TIME-MEAN VELOCITY FOR WAVES PROPAGATING AGAINST A TURBULENT CURRENT OVER A ROUGH BED

HUANG ZHENHUA,DING LEI 한국수자원학회 2005 한국수자원학회 학술대회 Vol.2005 No.1

Efficient Query Processing Platform for Uncertain Big Data

Zhenhua Huang,Jiawen Zhang,Qiang Fang 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.5

Query processing technology has recently received a lot of attention in the business intelligence and information service communities. However, the existing approaches can not efficiently optimize the query performance in the uncertain big data environment. In this paper, we propose QPPUBG, a novel and efficient query processing platform for uncertain big data. QPPUBG mainly includes four modules: (i) query equivalence reconstructing for uncertain big data; (ii) multiple query optimization over probability relation components; (iii) query execution plan constructing over probability relation components, and (iv) physical implementation solution of query for uncertain big data. Specially, QPPUBG can support the possible world instance semantics and efficiently handle arbitrary decision spaces. Moreover, QPPUBG can seamlessly integrate the above four modules into the modern parallel computation frameworks. We present the extensive experiments that demonstrate QPPUBG is both efficient and effective.

First-principles study of Ti doping in FeF3$0.33H2O

Zhenhua Yang,Zhijuan Zhang,Yalong Yuan,Yunqing Huang,Xianyou Wang,Xiaoying Chen,Shuangying Wei 한국물리학회 2016 Current Applied Physics Vol.16 No.8

The effect of Ti doping on the geometrical and electronic structures of FeF3$0.33H2O are systematically investigated by using the first principles calculations. We focused on TixFe1-xF3$0.33H2O systems, in which x is equal to 0, 0.08, 0.17 and 0.25, respectively. Different kinds of Ti dopant sites are checked and the most stable structure can be obtained by comparison of total energy. The crystal volume of TixFe1- xF3$0.33H2O expands gradually with increasing Ti doping concentration. Calculated formation energies indicate TixFe1-xF3 is easiest to fabricate and the difficulty of Ti doping FeF3 with hexagonal-tungstenbronze( HTB) structure decreases with the increase of Ti doping concentration under the Fe-rich and Ti-rich growth conditions. Moreover, TixFe1-xF3$0.33H2O is thermodynamically stable, indicating that water molecule can preferentially occupy one-dimensional cavity in the TixFe1-xF3. The band gap of TixFe1-xF3$0.33H2O decreases with increasing Ti doping concentration and Ti0.25Fe0.75F3$0.33H2O exhibits character of half metal, indicating that the conductivity of FeF3$0.33H2O can be improved by Ti-doping. Besides, it can be confirmed that Ti-doping also can broaden the hexagonal cavity in the FeF3$0.33H2O by analyzing the crystal structure of FeF3$0.33H2O and TixFe1-xF3$0.33H2O. With excellent conductivity and larger hexagonal cavity, TixFe1-xF3$0.33H2O can afford open diffusion channels. Therefore, Li ions can remain unblocked, which is beneficial to fast charge and discharge.

First-principles study on the doping effects of Al in a-MnO2

Zhenhua Yang,Xianyou Wang,Yunqing Huang 한국물리학회 2015 Current Applied Physics Vol.15 No.11

In this paper, first-principles calculations have been implemented to study the structural relaxation, formation energies and electronic structure of Al doped a-MnO2. Both Al insertion and Al substitution reactions in the a-MnO2 were considered. Calculated formation energies indicate that Mn atom is easier to be displaced by Al atom under the O-rich growth condition compared with Al insertion reaction. Besides, it can be found that Al doping can afford acceptor impurity level which can accommodate electrons, thus contributing to the improvement of conductivity of a-MnO2. The conductivity of a-MnO2 is gradually improved with the increasing doping concentration of Al, and Al0.0417Mn0.9583O2 exhibits the best conductivity. Lastly, the electronic structure of Al0.0417Mn0.9583O2 was further investigated by analysis of total charge density and Bader charge. It is clear that Al doping can afford more electrons for a-MnO2, which also contributes to improvement of its conductivity.

PCSK9 regulates myocardial ischemia–reperfusion injury through parkin/pink1-mediated autophagy pathway

Huang Guangwei,Bao Hailong,Zhan Peng,Lu Xiyang,Duan Zonggang,Xiong Xinlin,Lin Muzhi,Wang Bing,An Hongxin,Xiahou Luanda,Zhou Haiyan,Luo Zhenhua,Li Wei 대한독성 유전단백체 학회 2024 Molecular & cellular toxicology Vol.20 No.2

