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허진영 대구대학교 인문과학 예술문화연구소 2005 人文科學硏究 Vol.29 No.-
La plupart des professeurs enseigne eux-memes sans tenir compte des intéréts des étudiants. Mais de plus en plus souvent, les professeurs commenéent é s`int?resser aux nouvelles méthodes didactiques. Ceci, parce que les étudiants demandent des cours avec utilisation de nouveaux supports et matériaux éducatifs. Nous avons donc analysé des enquétes realisées auprés des étudiants sur leur perfection de leurs besoins d`apprentissage. 43% des étudiants intérrogés ont besoin de manuels pour passer l`examen dans la classe. 38% des étudiants affirement avoir besoin de manuels pour aider le contenu des cours. Parmi les matériaux éducatifs cités, les étudiants préférent la video pour améliorer la compréhension. L`avantage de léexposés en groupe, 15% des étudiants desirent coopérer et partager leur travail. Mais dans ce cadre, un défaut important de la présentation en groupe, le manque du temps pour la discussion, est noté par 24% des étudiants. Concernant les devoirs, 15% des étudiants sondés veulent noter leur idées, 29% des étudiants n'aiment pas que les professeurs lisent leurs manuels dans la classe. Nous avons proposé une nouvelle méthode d`enseignememt et d`apprentissage en nous basant sur notre expérience en classe. Il faut renforcer non seulememt les cours de discussions mais aussi l`étude de l`enseignement et de l`apprentissage, c`est-é-dire, introduire une refléxion sur les techniques didactiques et les supports afférents.
프랑스어 상호·상표에 대한 인식실태와 교실에서의 활용교육에 관한 연구
허진영 대구대학교 인문과학연구소 2008 人文科學硏究 Vol.31 No.-
Nous observont souvent les mots français utilisés comme noms d'entreprise ou de produits dans la vie coréene. Cependant les Coréens ne connaissent pas bien le sens et la prononciation de ces mots français. Pour combler cette lacune, nous avons essayé de savoir ce que les étudiants coréens se souviennent 25 mots français supposés tels que Tous les jours, Mon ami, La neige, Elle. Cette ê̂nquete nous amène aux faits suivants: En premier lieu, les femmes se rappellent plus de mots que les hommes. En deuxième lieu, nous ne demandons cet exercice qu'aux étudiants de l'Université de Daegu. C'est la raison pour laquelle, nos items et nos informants sont limités et nous ne prétendons pas que nos faits soient de nature absolue et durable. Mais notre étude est l'un des premiers essais pour mettre à profit dans l'enseignement des mots français utilisés comme noms d'entreprise ou de produits dans la vie coréene. Notamment, du point de vue de l'enseignement des mots français, nous pouvons proposer en cours non seulement les expressions en langue française utilisées, mais aussi nous servir de ce lexique comme support de conversation quotidienne simple. L'enseignant montrera aussi les différences phonologiques, les erreurs, l'intégration ou l'absence des articles, les problèmes de trancription qui apparaissent dans ce corpus.
A novel approch of usage of Gram staining to indentify Mycobacterium tuberculosis from tissues
Jin Mok Kim(Jin Mok Kim),Ji Eun Oh(Ji Eun Oh),Reye Kim(Reye Kim),Yeong-Jin Heo(Yeong-Jin Heo),Jae-Hyeon Cho(Jae-Hyeon Cho) 한국예방수의학회 2023 예방수의학회지 Vol.47 No.1
Tuberculosis is a potentially deadly infectious disease caused by the Mycobacterium tuberculosis (M. tuberculosis). Tuberculosis is diagnosed by proving the M. tuberculosis in sputum samples based on the results of acid-resistant staining, culture, and nucleic acid amplification tests. However, there is a report that the detection rate of M. tuberculosis is low in acid-resistant staining using tissue specimens. It has been suspected that the cause is a potential loss of acid resistance by the organic solvents used for tissue specimen preparation. Therefore, this study was pursued to find out if Gram staining and fluorescent staining in addition to acid-resistant staining would be helpful in diagnosing tuberculosis. We used four tissue (lung, small intestine, large intestine, and lymph node) samples with chronic granulomatous inflammation observed in HE staining and positive results in real-time PCR. These detection rates and staining properties were investigated through microscopic examination using the Ziehl-Neelsen, Gram, and Auramin rhodamine staining. In this studies, M. tuberculosis were observed by Ziehl-Neelsen, Gram, and Auramin rhodamine staining in all four samples. In the evaluation of clinical microbiology proficiency testing (CMPT), the Ziehl-Neelsen and Gram staining were the same result, but the Auramin rhodamine staining was relatively low. These data indicated that Gram staining is useful for detecting M. tuberculosis in formalin-fixed tissue specimens. Therefore, if the Ziehl-Neelsen and Gram staining are combined as the M. tuberculosis staining method in tissue specimens, a better direction may be provided for tuberculosis diagnosis.
