정신분열장애 환자에서의 뇌간청각유발반응

정염성 최신의학사 1987 最新醫學 Vol.30 No.1

전기충격요법에 대한 임상적 고찰

정염성,방승규 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.2

저자들은 1977년 1월 1일부터 1980년 12월 31일까지 카톨릭의과대학 부속 여의도 성모병원 신경정신과 입원환자중 전기충격요법을 받은 272명을 대상으로 임상적 고찰을 하여 다음과 같은 결과를 얻었다. 1. 총 입원환자 1,709명중 272명(15.9%)이 전기충격요법을 받았으며 정신분열증이 75.7%, 주요정동장애가 15.5%, 기타질환이 8.8%이었다. 2. 진단별로 보면 정신분열증의 30.4%, 주요정동장애의 22.5%, 기타질환의 2.8%가 전기충격요법을 받았다. 3. 전기충격요법의 시행횟수는 1인당 평균 8.3회(정신분열증, 8.9회;주요정동장애, 6.3회;기타질환, 7회)이었다. 4. 치료의 대상이 되었던 증상은 정신분열증의 경우 피해망상(20.3%)이 가장 많았으며 주요정동장애의 경우 정신운동성지체 혹은 초조(23.0%)가 가장 많았다. The authors performed this preliminary study to investigate the effect of ECT. The 272 psychiatric inpatients who received ECT atthe Department of Neuropsychiatry of Catholic Medical College from 1977 to 1980 were evaluated for clinical features. The results were as follows; 1. ECT was performed in 15.9% of a total of 1,709 inpatients who were admitted during the study period. Of them, 75.7% were diagnosed as schizophrenia, 15.5% as major affective disorder and 8.8% as others. 2. ECT was performed in 30.4% of the schizophrenics, 22.5% of those with major affective disorder and 2.8% of others. 3. Mean number of ECT was 8.3 times a patient. 4. The most common target symptom was persecutory delusion in schizophrenia and psychomotor retardation or agitation in major affective disorder.

초등 실과 바느질 단원의 모듈 수업이 학업 성취도에 미치는 영향

최염숙 韓國實科敎育硏究學會 1999 實科敎育硏究 Vol.5 No.2

For this study to determine the effect of modules instruction of sewing in elementary schools, two fifth-grade classes were selected: one as the experimental group receiving modular sewing lessons, and the other as the control group receiving conventional sewing lessons, for a period of four weeks. The cognitive, functional, and definitive aptitudes of each student from both groups wee assessed right before and after the experiment. The result showed that functional and definitive achievements were higher in the experimental group while cognitive achievement did not indicate any significant difference. In conclusion, a modular sewing lesson, coping with difference in individual learning abilities, was found to be a better educational method in functional and definitive areas, but not in cognitive area.

韓國輸出産業高度化에 따른 輸出 增大 方案

崔念淳 건국대학교 1979 樂圓誌 Vol.14 No.1

고 아밀라아제 혈증을 보인 급성 Lithium Carbonate 중독증 1례

홍현상,박흥수,정염성,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.2

Lithium carbonate is a widely used and invaluable drug in the treatment and prevention of manic-depressive illness. However, lithium cardonate may induce multisystemic adverse effects and toxic effects that, when not recognized, may lead to severe, life-threatening complications. The authors experienced a manic patient who showed severe lithium toxic reactions with hyperamylasemia. The patient was 41-year-old woman who had received lithium carbonate treatment for 3 months. The patient's symptoms and signs of toxic reaction had disappeared after hydration, insulin therapy, and hemodialysis.

Ectopic pregnancy rates in natural versus hormone replacement endometrial preparation in frozen embryo transfer: A meta-analysis

( Hyun Sik Youm ),( Hyun Sik Youm ),( Jong-ryeol Choi ),( Daesik Oh ),( Young Ho Rho ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: To evaluate whether ectopic pregnancy rates differ between natural and hormone replacement endometrial preparation in frozen embryo transfer. 방법: Meta-analysis was performed on the 3 selected studies in the statistical framework R using ‘meta’ package (random effects model: DerSimonian-Laird estimator). The outcome considered in this study was the ectopic pregnancy rates. 결과: The ectopic pregnancy rates were not different between natural and hormone replacement endometrial preparation in frozen embryo transfer (odds ratio [OR] 0.91, 95% confidence interval [CI] 0.40-2.06). 결론: The data presented in this meta-analysis do not support a different risk in ectopic pregnancy between natural and hormone replacement endometrial preparation in frozen embryo transfer.

