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Zhijian Lin,Bing Zhang,Xiaoqing Liu,Rui Jin,Wenjing Zhu 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.11
Inulin, a group of dietary fibers, is reported to improve the metabolic disorders. In the present study, we investigated the effects of chicory inulin on serum metabolites of uric acid (UA), lipids, glucose, and abdominal fat deposition in quail model induced by a purine-rich diet. In this study, 60 male French quails were randomly allocated to five groups: CON (control group), MOD (model group), BEN (benzbromarone-treated group), CHI-H (high-dosage chicory inulin-treated group), and CHI-L (low-dosage chicory inulin-treated group). The serum UA level was significantly increased in the model group from days 7 to 28, as well as triglyceride (TG) and free fatty acid (FFA) increased later in the experimental period. The abdominal fat ratio was increased on day 28. Benzbromarone can decrease UA levels on days 14 and 28. The high and low dosage of chicory inulin also decreased serum UA levels on days 7, 14, and 28. The abdominal fat ratio, activity, and protein of acetyl-CoA carboxylase (ACC) were decreased in chicory inulin-treated groups. The activities of xanthine oxidase (XOD) and fatty acid synthase (FAS) were increased in the model group and decreased in the benzbromarone and chicory inulin groups. This study evaluated a quail model of induced hyperuricemia with other metabolic disorders caused by a high-purine diet. The results indicated that a purine-rich diet might contribute to the development of hyperuricemia, hypertriglyceridemia, and abdominal obesity. Chicory inulin decreased serum UA, TG, and abdominal fat deposition in a quail model of hyperuricemia by altering the ACC protein expression and FAS and XOD activities.
Zhu, Kankai,Jin, Hailong,Li, Zhijian,Gao, Yuan,Zhang, Qing,Liu, Xiaosun,Yu, Jiren The Korean Gastric Cancer Association 2021 Journal of gastric cancer Vol.21 No.1
Purpose: This study aimed to investigate the prognostic value of lymph node ratio (LNR) in patients with locally advanced gastric cancer who received neoadjuvant chemotherapy. Materials and Methods: We retrospectively enrolled gastric cancer patients treated with neoadjuvant chemotherapy and curative surgery at the First Affiliated Hospital of Zhejiang University from 2004 to 2015 as the study cohort. Patients with the same inclusion criteria treated in 2016-2017 were enrolled as the validation cohort. Kaplan-Meier curves were assessed using the log-rank test to analyze the differences in overall survival (OS). Multivariate survival analysis was performed using the Cox proportional hazards model. The areas under the receiver operating characteristic curve of ypN and LNR categories for predicting the actual 3-year OS were compared. Results: A total of 265 patients were included in the proposal cohort. The median number of retrieved lymph nodes (rLNs) was 32. The number of positive lymph nodes (pLNs) increased as rLN increased (P=0.037), but the LNR remained relatively constant (P=0.462). The LNR was categorized into 4 groups according to the prognosis: ypNr0, node-negative with rLN>25; ypNr1, node-negative with rLN≤25 or 0<LNR≤0.1; ypNr2, 0.1<LNR≤0.3; and ypNr3, LNR>0.3. In the validation cohort of 43 enrolled patients, there was a clear distinction in OS that significantly (P<0.001) varied depending on the LNR values and LNR was the only independent prognostic factor in multivariate analysis (P<0.001). Conclusions: LNR was an independent prognostic factor for survival of patients with gastric cancer after preoperative chemotherapy and might be an alternative predictor for ypN stage.
Effective 3-D FEM for large-scale high temperature superconducting racetrack coil
Xiangyu Huang,Zhen Huang,Xiaoyong Xu,Wan Li,Zhijian Jin 한국초전도.저온공학회 2019 한국초전도저온공학회논문지 Vol.21 No.3
In various types of large-scale electrical applications, the number of coil turns in such machines is usually large. Electromagnetic simulation of large-scale superconducting coils (tens to hundreds of turns) is indispensable in the design process of superconducting electrical equipment. However, due to the large scale of the coil and the large aspect ratio of super-conducting material layer in HTS coated conductor, it is usually difficult or even unable to perform 3-D transient electromagnetic simulation. This paper introduces an effective 3-D electromagnetic simulation method for large-scale HTS coated conductor coil based on T-A formulation. The simulation and experimental results show that the 3-D model based on the T-A formulation using homogeneous strategy is more accurate than the traditional 2-D models. The memory usage is not sensitive to the number of turns and this model will be even more superior as the number of turns becomes larger.
