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Atomistic Numerical Simulation on Nanoupsetting Process of Copper Brick
Ji Zhong,Hou Shuai,Liu Ren 한국소성가공학회 2010 기타자료 Vol.2010 No.6
Nanofabrication techniques such as nanoforging have been used to fabricate nanosize components in recent years. As a basic form of nanoforging process, nanoupsetting was studied in this paper via atomistic simulation. First a simplified computation model for upsetting process of single crystalline copper was created, and then the deformation mechanism was investigated at the atomic scale. The results show that the plastic deformation was initiated by the highlevel strain at the corners of the brick; partial dislocations nucleated at the corners and propagated along the [101] and [011] directions in the ( ? ? 1) plane; after unloading, the defects did not disappear or move out to the surface due to lattice friction; the computed load during nanoupsetting agrees well with the theoretical value. At last, the FEM simulation results for this single crystal were also shown, but no load drop was found in its load-displacement curve, which indicates that atomistic simulation is more elaborate than crystal plasticity FEM for nanoscale forming problems.
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( Ji-wei Ma ),( Yong Zhang ),( Ji-cheng Ye ),( Ru Li ),( Yu-lin Wen ),( Jian-xian Huang ),( Xue-yun Zhong ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.2
Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has been reported to have a radiosensitization effect on tumors. However, its effects on human glioma and the specific molecular mechanisms of these effects remain unknown. In this study, we demonstrated that Tet has a radiosensitization effect on human glioma cells. It has been hypothesized that Tet has a radiosensitization effect on glioma cells by affecting the glioma cell cycle and DNA repair mechanism and that ERK mediates these activities. Therefore, we conducted detailed analyses of the effects of Tet on the cell cycle by performing flow cytometric analysis and on DNA repair by detecting the expression of phosphorylated H2AX by immunofluorescence. We used western blot analysis to investigate the role of ERK in the effect of Tet on the cell cycle and DNA repair. The results revealed that Tet exerts its radiosensitization effect on glioma cells by inhibiting proliferation and decreasing the expression of phosphorylated ERK and its downstream proteins. In summary, our data indicate that ERK is involved in Tet-induced radiosensitization of glioma cells via inhibition of glioma cell proliferation or of the cell cycle at G0/G1 phase.
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