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Zhang Ziyi,Ding Honglei,Zhou Qi,Pan Weiguo,Qiu Kaina,Mu Xiaotian,Ma Junchi,Zhang Kai,Zhao Yuetong 한국탄소학회 2023 Carbon Letters Vol.33 No.4
In recent years, people are increasingly interested in CO2 hydrogenation to produce value-added chemicals and fuels (CH4, CH3OH, etc.). In the quest for an efficient treatment in CO2 methanation and methanolization, several technologies have been practiced, and DBD plasma technology gain attention due to its easily handling, mild operating conditions, strong activation ability, and high product selectivity. In addition, its reaction mechanism and the effect of packing materials and reaction parameters are still controversial. To address these problems efficiently, a summary of the reaction mechanism is presented. A discussion on plasma-catalyzed CO2 hydrogenation including packing materials, reaction parameters, and optimizing methods is addressed. In this review, the overall status and recent findings in DBD plasma-catalyzed CO2 hydrogenation are presented, and the possible directions of future development are discussed.
Simultaneous immunoassays of dual prostate cancer markers using a SERS-based microdroplet channel
Gao, Rongke,Cheng, Ziyi,Wang, Xiaokun,Yu, Liandong,Guo, Zhongyi,Zhao, Gang,Choo, Jaebum Elsevier 2018 Biosensors & Bioelectronics Vol.119 No.-
<P><B>Abstract</B></P> <P>The simultaneous detection of multiple biomarkers plays an important role in the accurate diagnosis of cancer. In this study, we developed a novel, surface-enhanced Raman scattering (SERS)-based microfluidic device for the simultaneous detection of free prostate-specific antigen (f-PSA) and total PSA (t-PSA) markers. A fully automatic droplet-based microfluidic platform for the rapid and sensitive detection of f-PSA and t-PSA was designed. Magnetic immunocomplexes were aligned on one side of the channel using a permanent magnet embedded in the microfluidic device, and parent microdroplets containing magnetic immunocomplexes and supernatant solutions were split into two smaller daughter droplets at the Y-shaped junction of the channel. Then, Raman signals of sequential droplets including supernatant solutions were measured for the quantitative analysis of the PSA markers. Two parallel microfluidic channels were designed and fabricated for the simultaneous detection of f-PSA and t-PSA. Our results showed a good linear response for both PSA markers in the range from 0.05 to 100 ng mL<SUP>−1</SUP>. The limits of detection were estimated to be below 0.1 ng mL<SUP>−1</SUP> for both the f-PSA and t-PSA. This SERS-based assay in a microfluidic channel was completed in 10 min without any manual incubation and washing steps. Our method is a very promising clinical tool for PSA-based screening test of prostate cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We report a SERS-based microfluidic device for the detection of two prostate cancer markers. </LI> <LI> Quantitative analysis of two cancer markers in the low concentration range is possible using this device. </LI> <LI> This approach provides new insights into the accurate screening test of prostate cancer. </LI> </UL> </P>
Zhang Shaolong,Zhou Jingping,Shang Pengzhao,Zhao Guomeng,Wang Anlei,Mao Jinlei,Tao Yuhang,Chen Ziyi,Wang Xuehao,Guo Changying 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Tumor-associated macrophages (TAMs) are one of the main cellular components in the tumor microenvironment (TME). In many types of solid tumors, TAMs tend to accumulate in hypoxic areas and are intimately related to poor patient prognosis. However, the underlying mechanisms by which TAMs infiltrate hypoxic tumor regions remain unclear. In this study, we report that genetic deletion of SE translocation (SET) in myeloid cells inhibited the entry of TAMs into the hypoxic tumor region and abated their proangiogenic and immunosuppressive functions, ultimately inhibiting tumor growth. Mechanistically, in response to hypoxic tumor supernatant stimulation, SET in macrophages shuttled between the nucleus and cytoplasm via the PKC-CK2α signaling axis. Cytoplasmic retention of SET increased ERK and P38 signaling by inhibiting PP2A, which promoted TAM migration into the hypoxic area and polarization toward the M2 phenotype. Therefore, we conclude that SET modulates tumor immunity by acting as a key regulator of macrophage positioning and function in the tumor.
Yuping Zhu,Suzhen Zhai,Bei Li,Ziyi Zhao,Jiao Xie,Tingyuan Ren 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.11
To explore hypoglycemic effect of wild Rosa roxburghii tratt (RRT) juice at different altitudes on type 1diabetes mellitus (T1DM). The T1DM mouse model was induced by streptozotocin (STZ), and the experiment included anormal group (NC), model group (MC), wild RRT juice groups high (HF), medium (MF), low altitude (DF) and cultivatedcontrol group (PC). During experiment, food intake, water intake, body weight, and fasting blood glucose were measured. After 28 days of administration, glucose tolerance, glycogen level, lipid profiles, and antioxidation levels in serum and liverwere measured, and histomorphological changes of liver and kidney were observed by hematoxylin and eosin staining. The results showed that wild RRT juice reduced blood glucose level, alleviated liver and kidney tissue damage, improvedglucose and lipid metabolism disorders and attenuated oxidative damage in T1DM mice. Western blot showed that wild RRTjuice at grown at different altitudes significantly increased protein abundance of PI3K, Akt, and GLUT2 in liver of T1DMmice. In conclusion, wild RRT juice from different altitudes improved glucose and lipid metabolism disorders and oxidativedamage in T1DM mice, which may be attributed to activation of PI3K/Akt pathway. Overall effect: MF > PC > HF > DF.