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Choi, Yusung,Pham, Thuy-Vy,Mai, Xuan-Lan,Truong, Quoc-Ky,Le, Thi-Anh-Tuyet,Nguyen, Thi-Ngoc-Van,Lee, Gunhee,Kang, Jong-Seong,Mar, Woongchon,Kim, Kyeong Ho The Korean Society of Analytical Science 2019 분석과학 Vol.32 No.5
Over the past decades, chiral switch of the proton pump inhibitors (PPIs) has been received widespread attention in therapeutic advantages as well as pharmaceutical analysis. In present study, the influence of cyclodextrins (CDs) on the chiral separation of four common PPIs (lansoprazole, omeprazole, pantoprazole, and rabeprazole) was investigated. The results demonstrated that capillary electrophoresis (CE) with dual CDs as a chiral selector system is a possible and promising method for the enantioseparation of these PPIs. Rabeprazole, which is the most challenging and acid-labile candidate among four PPIs, was selected for further development of the technique. To optimize CE condition, the effects of capillary parameters and background electrolytes on the enantioseparation were investigated. Finally, the best chiral separation was acheived by using sulfobutyl ether-${\beta}$-CD, and ${\gamma}$-CD as dual chiral selectors. The developed CE method not only provided the effective chiral separation but also showed the good stability of rabeprazole. The proposed method was successfully validated according to the International Conference on Harmonization guideline and effectively applied to determine rabeprazole enantiomers in commercial rabeprazole tablets, with recoveries ranging from 97.17 % to 103.29 % of the label content.
Yusung Choi,Thuy-Vy Pham,Xuan-Lan Mai,Quoc-Ky Truong,Thi-Anh-Tuyet Le,Thi-Ngoc-Van Nguyen,Gunhee Lee,Jong-Seong Kang,Woongchon Mar,김경호 한국분석과학회 2019 분석과학 Vol.32 No.5
Over the past decades, chiral switch of the proton pump inhibitors (PPIs) has been received widespread attention in therapeutic advantages as well as pharmaceutical analysis. In present study, the influence of cyclodextrins (CDs) on the chiral separation of four common PPIs (lansoprazole, omeprazole, pantoprazole, and rabeprazole) was investigated. The results demonstrated that capillary electrophoresis (CE) with dual CDs as a chiral selector system is a possible and promising method for the enantioseparation of these PPIs. Rabeprazole, which is the most challenging and acid-labile candidate among four PPIs, was selected for further development of the technique. To optimize CE condition, the effects of capillary parameters and background electrolytes on the enantioseparation were investigated. Finally, the best chiral separation was acheived by using sulfobutyl ether-β-CD, and γ-CD as dual chiral selectors. The developed CE method not only provided the effective chiral separation but also showed the good stability of rabeprazole. The proposed method was successfully validated according to the International Conference on Harmonization guideline and effectively applied to determine rabeprazole enantiomers in commercial rabeprazole tablets, with recoveries ranging from 97.17 % to 103.29 % of the label content.
질적 지표에 의거한 최근 10년간 학습장애 집단 실험 연구 동향 분석 및 학습장애 연구에 주는 시사점 연구
허유성 ( Yusung Heo ),박윤 ( Youn Park ),장은미 ( Eunmee Jang ),최은순 ( Eunsoon Choi ),양안숙 ( Annsook Yang ),김태강 ( Taegang Kim ) 대구대학교 한국특수교육문제연구소 2010 특수교육저널 : 이론과 실천 Vol.11 No.1
The purpose of this study was to analyze the last 10-year group experimental or quasi-experimental studies for student with LD based on quality indicators. The results of this study indicated that the group experimental and quasi-experimental researches were limited in numbers considering the current importance of evidence-based practices in special education. Second, they did not provide clear definition of LD with reliable references. It makes hard to replicate the studies. Third, they did not provide enough data for the participants that enable future replication studies. Fourth, the studies that employed random assignment were limited in numbers. It indicated that more large scale of studies should be implemented. Fifth, they provided relatively detail information on the interventions of experimental groups, however, the descriptions of comparison groups were not enough to replicate them. In addition, many studies skipped the reports on implementation fidelity. This study included the analysis of intervention implementers, measurements, data collection, and analysis.
