Clinical outcomes and characteristics of acute myocardial infarction patients with developing fever after percutaneous coronary intervention

Jae-Geun Lee,Yeekyoung Ko,Joon Hyouk Choi,Jeong Rae Yoo,Misun Kim,Ki Yung Boo,Jong Wook Beom,Song-Yi Kim,Seung-Jae Joo 제주대학교 의과학연구소 2022 The Journal of Medicine and Life Science Vol.19 No.2

The incidence of fever complicating percutaneous coronary intervention (PCI) is rare. However, little is known regarding the cause of fever after PCI. Therefore, this study aimed to determine the clinical characteristics of patients with acute myocardial infarction (AMI), with or without fever, after PCI. We enrolled a total of 926 AMI patients who underwent PCI. Body temperature (BT) was measured every 4 hours or 8 hours for 5 days after PCI. Patients were divided into two groups according to BT as follows: BT<37.7°C (nofever group) and BT ≥37.7°C (fever group). The 2 years clinical outcomes were compared subsequently. Fever after PCI was associated with higher incidence of major adverse cardiac events (MACE) (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.07-2.28; P=0.021), all-cause death (HR, 2.32; 95% CI, 1.18-4.45; P=0.014), cardiac death (CD) (HR, 2.57; 95% CI, 1.02-6.76; P=0.049), and any revascularization (HR, 1.69; 95% CI, 1.02-2.81; P=0.044) than without fever. In women, prior chronic kidney disease, lower left ventricular (LV) ejection fraction, higher LV wall motion score index, white blood cell count, peak creatine kinasemyocardial band level, and longer PCI duration were associated with fever after PCI. Procedures such as an intra-aortic balloon pump, extracorporeal membrane oxygenation, continuous renal replacement therapy, central and arterial line insertion, and cardiopulmonary resuscitation were related to fever after PCI. Fever after PCI in patients with AMI was associated with a higher incidence of MACE, all-cause death, CD, and any revascularization at the 2 years mark than in those without fever.

Triboelectrostatic Separation System for Separation of PVC and PS Materials Using Fluidized Bed Tribocharger

Jae-Keun Lee,Jin-Hyouk Shin,Yoo-Jin Hwang 대한기계학회 2002 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.16 No.10

A triboelectrostatic separation system using a fluidized bed tribocharger for the removal of PVC material in the mixture of PVC/PS plastics is designed and evaluated as a function of electric field strength, air flow rate, and the mixing ratio of two- component mixed plastics. It consists of a fluidized-bed tribocharger, a separation chamber, a collection chamber and a controller. PVC and PS particles can be imparted negative and positive surface charges, respectively, due to the difference in the work function values of plastics suspended in the fluidized-bed tribocharger, and can be separated by passing them through an external electric field. Experimental results show that separation efficiency is strongly dependent on the electric field strength and particle mixing ratio. In the optimum conditions of 150 lpm air flow rate and 2.6 kV/cm electric field strength a highly concentrated PVC (99.1 %) can be recovered with a yield of more than 99.2% from the mixture of PVC and PS materials for a single stage of processing.<br/>

원발성 담즙성 간경변증

유재영(Jae Young Yoo),신호균(Ho Kyun shin),고순희(Soon Hee Koh),김종혁(Jong Hyouk Kim),송숙희(Sook Hee Song),김규태(Kyu Tae Kim),김학양(Ho Kyun Shin),김진한(Jin Han Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4

Primary biliary cirrhosis is a relatively common liver disease with cholestasis in Western countries, especially in the middle aged women. The sex distributian of this disease between male to female was 1/9. 1n the Korean literatures, there were only 4 casea reported in female, not in male. We report a case of primary biliary cirrhosis with a review of literatures in a 62-year-old man whose serum bilirubin and alkaline phosphatase were persistently elevated.

