http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Zhuang Li Zheng ),( Xue Hong Qiu ),( Ri Chou Han ) 한국균학회 2015 韓國菌學會誌 Vol.43 No.1
A mutant library of Cordyceps militaris was constructed by improved Agrobacterium tumefaciens-mediated transformation and screened for degradation features. Six mutants with altered characters in in vitro and in vivo fruiting body production, and cordycepin formation were found to contain a single copy T-DNA. T-DNA flanking sequences of these mutants were identified by thermal asymmetric interlaced-PCR approach. ATP-dependent helicase, cytochrome oxidase subunit I and ubiquitin-like activating enzyme were involved in in vitro fruiting body production, serine/threonine phosphatase involved in in vivo fruiting body production, while glucose-methanol-choline oxidoreductase and telomerase reverse transcriptase involved in cordycepin formation. These genes were analyzed by bioinformatics methods, and their molecular function and biology process were speculated by Gene Ontology (GO) analysis. The results provided useful information for the control of culture degeneration in commercial production of C. militaris.
( Zhuang Ding ),( Tao Tao ),( Lili Wang ),( Yanna Zhao ),( Huiming Huang ),( Demeng Zhang ),( Min Liu ),( Zhengping Wang ),( Jun Han ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.5
Endophytic fungi are an important component of plant microbiota, and have the excellent capacity for producing a broad variety of bioactive metabolites. These bioactive metabolites not only affect the survival of the host plant, but also provide valuable lead compounds for novel drug discovery. In this study, forty-two endophytic filamentous fungi were isolated from Ficus elastica leaves, and further identified as seven individual taxa by ITS-rDNA sequencing. The antimicrobial activity of these endophytic fungi was evaluated against five pathogenic microorganisms. Two strains, Fes1711 (Penicillium funiculosum) and Fes1712 (Trichoderma harzianum), displayed broad-spectrum bioactivities. Our following study emphasizes the isolation, identification and bioactivity testing of chemical metabolites produced by T. harzianum Fes1712. Two new isocoumarin derivatives (1 and 2), together with three known compounds (3-5) were isolated, and their structures were elucidated using NMR and MS. Compounds 1 and 2 exhibited inhibitory activity against Escherichia coli. Our findings reveal that endophytic fungi from the rubber tree F. elastica leaves exhibit unique characteristics and are potential producers of novel natural bioactive products.
Detection of PCB77 by Indirect Competitive Enzyme-linked Immunosorbent Assay in Sea Sediment Samples
Han-Yu Chen,Hui-Sheng Zhuang,Guang-Xin Yang 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.3
3,3',4,4'-Tetrachlorobiphenyl (IUPAC PCB77) is one of seven indicative polychlorinated biphenyls (PCBs) in the surface sediments. The current study presents a novel polyclonal antibody for the determination of the PCB77 using indirect competitive enzyme-linked immunosorbent assay. Under optimum conditions, PCB77 was determined within the concentration range of 0.01-100 μg L–1, with a detection limit of 0.057 μg L–1. The assays were tested for their cross-reactivity profiles using 3 selected congeners and 4 Aroclor products. The assays were highly specific for coplanar PCB congeners, but less specific for Aroclor1248. The spiked recoveries from five sediment samples were 86%-114% for PCB77 from ELISA, which were satisfactory. The current study demonstrated that the developed antiserum and immunoassay procedure can be used to detect PCB77 in environmental samples. The results of the sediment analysis were confirmed by conventional GC/ ECD.
Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis
Han, Jun,Meng, Qing-Yang,Liu, Xiao,Xi, Qiu-Lei,Zhuang, Qiu-Lin,Wu, Guo-Hao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results.
Temperature-constrained topology optimization of nonlinear heat conduction problems
Zhuang Chungang,Xiong Zhenhua,Ding Han 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.4
This paper presents topology optimization of nonlinear heat conduction problems with multiple domains and multiple constraints, including regional temperature and material volume for reducing temperature. Maximum approximation temperatures in the constraint regions are accurately and dynamically calculated, though temperature and temperature-dependent thermal conductivity change with the update of material distribution. A temperature measure with constant error to approximate regional maximum temperature is adaptive to different temperature ranges. A strategy of hole nucleation generation combined with the regional temperature constraints is presented for the level set-based topology optimization. The solid isotropic material with penalization (SIMP) and parametrized level set methods are compared for the temperature-constrained topology optimization. Finally, several numerical examples are solved by the SIMP and parametrized level set methods. The results demonstrate that the proposed approach can obtain intricate topological details and reduce regional temperatures for the nonlinear heat conduction problems.
Zheng, Zhuang-Li,Qiu, Xue-Hong,Han, Ri-Chou The Korean Society of Mycology 2015 Mycobiology Vol.43 No.1
A mutant library of Cordyceps militaris was constructed by improved Agrobacterium tumefaciens-mediated transformation and screened for degradation features. Six mutants with altered characters in in vitro and in vivo fruiting body production, and cordycepin formation were found to contain a single copy T-DNA. T-DNA flanking sequences of these mutants were identified by thermal asymmetric interlaced-PCR approach. ATP-dependent helicase, cytochrome oxidase subunit I and ubiquitin-like activating enzyme were involved in in vitro fruiting body production, serine/threonine phosphatase involved in in vivo fruiting body production, while glucose-methanol-choline oxidoreductase and telomerase reverse transcriptase involved in cordycepin formation. These genes were analyzed by bioinformatics methods, and their molecular function and biology process were speculated by Gene Ontology (GO) analysis. The results provided useful information for the control of culture degeneration in commercial production of C. militaris.
Estimating Escalator vs Stairs Choice Behavior in the Presence of Entry Railing: A Field Study
Yifan Zhuang,Andreas Schadschneider,Han Cheng,Lizhong Yang 대한토목학회 2018 KSCE Journal of Civil Engineering Vol.22 No.12
Entry railings at escalator/stairs system are intervention measures for passenger flow and play a crucial role in local infrastructure optimization in mass transit stations. This paper presents an analysis of the choice between escalators and stairs with mixed logit models, by considering for the first time the length of the entry railing as one of the crucial parameters. Based on a pilot questionnaire survey, a large-scale field study was conducted in Changsha, China and a sample of 11010 passengers was drawn. The datasets of the whole sample and the grouped samples were applied for model calibrations, respectively. The results indicate that the sensitivity to the railing length show significant heterogeneity in preferences, as well as middle age, luggage carrying and density in front of the escalator (ESDEN). All models are validated to have good prediction accuracy. The mixed model outperforms the binary model in predicting the stairs usage, but slightly overestimates the escalator usage. The analysis reinforces earlier findings showing that lengthening the railing (2.5 ~ 3.9 m) reduces the sensitivity of individual diversity to dynamic ESDEN, thus further enhancing the predictive ability by 4.35%. Our results provide unique insights for planners and policymakers on designing and managing transportation systems.