Stretch-activated K^(+) Channels in Rat Atrial Myocytes

Youm, Jae Boum The Korean Physiological Society and The Korean So 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.6

Optimal vitrification protocol for mouse ovarian tissue cryopreservation: effect of cryoprotective agents and <i>in vitro</i> culture on vitrified–warmed ovarian tissue survival

Youm, Hye Won,Lee, Jung Ryeol,Lee, Jaewang,Jee, Byung Chul,Suh, Chang Suk,Kim, Seok Hyun Oxford University Press 2014 Human reproduction Vol.29 No.4

<P><B>STUDY QUESTION</B></P><P>What is the optimal vitrification protocol according to the cryoprotective agent (CPA) for ovarian tissue (OT) cryopreservation?</P><P><B>SUMMARY ANSWER</B></P><P>The two-step protocol with 7.5% ethylene glycol (EG) and 7.5% dimethyl sulfoxide (DMSO) for 10 min then 20% EG, 20% DMSO and 0.5 M sucrose for 5 min showed the best results in mouse OT vitrification.</P><P><B>WHAT IS KNOWN ALREADY</B></P><P>Establishing the optimal cryopreservation protocol is one of the most important steps to improve OT survival. However, only a few studies have compared vitrification protocols with different CPAs and investigated the effect of <I>in vitro</I> culture (IVC) on vitrified–warmed OT survival. Some recent papers proposed that a combination of CPAs has less toxicity than one type of CPA. However, the efficacy of different types and concentrations of CPA are not yet well documented.</P><P><B>STUDY DESIGN, SIZE, DURATION</B></P><P>A total of 644 ovaries were collected from 4-week-old BDF1 mice, of which 571 ovaries were randomly assigned to 8 groups and vitrified using different protocols according to CPA composition and the remaining 73 ovaries were used as controls. After warming, each of the eight groups of ovaries was further randomly divided into four subgroups and <I>in vitro</I> cultured for 0, 0.5, 2 and 4 h, respectively. Ovaries of the best two groups among the eight groups were autotransplanted after IVC.</P><P><B>PARTICIPANTS/MATERIALS, SETTING, METHODS</B></P><P>The CPA solutions for the eight groups were composed of EDS, ES, ED, EPS, EF, EFS, E and EP, respectively (E, EG; D, DMSO; P, propanediol; S, sucrose; F, Ficoll). The IVC medium was composed of α-minimal essential medium, 10% fetal bovine serum and 10 mIU/ml follicle-stimulating hormone (FSH). Autotransplantation of vitrified–warmed OTs after IVC (0 to 4 h) using the EDS or ES protocol was performed, and the grafts were recovered after 3 weeks. Ovarian follicles were assessed for morphology, apoptosis, proliferation and FSH level.</P><P><B>MAIN RESULTS AND THE ROLE OF CHANCE</B></P><P>The percentages of the morphologically intact (G1) and apoptotic follicles in each group at 0, 0.5, 2 and 4 h of IVC were compared. For G1 follicles at 0 and 4 h of IVC, the EDS group showed the best results at 63.8 and 46.6%, respectively, whereas the EP group showed the worst results at 42.2 and 12.8%, respectively. The apoptotic follicle ratio was lowest in the EDS group at 0 h (8.1%) and 0.5 h (12.7%) of IVC. All of the eight groups showed significant decreases in G1 follicles and increases in apoptotic follicles as IVC duration progressed. After autotransplantation, the EDS 0 h group showed a significantly higher G1 percentage (84.9%) than did the other groups (42.4–58.8%), while only the ES 4 h group showed a significant decrease in the number of proliferative cells (80.6%, 87.6–92.9%). However, no significant differences in apoptotic rates and FSH levels were observed between the groups after autotransplantation.</P><P><B>LIMITATIONS, REASONS FOR CAUTION</B></P><P>The limitation of this study was the absence of <I>in vitro</I> fertilization using oocytes obtained from OT grafts, which should be performed to confirm the outcomes of ovarian cryopreservation and transplantation.</P><P><B>WIDER IMPLICATIONS OF THE FINDINGS</B></P><P>We compared eight vitrification protocols according to CPA composition and found the EDS protocol to be the optimal method among them. The data presented herein will help improve OT cryopreservation protocols for humans or other animals.</P><P><B>STUDY FUNDING/COMPETING INTEREST(S)</B></P><P>This study was supported by a grant (No. A120080) from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea.</P>

