Syntheses, Structures, and Characterization of Quaternary Tellurites, Li₃MTe₄O₁₁ (M = Al, Ga, and Fe)

Lü,, Minfeng,Jo, Hongil,Oh, Seung-Jin,Lee, Suheon,Choi, Kwang-Yong,Yu, Yang,Ok, Kang Min ACS AMERICAN CHEMICAL SOCIETY 2017 Inorganic Chemistry Vol.56 No.10

<P>Three new quaternary lithium metal tellurites, Li3MTe4O11 (M = Al, Ga, and Fe), have been synthesized through hydrothermal and solid-state reactions by heating a mixture of LiOH center dot H2O, TeO2, and M2O3. The structures of the title compounds have been determined by single-crystal and powder X-ray diffraction. Li3MTe4O11 reveal three-dimensional (3D) frameworks that consist of MO6 octahedra, TeO3 trigonal pyramids, and TeO4 polyhedra. The variable coordination mode of Te4+ within the framework leads to the formation of 1D channels that host Li+ cations on both tetrahedral and octahedral sites. The bulk and grain boundary Li+ ion conductivities for a Li3FeTe4O11 pellet in open air are estimated to be 1.0 x 10(-4) and 2.7 x 10(-6) S cm(-1), respectively, at room temperature from the impedance profile analysis. A lower activation energy of 19.9 kJ mol(-1) is obtained for the system, which is similar to that of Li10GeP2S12 (24 kJ mol(-1)). Detailed characterizations such as thermal, spectroscopic, and magnetic properties for the reported materials are also reported.</P>

Harm Avoidance is Correlated with the Reward System in Adult Patients with Attention Deficit Hyperactivity Disorder: A Functional Magnetic Resonance Imaging Study

Tsung-Hua Lu(Tsung-Hua Lu),Shih-Hsien Lin(Shih-Hsien Lin),Mei Hung Chi(Mei Hung Chi),Ching-Lin Chu(Ching-Lin Chu),Dong-Yu Yang(Dong-Yu Yang),Wei Hung Chang(Wei Hung Chang),Po See Chen(Po See Chen),Yen 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Objective: Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce. Methods: Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study. Results: Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed. Conclusion: Understanding the roles of harm avoidance and brain activation during risk tasks is important.

Human lactoferrin efficiently targeted into caprine beta-lactoglobulin locus with transcription activator-like effector nucleases

Yu-Guo Yuan,Shao-Zheng Song,Meng-Ming Zhu,Zheng-Yi He,Rui Lu,Ting Zhang,Fei Mi,Jin-Yu Wang,Yong Cheng 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.8

Objective: To create genetically modified goat as a biopharming source of recombinant human lacotoferrin (hLF) with transcription activator-like effector nucleases. Methods: TALENs and targeting vector were transferred into cultured fibroblasts to insert hLF cDNA in the goat beta-lactoglobulin (BLG) locus with homology-directed repair. The gene targeted efficiency was checked using sequencing and TE7I assay. The bi-allelic gene targeted colonies were isolated and confirmed with polymerase chain reaction, and used as donor cells for somatic cell nuclear transfer (SCNT). Results: The targeted efficiency for BLG gene was approximately 10%. Among 12 Bi-allelic gene targeted colonies, five were used in first round SCNT and 4 recipients (23%) were confirmed pregnant at 30 d. In second round SCNT, 7 (53%), 4 (31%), and 3 (23%) recipients were confirmed to be pregnant by ultrasound on 30 d, 60 d, and 90 d. Conclusion: This finding signifies the combined use of TALENs and SCNT can generate bi-allelic knock-in fibroblasts that can be cloned in a fetus. Therefore, it might lay the foundation for transgenic hLF goat generation and possible use of their mammary gland as a bioreactor for large-scale production of recombinant hLF.

Path Loss Exponent Estimation for Indoor Wireless Sensor Positioning

( Yu-sheng Lu ),( Chin-feng Lai ),( Chia-cheng Hu ),( Yueh-min Huang ),( Xiao-hu Ge ) 한국인터넷정보학회 2010 KSII Transactions on Internet and Information Syst Vol.4 No.3

Rapid developments in wireless sensor networks have extended many applications, hence, many studies have developed wireless sensor network positioning systems for indoor environments. Among those systems, the Global Position System (GPS) is unsuitable for indoor environments due to Line-Of-Sight (LOS) limitations, while the wireless sensor network is more suitable, given its advantages of low cost, easy installation, and low energy consumption. Due to the complex settings of indoor environments and the high demands for precision, the implementation of an indoor positioning system is difficult to construct. This study adopts a low-cost positioning method that does not require additional hardware, and uses the received signal strength (RSS) values from the receiver node to estimate the distance between the test objects. Since many objects in indoor environments would attenuate the radio signals and cause errors in estimation distances, knowing the path loss exponent (PLE) in an environment is crucial. However, most studies preset a fixed PLE, and then substitute it into a radio propagation loss model to estimate the distance between the test points; such method would lead to serious errors. To address this problem, this study proposes a Path Loss Exponent Estimation Algorithm, which uses only four beacon nodes to construct a radio propagation loss model for an indoor environment, and is able to provide enhanced positioning precision, accurate positioning services, low cost, and high efficiency.

