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- 저자 : Yingwei Li (검색결과 10 건)
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IL-6-miR-210 Suppresses Regulatory T Cell Function and Promotes Atrial Fibrosis by Targeting Foxp3
Chen, YingWei,Chang, GuoDong,Chen, XiaoJie,Li, YunPeng,Li, HaiYu,Cheng, Dong,Tang, Yi,Sang, HaiQiang Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.5
The aim of this study was to explore the role of IL-6-miR-210 in the regulation of Tregs function and atrial fibrosis in atrial fibrillation (AF). The levels of interleukin (IL)-6 and IL-10 in AF patients were detected by using ELISA. Proportions of Treg cells were detected by fluorescence activated cell sorting analysis in AF patients. The expression of Foxp3, α-SMA, collagen I and collagen III were determined by western blot. The atrial mechanocytes were authenticated by vimentin immunostaining. The expression of miR-210 was performed by quantitative real-time polymerase chain reaction (qRT-PCR). TargetScan was used to predict potential targets of miR-210. The cardiomyocyte transverse sections in AF model group were observed by H&E staining. The myocardial filaments were observed by masson staining. The level of IL-6 was highly increased while the level of IL-10 (Tregs) was significantly decreased in AF patients as compared to normal control subjects, and IL-6 suppressed Tregs function and promoted the expression of α-SMA, collagen I and collagen III. Furthermore, miR-210 regulated Tregs function by targeting Foxp3, and IL-6 promoted expression of miR-210 via regulating hypoxia inducible factor-1α (HIF-1α). IL-6-miR-210 suppresses regulatory T cell function and promotes atrial fibrosis by targeting Foxp3.
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Li, Yuanming,Yuan, Pan,Ren, Quan-yao,Su, Guanghui,Yu, Hongxing,Wang, Haoyu,Zheng, Meiyin,Wu, Yingwei,Ding, Shurong Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.5
The plate-type fuel assembly adopted in nuclear research reactor suffers from complicated effect induced by non-uniform irradiation, which might affect its stress conditions, mechanical behavior and thermal-hydraulic performance. A reliable numerical method is of great importance to reveal the complex evolution of mechanical deformation, flow redistribution and temperature field for the plate-type fuel assembly under non-uniform irradiation. This paper is the first part of a two-part study developing the numerical methodology for the thermal-fluid-structure coupling behaviors of plate-type fuel assembly under irradiation. In this paper, the thermal-fluid-structure coupling methodology has been developed for plate-type fuel assembly under non-uniform irradiation condition by exchanging thermal-hydraulic and mechanical deformation parameters between Finite Element Model (FEM) software and Computational Fluid Dynamic (CFD) software with Mesh-based parallel Code Coupling Interface (MpCCI), which has been validated with experimental results. Based on the established methodology, the effects of non-uniform irradiation and fluid were discussed, which demonstrated that the maximum mechanical deformation with irradiation was dozens of times larger than that without irradiation and the hydraulic load on fuel plates due to differential pressure played a dominant role in the mechanical deformation.
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A Novel FCM Algorithm Incorporating Spatial Information for Color Image Segmentation
Li Ling,Song Yingwei,Yin Zhongnan,Yang Xiuhua 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.8
Fuzzy c-means clustering (FCM) with spatial information (FCM_S) is an effective algorithm for image segmentation. However, the FCM_S algorithm is not used for color image segmentation and also it produces over-segmentation results. In this paper, we present a novel fuzzy c-means algorithm named nFCM_S that incorporates spatial information into the membership function and cluster center function for segmentation of color images. Firstly, HSV color space is used for decomposition of color images. Then, to label the data points reliably, a linearly-weighted sum image is calculated on each HSV component before clustering process. Finally, spatial information is incorporated in the standard FCM algorithm and nFCM_S is applied separately on each component of HSV color space. Experiment results have shown that the nFCM_S algorithm achieves competitive segmentation results compared to other FCM-based algorithms.
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Li, Yuanming,Ren, Quan-yao,Yuan, Pan,Su, Guanghui,Yu, Hongxing,Zheng, Meiyin,Wang, Haoyu,Wu, Yingwei,Ding, Shurong Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.5
The plate-type fuel assembly adopted in nuclear research reactor suffers from complicated effect induced by non-uniform irradiation, which might affect stress conditions, mechanical behaviors and thermal-hydraulic performance of the fuel assembly. This paper is the Part II work of a two-part study devoted to analyzing the complex unique mechanical deformation and thermal-hydraulic characteristics for the typical plate-type fuel assembly under irradiation effect, which is on the basis of developed and verified numerical thermal-fluid-structure coupling methodology under irradiation in Part I of this work. The mechanical deformation, thermal-hydraulic performance and Mises stress have been analyzed for the typical plate-type fuel assembly consisting of support plates under non-uniform irradiation. It was interesting to observe that: the plate-type fuel assembly including the fuel plates and support plates tended to bend towards the location with maximum fission rate; the hot spots in the fuel foil appeared at the location with maximum thickness increment; the maximum Mises stress of fuel foil was located at the adjacent location with the maximum plate thickness increment et al.