막유화법에 의한 알지네이트 Microsphere의 제조

Youm Kyung Ho,Choi Yong Han,Dianne E. Wiley 한국막학회 2004 멤브레인 Vol.14 No.3

SPG (Shirasu porous glass) 관형 막이 설치된 회분식 막유화 장치를 사용하여 단분산 칼슘 알지네이트 미립자를 제조하기 위한 막유화 공정변수의 최적조건을 결정하였다. 막유화의 공정변수로는 연속상에 대한 분산상의 비율, 알지네이트 농도, 유화제의 종류와 농도, 안정제 농도, 가교제 농도, 교반속도, 막간 압력차 및 SPG 막의 세공크기로 설정하고, 이들 변수가 제조된 알지네이트 미립자의 입자 크기와 분포에 미치는 영향을 검토하였다. 막유화의 공정변수들 중에서 연속상에 대한 분산상의 비율, 막간 압력차 그리고 알지네이트 농도가 증가할수록 미립자의 크기가 증가하였다. 반면 유화제의 농도, 교반속도 그리고 가교제의 농도가 증가할수록 미립자의 크기가 감소하였다. 세공 크기 2.9mum인 SPG막을 사용한 경우 막유화의 공정변수 조절을 통해 최종적으로 평균 입자 크기 6mum, 크기 분산도 1.1인 단분산 알지네이트 미립자의 제조가 가능하였다. We prepared monodispersed calcium alginate microspheres by controlling various conditions of emulsification procedure using a lab-scale batch type membrane emulsification system equipped with SPG (Shirasu porous glass) tubular membranes. We determined the effects of process parameters of membrane emulsification (ratio of dispersed phase to continuous phase, alginate concentration, emulsifier concentration, type and concentration of stabilizer, transmembrane pressure, concentration of crosslinking agent, stirring speed and membrane pore size) on the mean size and size distribution of alginate microspheres. The increase of the ratio of dispersed phase to continuous phase, transmembrane pressure and alginate concentration led to the increase in the mean size of alginate microspheres. On the contrary, the increase in emulsifier concentration, stirring speed of the continuous phase and concentration of the crosslinking agent caused the reduction of the mean size of microspheres. Through controlling these parameters, monodisperse alginate microspheres with about 6mum of the mean size and 1.1 of the size distribution value were finally prepared in case of the using SPC membrane with the pore size of 2.9mum.

DW2008S and its major constituents from <i>Justicia procumbens</i> exert anti‐asthmatic effect via multitargeting activity

Youm, Jihyun,Lee, Hyunyong,Choi, Youngwoo,Yoon, Joobyoung John Wiley and Sons Inc. 2018 Journal of cellular and molecular medicine Vol.22 No.5

<P><B>Abstract</B></P><P>Our previous study revealed that the ethanolic extract of <I>Justicia procumbens</I> ameliorates ovalbumin‐induced airway inflammation and airway hyper‐responsiveness in a mouse model of asthma. However, the mechanism of action of the extract remains unknown. In this study, we prepared DW2008S, an optimized and standardized powder extracted from <I>J. procumbens</I> using anhydrous ethanol, and investigated its anti‐asthmatic effect and mechanism of action. Our results showed that DW2008S contains two major ingredients, justicidin A (JA) and justicidin B (JB), which selectively inhibit T helper 2 (Th2) cell responses in concanavalin A‐activated spleen cells and polarized Th2 cells. Blockade of T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine‐based inhibition motif domains (TIGIT) using a neutralizing antibody also selectively inhibited Th2 cell responses. Furthermore, DW2008S regulated TIGIT expression in the mice and cultured cells. Additionally, DW2008S and JA antagonized human adenosine receptor A<SUB>3</SUB> (A<SUB>3</SUB>AR), which mediates mast cell‐dependent inflammation and bronchoconstriction. DW2008S and JB inhibited human phosphodiesterase 4 (PDE4), which is known to cause bronchoconstriction; however, the required concentrations were higher than those needed to affect TIGIT . These findings suggest that DW2008S can potentially ameliorate Th2‐driven airway inflammation and bronchoconstriction through negative regulation of TIGIT and blockade of A<SUB>3</SUB>AR and PDE4 activities.</P>