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Guo-An Wang,Xiaomei Qi,Shan Zheng 중앙대학교 한국전자무역연구소 2009 전자무역연구 Vol.7 No.3
지난 10년간의 개발기간동안 알리바바는 고유의 비즈니스 방식을 만들었는데 즉, 기업과 개인에게 시간과 공간의 단절 없이 운영하고 그 자체와 수백만의 중소기업들에게 전례가 없는 사업 기회를 제공하고 있는 국경 없는 전자무역 시장이다. 알리바바의 혁신적인 마케팅 전략은 그들의 개발을 가속화시켰고 세계의 전자상거래 분야에서 두드러졌다. 이 논문은 알리바바의 성공 경로에 대해 처음으로 연구되는 것이며 McCarthy 교수의 4Ps 이론에 기초한 효과적인 마케팅 전략에 대해 살펴본다. 마지막으로 2008년에 있었던 세계 금융 위기에 맞선 마케팅 전략의 향상에 관한 제안을 제공한다. During the 10 years of development, Alibaba has established a unique business mode, a borderless e-trade market running around the clock on the Internet for enterprises and individuals without limit in time and space and providing itself and millions of small and medium-sized enterprises(SME) with unprecedented business opportunities. The innovative marketing strategies of Alibaba has accelerated its development and distinguished itself in the field of e-commerce in the world. This paper at first offers an overview of Alibaba’s path of development, and then discusses its effective marketing strategies based on Professor McCarthy’s 4Ps theory. Finally it provides some suggestions on the improvement of its marketing strategies regarding the fight against the financial crisis worldwide which began in 2008.
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터널굴착 중 지하수위 강하 및 깊이별 투수계수 변화를 적용한 지하수 유입량 변화 분석
문준식,쩡안치,장서용,Moon, Joon-Shik,Zheng, An-Qi,Jang, Seoyong 한국터널지하공간학회 2017 한국터널지하공간학회논문집 Vol.19 No.2
터널 내 지하수 침투는 터널붕괴와 그에 따른 지반침하의 주요 원인 중 하나이다. 따라서 터널굴착 중 시간에 따른 지하수 침투량과 간극수압 변화를 적절히 예측하는 것이 중요하다. 실무에서는 균질한 지반조건으로 가정하는 Goodman의 산정법을 사용하여 지하수 침투량을 계산하지만, 터널굴착 중 지하수위 강하와 깊이에 따른 투수계수 변화를 고려하지 않아 설계단계에서 지하수 유입량을 과다하게 산정할 우려가 있다. 따라서 본 연구에서는 지하수위 강하 및 깊이별 투수계수의 감소를 적용한 매개변수분석을 통해 지하수 유입량 변화를 분석 비교하였으며, 시간에 따른 지하수 침투량 변화와 지하수위 및 간극수압 분포 변화를 분석하기 위해 비정상류 해석을 수행하였다. Groundwater seepage into a tunnel is one of the main causes triggering tunnel collapse and the consequent ground subsidence. Thus, it is important to estimate adequately the groundwater inflow rate and porewater pressure change during tunneling with time elapse. In current practice, Goodman's analytical solution (or image tunnel method) assuming homogeneous ground condition around a tunnel is commonly used for estimating groundwater inflow rate. However, the generally-used analytical solution for estimating groundwater inflow rate does not consider groundwater level drawdown and permeability change with depth, and the inflow rate can be overestimated in design phase. In this study, parametric study was performed in order to investigate the effect of groundwater level drawdown and permeability reduction with depth, and transient flow analysis was carried out for studying the inflow rate change as well as groundwater level and porewater pressure change around a tunnel with time elapse.
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Lei Guo,Wen-Cheng Zhu,Ya-Ting Liu,Jiu-Yu Wu,An-Qi Zheng,Yan-Li Liu 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.5
The optimized extraction conditions of total flavonoids from mimenghua were determined by the Box-Behnken design and response surface methodology. The optimal conditions to achieve the maximum yield of flavonoids were determined as follows: ethanol concentration 68%(v/v), extraction temperature 72.4oC, liquid/material ratio 48:1mL/g, and extraction time 2 h. Under the optimized conditions, the extraction ratio of flavonoids was 15.44%. The crude extract was then purified by AB-8 macroporous adsorption resin, the flavonoids content in the purified extract increased to 90.43%. The antioxidant activities of the purified flavonoids were evaluated in vitro by scavenging capabilities of DPPH radical, hydroxyl radical and superoxide radical, reducing power and total antioxidant capacity. The results showed that the flavonoids have significant antioxidant activities, which can be used as a source of potential antioxidant.
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Yi-Jing Wang,Pan Zhao,Bing-Dong Sui,Nu Liu,Cheng-Hu Hu,Ji Chen,Chen-Xi Zheng,An-Qi Liu,Kun Xuan,Ya-Ping Pan,Yan Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Mesenchymal stem cell (MSC)-based regeneration, specifically cell aggregate or cell sheet engineering, is a promising approach for tissue reconstruction. Considering the advantages of ease of harvest and lack of immune rejection, the application of autologous MSCs (i.e., patients’ own MSCs) in regenerative medicine has developed considerable interest. However, the impaired cell viability and regenerative potential following MSCs impacted by disease remain a major challenge. Resveratrol (RSV) exhibits reliable and extensive rejuvenative activities that have received increasing clinical attention. Here, we uncovered that resveratrol enhances the functionality and improves the regeneration of mesenchymal stem cell aggregates. Periodontal ligament MSCs (PDLSCs) from normal control subjects (N-PDLSCs) and periodontitis patients (P-PDLSCs) were investigated. Compared to N-PDLSCs, P-PDLSCs were less capable of forming cell aggregates, and P-PDLSC aggregates showed impaired osteogenesis and regeneration. These functional declines could be mimicked in N-PDLSCs by tumor necrosis factor alpha (TNF-α) treatment. Notably, a TNF-α-induced functional decline in N-PDLSC aggregates was rescued by RSV application. More importantly, in both N-PDLSCs and P-PDLSCs, RSV promoted cell aggregate formation and improved their osteogenic potential. Furthermore, as proven ectopically in vivo, the tissue regenerative capability of P-PDLSC aggregates was also enhanced after RSV treatment during aggregate formation in vitro. Finally, in a rat in situ regeneration model, we successfully applied both N-PDLSC aggregates and P-PDLSC aggregates to repair periodontal defects upon long-term functional improvements by RSV preconditioning. Together, our data unravel a novel methodology for using pharmacology (i.e., RSV)-based cell aggregate engineering to improve the functionality and facilitate the regeneration of MSCs from both healthy and inflammatory microenvironments, shedding light on improving the application of autologous MSC-mediated regenerative medicine.
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