Radical Scavenging Activities of Phellinus pini

Byung Hyouk Nam(남병혁),Wol Soon Jo(조월순),Yong Cui(최영),Yoo Jin Choi(최유진),Jae Dong Lee(이재동),Min Ho Jeong(정민호) 한국생명과학회 2010 생명과학회지 Vol.20 No.3

Phellinus pini (CY001) 추출물에서의 페놀류성분의 농도는 P. pini (CY001)분획 g 당 GAEs ㎎으로 나타내었고, P. pini 의 EtOAc 분획(436.5 ㎎ GAEs/g)이 다른 분획에 비해 가장 높은 함량을 나타내었다. 환원력과 같은 항산화 활성을 screening 하기 위해 몇 가지 생화학적 시험이 수행되었고, 그것은 2, 2-diphenyl-1-picrylhydrazyl (DPPH) 라디칼 소거작용, NBT/XO superoxide system, DCF/AAPH peroxyl radicals 저해능 등이다. 여섯개의 버섯추출물 분획 중에서 EtOAc 분획이 DPPH, superoxide 라디칼, peroxyl 라디칼 소거작용이 뛰어났고, IC50 values는 각각 11.49 ㎍/㎖, 8.32 ㎛/㎖, and 1.91 ㎍/㎖이었다. P. pini (CY001)의 EtOAc 분획은 중요한 효소적 지질과산화 저해와 cytotoxicity 없이 RAW 264.7 macrophages의 LPS 유도 NO 생성을 효과적으로 감소시켰다. 또한 EtOAc 분획이 HepG2 cell의 타크린 유도 cytotoxicity에서 간 보호 작용을 나타내었다. 이러한 결과를 바탕으로 P. pini (CY001)가 라디칼 소거작용을 하는 성분을 함유한 천연 항산화제로써의 잠재력을 갖고 있는 것으로 사료된다. The concentration of phenolics in Phellinus pini (CY001) extracts, expressed as mg of GAEs per g of P. pini fractions, and the EtOAc fraction (436.5 ㎎ GAEs/g) of P. pini had a higher phenolic content than other fractions. Several biochemical assays were used to screen antioxidant properties such as reducing power, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity, NBT/XO superoxide system and inhibition of DCF/AAPH peroxyl radicals. Among the six mushroom extracts, the EtOAc fraction from P. pini (CY001) showed the most potent DPPH radical, superoxide radical, and peroxyl radical scavenging activities, with IC50 values of 11.49 ㎍/ml, 8.32 ㎍/㎖, and 1.91 μg/㎖, respectively. The EtOAc fraction of P. pini (CY001) significantly inhibited enzymatic lipid peroxidation and effectively attenuated LPS-induced NO production of RAW 264.7 cells without cytotoxicity. We also found that the EtOAc fraction had a significant hepato-protectant effect on tacrine-induced cytotoxicity in HepG2 cells. These findings suggest that P. pini (CY001) may have potential as a natural antioxidant, which contains compound(s) with radical scavenging activity.

Triboelectrostatic Separation System for Separation of PVC and PS Materials Using Fluidized Bed Tribocharger

Lee, Jae-Keun,Shin, Jin-Hyouk,Hwang, Yoo-Jin The Korean Society of Mechanical Engineers 2002 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.16 No.10

A triboelectrostatic separation system using a fluidized bed tribocharger for the removal of PVC material in the mixture of PVC/PS plastics is designed and evaluated as a function of electric field strength, air flow rate, and the mixing ratio of two-component mixed plastics. It consists of a fluidized-bed tribocharger, a separation chamber, a collection chamber and a controller. PVC and PS particles can be imparted negative and positive surface charges, respectively, due to the difference in the work function values of plastics suspended in the fluidized-bed tribocharger, and can be separated by passing them through an external electric field. Experimental results show that separation efficiency is strongly dependent on the electric Deld strength and particle mixing ratio. In the optimum conditions of 150 Ipm air flow rate and 2.6 kV/cm electric field strength a highly concentrated PVC (99.1%) can be recovered with a yield of more than 99.2% from the mixture of PVC and PS materials for a single stage of processing.

ITO/Glass 기판위에 PFO-poss 유기 발광층을 가지는 고분자 발광다이오드의 제작

유재혁,장호정,Yoo, Jae-Hyouk,Chang, Ho-Jung 한국마이크로전자및패키징학회 2006 마이크로전자 및 패키징학회지 Vol.13 No.4

