Efficacy of Different Number of XELOX or SOX Chemotherapy Cycles After D₂ Resection for Stage III Gastric Cancer

Yu, Yuanyuan,Zhang, Zicheng,Meng, Qianhao,Wang, Ke,Li, Qingwei,Ma, Yue,Yao, Yuanfei,Sun, Jie,Wang, Guangyu The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.2

Purpose: We aimed to explore whether the prognosis of patients treated with capecitabine and oxaliplatin (XELOX) or S-1 and oxaliplatin (SOX) regimens who received fewer cycles of chemotherapy after D2 radical resection for gastric cancer (GC) would be non-inferior to that of patients who received the standard number of cycles of chemotherapy. Materials and Methods: Data on patients who received XELOX or SOX chemotherapy after undergoing D2 radical resection at Harbin Medical University Cancer Hospital between January 2011 and May 2016 were collected. Results: In patients who received 4, 6, and 8 cycles of chemotherapy, the 5-year overall survival (OS) rates were 59.4%, 64.8%, and 62.7%, respectively. Compared to patients who received 4 cycles of chemotherapy, those who received 6 cycles (hazard ratio [HR], 0.882; 95% confidence interval [CI], 0.599-1.299; P=0.52) or 8 cycles (HR, 0.882; 95% CI, 0.533-1.458; P=0.62) of chemotherapy did not exhibit significantly prolonged OS. The 3-year disease-free survival (DFS) rate of patients who received 4, 6, and 8 cycles of chemotherapy was 62.1%, 67.2%, and 60.8%, respectively. Compared to patients who received 4 cycles of chemotherapy, those who received 6 cycles (HR, 0.835; 95% CI, 0.572-1.221; P=0.35) or 8 cycles (HR, 0.972; 95% CI, 0.606-1.558; P=0.91) of chemotherapy did not show significantly prolonged DFS. However, the 3-year DFS and 5-year OS rates of patients who received 6 cycles of chemotherapy appeared to be superior to those of patients who received 4 and 8 cycles of chemotherapy. Conclusions: For patients with stage III GC, 4 to 6 cycles of XELOX or SOX chemotherapy may be a favorable option. This study provides a rationale for further randomized clinical trials.

MCT2 overexpression promotes recovery of cognitive function by increasing mitochondrial biogenesis in a rat model of stroke

Xiaorong Yu,Rui Zhang,Cunsheng Wei,Yuanyuan Gao,Yanhua Yu,Lin Wang,Junying Jiang,Xuemei Zhang,Junrong Li,Xuemei Chen 한국통합생물학회 2021 Animal cells and systems Vol.25 No.2

Monocarboxylate transporter 2 (MCT2) is the predominant monocarboxylate transporter expressed by neurons. MCT2 plays an important role in brain energy metabolism. Stroke survivors are at high risk of cognitive impairment. We reported previously that stroke-induced cognitive impairment was related to impaired energy metabolism. In the present study, we report that cognitive function was impaired after stroke in rats. We found that MCT2 expression, but not that of MCT1 or MCT4, was markedly decreased in the rat hippocampus at 7 and 28 days after transient middle cerebral artery occlusion (tMCAO). Moreover, MCT2 overexpression promoted recovery of cognitive function after stroke. The molecular mechanism underlying these effects may be related to an increase in adenosine monophosphate-activated protein kinase-mediated mitochondrial biogenesis induced by overexpression of MCT2. Our findings suggest that MCT2 activation ameliorates cognitive impairment after stroke.

Peat-accumulation models affected by the transgressionregression: a case study of mineralogy and geochemistry of the Permo-Carboniferous coals in the Lingshi Deposit, Qinshui Basin, China

Yu Zou,Fenghua Zhao,Dongna Liu,Yuanyuan Wang,Jianbo Chen 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.5

Mineralogy and geochemistry of Nos.1, 9 and 10 coals in the Lingshi Deposit, Qinshui Basin, China, are investigated in this paper, using industrial analysis, total sulfur and forms of sulfur analyses, optical microscope, scanning electron microscope equipped with energy dispersive X-ray spectrometer, X-ray powder diffraction, X-ray fluorescence, and inductively coupled plasma-mass spectrometers. The results show that the minerals in coals are mainly kaolinite, nacrite, dickite, palygorskite, calcite, pyrite, anatase, dolomite, siderite and barite. Kaolinite of terrigenous origin is commonly discovered in No. 1 coal, which results in a high concentration of SiO2 (up to 6.81%) and Al2O3 (up to 8.42%); In the process of coalification, kaolinite could be converted into dickite and nacrite in Nos. 9 and 10 coal; Pyrite, the host of W, Tl, and As, and palygorskite in Nos. 9 and 10 coals are formed under the influence of the transgression. Besides, Nos. 9 and 10 coals, affected by transgression, are similar in the element contents and distribution patterns with positive δYN anomalies (up to 1.44). However, No. 1 coal, normalized by No. 10 coal, is characterized by high concentration coefficients of Co, Ni, Sb, Li, Be, Sc, V, Cu, Ga, Rb, Cs, Ba, Pb and Th (2 < CC < 10), and these elements are derived from clay minerals of terrigenous origin, which means that Permo-Carboniferous coals in the Lingshi Deposit show the evolution of a regressive process in general.

