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On the Estimation of Heritability with Family-Based and Population-Based Samples
Kim, Youngdoe,Lee, Young,Lee, Sungyoung,Kim, Nam Hee,Lim, Jeongmin,Kim, Young Jin,Oh, Ji Hee,Min, Haesook,Lee, Meehee,Seo, Hyeon-Jeong,Lee, So-Hyun,Sung, Joohon,Cho, Nam H.,Kim, Bong-Jo,Han, Bok-Ghee Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>For a family-based sample, the phenotypic variance-covariance matrix can be parameterized to include the variance of a polygenic effect that has then been estimated using a variance component analysis. However, with the advent of large-scale genomic data, the genetic relationship matrix (GRM) can be estimated and can be utilized to parameterize the variance of a polygenic effect for population-based samples. Therefore narrow sense heritability, which is both population and trait specific, can be estimated with both population- and family-based samples. In this study we estimate heritability from both family-based and population-based samples, collected in Korea, and the heritability estimates from the pooled samples were, for height, 0.60; body mass index (BMI), 0.32; log-transformed triglycerides (log TG), 0.24; total cholesterol (TCHL), 0.30; high-density lipoprotein (HDL), 0.38; low-density lipoprotein (LDL), 0.29; systolic blood pressure (SBP), 0.23; and diastolic blood pressure (DBP), 0.24. Furthermore, we found differences in how heritability is estimated—in particular the amount of variance attributable to common environment in twins can be substantial—which indicates heritability estimates should be interpreted with caution.</P>
Kim DongHee,Oh YoungDo,Tae BongHo,Lee JeongEun 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.78 No.3
A search for a new heavy charged gauge boson W produced via a vector boson fusion process with two hard jets in pp collisions in the high-luminosity Large hadron collider (HL-LHC) environment is presented. The HL-LHC will increase the peak instantaneous luminosity to 7.5 × 1034 cm−2 s−1 and the center of mass energy of 14 TeV to collect integrated luminosities up to 3 ab−1 , which will significantly improve sensitivity for the observation of new heavy particles via rare processes. In this paper, to investigate the signal sensitivity for a W we use the heavy vector triplet model, in the context of a simplified phenomenological approach, under Monte-Carlo simulations. The search targets events with one energetic electron and large missing transverse momentum, as well as two jets with a large separation in pseudorapidity. The expected upper limit for the mass of W and exclusion limit contour on coupling parameters are presented at the 95% confidence level for an integrated luminosity of 3 ab−1.