ITO(Indium tin oxide)glass 기판 위에 PEDOT:PSS[poly(3,4-ethylenedioxythiophene):poly (styrene sulfonate)]와 PVX[poly(N-vinyl carbazole)] 고분자 물질을 정공 주입 및 수송층으로, 발광층으로 PFO-poss[Poly(9,9-dioctylfluorenyl-2,7-diyl) end capped with poss]를 사용하여 ITO/PEDOT:PSS/PVK/PFO-poss/LiF/Al 구조의 고분자 발광다이오드를 제작하였다. 이때 스핀코팅을 위한 발광 유기재료의 농도와 열처리 온도가 소자의 전기적, 광학적 특성에 미치는 영향을 조사하였다. 동일한 PFO-poss 농도에서 열처리 온도가 $100^{\circ}C$에서 $200^{\circ}C$로 증가할 경우 PLED 소자의 전류밀도와 휘도특성이 증가하는 경향을 나타내었다. 1.0 wt% 농도를 갖는 PFO-poss 유기물 발광충을 $200^{\circ}C$ 온도로 열처리 할 경우 $958\;cd/m^{2}$의 최대 휘도를 나타내었으며 발광파장은 523 nm 녹색계통의 파장이 크게 증가하여 청백색에 가까운 발광을 나타내었다. PFO-poss 농도증가(0.5 wt%에서 1.0 wt%)와 함께 PLED 소자의 열처리 온도를 $100^{\circ}C$에서 $200^{\circ}C$로 증가할 경우 CIE 색좌표는 청색 (x, y : 0.17, 0.14)에서 청백색 (x, y = 0.29, 0.41)발광으로 천이하는 경향을 나타내었다. Polymer light emitting diodes (PLEDs) with ITO/EDOT:PSS/PVK/PFO-poss/LiF/Al structures were prepared by the spin coating method on ITO(indium tin oxide)/glass substrates. PFO-poss[Poly(9,9-dioctylfluorenyl-2,7-diyl) end capped with poss] was used as light emitting polymer. PVK[poly(N-vinyl carbazole)] and PEDOT:PSS [poly(3,4-ethylenedioxythiophene):poly(styrene sulfolnate)] polymers were used as the hole injection and transport materials. The effect of PFO-poss concentration and the heating temperatures on the electrical and optical properties of the devices were investigated. At the same concentration of PFO-poss solution, the current density and luminance of PLED device tend to increase as the annealing temperature increase from $100^{\circ}C$ to $200^{\circ}C$. The maximum luminance was found to be about 958 cd/m2 at 13V for the PLED device with 1.0 wt% PFO-poss at the annealing temperature of $200^{\circ}C$. In addition, the PLED device showed bluish white emission through the strong greenish peak with 523 nm in wavelength. As the concentration of PFO-poss increase from 0.5 wt% to 1.0 wt% and temperature of PLEDs increase from $100^{\circ}C$ to $200^{\circ}C$, the emission color tend to be shifted from blue with (x, y) = (0.17,0.14) to bluish white with (x, y) : (0.29,0.41) in CIE color coordinate.

보문 : 밀리타리스 동충하초 열수추출물의 멜라닌 분비 억제능 효과

남병혁 ( Byung Hyouk Nam ),조월순 ( Wool Soon Jo ),최유진 ( Yoo Jin Choi ),이재윤 ( Jae Yun Lee ),강은영 ( Eun Young Kang ),정민호 ( Min Ho Jeong ),이재동 ( Jae Dong Lee ) 한국균학회 2010 韓國菌學會誌 Vol.38 No.2

The present study aims to evaluate Cordyceps militaris water extract (CMWE) with a view to develop melanogenesis inhibitors. Inhibitory activities of CMWE against tyrosinase, L-DOPA(L-3,4-dihydroxyphenylalanine) oxidation, and melanin biosynthesis in B16 mouse melanoma cells were investigated. CMWE, at 5000 μg/ml, inhibited tyrosinase activity of 71% and DOPA oxidation of 40% as reacting with L-DOPA. Furthermore, B16 mouse melanoma cell survived over 50% from low to high dose on MTT assay, and CMWE markedly inhibited (>50%) melanin synthesis at 5000 μg/ml. The inhibitory effect of CMWE on melanogenesis was attributed to enhancement of tyrosinase degradation. Key enzyme of melanin biosynthesis is tyrosinase which catalyses a beginning step from tyrosine to DOPA quinine and melanin formation step, respectively. These results indicated that CMWE may be a potential source of novel whitening agents for cosmetic or therapeutic application.