Objectives This study aimed at investigating the role of the proprotein convertase subtilisin/Kexin type 9 (PCSK9)-mediated autophagy on myocardial ischemia/reperfusion injury (MIRI). To determine the relationship between autophagy, apoptosis, fibrosis, and inflammation in the myocardium, to provide experience in preventing and treating the myocardial ischemia/reperfusion (I/R) injury. Methods An AC16 hypoxia-reoxygenation model and a rat myocardial ischemia–reperfusion model were established. The concentrations of cardiac troponin T (cTnT) and creatine kinase-MB (CKMB) in plasma were measured by ELISA. To determine the size of the myocardial infarction, TTC/EB staining was performed. In addition to identifying pathological changes in myocardial tissue, Masson’s trichrome stains and H&E stains were used to identify pathological changes. Echocardiography was employed to detect cardiac function. Western blot analysis was then performed to detect the protein expression of Parkin, Pink1, and markers associated with autophagy (Beclin-1, p62, LC3). Results A significant increase in PCSK9 was observed in the myocardium during H/R. In the cardiac-specific PCSK9 knockdown model, cardiac autophagy was significantly inhibited, whereas cardiac-specific PCSK9 overexpression promoted cardiac autophagy. In vivo studies have demonstrated a significant decrease in cardiac autophagy when the PCSK9 inhibitor was administered. Apoptosis induced by I/R was greatly decreased, and myocardial infarction size and function were both improved by PCSK9 inhibitors. Mechanistically, the PCSK9 inhibitor improved the degree of myocardial fibrosis and inhibited the development of inflammation. Conclusions Our results demonstrated that increased PCSK9 via the parkin/pink1 signaling pathway contributes to I/R and H/R by exaggerating excessive autophagy during reperfusion/reoxygenation. In addition, the PCSK9 inhibitor blocked the development of inflammation and improved Infarct size, myocardial function, and myocardial fibrosis.

Experimental Investigation on Tensile Strength of Jurassic Red-Bed Sandstone under the Conditions of Water Pressures and Wet-Dry Cycles

Zhenhua Zhang,Xiaochuan Chen,Huayan Yao,Xiang Huang,Luwang Chen 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.7

Jurassic Red-Bed sandstone is one of the main types of rock composing unstable slopes on both banks of the Three Gorges Reservoir (TGR) in China. It is vulnerable to tensile strength degradation when exposed to cyclic wet-dry conditions under reservoir operation. Therefore, the law behind this needs to be clarified in order to accurately evaluate the stability of a sandstone slope located in the drawdown area of the TGR. In this paper, Jurassic Red-Bed sandstone specimens from the Majiagou landslide in the TGR area were collected for experiments with cyclic wet-dry procedures. After each wet-dry cycle, efforts were made to implement splitting tests, measure clay mineral contents and ion contents in the soak solution, and observe changes in microstructures. The tensile strength is experimentally demonstrated to be a process of damage accumulation under the integrated actions of water pressure, calcite dissolution, and clay mineral hydration, among which hydration of illite contributes the most to the damage. The loss of the cement material and the cyclic expansion and shrinkage of clay minerals weaken the cementation between grains, leading to the tensile strength degradation.

First-principles study on doping effect of Sn in BiF3 as cathode materials for Li-ion battery

Zhenhua Yang,Shuncheng Tan,Yunqing Huang 한국물리학회 2016 Current Applied Physics Vol.16 No.1

First-principles calculations were carried out to investigate the structural relaxation, formation energy, electronic structure and electrochemical properties of Sn-doped BiF3. When Sn was doped into BiF3, two common oxidation states of Sn, þ2 and þ4, were considered. In addition, some typical neutral and charge defects (Sn0 Bi,Sn1 Bi ,Sn1þ Bi ,V2 Bi1 V2 Bi2 and V0 F ) were discussed in detail. Calculated formation energies indicate that Sn4þ ion is much easier to dope into BiF3 than Sn2þ ion. When Fermi level lies at the bottom of conduction band, Sn1/32Bi30/32F3 with V2 Bi1 (Bi vacancy defect) induced by Sn4þ ion doping has the most stable structure under the rich-F growth condition. Here, DmSn, DmBi and DmF are 13.18 eV,9.71 eV and 0, respectively. What's more, the crystal structure, electronic structure and electrochemical properties of Sn1/32Bi30/32F3 with V2 Bi1 were further investigated. It is found that the crystal volume of Sn1/32Bi30/32F3 with V2 Bi1 is larger than that of pure BiF3 because the length of BieF bond around V2 Bi1 in the Sn1/32Bi30/ 32F3 becomes much longer relative to the length of BieF bond in the pure BiF3. Besides, the calculated band gap of Sn1/32Bi30/32F3 with V2 Bi1 is 2.70 eV, which is smaller than that of pure BiF3. Furthermore, Sn1/ 32Bi30/32F3 with V2 Bi1 has better theoretical voltage and theoretical capacity than pure BiF3.

