Safety of nighttime elective hepatectomy for hepatocellular carcinoma patients: a retrospective study

Zhan-cheng Qiu,You-wei Wu,Wei-li Qi,Chuan Li 대한외과학회 2024 Annals of Surgical Treatment and Research(ASRT) Vol.106 No.2

Purpose: This study aimed to investigate whether nighttime elective surgery influenced the short-term outcomes and prognosis of hepatocellular carcinoma (HCC) patients. Methods: The 1,339 HCC patients who underwent hepatectomy were divided into the daytime surgery group (8 a.m.–6 p.m., n = 1,105) and the nighttime surgery group (after 6 p.m., n = 234) based on the start time of surgery. The 1:2 propensity score matching (PSM) analysis was used to control confounding factors. The short-term outcomes of HCC patients in the 2 groups were compared before and after PSM. Factors associated with major complications (Clavien-Dindo grade, ≥III) and textbook oncologic outcomes (TOO) were separately identified by multivariable logistic regression based on variables screened via least absolute shrinkage and selection operator (LASSO). The Kaplan-Meier method was used to analyze overall survival (OS) and recurrence-free survival (RFS). Results: TOO was achieved after surgery in 897 HCC patients. HCC patients in the nighttime surgery group had a higher body mass index (P = 0.010). After 1:2 PSM, the baseline characteristics of patients between the 2 groups were similar. Short-term outcomes in HCC patients were comparable both before and after PSM (all Ps > 0.05), as were TOO in the 2 groups before (P = 0.673) and after PSM (P = 0.333). In our LASSO-logistic regression, nighttime surgery was not an independent factor associated with major complications or TOO. Both groups also had similar OS (P = 0.950) and RFS (P = 0.740) after PSM. Conclusion: Our study revealed the safety of nighttime elective hepatectomy for HCC patients.

Quantitative Presentation of the Systematic Relationships Between S. sudanense and S. bicolor

Qiu-Wen Zhan,Ping Lin,Jie-Qin Li,Min Zu,Jun-Cheng Fan,Ya Chen,Fei Fan,Shi-fu Shu 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08

Fifty-four biological characters were used for quantitative classification of sorghum and sudangrass and their relationship. Discriminant analysis of all 240 individuals of 48 accessions suggested that 100% of originally grouped cases were correctly classified. Analysis of variance results showed that the differences among 48 accessions in characters were significant at the 0.01 level. Cluster analysis showed that the 48 accessions were obviously divided into two clusters by a Euclidean distance of 17.46 as the classification standards, i.e. the genus maize and genus sorghum. The 48 accessions were divided into four clusters by a Euclidean distance of 9.86, i.e. Sorghum-Sudangrass, Sorghum related species (S. propinquum and S. halepense), Zea mexicana and Z. mays. All accessions were divided into five clusters by a Euclidean distance of 8.91, namely group Ⅰ (Sudangrass-Chinese sorghum), group Ⅱ (Non-Chinese sorghum), group Ⅲ (Sorghum related species), group Ⅳ (Zea mexicana), and group Ⅴ (Z mays).

Maximizing Property Tuning of Phosphorus Corrole Photocatalysts through a Trifluoromethylation Approach

Zhan, Xuan,Teplitzky, Peter,Diskin-Posner, Yael,Sundararajan, Mahesh,Ullah, Zakir,Chen, Qiu-Cheng,Shimon, Linda J. W.,Saltsman, Irena,Mahammed, Atif,Kosa, Monica,Baik, Mu-Hyun,Churchill, David G.,Gros ACS AMERICAN CHEMICAL SOCIETY 2019 Inorganic Chemistry Vol. No.

