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Hwang, Su Jung,Ahn, Eun-Young,Park, Youmie,Lee, Hyo-Jong Elsevier 2018 BIOMEDICINE AND PHARMACOTHERAPY Vol.100 No.-
<P><B>Abstract</B></P> <P>The recent mass emergence of Nomura’s jellyfish (<I>Nemopilema nomurai</I>) has caused much economic and environmental damage. However, there is no innovative strategy to dispose of or utilize these jellyfish. Some reports suggest that the jellyfish may be bioactive resources and a source of important compounds with antibacterial activity. Here, we examined the effect of an aqueous extract of Nomura’s jellyfish (AENJ) on lipopolysaccharide (LPS)-stimulated Raw 264.7 macrophages and a zebrafish model of inflammation and analyzed the underlying molecular mechanisms.</P> <P>AENJ downregulated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA levels in LPS-stimulated Raw 264.7 macrophages, with no apparent cytotoxic effects. However, AENJ had no effect on expression of other inflammation-related genes such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and MCP-1. Furthermore, AENJ reduced expression of nerve injury-induced protein 1 (Ninj1), which is an important adhesion molecule, thereby reducing cell adhesion to the extracellular matrix (ECM) <I>in vitro.</I> The inhibitory effect of AENJ on leukocytes was confirmed in LPS-microinjected zebrafish larvae; AENJ reduced the number of the infiltrate accumulating at the site of inflammation. In addition, AENJ suppressed the expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 in LPS-stimulated Raw 264.7 cells. Finally, AENJ blocked nuclear translocation of nuclear factor kappa B (NF-κB), a key transcription factor for inflammatory responses, in Raw 264.7 cells in a dose-dependent manner.</P> <P>Collectively, the data suggest that AENJ inhibits expression of COX and iNOS by blocking NF-κB signaling pathways and suppresses the activity of macrophages by downregulating Ninj1 and MMPs. Therefore, AENJ may be a useful preventive neutraceutical, or therapeutic agent against inflammatory disorders.</P>
Jo, Youmi,Oh, Hye-Min,Yoon, Yohan,Lee, Sun-Young,Ha, Ji-Hyoung,Kim, Won-Il,Kim, Hwang-Yong,Han, Sanghyun,Kim, Se-Ri ational Association for Food Protection 2017 Journal of food protection Vol. No.
<B>ABSTRACT</B><P>Although campylobacteriosis caused by Campylobacter jejuni and Campylobacter coli has been increasingly reported worldwide owing to the consumption of contaminated poultry and fresh produce, the current detection protocols are not selective enough to inhibit unspecific microbes other than these pathogens. Five antibiotics were separately added to Bolton broth, and the survival rates of 18 Campylobacter spp. and 79 non-Campylobacter spp. were evaluated. The survival rate of the non-Campylobacter spp. was the lowest in Bolton broth with rifampin (6.3%), followed by cefsulodin (12.7%), novobiocin (16.5%), and potassium tellurite and sulfamethozaxole (both 17.7%). Also the most effective concentration of rifampin was found to be 12.5 mg/L, which markedly inhibited non-Campylobacter strains while not affecting the survival of Campylobacter strains. After the Campylobacter spp. were enriched in Bolton broth supplemented with 12.5 mg/L rifampin (R-Bolton broth), CampyFood Agar (CFA) was found to be better in selectively isolating the pathogens in the enrichment broth than the International Organization for Standardization method of using modified charcoal cefoperazone deoxycholate agar (mCCDA) for this step. When applied to natural food samples-here, romaine lettuce, pepper, cherry tomato, Korean leek, and chicken-the R-Bolton broth-CFA combination decreased the number of false-positive results by 50.0, 4.2, 20.8, 50.0, and 94.4%, respectively, compared with the International Organization for Standardization method (Bolton broth-mCCDA combination). These results demonstrate that the combination of R-Bolton broth and CFA is more efficient in detecting C. jejuni and C. coli in poultry and fresh produce and thus should replace the Bolton broth-mCCDA combination.</P>
Chen, Lei,Hwang, Ji-Eun,Choi, Boram,Gu, Kang Mo,Park, Youmie,Kang, Young-Hwa The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.1
Methanol extracts from 100 Korean varieties of red pepper (Capsicum annuum L) were obtained. Chromatic parameters ($L^*$, $a^*$, and $b^*$) and total phenolic content were analyzed. By evaluation of total phenolic content and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging based-antioxidant associated with surface color measurement, red pepper varieties were classified into four groups by hierarchical cluster analysis. Cultivars of 'PR-Sangsaeng', 'PR-Jijon', 'PR-Eowoolrim', 'PR-Chambut', 'PAK37', and 'Hojanggoonbigalim" had high quantity of pigments and high phenolic content. These six cultivars also with higher levels of antioxidant might give an advantage to local growers in Korea. For further cytostatic activity evaluation, extracts from various parts including pericarp, seed, and stalk of cultivar 'PAK37' and 'Hojanggoonbigalim' were prepared. Four human cancer cells (HepG2, AGS, MCF-7, and HT-29) were used. The tumor cell growth inhibitory effect was evaluated by in vitro MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. High capsaicin content and antioxidant activity-containing red pepper stalk extract showed the strongest cytostatic activity. Tumor cell growth inhibitory activity was positively correlated with the capsaicin content. The anticancer potentials of various red pepper parts were in the following order: stalk > seed > pericarp. The data suggest that red pepper parts might have a promising health benefit against liver cancer, colon cancer and gastric cancer more than breast cancer.
