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항생물질 생산 토양 Actinomycetes 균주 선별과 항생물질 생산특성 조사
구양모(Yang Mo Goo),이윤영(Youn Young Lee),정연숙(Youn Sook Chung),이영복(Young Bok Lee),조영애(Young Ae Joe),조희영(Hee Yeong Cho),고영선(Young Sun Koh),이창훈(Chang Hoon Lee) 대한약학회 1991 약학회지 Vol.35 No.3
Selective culture of actinomycetes from soil microbes and their antibiotic producing characters by agar-disk method were examined. Some of the organisms which produced antibiotics on agar disk did not produce antibiotics in liquid culture. Further examination indicated that production of antibiotic was dependent on the composition of medium. Many streptomycestes produced antibacterial substances in tryptic soy broth but others produced antifungal antibiotics in V-8 broth. Production of antibacterial substances by Streptomyces sp. was also dependent on the medium composition.
항생물질을 생성하는 토양균의 대량 검색을 위한 새로운 방법
구양모(Yang MoGoo),이윤영(Youn Young Lee),조영애(Young Ae Joe),이영복(Young Bok Lee),정원윤(Won Yun Chung),이창훈(Chang Hoon Lee),고영선(Young Sun Koh),조희영(Hee Yeung Joe),정연숙(Youn Sook Chung) 대한약학회 1991 약학회지 Vol.35 No.4
A new agar-disk method was developed from the fast selection and characterization of antibiotic producing organisms.
천영훈(Young-Hoon Cheon),조근호(Keun-Ho Joe),김대진(Dai-Jin Kim) 대한노인정신의학회 2012 노인정신의학 Vol.16 No.2
Chronic alcohol use may have direct or indirect neurotoxic effects on the brain that can lead to cognitive impairment. However, the precise relationship between alcohol and dementia remains unclear. There are several epidemiological studies suggest that the protective effect of light-moderate alcohol drinking in dementia. But obviously the heavy alcohol drinking can lead to brain dam-age and increase the risk of various types of dementia. The clinicopathological issues and criteria regarding so-called ‘alcoholic de-mentia’ remain under debate. Alcohol-induced persisting amnestic disorder, alcohol-induced persisting dementia, and Wernicke-Korsakoff syndrome (thiamine deficiency) may constitute distinct disease entities, but they may also share some common features. Based on this theory, Oslin and colleagues proposed the broader diagnostic scheme and criteria for Alcohol Related Dementia (ARD), which may include cases of Wernicke-Korsakoff syndrome and also other cases of dementia that appear to be alcohol-re-lated. In pathogenesis of the alcoholic dementia, the chronic exposure to ethanol results in the adaptive up-regulation of NMDA re-ceptor sensitivity, which can result in an increased vulnerability to glutamate induced excitotoxicity. Despite the clinical importance of ARD, few medical treatments for ARD have been proposed and studied. Most of all, the gold standard of the treatment in alco-holic dementia is the maintaining abstinence. Some therapeutic trials with cholinesterase inhibitors (donepezil and rivastigmine) and memantine (NMDA receptor antagonist) have been conducted for the patients with Wernicke-Korsakoff syndrome and alco-hol-related dementia, and these studies reported favorable outcomes. Especially memantine can be a more effective agent in the treatment of alcoholic dementia because of anti-craving effect reported in several studies.
Seok Hoon Yoon,Young Jin Joe,Chang Seong Koh,Ju Hwan Woo,Hyun Suk Lee 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.1
The Horn River Basin in the northeastern British Columbia, Canada, is one of the largest unconventional gas-bearing basins in North America. The main reservoir of this gas accumulation is the Devonian Horn River Formation that is stratigraphically divided into three members, the Evie, Otterpark and Muskwa in ascending order. This study focuses on sedimentary processes and depositional environments of the Horn River Formation based on sedimentary facies analysis by the aid of well-log mineralogy (ECS) and total organic carbon (TOC) data from the Kiwigana well. The shales of the formation consist dominantly of silicate minerals (quartz, feldspar and mica) and subordinate clay mineral and carbonate materials, with TOC ranging from 0.3 to 7.6%. Three sedimentary facies were identified on the basis of centimeter-scale description of sedimentary structures and texture in borehole cores: homogeneous mudstone (HM), indistinctly laminated mudstone (ILM), and planar laminated mudstone (PLM). Integration of sedimentary facies, lithology and TOC suggests that the Horn River shale was primarily deposited in overall distal marine setting deeper than shelf or marginal slope, possibly base-of-slope to deeper basin plain off the carbonate reef (or shelf). Facies HM is siliceous and organic-rich, and dominant in the Evie and the overlying lowermost Otterpark members. It is interpreted as a pelagic to hemipelagic deposit formed mainly by suspension fall-out in an anoxic setting below maximum storm wave base. Likewise, facies ILM shows relatively high proportion of silicate minerals and TOC. This facies is identified frequently in the Muskwa and rarely in the Otterpark; it reflects a deposition from hemipelagic settling with an influence of persistent and weak bottom currents or nepheloid flows. Facies PLM, dominant in the large part of the Otterpark, is relatively depleted in silicate minerals and TOC. This facies indicates more frequent inflow of episodic turbidity currents punctuating the hemipelagic settling of the background sedimentation process. During the deposition of the Horn River Formation, the depositional site has experienced an earlier relative sea-level fall changing from a deep basin (Evie) to shallower marginal slope (middle Otterpark), and subsequent relative sea-level rise turning back to a deeper marine environment (Muskwa).