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JinHyeong Jhoo,KiWoong Kim,YoungJu Suh,DongYoung Lee,JongChul Youn,JungHie Lee,JongInn Woo 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.1
Objectives-The aim of this study is to examine the impact of the apolipoprotein E (APOE) polymorphism on the risk of Alzheimer s disease (AD) in Koreans. Materials and Methods-We determined the APOE genotype of 303 probable AD patients and 1,052 non-demented normal controls, and compared their genotypic and allelic frequencies. Then, we determined the odds ratios for AD of the APOE polymorphism in the subjects, stratified by age and gender. Results-The APOE 4 allele was more prevalent in the AD patients than in the controls (P<0.0001). The APOE 4 allele increased the risk of AD in a dose-dependent manner; the odds ratios for AD of the APOE 4-heterozygous and the APOE 4-homozygous subjects were 3.9 (95% CI=2.8-5.3) and 15.6 (95% CI=6.6-36.7), respectively. The APOE 4-conferred AD risk was also dependent on the age and gender of the subjects; the odds ratios for AD were highest in the subjects aged 75-79 years and higher in the women than in the men. Conclusions-The APOE 4 allele is a significant genetic risk factor for AD and confers the AD risk in a dose-, age- and genderdependent manner in Koreans.
플래시 변환 계층에 대한 TPC-C 벤치마크를 통한 성능분석 (pp.201-205)
박성환(Sunghwan Park),장주연(Juyeon Jang),서영주(Youngju Suh),박원주(Wonjoo Park),박상원(Sangwon Park) 한국정보과학회 2008 정보과학회 컴퓨팅의 실제 논문지 Vol.14 No.2
최근 플래시 메모리는 소형 정보기기의 주된 저장매체로서 그 사용이 급격히 증가하고 있다. 또한, 플래시메모리의 용량이 점점 증가함에 따라 더욱 많은 정보를 저장하고 관리하려는 시도가 이루어지고 있다. 따라서 효율적으로 정보를 관리하는 시스템인 데이타베이스가 플래시 메모리에서도 필요로 하게 되었다. 그러나 데이타베이스는 임의적인 디스크 I/O를 발생시키는 특징이 있어 현재의 플래시 메모리 시스템에서 그 성능이 매우 좋지 않다. 본 논문에서는 이러한 문제점을 고찰하고자 기존의 FTL 알고리즘들이 플래시 기반의 데이타베이스 시스템에서 어떠한 성능을 보이는지 실험하였다. 그 결과 실험에 사용한 FTL 알고리즘 모두가 매우 좋지 않은 성능을 보였다. 특히 지금까지 상당히 좋은 FTL 알고리즘으로 평가되었던 것들이 데이타베이스 응용에서는 나쁜 성능을 보였다. 또한 현재 플래시 메모리의 성능을 개선하고자 사용되는 칩 인터리빙 기술 또한 모든 FTL 알고리즘에서 좋은 성능을 내지 못하였다. 본 논문에서는 실험 결과를 바탕으로 데이타베이스 시스템을 잘 지원하는 새로운 FTL 알고리즘이 필요한 이유와 그 방향을 제시한다. The flash memory is widely used as a main storage of embedded devices. It is adopted as a storage of database as growing the capacity of the flash memory. We run TPC-C benchmark on various FTL algorithms. But, the database shows poor performance on flash memory because the characteristic of I/O requests is full random. In this paper, we show the performance of all existing FTL algorithms is very poor. Especially, the FTL algorithm known as good at small mobile equipment shows worst performance. In addition, the chip-inter-leaving which is a technique to improve the performance of the flash memory doesn't work well. In this paper, we inform you the reason that we need a new FTL algorithm and the direction for the database in the future.
Park Yeong-Ju,Hwang Unsik,Park Suyeon,Sim Sol,Jeong Soyeon,Park Misun,Kang Minji,Lee Youngsoo,Song Youngju,Park Hoon,Suh Hee-Jae 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.1
Compound K (CK; 20-O-β-(d-glucopyranosyl)-20(S)-protopanaxadiol) is one of the metabolites of ginsenosides contained in red ginseng (RG) and is known to have high bioavailability. This study aimed to establish the optimal conditions for enzyme treatment to convert ginsenosides from RG extract to CK, and to prove the characteristics of bioconverted red ginseng (BRG) extract. CK was not detected in unenzyme-treated RG extract, and in the single-step enzyme treatment, it was produced at less than 4.58 mg/g only in treatment group with Pyr-flo or Sumizyme AC (at 50 °C for 48 h). The highest yield of CK (14.32 mg/g) was obtained by Ultimase MFC treatment at 50 °C for 48 h after treatment with a mixture of Pyr-flo and Rapidase at 50 °C for 24 h. Total polyphenol, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) (ABTS) radical scavenging activity were higher in BRG than in RG (p < 0.5). High-fat diet (HD) rat fed 1% BRG had significantly lower body weight, heart weight, fat pads (periosteal fat, epididymal fat), serum glucose levels, and hepatic triglyceride levels than those HD rat fed 1% RG (p < 0.05). In conclusion, the sequential enzymatic bioconversion was produces higher CK in RG root extract than single-step enzyme treatment.