Yoon, Yeojoon,Hwang, Yunyoung,Kwon, Minhwan,Jung, Youmi,Hwang, Tae-Mun,Kang, Joon-Wun Elsevier 2014 Journal of industrial and engineering chemistry Vol.20 No.5
<P><B>Abstract</B></P> <P>This study was aimed to evaluate the use of ozone (O<SUB>3</SUB>) alone and peroxone (a combination of ozone and hydrogen peroxide; O<SUB>3</SUB>/H<SUB>2</SUB>O<SUB>2</SUB>) as post-treatment processes for color removal in swine wastewater from a membrane filtration system. Results showed that the application of ozone-alone process or the peroxone process could reduce both capital and operating costs compared to reverse osmosis (RO) treatment. Of the two oxidation processes, the ozone-alone process was the most effective for treating nanofiltration (NF)-filtered wastewater, while the peroxone process was the most effective for treating ultrafiltration (UF)-filtered wastewater.</P>
Kwon, Minhwan,Yoon, Yeojoon,Kim, Seonbaek,Jung, Youmi,Hwang, Tae-Mun,Kang, Joon-Wun Elsevier 2018 Science of the Total Environment Vol.637 No.-
<P><B>Abstract</B></P> <P>The aim of this study is to evaluate the micropollutant removal capacity of a 275 nm light-emitting diode (LED)-UV/chlorine system. The sulfamethoxazole, ibuprofen, and nitrobenzene removal efficiencies of this system were compared with those of a conventional 254 nm low-pressure (LP)-UV system as a function of the UV dose. In a direct photolysis system, the photon reactivity of sulfamethoxazole is higher than that of nitrobenzene and ibuprofen at both wavelengths. The molar absorption coefficients and quantum yields of each micropollutant were as follows: sulfamethoxazole (<I>ε</I> <SUB> <I>SMX</I>, 275 <I>nm</I> </SUB> <SUP> <I>protonated</I> </SUP> = 17,527 M<SUP>−1</SUP> cm<SUP>−1</SUP>, Φ<SUB> <I>SMX</I>, 275 <I>nm</I> </SUB> <SUP> <I>protonated</I> </SUP> = 0.239, <I>ε</I> <SUB> <I>SMX</I>, 275 <I>nm</I> </SUB> <SUP> <I>deprotonated</I> </SUP> = 8430 M<SUP>−1</SUP> cm<SUP>−1</SUP>, and Φ<SUB> <I>SMX</I>, 275 <I>nm</I> </SUB> <SUP> <I>deprotonated</I> </SUP> = 0.026), nitrobenzene (<I>ε</I> <SUB> <I>NB</I>, 275 <I>nm</I> </SUB> = 7176 M<SUP>−1</SUP> cm<SUP>−1</SUP> and Φ<SUB> <I>NB</I>, 275 <I>nm</I> </SUB> = 0.057), and ibuprofen (<I>ε</I> <SUB> <I>NB</I>, 275 <I>nm</I> </SUB> = 200 M<SUP>−1</SUP> cm<SUP>−1</SUP> and Φ<SUB> <I>IBF</I>, 275 <I>nm</I> </SUB> = 0.067). The photon reactivity of chlorine species, i.e., HOCl and OCl-, were determined at 275 nm (<I>ε</I> <SUB> <I>HOCl</I>, 275 <I>nm</I> </SUB> = 28 M<SUP>−1</SUP> cm<SUP>−1</SUP>, Φ<SUB> <I>HOCl</I>, 275 <I>nm</I> </SUB> = 1.97, <I>ε</I> <SUB> <I>OCl</I>−, 275 <I>nm</I> </SUB> = 245 M<SUP>−1</SUP> cm<SUP>−1</SUP>, and Φ<SUB> <I>OCl</I>−, 275 <I>nm</I> </SUB> = 0.8), which indicate that the decomposition rate of OCl<SUP>−</SUP> is higher and that of HOCl is lower by 275 nm photolysis than that by 254 nm photolysis (<I>ε</I> <SUB> <I>HOCl</I>, 254 <I>nm</I> </SUB> = 60 M<SUP>−1</SUP> cm<SUP>−1</SUP>, Φ<SUB> <I>HOCl</I>, 254 <I>nm</I> </SUB> = 1.46, <I>ε</I> <SUB> <I>OCl</I>−, 254 <I>nm</I> </SUB> = 58 M<SUP>−1</SUP> cm<SUP>−1</SUP>, and Φ<SUB> <I>OCl</I>−, 254 <I>nm</I> </SUB> = 1.11). In the UV/chlorine system, the removal rates of ibuprofen and nitrobenzene were increased by the formation of OH and reactive chlorine species. The 275-nm LED-UV/chlorine system has higher radical yields at pH 7 and 8 than the 254 nm LP-UV/chlorine system.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Micropollutants could be oxidized by 275 nm LED-UV alone and -UV/chlorine systems </LI> <LI> Direct photolysis reactivity of selected micropollutants were determined at 275 nm </LI> <LI> Radical yields from chlorine photolysis depend on the wavelength, pH, and Cl<SUB>2</SUB> dose </LI> <LI> 275 nm UV/chlorine system has higher removal efficiencies at pH 7 and 8 than 254 nm </LI> <LI> Higher photo-reactivity of OCl<SUP>−</SUP> at 275 nm than at 254 nm gives higher radical yields </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Sung-Hwan Kim,Yong-Seog Oh,Young Choi,Youmi Hwang,Ju Youn Kim,Tae-Seok Kim,Ji-Hoon Kim,Sung-Won Jang,Man Young Lee,정보영,Kee-Joon Choi 대한심장학회 2021 Korean Circulation Journal Vol.51 No.1
