenomena and mechanism. </LI> <LI> Effect of hole-doping on the detection range is explored. </LI> <LI> The bimodal sensors can detect hydrogen from 10 ppm to over 10%. </LI> <LI> Transition from p-to n-type behavior of the nanohybrid can cause its response saturation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Diagnostic Roots Radiofrequency Sensory Stimulation Looking for Symptomatic Injured Roots in Multiple Lumbar Stenosis

Jun Mo Kim,Sukhyung Kang,Steve Sungwon Cho,Peter D. Chang,Jinseo Yang,Jin Pyeong Jeon,Hyuk Jai Choi 대한신경손상학회 2022 Korean Journal of Neurotrauma Vol.18 No.2

Objective: We present how to perform radiofrequency sensory stimulation (RFSS) and whether RFSS could be helpful in identifying symptomatic injured roots in multilevel lumbar stenosis. Methods: Consecutive patients who underwent RFSS from 2010 to 2012 were enrolled. To identify pathologic lesions, RFSS was performed for suspicious roots, as determined using lumbar magnetic resonance imaging (MRI). The RFSS procedure resembled transforaminal root block. During RFSS of the suspicious root, patients could indicate whether stimulation induced their usual pain and/or sensory changes and could indicate whether the same leg area was affected. The number of possible symptomatic roots on MRI was evaluated before and after RFSS. Based on the RFSS results, we confirmed the presence of symptomatic nerve root(s) and performed surgical decompression. Surgical results, such as numeric rating scale (NRS) scores for low back pain (LBP) and leg pain (LP), and Oswestry disability index (ODI), were evaluated. Results: Ten patients were enrolled in the study. Their mean age was 70.1±9.7 years. Clinically, NRS-LBP, NRS-LP, and ODI before surgery were 5.1%, 7.5%, and 53.2%, respectively. The mean number of suspicious roots was 2.6±0.8. After RFSS, the mean number of symptomatic roots was 1.6±1.0. On average, 1.4 lumbar segments were decompressed. The follow-up period was 35.3±12.8 months. At the last follow-up, NRS-LBP, NRS-LP, and ODI were 3.1%, 1.5%, and 35.3%, respectively. There was no recurrence or need for further surgical treatment for lumbar stenosis. Conclusion: RFSS is a potentially helpful diagnostic tool for verifying and localizing symptomatic injured root lesions, particularly in patients with multilevel spinal stenosis.