Rheological behavior of acylated pepsin-solubilized collagen solutions: Effects of concentration

Conghu Li,Lian Duan,Zhenhua Tian,Wentao Liu,Guoying Li,Xiaoping Huang 한국유변학회 2015 Korea-Australia rheology journal Vol.27 No.4

Effects of concentration on the rheological behavior of acylated pepsin-solubilized collagen solutions were investigated by steady shear tests, dynamic frequency sweep, creep tests and thixotropic loop measurements in this paper. The results showed that both acylated collagen and native collagen solutions exhibited the typical pseudoplastic behavior and displayed shear thinned behavior with the increase of shear rate. With the increase of acylated collagen concentrations from 5 to 10 mg/mL, shear viscosity, elasticity modulus (G'), viscous modulus (G''), complex viscosity (η*), and the ability to resist deformation increased due to the physical entanglement, whilst loss tangent (tan δ) decreased. Additionally, with the increase of acylated collagen concentrations, the area of thixotropic loop increased from 6.94 to 44.40 watts/m3, indicating that the thixotropy of acylated collagen increased. Compared with native collagen solution, acylated collagen solution had stronger shear viscosity, η*, thixotropy, and ability to resist deformation. Furthermore, Power law model, Carreau model, Cross model, Leonov model and Burger model, were suitable for the fitting of the experimental data

Whole RNA-sequencing and gene expression analysis of Trichoderma harzianum Tr-92 under chlamydospore-producing condition

Min Yuan,Yuanyuan Huang,Zhenhua Jia,Weina Ge,Lan Zhang,Qian Zhao,Shuishan Song,Yali Huang 한국유전학회 2019 Genes & Genomics Vol.41 No.6

Background Trichoderma is one of the most important biocontrol fungi, which could produce mycelia, conidiospores, and chlamydospores three types of propagules under different conditions. Chlamydospores are produced in harsh conditions in various fungi, and may be more resistant to adverse conditions. However, the knowledge associated with the mechanism of chlamydospore formation remained unclear in Trichoderma. Objectives This study is aimed to explore the essential genes and regulatory pathways associated with chlamydospore formation in Trichoderma. Methods The culture condition, survival rate, and biocontrol effects of chlamydospores and conidiospores from Trichoderma. harzianum Tr-92 were determined. Furthermore, the whole transcriptome profiles of T. harzianum Tr-92 under chlamydospore-producing and chlamydospore-nonproducing conditions were performed. Results T. harzianum Tr-92 produced chlamydospores under particular conditions, and chlamydospore-based formulation of T. harzianum Tr-92 exhibited higher biocontrol ability against Botrytis cinerea in cucumber than conidoiospore-based formulation. In the transcriptome analysis, a total of 2,029 differentially expressed genes (DEGs) were identified in T. harzianum Tr-92 under chlamydospore-producing condition, compared to that under chlamydospore-nonproducing condition. GO classification indicated that the DEGs were significantly enriched in 284 terms among biological process, cellular components and molecular function categories. A total of 19 pathways were observed with DEGs by KEGG analysis. Furthermore, fifteen DEGs were verified by quantitative real-time PCR, and the expression profiles were consistent with the transcriptome data. Conclusion The results would provide a basis on the molecular mechanisms underlying Trichoderma sporulation, which would assist the development and application of fungal biocontrol agents.

Cloning and Characterization of the Ammonium Transporter Genes BaAMT1;1 and BaAMT1;3 from Chinese Kale

Shiwei Song,Riyuan Chen,Zhenhua He,Xinmin Huang,Lihua Zhong,Houcheng Liu,Guangwen Sun 한국원예학회 2017 Horticulture, Environment, and Biotechnology Vol.58 No.2

Chinese kale (Brassica alboglabra L.) is a popular vegetable rich in important nutrients. Fertilization withappropriate ammonium:nitrate ratios enhances biomass production and quality. AMT-type ammonium transporters havebeen shown to mediate ammonium uptake across the plasma membrane. However, very little is known about themolecular regulation of growth and development by ammonium in Chinese kale, including how ammonium regulatesthe expression of AMT1 genes. In this study, we identified and characterized two AMT1 genes from B. alboglabra,BaAMT1;1 and BaAMT1;3. The full-length open reading frames of BaAMT1;1 and BaAMT1;3 were 1512 bp and1515 bp, respectively. Transient expression of the fusion proteins pBE-EGFP-BaAMT1;1 and pBE-EGFP-BaAMT1;3 inonion epidermal cells indicated that these transporters are located on the plasma membrane. BaAMT1;1 and BaAMT1;3were functional in yeast and complemented a mutant defective in ammonium transport. BaAMT1;1 was expressed invegetative organs and at high levels in roots, while BaAMT1;3 expression was root specific. In addition, we observedopposite responses of BaAMT1;1 and BaAMT1;3 expression to nitrogen starvation and ammonium resupply in roots. These results provide new insights into the molecular mechanisms underlying ammonium absorption in Chinese kale.