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Song, Shubin,Cong, Xiliang,Li, Fengke,Xue, Yingwei The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.4
Purpose: Fibrinogen and platelets have been reported to play important roles in tumorigenesis and cancer progression. The aim of this research was to investigate the combination of functions of fibrinogen, platelets, and mean platelet volume (MPV) in predicting the survival of patients with gastric cancer (GC). Materials and Methods: A retrospective study was conducted with 1,946 patients with GC and 299 patients with benign gastric tumor to analyze their fibrinogen, platelet, and MPV levels, and other clinicopathological characteristics along with their prognoses. Several indicators were evaluated along with fibrinogen, platelets, and MPV and their prognostic abilities were assessed. Univariate and multivariate survival analyses were conducted to determine the independent risk factors for overall survival. Results: Increased levels of fibrinogen, platelets, and MPV were observed with the progress of the GC stages. Elevated fibrinogen, platelets, and the combined indicators, including fibrinogen*MPV (FM), platelet*fibrinogen*MPV (PFM), fibrinogen/MPV (FMR), platelet*fibrinogen (PF), platelet*fibrinogen/MPV (PFMR), platelet*MPV (PM), and platelet/MPV (PMR), foreboded poor prognosis. Meanwhile fibrinogen and FMR can be considered as independent risk factors for overall survival in patients with non-metastatic GC. But these indicators can hardly predict survival of patients in stage IV. Conclusions: Elevated fibrinogen, platelets, and MPV levels were in accordance with advanced stages, and fibrinogen, platelet, and MPV, in combination, can be used to predict survival of patients with non-metastatic GC. FMR was an independent prognostic factor for overall survival of patients with GC.
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Jing-Guang Lu,Yingwei Wang,Ming-Rong Yang,Cai-Yun Wang,Jieru Meng,Jiazheng Liu,Zifeng Yang,Kongsong Wu,Li-Ping Bai,Guo-Yuan Zhu,Zhi-Hong Jiang 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.9
(±)-Decumicorine A ( 1 ) and (±)- epi -decumicorine A ( 2 ), two pairs of enantiomeric isoquinoline alkaloids featuring a novel phenylpropanoid-conjugated protoberberine skeleton, were isolated and purifi ed from the rhizomes of Corydalis decumbens . The separation of (±)- 1 and (±)- 2 was achieved by chiral HPLC to produce four optically pure enantiomers. The structures and absolute confi gurations of compounds (−)- 1 , (+)- 1 , (−)- 2 , and (+)- 2 were elucidated by spectroscopic analysis, ECD calculations, and X-ray crystallographic analyses. The two racemates were generated from a Diels-Alder [4 + 2] cycloaddition between jatrorrhizine and ferulic acid in the proposed biosynthetic pathways, which were fully verifi ed by a biomimetic synthesis. Moreover, compound (+)- 1 exhibited an antiviral entry eff ect on SARS-CoV-2 pseudovirus by blocking spike binding to the ACE2 receptor on HEK-293T-ACE2 h host cells.
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Chen, Ping,Qiu, Bowen,Li, Yuanming,Wu, Yingwei,Hui, Yongbo,Deng, Yangbin,Zhang, Kun Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.4
Although there are still controversial opinions and uncertainty on application of SiC<sub>f</sub>/SiC composite cladding as next-generation cladding material for its great oxidation resistance in high temperature steam environment and other outstanding advantages, it cannot deny that SiC<sub>f</sub>/SiC cladding is a potential accident tolerant fuel (ATF) cladding with high research priority and still in the engineering design stage for now. However, considering its disadvantages, such as low irradiated thermal conductivity, ductility that barely not exist, further evaluations of its in-pile behaviors are still necessary. Based on the self-developed code we recently updated, relevant thermohydraulic and mechanical models in FROBA-ATF were applied to simulate the cladding behaviors under normal and accident conditions in this paper. Even through steady-state performance analysis revealed that this kind of cladding material could greatly reduce the oxidation thickness, the thermal performance of UO<sub>2</sub>-SiC was poor due to its low inpile thermal conductivity and creep rate. Besides, the risk of failure exists when reactor power decreased. With geometry optimization and dopant addition in pellets, the steady-state performance of UO<sub>2</sub>-SiC was enhanced and the failure risk was reduced. The thermal and mechanical performance of the improved UO<sub>2</sub>-SiC was further evaluated under Loss of coolant accident (LOCA) and Reactivity Initiated Accident (RIA) conditions. Transient results showed that the optimized ATF had better thermal performance, lower cladding hoop stress, and could provide more coping time under accident conditions.
