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Lim So Yun,Yoon Young-In,Kim Ji Yeun,Tak Eunyoung,송기원,김성한,Lee Sung-Gyu 대한면역학회 2022 Immune Network Vol.22 No.3
Coronavirus disease 2019 (COVID-19) vaccination in immunocompromised, especially transplant recipients, may induce a weaker immune response. But there are limited data on the immune response after COVID-19 vaccination in liver transplant (LT) recipients, especially on the comparison of Ab responses after different vaccine platforms between mRNA and adenoviral vector vaccines. Thus, we conducted a prospective study on LT recipients who received two doses of the ChAdOx1 nCoV-19 (ChAdOx1), mRNA-1273, or BNT162b2 vaccines compared with healthy healthcare workers (HCWs). SARS-CoV-2 S1-specific IgG Ab titers were measured using ELISA. Overall, 89 LT recipients (ChAdOx1, n=16 [18%]) or mRNA vaccines (mRNA-1273 vaccine, n=23 [26%]; BNT162b2 vaccine, n=50 [56%]) received 3 different vaccines. Of them, 16 (18%) had a positive Ab response after one dose of COVID-19 vaccine and 62 (73%) after 2 doses. However, the median Ab titer after two doses of mRNA vaccines was significantly higher (44.6 IU/ml) than after two doses of ChAdOx1 (19.2 IU/ml, p=0.04). The longer time interval from transplantation was significantly associated with high Ab titers after two doses of vaccine (p=0.003). However, mycophenolic acid use was not associated with Ab titers (p=0.53). In conclusion, about 3-quarters of LT recipients had a positive Ab response after 2 doses of vaccine, and the mRNA vaccines induced higher Ab responses than the ChAdOx1 vaccine.
Hydroxyapatite Coating on TiO<sub>2</sub> Nanotube by Sol—Gel Method for Implant Applications
Lim, Hyun-Pil,Park, Sang-Won,Yun, Kwi-Dug,Park, Chan,Ji, Min-Kyung,Oh, Gye-Jeong,Lee, Jong-Tak,Lee, Kwangmin American Scientific Publishers 2018 Journal of Nanoscience and Nanotechnology Vol.18 No.2
<P>The aim of this study was to determine the effect of hydroxyapatite (HA) coating on titanium dioxide (TiO2) nanotube by sol-gel process on viability of osteoblast like cell (MC3T3-E1) and bone formation in rat tibia. Specimens were divided into three groups including commercially pure titanium (control group), TiO2 nanotubes (group N), and HA coated TiO2 nanotubes (group HN). Surface characteristics were determined using field emission scanning electron microscope (FE-SEM; S-4700, Hitachi, Japan) and contact angles were measured. Cell viability was investigated in vitro after 1 day, 3 days, and 7 days of incubation. Implants (2.0 mm in diameter and 5.0 mm in length) were inserted into the tibia of rats. After 4 weeks, histomorphometric analysis was performed. Both N and HN groups showed enhanced hydrophilicity compared to control group. After 7 days of implantation, group HN showed higher cell viability with marginal significance (0.05 < P < 0.1). Bone to implant contact (BIC) ratio in the control group, group N, and group HN were 32.5%, 33.1%, and 43.8%, respectively. Results of this study showed that HA coated TiO2 nanotube using sol-gel process could be used to enhance hydrophilicity and improve osseointegration of dental implant surface.</P>
Yun, Ui-Jin,Jo, Min-Je,Lee, Jong-Won,Lee, Seung-Bok,Lim, Tak-Hyoung,Park, Seok-Joo,Song, Rak-Hyun American Chemical Society 2013 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.52 No.44
<P>A tubular direct carbon fuel cell (DCFC) based on a general anode support solid oxide fuel cell was fabricated and studied. For this purpose, we fabricated tubular anode support tubes through an extrusion process, and the essential fuel cell components, the electrolyte and the electrode, were coated on the surface of the anode support consecutively using a vacuum slurry and dip-coating method. Carbon black and molten carbonate as the fuel and the electrochemical mediator were filled in the inner part of the tubular DCFC. The performance of the tubular DCFC in carbon + carbonate (1:1 wt %) and air at 900 °C had a maximum power density of 122 mW/cm<SUP>2</SUP>. It was operated at variable operating conditions: operating temperature, anode and cathode gas supply, and so on. These results indicate that the fabricated tubular DCFC is a promising candidate for many other practical applications, such as residential power generation and auxiliary power unit systems.</P>
Oh, Tak Kyu,Lim, Myong Cheol,Lee, Yumi,Yun, Jung Yeon,Yeon, Seungmin,Park, Sang-Yoon Lippincott WilliamsWilkins 2016 International journal of gynecological cancer Vol.26 No.3
<P><B>Objective</B></P><P>Many studies have compared different methods of postoperative pain management in abdominal laparotomy patients; however, the conclusions have been inconsistent and controversial. This study aimed to compare the pain scores and complications of patients who underwent cytoreductive surgery for ovarian cancer and used either patient-controlled epidural analgesia (PCEA) or patient-controlled intravenous analgesia (PCA) for postoperative pain management. We hypothesized that PCEA would be superior to PCA for postoperative pain management in ovarian cancer surgery.</P><P><B>Materials and Methods</B></P><P>The medical records of women who underwent ovarian cancer surgery in 2014 were reviewed retrospectively. Pain scores for postoperative days (PODs) 0 to 5 days and the incidence of complications were examined and compared in patients who received PCEA and PCA. Means were compared using an independent sample <I>t</I> test or Wilcoxon rank sum test, and proportions were compared using Fisher exact test or a χ<SUP>2</SUP> test at each time point. A mixed-effects model was applied to determine correlations among repeated measurements. A <I>P</I> value less than 0.05 was considered significant.</P><P><B>Results</B></P><P>Of the 105 study patients, 38 received PCEA and 67 received PCA. Pain scores were significantly lower in the PCEA group than the PCA group at POD 0 (2.47 ± 1.75 vs 4.39 ± 1.17; <I>P</I> < 0.001), 1 (2.65 ± 1.02 vs 3.32 ± 1.09; <I>P</I> < 0.001), and 3 (2.17 ± 1.13 vs 2.79 ± 1.08; <I>P</I> = 0.011), and tended to be lower in the PCEA group at PODs 2, 4, and 5. Patient-controlled epidural analgesia provided significantly better pain relief as analyzed by a mixed-effect model. Complications were not significantly different between both groups. There was no significant difference in pain relief between both groups at PODs 4 and 5.</P><P><B>Conclusions</B></P><P>Patient-controlled epidural analgesia was more effective for postoperative pain management compared with PCA from POD 0 to POD 3 in patients with ovarian cancer who underwent cytoreductive surgery, without increasing the morbidity.</P>