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Yoshitaka Fukaya,Yasuyuki Aoyagi,Sakiyo Asada,Yoshitaka Kubota,Yoshitaka Okamoto,Toshinori Nakayama,Yasushi Saito,Kaneshige Satoh,Masayuki Kuroda,Hideaki Bujo 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.5
Auto-transplantation of adipose tissue is commonly used for the treatment of tissue defects in plastic surgery. The survival of the transplanted adipose tissue is not always constant, and one of reasons is the accelerated apoptosis of the implanted preadipocytes. We have recently established highly homogeneous preadipocytes, named ccdPAs. The aim of the current study was to evaluate the regulation of the potency of platelet-rich plasma (PRP) on the apoptosis of ccdPAs in vitro. PRP stimulated the proliferation of the preadipocytes in a dose-dependent manner, and the stimulatory activity of 2% PRP was significantly higher than that of 2% FBS or 2% platelet-poor plasma (PPP). The presence of 2% PRP significantly inhibited serum starvation-or TNF-α/cycloheximide-induced apoptosis in comparison to 2% FBS or 2% PPP. DAPK1 and Bcl-2-interacting mediator of cell death (BIM) mRNAs were reduced in the preadipocytes cultured with 2% PRP in comparison to those cultured in 2% FBS. The gene expression levels were significantly higher in cells cultured without serum in comparison to cells cultured with 2% FBS, and the levels in the cells with 2% PRP were reduced to 5-10% of those in the cells without serum. These results indicated that ccdPAs exhibit anti-apoptotic activities, in addition to increased proliferation,when cultured in 2% PRP in comparison to the same concentration of FBS, and that this was accompanied with reduced levels of DAPK1 and BIM mRNA expression in in vitro culture. PRP may improve the outcome of transplantation of adipose tissue by enhancing the anti-apoptotic activities of the implanted preadipocytes.
( Takeshi Suzuki ),( Yosuke Seki ),( Tomoaki Matsumura ),( Makoto Arai ),( Toyoyuki Hanazawa ),( Yoshitaka Okamoto ),( Haruhiko Suzuki ),( Kazunori Kasama ),( Akiko Umezawa ),( Yoshimoti Kurokawa ),( 대한소화기기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.1
Background/Aims The Lyon Consensus defined parameters based on upper endoscopy and 24-hour combined multichannel intraluminal impedancepH (MII-pH), that conclusively establish the presence of gastroesophageal reflux disease (GERD). However, the true role of upper endoscopy and MII-pH to evaluate patients with extraesophageal symptoms (EES) has not been well established. Hypopharyngeal MII (HMII), which directly measures laryngopharyngeal reflux (LPR) events, has been utilized to evaluate patients with EES suggestive of LPR. Methods This was a retrospective study involving patients with EES for > 12 weeks despite proton pump inhibitor therapy, and had no endoscopic confirmatory evidence for GERD and negative MII-pH. All patients were subsequently referred for further evaluation of EES with “unknown” etiology and underwent laryngoscopy and HMII. Based on HMII, abnormal proximal exposure (APE) was defined as LPR ≥ 1/day and/or full column reflux (reflux 2 cm distal to the upper esophageal sphincter) > 4/day. Patients with APE were offered antireflux surgery (ARS) and the outcome of ARS was objectively assessed using Reflux Symptom Index. Results Of 21 patients with EES which was thought to be GERD-unrelated based on endoscopy and MII-pH, 17 patients (81%) had APE. Eight patients with APE who had undergone ARS had significant symptomatic improvement in the Reflux Symptom Index score (19.6 ± 4.9 pre-ARS to 5.8 ± 1.4 post-ARS, P = 0.008). Conclusions A conventional diagnostic approach using endoscopy and MII-pH may not be sufficient to evaluate patients with EES suggestive of LPR. HMII is essential to evaluate patients with EES, and APE could be a reliable indicator for successful treatment outcomes. (J Neurogastroenterol Motil 2022;28:69-77)
Detrital zircon evidence for the antiquity of Taiwan
Ching-Ying Lan,Tadashi Usuki,Kuo-Lung Wang,Tzen-Fu Yui,Kazuaki Okamoto,Yuan-Hsi Lee,Takafumi Hirata,Yoshitaka Kon,Yuji Orihashi,Juhn G. Liou,Chun-Sun Lee 한국지질과학협의회 2009 Geosciences Journal Vol.13 No.3
In-situ U–Pb geochronology and Hf isotopic studies of zircons from the Pre-Tertiary basement complex and Eocene rocks of the Central Range of Taiwan were carried out to elucidate the history of detrital zircons older than 2.3 Ga. Zircons from the eastern Backbone Range and Eastern Central Range show Paleoproterozoic to late Neoarchean ages (2.3 –³2.5 Ga), whereas those from the Hsuehshan Range yield Neoarchean to Mesoarchean ages (2.6–3.2 Ga). The εHf(T) for the Paleoproterozoic to late Neoarchean zircons varies from –7.4 to +5.1, implying both juvenile crustal growth and reworking of old crusts. This dual origin could extend back to Mesoarchean–Paleoarchean (3.0–3.4 Ga) based on Hf isotopic model ages. Consistent but narrower εHf(T) values and Hf crustal model ages for zircons from Taiwan compared to Cathaysia suggest a possible common origin for these zircons, although Taiwan has a generally younger crustal evolution history than SE China.