지능정보사회에서의 중국지역간 정보격차와 지각된 학업성과에 관한 연구

YU DENG SHENG,ZHANG YUANYUAN,SONG ZHANMEI,임규건(Gyoo Gun Lim) 한국IT서비스학회 2019 한국IT서비스학회 학술대회 논문집 Vol.2019 No.2

2000년대부터 중국 경제성장을 주도하는 핵심적 산업인 정보통신산업에 대해 집중적으로 육성 및 지원함으로써 정보통신기술의 사회적 확산도 매우 빠른 속도로 진전되었다. 그러나 정보통신 기술산업의 생산품과 개인 소득의 측면에서 지역 간의 경제성장이 빠른 지역과 그렇지 못한 지역간의 정보통신기술의 확산 속도 및 보급의 격차는 여전히 심한 것으로 나타났다. 또한 중국인터넷발전상황통계보고에 따르면 도시와 농촌의 인터넷 보급률을 살펴보면 보급률은 모두 증가세를 보이지만 격차는 여전히 큰 것으로 확인할 수 있다. 본 연구는 정보격차가 지각된 학업성과에 어떠한 영향을 미치는 지에 파악하고자 한다. 또한지역 간의 정보격차에 따른 지각된 학업성과의 차이가 존재하는 지에 확인하고자 한다. 향후 중국 지역 간의 정보격차를 해소할 수 있는 방안을 모색함으로써 교육성과를 제고하고 교육역량 활성화에 기여할 수 있는 것으로 기대된다.

중국 지역 간의 정보격차와 G2C전자정부서비스의 이용의도에 관한 연구

YU DENG SHENG,ZHANG YUANYUAN,Gyoo Gun Lim 한국IT서비스학회 2020 한국IT서비스학회 학술대회 논문집 Vol.2020 No.1

2000년대부터 중국 경제성장을 주도하는 정보통신산업에 대해 집중적으로 육성함으로써 정보통신기술이 급속한 속도로 발전하여 확산되었다. 그러나 지역 간의 경제성장이 빠른 지역과 그렇지 못한지역 간의 정보통신기술의 확산 속도 및 스마트 기기 보급의 격차는 여전히 심한 것으로 나타났다.인터넷 및 정보통신기술을 기반으로 전자정부서비스를 이용자 수가 지속적으로 증가하고 있지만 지역경제가 높은 도시와 낮은 도시 간에 전자정부서비스의 활용지수의 격차가 여전히 큰 것으로 현성 되어 있다. 본 연구는 정보격차의 변수인 접근성, 역량성, 활용성 및 역기능가 G2 C전자정부서비스의 이용의도에 어떠한 영향을 미치는 지에 파악하여 밝히고자 한다. 또한 인구사 회학적 특성 및 지역특성측면에 지각된 정보격차의 차이가 존재하는 지에 검토하여 확인하고자 한다. 본 연구의 결과를통해 지능정보사회에 더욱 편리하고 스마트할 수 있는 전자정부서비스를 구축 시에 기본 자료가될 수 있도록 기대된다. 또한 향후 중국 지역 간의 정보격차를 해소할 수 있는 방안을 모색함으로써 전자정부서비스 시민활용성 및 활성화에 기여할 수 있는 것으로 기대된다.

Interfacial micromechanics modeling for bolted joints in ultra-precision machine tools

Yu Chang,Jianguo Ding,Hui Fan,Yuanyuan Ding,Hui Zhuang,Peng Chen 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.8

Bolted joints are widely adopted in various mechanical structures. However, the uncertainty and complexity of the contact surfaces affect accurate modeling. Herein, an interfacial micromechanics model is proposed to characterize the contact behaviors of bolted joints in an ultra-precision machine tool (UMT). The bolted joint is modeled as a virtual material layer with transversely isotropic behaviors, whose constitutive relation is identified by fractal theory. The proposed model accurately formulates the multi-scale contact characteristics and allows convenient integration with the structural dynamic modeling of UMT. Dynamic analysis of the simulation results and the experimental measurements in the time and frequency domains was conducted to identify the most sensitive factor affecting the tool tip vibration. On this basis, the structural optimization for the UMT was further implemented, which effectively reduced vibration by 15.5 %. The dynamic predictions were validated by modal and vibration response tests.

