http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability
Zhang Nan,Shen Yan,Li Huan,Chen Ying,Zhang Ping,Lou Shifeng,Deng Jianchuan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
N6-methyladenosine (m6A) is the most abundant posttranscriptional modification of mRNA in eukaryotes. Recent evidence suggests that dysregulated m6A-associated proteins and m6A modifications play a pivotal role in the initiation and progression of diseases such as cancer. Here, we identified that IGF2BP3 is specifically overexpressed in acute myeloid leukemia (AML), a subtype of leukemia associated with poor prognosis and high genetic risk. IGF2BP3 is required for maintaining AML cell survival in an m6A-dependent manner, and knockdown of IGF2BP3 dramatically suppresses the apoptosis, reduces the proliferation, and impairs the leukemic capacity of AML cells in vitro and in vivo. Mechanistically, IGF2BP3 interacts with RCC2 mRNA and stabilizes the expression of m6A-modified RNA. Thus, we provided compelling evidence demonstrating that the m6A reader IGF2BP3 contributes to tumorigenesis and poor prognosis in AML and can serve as a target for the development of cancer therapeutics.
Infl uence of Multiple Earthquakes on Single-Layer Reticulated Dome and Its Shaking-Table Test
Ying-Nan Zhang,Xudong Zhi,Feng Fan 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.1
In this paper, a primary dataset of mainshock–aftershock sequences is constructed from the Pacifi c Earthquake Engineering Research Center. This is followed by the collection of 342 groups of mainshock–aftershock ground motions for the dynamic time history analysis of a single-layer reticulated dome in the full process domain. According to the change curves between the characteristic factors and acceleration amplitudes, four diff erent levels of infl uence (i.e. no infl uence, slight infl uence, signifi cant infl uence and collapse under aftershocks) of multiple earthquakes on the seismic responses of a single-layer reticulated dome are defi ned. On this basis, a shaking-table test of a single-layer reticulated dome model, taking aftershocks into consideration, is conducted to obtain the full failure history under multiple earthquakes intuitively. Spherical joints are located accurately, using total station surveying equipment and lead screws during model processing. Experimental results verify the above four levels of infl uence of multiple earthquakes and provide a dependable reference for seismic design.
Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
Extensional midline framework built with porous polyethylene implant (Medpor) in rhinoplasty
Chen Zhang,Xiao-Li Jiang,Chun-Ying Ge,Li-Nan Song 대한미용의학회 2017 대한미용의학회지 Vol.1 No.1
Background: In East Asians, the main steps of rhinoplasty include the regulation of the nasal tip projection along with dorsal augmentation. A complete septal extension graft and columella strut graft are effective tools for the correction of unprojected tips and short noses. However, autologous cartilages cannot provide enough cartilage for the graft. Moreover, use of rib cartilages will leave an additional scar on the patient’s chest, and these are not considered a common source of cartilage. Therefore, the authors used porous high-density polyethylene (Medpor) sheets to rebuild extensional midline framework in rhinoplasty. Objective: To study the possibility and the method of porous high-density polyethylene (Medpor) sheets used as extensional midline framework in rhinoplasty. Methods: From May 2012 to May 2016, 78 patients underwent primary rhinoplasty with a midline framework built with Medpor. The patients’ ages ranged from 22 to 48 years (mean±SD, 26±5.2 years). Seventy-five patients were women, and three were men. The patients selected Medpor because of a lack of adequate autogenous septal cartilage and refusal to use rib cartilage. Results: The patients were followed up for 6 months to 4 years, with a mean follow-up period of 18 months, in 3-month intervals, and examined for extrusion, infection, and aesthetic outcomes. In the 78 patients, 156 pieces of Medpor graft were used with 78 extensional septal grafts and 78 columella strut grafts. Nasal tip projection and columella-labial angle were changed significantly after the surgery in 67 of the 78 patients. Complications occurred in 11 patients, of whom one had two minor complications of deviated tip and columella. Conclusion: The porous high-density polyethylene sheets are easier to handle and effective as materials to build an extensional midline framework in rhinoplasty. However, the size of the porous high-density polyethylene sheets should be tailored carefully based on the preoperative assessment; otherwise, severe complications will occur.
Risk Assessment of Breast Cancer in Guangdong, China: A Community-based Survey
Lin, Ying,Shao, Nan,Zhang, Yun-Jian,Wu, Zhuang-Hong,Li, Zhi-Bin,Ren, Ze-Fang,Wang, Shen-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Objectives: Compared with Western countries, the incidence rates for breast cancer in China are still low. However, breast cancer appears to be hitting Chinese women at a much younger age, with a peak between 40 and 50 years. Furthermore, breast tumors of Asian women have molecular and genetic characteristics that are different from those of Caucasian women. Methods: A community-based study was designed to evaluate the relationship between lifestyles and breast cancer risk in Chinese women residing in Guangzhou. 16,314 subjects completed the questionnaire. Potential confounding factors included sociodemographic characteristics. Results: 33 individuals reported a history of breast cancer, yielding a prevalence rate of 202.3/100000. Associations between subjects' demographic and breast cancer risk factors were assessed. Breast cancer is associated with family history of breast cancer, X-rays received, benign breast disease and hyperlipoidemia or hypercholesteremia with elevated odds ratios. Conclusions: Family history of breast cancer, X-ray received benign breast disease and hyperlipoidemia or hypercholesteremia were significantly associated with risk of breast cancer and may havepotential for breast cancer risk assessment.