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Weihang Kong,Lei Li,Lingfu Kong,Yingwei Li,Na Xie 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.12
Due to the advantages of scale invariant feature transform (SIFT) feature points on the invariant to image scale, brightness, rotation, occlusion, noise and so on, this paper proposes a Particle Tracking Velocimetry (PTV) method, based on SIFT feature points matching for velocity measurement of oil-water two-phase flow in horizontal pipelines. The oil-water two-phase flow with large droplet diameter, oil droplets overlap, ununiform lighting, and the centroid position of oil droplets can’t be obtained only by using traditional PTV methods through morphological processing. However, in this paper, the algorithm can directly achieve the average velocity of the flow field according to the positions of correctly matched SIFT feature points, and there is no need to extract the centroid coordinates of each oil droplet. The experimental results show that the proposed algorithm not only can be used in the average velocity measurement of oil-water two-phase flow in horizontal pipelines, but also can reach 95% in the measuring accuracy when the matching feature points are enough sufficient.
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Shubin Song,Xiliang Cong,Fengke Li,Yingwei Xue 대한위암학회 2018 Journal of gastric cancer Vol.18 No.4
Purpose: Fibrinogen and platelets have been reported to play important roles in tumorigenesis and cancer progression. The aim of this research was to investigate the combination of functions of fibrinogen, platelets, and mean platelet volume (MPV) in predicting the survival of patients with gastric cancer (GC). Materials and Methods: A retrospective study was conducted with 1,946 patients with GC and 299 patients with benign gastric tumor to analyze their fibrinogen, platelet, and MPV levels, and other clinicopathological characteristics along with their prognoses. Several indicators were evaluated along with fibrinogen, platelets, and MPV and their prognostic abilities were assessed. Univariate and multivariate survival analyses were conducted to determine the independent risk factors for overall survival. Results: Increased levels of fibrinogen, platelets, and MPV were observed with the progress of the GC stages. Elevated fibrinogen, platelets, and the combined indicators, including fibrinogen*MPV (FM), platelet*fibrinogen*MPV (PFM), fibrinogen/MPV (FMR), platelet*fibrinogen (PF), platelet*fibrinogen/MPV (PFMR), platelet*MPV (PM), and platelet/ MPV (PMR), foreboded poor prognosis. Meanwhile fibrinogen and FMR can be considered as independent risk factors for overall survival in patients with non-metastatic GC. But these indicators can hardly predict survival of patients in stage IV. Conclusions: Elevated fibrinogen, platelets, and MPV levels were in accordance with advanced stages, and fibrinogen, platelet, and MPV, in combination, can be used to predict survival of patients with non-metastatic GC. FMR was an independent prognostic factor for overall survival of patients with GC.
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Clinical Study on Safety and Efficacy of Microwave Ablation for Primary Hyperparathyroidism
Ying Wei,Lili Peng,Yan Li,Zhen-long Zhao,Ming-an Yu 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.5
Objective: To evaluate the safety, feasibility, and efficacy of microwave ablation (MWA) for the treatment of primary hyperparathyroidism (PHPT). Materials and Methods: This study enrolled 67 PHPT patients (22 men, 45 women; mean age, 56.0 ± 16.3 years; range, 18– 83 years) from January 2015 to December 2018. The laboratory data, including the serum intact parathyroid hormone (iPTH), calcium, phosphorus, and alkaline phosphatase (ALP) levels, were evaluated before MWA and again 2 hours, 1 day, 7 days, 1 month, 3 months, 6 months, 12 months, 18 months, and 24 months after. Results: Complete ablation was achieved with all 72 hyperplastic parathyroid glands found on the 67 patients enrolled, 64 of whom were treated in one session and 3 were treated over two sessions. The technical success rate was 100%. The median follow-up time was 13.6 months (range, 10.0–31.1 months). The clinical success rate was 89.4%. The volume reduction rate was 79.4% at 6 months. Compared to pre-MWA, the serum iPTH, calcium, phosphorus, and ALP levels had significantly improved 6 months post-MWA (iPTH, 157.3 pg/mL vs. 39.2 pg/mL; calcium, 2.75 ± 0.25 mmol/L vs. 2.34 ± 0.15 mmol/L; phosphorus, 0.86 ± 0.20 mmol/L vs. 1.12 ± 0.22 mmol/L; ALP, 79 U/L vs. 54 U/L, respectively; all, p < 0.01). Hoarseness was a major complication in 4 patients (6.0%), but it improved spontaneously within 2–3 months. Conclusion: MWA is safe, feasible, and effective for the treatment of PHPT.
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