시각 장애인을 위한 분리수거 도움 시스템, ‘Re-트리버’
최성(Seong Choi),박애리(Aeri Park),장대규(Daegyu Jang),김경현(Kyunghyun Kim),진기찬(Gichan Jin),유민형(Minhyeong Yu),김승재(Seungjae Kim),이유성(Yusung Lee),김진형(Jinhyeong Kim),김아현(Ahyeon Kim),박수인(Sooin Park),피우리(Woori Pi),소 한국정보기술학회 2024 Proceedings of KIIT Conference Vol.2024 No.5
본 시스템은 실생활에서 시각장애인이 스스로 쓰레기를 분류하고 처리할 수 있도록 지원하는 것을 목표로 한다. 시각장애인이 폐기물의 사진을 찍으면 학습된 AI가 사진을 분석하고 분리수거를 음성으로 안내하도록 구현한다. Re-트리버의 주 기능은 쓰레기 항목 인식, 분류 지원, 그리고 음성 피드백을 통한 상호작용이고, 이러한 기능들은 시각장애인의 독립성을 높이고 일상생활에서의 자립을 가능하게 하여 시각장애인들의 삶의 질을 향상시켜 줄 것이다. This application is designed to support visually impaired individuals in autonomously sorting and managing waste in everyday life. When a visually impaired user takes a photo of waste, the trained AI analyzes the image and provides recycling instructions through voice guidance. The main features of Re-Triever include waste item recognition, classification support, and interaction via voice feedback. These functionalities enhance the independence of visually impaired users and enable self-reliance in daily activities, ultimately improving their quality of life.
Therapeutic New Era for Atopic Dermatitis: Part 2. Small Molecules
( Jiyoung Ahn ),( Yusung Choi ),( Eric Lawrence Simpson ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.2
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. Currently, we are experiencing a new era of understanding of the pathogenesis of AD and, as a consequence, a new era of innovation in therapeutics, including small molecules and biologic therapy. In contrast to biologics, small molecules are similar to conventional pharmacologic chemical agents used as drugs and are generally prepared by chemical synthesis. Unlike biologics, these drugs often are taken orally or formulated for topical use. The purpose of this review is to summarize the efficacy and safety of the current topical and systemic new therapies in AD by reviewing recently published papers on therapies currently in phase 2 or 3 clinical trials. In this review, it is important to note the characteristics of the study population, the primary endpoints, and whether or not there was concomitant topical therapy allowed. These study design elements may significantly alter the results of studies and should be taken into account. Targeted therapy help push AD treatment into a new era of personalized medicine. (Ann Dermatol 33(2) 101 ∼107, 2021)
Therapeutic New Era for Atopic Dermatitis: Part 1. Biologics
( Jiyoung Ahn ),( Yusung Choi ),( Eric Lawrence Simpson ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.1
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. We are currently experiencing a new era of understanding of the pathogenesis of AD and, as a consequence, a new era of innovation in therapeutics, including small molecules and biologic therapy. Recently, advances in translational research have challenged the traditional AD pathogenesis paradigm of AD being solely a Th2-dominant disease. Other immune pathways seem to play a role in the complex AD pathophysiology, although the clinical relevance of these additional immune pathway abnormalities is unclear. Type 1, type 22, and type 17 pathway activation (with related cytokines/chemokines) have been demonstrated in the skin and blood of AD patients. Type 2 (interleukin [IL]-4, IL-13), IL-31, and type 22 (IL-22) pathway cytokines are increased in AD acute lesions. IL-22 induces both an epidermal hyperplasia at the onset of acute AD and a marked increase in the terminal differentiation S100 genes. This understanding of pathogenesis corresponds to a historic increase in therapeutic development in AD. The extreme clinical heterogeneity and the chronic progression of AD establish the need for newer, safer, and more effective treatments, control the disease, and improve the quality of life of affected patients. (Ann Dermatol 33(1) 1∼10, 2021)
Xuan-Lan Mai,Yusung Choi,Quoc-Ky Truong,Thi-Ngoc-Van Nguyen,Sang Beom Han,Kyeong Ho Kim 한국분석과학회 2020 분석과학 Vol.33 No.4
Separation of basic compounds using reverse phase chromatography on a silica-based stationary phase represents a major challenge, because of the interaction between the cationic sites of the basic compounds with the anionic silanols of the stationary phase. This study presents a simple, reliable, and organic solvent - free liquid chromatographic method for the determination of terbutaline and salbutamol, in which a room temperature ionic liquid (RTIL) is used as mobile phase additive. We investigated various mobile phase parameters affecting the retention of the two compounds, such as types and concentration of RTILs and, pH of the mobile phase were investigated. The developed method was validated according to International Conference on Harmonization (ICH) guidelines and successfully applied effectively to determine salbutamol sulfate in pharmaceutical preparations.