<P>An eight-member series of CF<SUB>3</SUB>-substituted difluorophosphorus corroles was prepared for establishing a structure-activity profile of these high-potential photosensitizers. It consisted of preparing all four possible isomers of the monosubstituted corrole and complexes with 2-, 3-, 4-, and 5-CF<SUB>3</SUB> groups on the macrocycle’s periphery. The synthetic pathway to these CF<SUB>3</SUB>-substituted derivatives, beginning with (<B>tpfc</B>)<B>PF</B><SUB><B>2</B></SUB>, involves two different initial routes: (i) direct electrophilic CF<SUB>3</SUB> incorporation using FSO<SUB>2</SUB>CF<SUB>2</SUB>CO<SUB>2</SUB>Me and copper iodide, or (ii) bromination to achieve the 2,3,8,17,18-pentabrominated compound using excess bromine in methanol. Crystallographic investigations revealed that distortion of the original planar macrocycle is evident even in the monosubstituted case and that it becomes truly severe for the penta-CF<SUB>3</SUB>-substituted derivative <B>5</B>. There is a shift in redox potentials of about 193 mV per -CF<SUB>3</SUB> group, which decreases to only 120 mV for the fifth one in <B>5</B>. Differences in the electronic spectra suggest that the Gouterman four orbital model decreases in relevance upon gradual -CF<SUB>3</SUB> substitution, a conclusion that was corroborated by DFT calculations. The very significant energy lowering of the frontier orbitals suggested that photoexcitation should lead to a highly oxidizing photocatalyst. This hypothesis was proven true by finding that the most synthetically accessible CF<SUB>3</SUB>-substituted derivative is an excellent catalyst for the photoinduced conversion of bromide to bromine (phenol, toluene, and benzene assay).</P><P>CF<SUB>3</SUB>-substituted difluorophosphorus corroles were synthesized and studied by CV, NMR spectroscopy, crystallography, and DFT. All four possible isomers of the monosubstituted corrole and complexes with 2-, 3-, 4-, and 5-CF<SUB>3</SUB> groups on the macrocycle’s periphery were prepared. The sterical and electronic role of the -CF<SUB>3</SUB> unit became evident through the study of the 5-CF<SUB>3</SUB> species which was found to be an excellent bromide photocatalyst (photoxidation with phenol, toluene, and benzene assays).</P> [FIG OMISSION]</BR>

Cadmium stress inhibits the growth of primary roots by interfering auxin homeostasis in Sorghum bicolor seedlings

Yi-hua Zhan,Cheng-hao Zhang,Qiu-xun Zheng,Zong-an Huang,Chen-liang Yu 한국식물학회 2017 Journal of Plant Biology Vol.60 No.6

Phytotoxic effects of cadmium (Cd), a heavy metalpollutant, on plants have been extensively examined. Auxinplays vital roles in many aspects of plant development. Theassociation between root growth and auxin signaling in CdstressedSorghum bicolor was analyzed in our study. Rootelongation, shoot length and the maximal photochemicalefficiency (Fv/Fm) in S. bicolor seedlings were dramaticallyreduced after Cd stress treatment. Cd was found to bepredominantly confined in the meristematic zone using a Cdstainingmethod. Cd stress remarkably influenced the cellcycle progression at the root tip as shown by EdU (ethynyldeoxyuridine) assay. The content of IAA was markedlydiminished in the roots of Cd-stressed S. bicolor, which wasalong with the increase of IAA oxidase activity. Auxintransport inhibitors, 1-naphthoxyacetic acid (1-NOA) or 1-naphthylphthalamic acid (NPA), greatly reduced plant toleranceto Cd stress, whereas exogenous application of 1-naphthaleneacetic acid (NAA) improved Cd tolerance in S. bicolor seedlings. Cd stress altered the transcript level ofsome putative auxin biosynthetic genes. In addition, NAAinterfered with the homeostasis of Cd-induced reactiveoxygen species (ROS). These results revealed that Cd stressdisturbed the growth of S. bicolor seedlings by affecting thehomeostasis of auxin and ROS.

Cloning of Phospholipase D from Grape Berry and Its Expression under Heat Acclimation

Wan, Si-Bao,Wang, Wei,Wen, Peng-Fei,Chen, Jian-Ye,Kong, Wei-Fu,Pan, Qiu-Hong,Zhan, Ji-Cheng,Tian, Li,Liu, Hong-Tao,Huang, Wei-Dong Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.4

To investigate whether phospholipase D (PLD, EC 3.1.4.4) plays a role in adaptive response of post-harvest fruit to environment, a PLD gene was firstly cloned from grape berry (Vitis Vinifera L. cv. Chardonnay) using RT-PCR and 3'- and 5'-RACE. The deduced amino acid sequence (809 residues) showed 84.7% identity with that of PLD from Ricinus communis. The secondary structures of this protein showed the characteristic C2 domain and two active sites of a phospholipid-metabolizing enzyme. The PLD activity and its expression in response to heat acclimation were then assayed. The results indicated PLD was significantly activated at enzyme activity, as well as accumulation of PLD mRNA and synthesis of new PLD protein during the early of heat acclimation, primary suggesting that the grape berry PLD may be involved in the heat response in post-harvest grape berry. This work offers an important basis for further investigating the mechanism of post-harvest fruit adaptation to environmental stresses.

Cloning of Phospholipase D from Grape Berry and Its Expression under Heat Acclimation

( Si Bao Wan ),( Wei Wang ),( Peng Fei Wen ),( Jian Ye Chen ),( Wei Fu Kong ),( Qiu Hong Pan ),( Ji Cheng Zhan ),( Li Tian ),( Hong Tao Liu ),( Wei Dong Huang ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.4