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RISS 인기검색어
- 검색키워드
- 저자 : Yingzi Shan (검색결과 3 건)
- 무료
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Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae
Yingzi He,Honglin Mei,Huiqian Yu,Shan Sun,Wenli Ni,Huawei Li 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-
Histone deacetylases are involved in many biological processes and have roles in regulating cell behaviors such as cell cycle entry, cell proliferation and apoptosis. However, the effect of histone deacetylases on the development of hair cells (HCs) has not been fully elucidated. In this study, we examined the influence of histone deacetylases on the early development of neuromasts in the lateral line of zebrafish. Hair cell development was evaluated by fluorescent immunostaining in the absence or presence of histone deacetylase inhibitors. Our results suggested that pharmacological inhibition of histone deacetylases with inhibitors, including trichostatin A, valproic acid and MS-275, reduced the numbers of both HCs and supporting cells in neuromasts. We also found that the treatment of zebrafish larvae with inhibitors caused accumulation of histone acetylation and suppressed proliferation of neuromast cells. Real-time PCR results showed that the expression of both p21 and p27 mRNA was increased following trichostatin A treatment and the increase in p53 mRNA was modest under the same conditions. However, the expression of p53 mRNA was significantly increased by treatment with a high concentration of trichostatin A. A high concentration of trichostatin A also led to increased cell death in neuromasts as detected in a TUNEL assay. Moreover, the nuclei of most of these pyknotic cells were immunohistochemically positive for cleaved caspase-3. These results suggest that histone deacetylase activity is involved in lateral line development in the zebrafish and might have a role in neuromast formation by altering cell proliferation through the expression of cell cycle regulatory proteins.
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Design and Implementation of a Novel Horizontal AFM Probe Utilizing a Quartz Tuning Fork
Yifu Chen,Yingzi Li,Guanqiao Shan,Yingxu Zhang,Zhenyu Wang,Mubing Wang,Hua Li,Jianqiang Qian 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.1
This paper presents a new structure of a novel horizontal atomic force microscope probe utilizing a quartz tuning fork. The horizontal structure exhibits high resistance to environmental noise, and thus the probe can maintain good stability throughout the imaging work. The quartz tuning fork, which is utilized as a force sensor due to its simple mechanical structure and self-actuating and self-sensing characteristics, can significantly simplify the mechanical structure of the probe. The probe is divided into three parts: an approximation device, a force sensor, and a three-dimensional scanner. Each part is carefully designed to guarantee the imaging performance. It is verified that the proposed horizontal AFM probe is stable by conducting finite-element analysis, including modal analysis and noise analysis. Furthermore, the probe is fabricated and the experiments are performed to verify its stability. The proposed horizontal AFM probe combined with the existing control system in the frequency modulation succeeds in imaging within 25 μm × 25 μm and 20 μm × 20 μm ranges stably.
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Privacy-Preserving, Energy-Saving Data Aggregation Scheme in Wireless Sensor Networks
Liming Zhou,Yingzi Shan 한국정보처리학회 2020 Journal of information processing systems Vol.16 No.1
Because sensor nodes have limited resources in wireless sensor networks, data aggregation can efficientlyreduce communication overhead and extend the network lifetime. Although many existing methods areparticularly useful for data aggregation applications, they incur unbalanced communication cost and waste lotsof sensors’ energy. In this paper, we propose a privacy-preserving, energy-saving data aggregation scheme(EBPP). Our method can efficiently reduce the communication cost and provide privacy preservation to protectuseful information. Meanwhile, the balanced energy of the nodes can extend the network lifetime in our scheme. Through many simulation experiments, we use several performance criteria to evaluate the method. Accordingto the simulation and analysis results, this method can more effectively balance energy dissipation and provideprivacy preservation compared to the existing schemes.
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