Grid Scheduling Strategy Considering Electric Vehicles Participating in Multi-microgrid Interaction

Yu Zexu,Dou Zhenhai,Zhao Ye,Xie Ruishuo,Qiao Mengmeng,Wang Yuanyuan,Liu Lianxin 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.3

With the expansion of the scale of power grid and the increase of the number of microgrids, the energy interaction between microgrids using contact lines will greatly increase the computation of the superior dispatching center. Therefore, the contact lines between microgrids are cancelled, so that the microgrids can realize energy interaction through the distribution network. However, this method may lead to overload of distribution network connections while reducing the computation. Due to its good transfer characteristics, the addition of electric vehicles (EVs) can alleviate the contact line pressure and realize the load transfer of microgrids. On this basis, a grid dispatching model based on the participation of EVs in microgrid interaction is proposed. Contact lines between microgrids are replaced by EVs and 100% transmission through the distribution network. The grid load is optimized with the goal of minimizing total cost, maximizing renewable energy utilization, and maximizing profit of each integrator. In the process of model optimization, aiming at the problem that the speed factor in the particle swarm optimization algorithm cannot take into account the optimal direction and the optimal step size, the adaptive time factor is added to establish a two-layer improved particle swarm optimization algorithm, which realizes the cooperative optimization of load and electricity price. The simulation results show that the total cost and underutilization of renewable energy of IEEE33-node system are reduced by 13.79% and 67.85%, compared with the traditional interaction mode, while they are reduced by 0.425% and 6.11% in IEEE43-node system.

Mechanical and Thermal Properties of Epoxy Resins Modified by a Novel Thermoplastic-polyimide

Yu Ji,Yan Zhang,Ping Wang,Yuanyuan Li,Jianhua Sui 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1

In this paper, a novel polyimide with trifluoromethyl group (PIS) was synthesized successfully and used toimprove the toughness of epoxy resins. Five modified epoxy resins (5, 7.5, 10, 12.5 and 15 wt%) were prepared andinvestigated, respectively. The structure, thermal properties, tensile properties, viscoelastic properties, toughness andmorphology of modified epoxy resins were studied by Fourier Transform Infrared Spectroscopy (FT-IR), thermogravimetricanalysis (TGA), Instron 5967, Dynamic Mechanical Analysis (DMA), and Scanning Electron Microscopy (SEM). Theresults showed that the epoxy resins modified with PIS exhibited good thermal stability which the glass transitiontemperatures increased from 135.9 oC to 146.4 oC. Tensile strength of modified epoxy resins increased from 40.4 MPa to92.3 MPa. The KIC values increased from 0.86 MPa·m1/2 to 1.56 MPa·m1/2 indicated that the toughness enhancement wasmarkedly. The fracture modes also were examined by SEM images and exhibited the fracture mode changed from the brittleone to ductile fracture with varied weight of the novel trifluoromethyl-polyimide.

High Temperature Oxidation Resistance of NiCoCrAl High Entropy Alloy Coating on the TiAl Alloy

Yuanyuan Sun,Qiang Miao,Wenping Liang,Kai Zang,Yuting Wu,Haiyang Yu,Mengjuan Yin,Xiguang Gao,Yindong Song 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.1

The high entropy alloy coating is considered as one of the most promising methods to improve the high-temperature oxidationresistance of titanium aluminum alloys due to its fine mechanical property and thermal stability. However, the high entropyalloy coating prepared so far has poor coating quality, and low coating forming efficiency and there are certain requirementsfor the substrate alloys. To this end, a NiCoCrAl high entropy alloy coating was developed using the double glow plasmaalloying technique on the TiAl alloy. The morphology, phase structure, and high temperature oxidation resistance of thecoating were comprehensively studied. The results indicate that a uniform and dense coating with a single solid solution offace-centered cube phase formed on the alloy surface. Furthermore, isothermal oxidation test was performed, and the oxidationfailure process of the TiAl substrate and the NiCoCrAl-coated sample with different oxidation times was analyzed. It isfound that the coating efficiently prevented the TiAl alloy from degeneration for up to 100 h at 900 °C.

Enrichment of C17:0-rich saturated fatty acids from sheep tail fat for adjuvant therapy of non-small-cell lung cancer

Xiaoqi Yu,Xiaoyi Liu,Yuanli Li,Huimin He,Xinxin Pei,Tengfei Ma,Yuanyuan Chen,Yi Wang,Hongxia Li,Wenchu Lin,Changzhi Xu,Buchang Zhang 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.8

Heptadecanoic acid (C17:0), an odd-chain saturated fatty acid (OCSFA) in ruminant lipid, has been demonstrated to be potential for treating cancers. Our results also showed that sheep tail fat (STF) with higher level of C17:0-containing saturated fatty acids (SFAs) whereas lower level of oleic acid (C18:1), performed remarkable inhibition against non-small-cell lung cancer (NSCLC) cells. To enrich the content of C17:0, a C17:0-rich SFA concentrate (HRSC) was prepared from STF by solvent crystallization and urea complexation methods (hexane/STF = 3.5/1, 4 °C for 8 h, and 80% ethanol/urea/free fatty acids = 8/1/1, 4 °C for 6 h). The content of C17:0 was up from 3.02 to 6.34% and the recovery was 4.17%. Biological experiments showed that HRSC exerted better antiproliferative effect against NSCLC cells. Moreover, HRSC performed enhanced inhibitory effect in A549 cell xenograft mouse model. Therefore, HRSC has the potential to be applied in adjuvant therapy for NSCLC.