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Dependence of Resonance Characteristics on Thermal Annealing in ZnO-Based FBAR Devices
Mai Linh,Yim Mun-Hyuk,Yoon Gi-Wan,Kim Dong-Hyun The Korea Institute of Information and Commucation 2004 Journal of information and communication convergen Vol.2 No.3
In this paper, we present the film bulk acoustic resonator (FBAR) devices fabricated by considering the effects of annealing temperature on zinc oxide (ZnO) film growth characteristics. In order to determine the annealing temperature and annealing time at which the ZnO film can have good material properties, the several resonators containing ZnO layers were fabricated and annealed at various temperatures from $27^{\circ}C\;to\;300^{\circ}C$ in Ar gas ambient. The effects of the annealing temperature and annealing time on the ZnO film properties were comprehensively studied in order to further improve the resonance characteristics of FBAR resonators.
Kim Deok-Gie,Yim Seung Hyuk,Min Eun-Ki,Choi Mun Chae,Lee Jae Geun,Kim Myoung Soo,Joo Dong Jin 대한의학회 2023 Journal of Korean medical science Vol.38 No.35
Background: The model for end-stage liver disease 3.0 (MELD3.0) is expected to address the flaws of the current allocation system for deceased donor liver transplantation (DDLT). We aimed to validate MELD3.0 in the Korean population where living donor liver transplantation is predominant due to organ shortages. Methods: Korean large-volume single-centric waitlist data were merged with the Korean Network for Organ Sharing (KONOS) data. The 90-day mortality was compared between MELD and MELD3.0 using the C-index in 2,353 eligible patients registered for liver transplantation. Patient numbers and outcomes were compared based on changes in KONOS-MELD categorization using MELD3.0. Possible gains in MELD points and reduced waitlist mortality were analyzed. Results: MELD3.0 performed better than MELD (C-index 0.893 for MELD3.0 vs. 0.889 for MELD). When stratified according to the KONOS-MELD categories, 15.9% of the total patients and 35.2% of the deceased patients were up-categorized using MELD3.0 versus MELD categories. The mean gain of MELD points was higher in women (2.6 ± 2.1) than men (2.1 ± 1.9, P < 0.001), and higher in patients with severe ascites (3.3 ± 1.8) than in controls (1.9 ± 1.8, P < 0.001); however, this trend was not significant when the MELD score was higher than 30. When the possible increase in DDLT chance was calculated via up-categorizing using MELD3.0, reducible waitlist mortality was 2.7%. Conclusion: MELD3.0 could predict better waitlist mortality than MELD; however, the merit for women and patients with severe ascites is uncertain, and reduced waitlist mortality from implementing MELD3.0 is limited in regions suffering from organ shortage, as in Korea.
Hye-Jin Kim,Soo Hyun Park,Jun-Hyuk Kim,Bomi Yim,Jeong-Hwan Mun,김호방,허윤영,유희주 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.3
Microsatellites are valuable resources for breeding and genetic studies of crop species. The development of simple sequencerepeat (SSR) markers, which are applied across closely related cultivars, has been slow, labor-intensive, and expensive, witha low success rate. In this study, we demonstrate an effi cient strategy for developing cross-species, amplifi able polymorphicSSR markers from grapevine ( Vitis vinifera ) based on sequence comparison and in silico polymerase chain reaction amplification of the genome sequences of grape cultivars. A total of 21 primer sets targeting unique SSR loci were screened frompolymorphism and heterozygosity analyses of 13 grape cultivars and four wild species. The number of alleles varied from3 to 12, with a mean of 7.52 alleles per locus. The lowest and highest observed heterozygosity values were 0.24 and 0.82,respectively, with an average of 0.54. Polymorphic information content values for the primer sets ranged from 0.32 to 0.86,with an average of 0.70. We successfully identifi ed genetic relationships among 17 grape genotypes using the unweightedpair group method with arithmetic average and principal coordinates analysis of the SSR markers. The results suggest thatthe strategy developed in this study is applicable to high-throughput cross-amplifi able SSR marker development for theidentifi cation of genotype, genetic study, and examination of genetic diversity in grapevines.
박수진 ( Soo Jin Park ),( Eun Ji Lee ),( Hee Su Lee ),( Junsik Kim ),( Sunwoo Park ),( Jiyeon Ham ),( Jaehee Mun ),( Haerin Paik ),( Hyunji Lim ),( Aeran Seol ),( Ga Won Yim ),( Seung-hyuk Shim ),( Beong 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
This study aims to evaluate the drug distribution, tissue concentrations, penetration depth, pharmacokinetic properties, and toxicities after rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) in pigs. Because relevant medical devices have not been introduced, we developed our prototype of pressurized intraperitoneal aerosol chemotherapy (PIPAC) and RIPAC by adding a conical pendulum motion device for rotating the nozzle. RIPAC and PIPAC were conducted using 150 ml of 1% methylene blue to evaluate the drug distribution and 3.5mg of doxorubicin in 50 ml of 0.9% NaCl to evaluate the tissue concentrations and penetration depth, pharmacokinetic properties, and toxicities. All agents were sprayed as aerosols via the nozzle, DreamPenVR (Dalim Biotech, Gangwon, South Korea), with a velocity of 5 km/h at a flow rate of 30 ml/min under a pressure of 7 bars, and capnoperitoneum of 12mmHg was maintained for 30 min. As a result, RIPAC showed a wider distribution and stronger intensity than PIPAC. Compared with PIPAC, RIPAC demonstrated high values of the tissue concentration in the central, right upper, epigastrium, left upper, left lower, right lower, and right flank regions (median, 375.5-2124.9 vs. 161.7- 1240 ng/ml; p_ .05), and higher values of the depth of concentrated diffusion and depth of maximal diffusion (median, 232.5- 392.7 vs. 116.9-240.1 lm; 291.2-551.2 vs. 250.5-362.4 lm; p_ .05) in all regions except for bowels. In RIPAC, the pharmacokinetic properties reflected hemodynamic changes during capnoperitoneum, and there were no related toxicities. Conclusively, RIPAC may have the potential to enhance drug delivery into the peritoneum compared to PIPAC.