Hepato-protective effect of fucoidan extracted from acid-processed Sargassum fusiformis in ethanol-treated Chang liver cells and in a zebrafish model

Yu-Lin Dai,Yun-Fei Jiang,Yu-Hang Nie,Yu-An Lu,Min-Cheol Kang,You-Jin Jeon 제주대학교 해양과학연구소 2020 해양과환경연구소 연구논문집 Vol.44 No.-

In our previous study, the anticancer effect of the active fucoidan (JHCF4) isolated from acid-processed Sargassum fusiformis was evaluated. In this study, the liver-protective effects of JHCF4 against ethanol-induced Chang liver cell damage and apoptosis-related responses were investigated. Furthermore, the low cytotoxicity and high cell viability of JHCF4 against ethanol-induced cell damage, as well as its protective effect against ethanol-induced cell apoptosis, were observed via nuclear staining with Hoechst 33342 in Chang liver cells. Additionally, the treatment of the 72 h post-fertilization (hpf) zebrafish model with JHCF4 increased the ethanol-stimulated survival rates as well as decreased oxidative stress, lipid peroxidation, and cell death levels. JHCF4 was found to significantly decrease steatosis production in the 128 hpf zebrafish model by Oil Red O staining, as well as attenuate the malondialdehyde and increase the glutathione contents, compared with the untreated group. These results demonstrate that JHCF4 has a potential hepato-protective effect against ethanol-induced damage both in vitro and in vivo.

The Stability Issue of the Voltage Regulators Using a Ripple-Based Constant On-Time Controller with DC Offset-Correction Circuit

Yu-Hsuan Lu,Dan Chen,Sheng-Fu Hsiao,Ching-Jan Chen,Hung-Shou Nien 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

In recent years, the ripple-based constant on-time (RBCOT) control scheme for voltage regulators has been adopted in many applications because of its high efficiency feature under light-load conditions. However, a RBCOT control suffers from output-voltage offset problem. Therefore, an offset correction circuit (OC) is often added to the basic RBCOT scheme to correct the problem. In the OC circuit, there is a RC filter. The size of this RC filter not only affects the circuit stability and converter transient responses but also directly affects the controller chip size/cost. The main focus of the present paper is to investigate the relationship between the RC filter value and the feedback stability so that RC value can be minimized while avoiding circuit instability. A time-domain analysis approach is proposed to model OCRBCOT scheme for a buck converter configuration. Experimental and simulation results are given for verification.

Biosynthesis of rare 20(R)-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes

Lu Yu,Yuan Chen,Jie Shi,Ru-Feng Wang,Ying-Bo Yang,Li Yang,Shujuan Zhao,Zheng-Tao Wang 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.1

Background: Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The present study provides an approach to produce such trace ginsenosides applying biotransformation through Escherichia coli modified with relevant genes. Methods: Seven uridine diphosphate glycosyltransferase (UGT) genes originating from Panax notoginseng, Medicago sativa, and Bacillus subtilis were synthesized or cloned and constructed into pETM6, an ePathBrick vector, which were then introduced into E. coli BL21star (DE3) separately. 20(R)-Protopanaxadiol (PPD), 20(R)-protopanaxatriol (PPT), and 20(R)-type ginsenosides were used as substrates for biotransformation with recombinant E. coli modified with those UGT genes. Results: E. coli engineered with GT95syn selectively transfers a glucose moiety to the C20 hydroxyl of 20(R)-PPD and 20(R)-PPT to produce 20(R)-CK and 20(R)-F1, respectively. GTK1- and GTC1-modified E. coli glycosylated the C3eOH of 20(R)-PPD to form 20(R)-Rh2. Moreover, E. coli containing p2GT95synK1, a recreated two-step glycosylation pathway via the ePathBrich, implemented the successive glycosylation at C20eOH and C3eOH of 20(R)-PPD and yielded 20(R)-F2 in the biotransformation broth. Conclusion: This study demonstrates that rare 20(R)-ginsenosides can be produced through E. coli engineered with UTG genes.

Online payload estimation for the control of underactuated mechanical systems

Yu-Sheng Lu,Hua-Hsu Chiu 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.7

This paper presents a payload estimation scheme for underactuated robotic manipulators with passive joints that are not driven by actuators. In the proposed scheme, only the payload, which can be quite uncertain when a robot performs various tasks, is estimated, becausethe manipulator’s electrical and other mechanical parameters are generally known in advance. In comparison to other adaptiveschemes for underactuated robotic manipulators, the proposed scheme produces satisfactory transient performance and also reduces thecomputational burden in real-time implementation. The proposed estimation law is also based on the theory of Variable Structure Systems. In contrast to existing adaptation laws that have an integral form, the proposed law estimates uncertain payload using lowpass filteringof a switching signal that is always bounded, which avoids the parameter-drifting problem that is often encountered when using theprevious integral laws. Real-time experiments are conducted using an inverted pendulum and the experimental results demonstrate thefeasibility and effectiveness of the proposed scheme.

Low-Frequency Compensation of Piezoelectric Accelerometers for Motion Control Systems

Lu Yu-Sheng,Lu Chun-Wei 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.4

This paper describes how piezoelectric accelerometers can be applied to motion control systems for performance enhancements. Piezoelectric accelerometers are known for their wide frequency ranges to sense dynamic acceleration. However, they are unable to measure static and quasi-static acceleration. Since positional sensors generally exist in motion control systems, this paper presents two acceleration observers that fuse piezoelectric accelerometers and positional sensors and are able to achieve high-quality observation of acceleration, including static and quasi-static components. The proposed observers are applied to a robotic manipulator, and experimental results confi rm feasibility and eff ectiveness of the proposed acceleration observers.

Lack of Association Between CYP1A1 Polymorphisms and Risk of Bladder Cancer: a Meta-analysis

Lu, Yu,Zhang, Xiao-Lian,Xie, Li,Li, Tai-Jie,He, Yu,Peng, Qi-Liu,Deng, Yan,Wang, Jian,Qin, Xue,Li, Shan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Material and Methods: A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Results: Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. Conclusion: The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.