Electrically controllable twisted-coiled artificial muscle actuators using surface-modified polyester fibers

Park, Jungwoo,Yoo, Ji Wang,Seo, Hee Won,Lee, Youngkwan,Suhr, Jonghwan,Moon, Hyungpil,Koo, Ja Choon,Choi, Hyouk Ryeol,Hunt, Robert,Kim, Kwang Jin,Kim, Soo Hyun,Nam, Jae-Do Institute of Physics Publishing 2017 Smart materials & structures Vol.26 No.3

<P>As a new class of thermally activated actuators based on polymeric fibers, we investigated polyethylene terephthalate (PET) yarns for the development of a twisted-coiled polymer fiber actuator (TCA). The PET yarn TCA exhibited the maximum linear actuation up to 8.9% by external heating at above the glass transition temperature, 160 °C–180 °C. The payload of the actuator was successfully correlated with the preload and training-load conditions by an empirical equation. Furthermore, the PET-based TCA was electrically driven by Joule heating after the PET surface was metallization with silver. For the fast and precise control of PET yarn TCA, electroless silver plating was conducted to form electrical conductive layers on the PET fiber surface. The silver plated PET-based TCA was tested by Joule heating and the tensile actuation was increased up to 12.1% (6 V) due to the enhanced surface hardness and slippage of PET fibers. Overall, silver plating of the polymeric yarn provided a fast actuation speed and enhanced actuation performance of the TCA actuator by Joule heating, providing a great potential for being used in artificial muscle for biomimetic machines including robots, industrial actuators and powered exoskeletons.</P>

Research Articles : The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage

( Wol Soon Jo ),( Yoo Jin Choi ),( Hyoun Ji Kim ),( Jae Yun Lee ),( Byung Hyouk Nam ),( Jae Dong Lee ),( Sang Wha Lee ),( Su Yeong Seo ),( Min Ho Jeong ) 한국균학회 2010 Mycobiology Vol.38 No.1

유입방식 변화에 따른 황 탈질조의 탈질효율 평가

유태경(Tae-Kyoung Yoo),최용범(Yong-Bum Choi),권재혁(Jae-Hyouk Kwon) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.12

황 탈질조 유입수질은 회분식 실험을 통한 질산화된 유출수를 사용하였으며, 유입수 주입방향에 따라 상향류와 하향류식으로 운전하여 주입방식에 따른 탈질효율 성능을 평가하였다. 또한, 탈질효율 평가에 따라 선정된 주입방식의 최적 운전조건을 산출하기 위해 EBCT(Empty bed contact time) 변화와 유입 질소농도를 증가시켜 유입부하 증가에 따른 질소 제거효율을 평가하였다. 유입방식 변화에 따른 황 탈질조의 탈질효율 평가결과, 상향류 방식이 탈리된 미생물과 유출 고형물의 재침전으로 인하여 하향류 방식보다 유출 유기물 농도가 낮은 것으로 조사되었다. 또한, 상향류 방식에서 T-N 제거 효율은 73.3∼90.2%로 하향류 방식보다 약 10.0% 이상 높은 것으로 조사되어 질소제거 측면에서도 상향류 방식이 유리한 것으로 판단된다. EBCT 변화에 따른 질소제거 효율 검토결과, 1hr에서는 47.4%, 3hr에서는 88.1%, 5hr에서는 90.5%로 조사되어, 황 탈질 공정의 최적EBCT는 3hr로 판단된다. 법 규정과 부하율에 따른 총질소 제거효율을 검토한 결과, T-N 법적 방류수질 20mg/L를 을 안정적으로 유지하기 위해서는 황 탈질조의 유입 T-N 부하율은 0.443kgT-N/㎥·day 이하로 유지하여야 한다. This study examined the influent of a sulfur denitrification reactor using nitrified effluent from a batch type reactor. The denitrification efficiency was compared according to the injection type. The nitrogen removal effects were compared with the changes in the EBCT and nitrogen concentration of the influent to determine the optimal operation conditions with the selected injection type. A denitrification efficiency evaluation of a reactor according to the change in injection type and up-flow was performed using a lower organic concentration of the effluent than the down-flow because of the re-precipitation of desorbed microbes and spilled solids. In the up-flow type, organics were controlled by the low concentration than the down-flow type because of solid re-precipitation. The T-N removal efficiency of the up-flow type was 73.3~90.2%, which was more that 10% higher that down-flow type. This means that the up-flow type has a great advantage in removing T-N and organics. The T-N removal efficiency by EBCT at 1hr was 47.3%, and was 88.1% and 90.5% by EBCT 3hr and 5hr, respectively. Therefore, the optimal operation conditions to remove nitrogen was considered to be EBCT for 3hr. After careful consideration of rule of law and T-N removal effects, the T-N load factor in the reactor should remain below 0.443kgT-N/㎥·day to maintain the legal total nitrogen concentration for discharge, which is 20mg/L.