Xiangyu Huang,Zhen Huang,Xiaoyong Xu,Wan Li,Zhijian Jin 한국초전도.저온공학회 2019 한국초전도저온공학회논문지 Vol.21 No.4
The critical current is one of the key parameters of high temperature superconducting (HTS) racetrack coils. Therefore, it is significant to calculate critical currents of HTS coils. This paper introduces a fast iterative algorithm for calculating the critical current of second generation (2G) HTS coils. This model does not need to solve long charging transients which greatly reduced the amount of calculation. To validate this model, the V-I curve of four 2G HTS double racetrack coils are measured. The effect of the silicon steel sheet on the critical current of the racetrack coil is also studied based on this algorithm.
Wei Zhang,Kaiqi Lian,Fan Yang,Yang Yang,Zhijian Zhu,Zixiang Zhu,Weijun Cao,Ruoqing Mao,Ye Jin,Jijun He,Jianhong Guo,Xiangtao Liu,Haixue Zheng 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.3
Integrin anb3 plays a major role in various signaling pathways, cell apoptosis, and tumor angiogenesis. To examine the functions and rolesof anb3 integrin, a stable CHO-677 cell line expressing the murine anb3 heterodimer (designated as “CHO-677-manb3” cells) wasestablished using a highly efficient lentiviral-mediated gene transfer technique. Integrin subunits an and b3 were detected at the gene andprotein levels by polymerase chain reaction (PCR) and indirect immunofluorescent assay (IFA), respectively, in the CHO-677-manb3 cellline at the 20th passage, implying that these genes were successfully introduced into the CHO-677 cells and expressed stably. A plaque-formingassay, 50% tissue culture infective dose (TCID50), real-time quantitative reverse transcription-PCR, and IFA were used to detect the replicationlevels of Foot-and-mouth disease virus (FMDV) in the CHO-677-manb3 cell line. After infection with FMDV/O/ZK/93, the cell line showeda significant increase in viral RNA and protein compared with CHO-677 cells. These findings suggest that we successfully established a stableanb3-receptor-expressing cell line with increased susceptibility to FMDV. This cell line will be very useful for further investigation of anb3integrin, and as a cell model for FMDV research.
Huang, Xiangyu,Huang, Zhen,Xu, Xiaoyong,Li, Wan,Jin, Zhijian The Korea Institute of Applied Superconductivity a 2019 한국초전도저온공학회논문지 Vol.21 No.4
The critical current is one of the key parameters of high temperature superconducting (HTS) racetrack coils. Therefore, it is significant to calculate critical currents of HTS coils. This paper introduces a fast iterative algorithm for calculating the critical current of second generation (2G) HTS coils. This model does not need to solve long charging transients which greatly reduced the amount of calculation. To validate this model, the V-I curve of four 2G HTS double racetrack coils are measured. The effect of the silicon steel sheet on the critical current of the racetrack coil is also studied based on this algorithm.
Effective 3-D FEM for large-scale high temperature superconducting racetrack coil
Huang, Xiangyu,Huang, Zhen,Xu, Xiaoyong,Li, Wan,Jin, Zhijian The Korea Institute of Applied Superconductivity a 2019 한국초전도저온공학회논문지 Vol.21 No.3
In various types of large-scale electrical applications, the number of coil turns in such machines is usually large. Electromagnetic simulation of large-scale superconducting coils (tens to hundreds of turns) is indispensable in the design process of superconducting electrical equipment. However, due to the large scale of the coil and the large aspect ratio of super-conducting material layer in HTS coated conductor, it is usually difficult or even unable to perform 3-D transient electromagnetic simulation. This paper introduces an effective 3-D electromagnetic simulation method for large-scale HTS coated conductor coil based on T-A formulation. The simulation and experimental results show that the 3-D model based on the T-A formulation using homogeneous strategy is more accurate than the traditional 2-D models. The memory usage is not sensitive to the number of turns and this model will be even more superior as the number of turns becomes larger.