Background and Objectives: Cavotricuspid isthmus (CTI) block is easily achieved, and prophylactic ablation can be performed during atrial fibrillation (AF) ablation. However, the previous study was too small and short-term to clarify the efficacy of this block. Methods: Patients who underwent catheter ablation for paroxysmal AF were enrolled, and patients who had previous or induced atrial flutter (AFL) were excluded. We randomly assigned 366 patients to pulmonary vein isolation (PVI) only and prophylactic CTI ablation (PVI vs. PVI+CTI). Results: There was no significant difference in procedure time between the two groups because most CTI blocks were performed during the waiting time after the PVI (176.8±72.6 minutes in PVI vs. 174.2±76.5 minutes in PVI+CTI, p=0.75). All patients were followed up for at least 18 months, and the median follow-up was 3.4 years. The recurrence rate of AF or AFL was not different in the 2 groups (25.7% in PVI vs. 25.7% in PVI+CTI, p=0.92). The recurrence rate of any AFL was not significantly different in the 2 groups (3.3% in PVI vs. 1.6% in PVI+CTI, p=0.31). The recurrence rate of typical AFL also was not different (0.5% in PVI vs. 0.5% in PVI+CTI, p=0.99). Conclusions: In this large and long-term follow-up study, prophylactic CTI ablation had no benefit in patients with paroxysmal AF without typical AFL.
Myung-Jin Cha,Jun Kim,Yoon Jung Park,Min Soo Cho,Hyoung-Seob Park,Soonil Kwon,Young Soo Lee,Jinhee Ahn,Hyung-Oh Choi,Jong-Sung Park,YouMi Hwang,Jin Hee Choi,Ki-Won Hwang,Yoo-Ri Kim,Seongwook Han,Seil 대한심장학회 2022 Korean Circulation Journal Vol.52 No.7
Background and Objectives: Atrial tachycardias (ATs) from noncoronary aortic cusp (NCC) uncovered after radiofrequency ablation for atrial fibrillation (AF) are rarely reported. This study was conducted to investigate the prevalence and clinical characteristics of NCC ATs detected during AF ablation and compare their characteristics with de novo NCC ATs without AF. Methods: Consecutive patients who underwent radiofrequency catheter ablation for AF were reviewed from the multicenter AF ablation registry of 11 tertiary hospitals. The clinical and electrophysiological characteristics of NCC AT newly detected during AF ablation were compared with its comparators (de novo NCC AT ablation cases without AF). Results: Among 10,178 AF cases, including 1,301 redo ablation cases, 8 (0.08%) NCC AT cases were discovered after pulmonary vein isolation (PVI; 0.07% in first ablation and 0.15% in redo ablation cases). All ATs were reproducibly inducible spontaneously or with programmed atrial stimulation without isoproterenol infusion. The P-wave morphological features of tachycardia were variable depending on the case, and most cases exhibited 1:1 atrioventricular conduction. AF recurrence rate after PVI and NCC AT successful ablation was 12.5% (1 of 8). Tachycardia cycle length was shorter than that of 17 de novo ATs from NCC (303 versus 378, p=0.012). No AV block occurred during and after successful AT ablation. Conclusions: Uncommon NCC ATs (0.08% in AF ablation cases) uncovered after PVI, showing different characteristics compared to de-novo NCC ATs, should be suspected irrespective of P-wave morphologies when AT shows broad propagation from the anterior interatrial septum.