Visible-light-driven dynamic cancer therapy and imaging using graphitic carbon nitride nanoparticles
Heo, Nam Su,Lee, Sun Uk,Rethinasabapathy, Muruganantham,Lee, Eun Zoo,Cho, Hye-Jin,Oh, Seo Yeong,Choe, Sang Rak,Kim, Yeonho,Hong, Won G,Krishnan, Giribabu,Hong, Won Hi,Jeon, Tae-Joon,Jun, Young-Si,Kim, Elsevier 2018 Materials Science and Engineering C Vol.90 No.-
<P><B>Abstract</B></P> <P>Organic graphitic carbon nitride nanoparticles (NP-g-CN), less than 30 nm in size, were synthesized and evaluated for photodynamic therapy (PDT) and cell imaging applications. NP-g-CN particles were prepared through an intercalation process using a rod-like melamine-cyanuric acid adduct (MCA) as the molecular precursor and a eutectic mixture of LiCl-KCl (45:55 wt%) as the reaction medium for polycondensation. The nano-dimensional NP-g-CN penetrated the malignant tumor cells with minimal hindrance and effectively generated reactive oxygen species (ROS) under visible light irradiation, which could ablate cancer cells. When excited by visible light irradiation (<I>λ</I> > 420 nm), NP-g-CN introduced to HeLa and cos-7 cells generated a significant amount of ROS and killed the cancerous cells selectively. The cytotoxicity of NP-g-CN was manipulated by altering the light irradiation and the BP-g-CN caused more damage to the cancer cells than normal cells at low concentrations. As a potential non-toxic organic nanomaterial, the synthesized NP-g-CN are biocompatible with less cytotoxicity than toxic inorganic materials. The combined effects of the high efficacy of ROS generation under visible light irradiation, low toxicity, and bio-compatibility highlight the potential of NP-g-CN for PDT and imaging without further modification.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NP-g-CN are metal free non-toxic organic matter. </LI> <LI> Bulk-g-CN are breakdown into uniform NP-g-CN through intercalation of LiCl. </LI> <LI> NP-g-CN has high efficacy to generate ROS under visible light irradiation </LI> <LI> NP-g-CN is biocompatible, selectively kills cancer cells and less toxic to normal cells. </LI> <LI> Being organic, NP-g-CN avoids the potential toxicity from heavy metal in humans. </LI> <LI> NP-g-CN can be used for both photodynamic therapy (PDT) and imaging applications. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
L’enseignement scolaire des langues vivantes étrangères et le dictionnaire
Jin-Yeong Heo 서울대학교 2011 외국어교육연구 Vol.14 No.-
Dans l’enseignement scolaire sont apparues des méthodologies officielles définies par des texts ministériels. Notamment, nous devont prendre en compte les situations d’enseigment scolaire des langues vivantes étrangères. C’est-a-dire que les rythmes scolaires, le nombre d’années de cours, d’heures d’enseignement par semaine, d’élèves par class et l’homogénéité de leur niveau, leur âge, leurs besoins et leurs motivations, la formation des professeurs, etc., qui peuvent varier considérablement. La méthodologie d’enseignement des langues vivantes étrangères est constituée du discours des méthodologues directs, du discours des méthodologies actifs, du discours des methodologies audiovisualistes, chacun dans les limites de sa propre problématique. Dans l’enseignement scolaire des langues vivantes étrangères, le statut du dictionnaire dans ces différentes methodologies est remarquable.
Heo, Seong-Yeong,Ko, Seok-Chun,Kim, Chang Su,Oh, Gun-Woo,Ryu, Bomi,Qian, Zhong-Ji,Kim, Geunhyung,Park, Won Sun,Choi, Il-Whan,Phan, Thi Tuong Vy,Heo, Soo-Jin,Kang, Do-Hyung,Yi, Myunggi,Jung, Won-Kyo UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.5
<P>In this study, a marine microalga <I>Spirulina</I> sp.-derived protein was hydrolyzed using gastrointestinal enzymes to produce an angiotensin I (Ang I)-converting enzyme (ACE) inhibitory peptide. Following consecutive purification, the potent ACE inhibitory peptide was composed of 7 amino acids, Thr-Met-Glu-Pro-Gly-Lys-Pro (molecular weight, 759 Da). Analysis using the Lineweaver-Burk plot and molecular modeling suggested that the purified peptide acted as a mixed non-competitive inhibitor of ACE. The inhibitory effects of the peptide against the cellular production of vascular dysfunction-related factors induced by Ang II were also investigated. In human endothelial cells, the Ang II-induced production of nitric oxide and reactive oxygen species was inhibited, and the expression of inducible nitric oxide synthase (iNOS) and endothelin-1 (ET-1) was downregulated when the cells were cultured with the purified peptide. Moreover, the peptide blocked the activation of p38 mitogen-activated protein kinase. These results indicated that this <I>Spirulina</I> sp.-derived peptide warrants further investigation as a potential pharmacological inhibitor of ACE and vascular dysfunction.</P>
Heo, Nam Su,Shukla, Shruti,Oh, Seo Yeong,Bajpai, Vivek K.,Lee, Sun Uk,Cho, Hye-Jin,Kim, Suji,Kim, Yeonho,Kim, Hae Jin,Lee, Sang Yup,Jun, Young-Si,Oh, Mi-Hwa,Han, Young-Kyu,Yoo, Seung Min,Huh, Yun Suk Elsevier 2019 Materials Science and Engineering C Vol. No.
<P><B>Abstract</B></P> <P>Bacterial pathogens of water origin have potential public threats thus suggesting the need of developing efficient and sustainable water disinfection strategies from waterborne pathogens. We set out to synthesize different controlled morphologies of graphitic carbon nitride (g-C<SUB>3</SUB>N<SUB>4</SUB>) polymer, evaluate their comparative effects on the generation of reactive oxygen species (ROS), and investigate potential applications in water purification systems. Characterization of the synthesized microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB>, such as melamine-cyanuric acid (MCA)-based rosette-type, rod-type, 2D hexagonal, and 3D cubic mesoporous silica was accomplished using Fourier transform infrared (FT-IR), energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), X-ray diffractometry (XRD), and transmission electron microscopy (TEM). The microbial inhibitory potential of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> photocatalyst against waterborne <I>Escherichia coli</I>, <I>Staphylococcus aureus</I>, and <I>Salmonella typhimurium</I> was evaluated based on the effective activity of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> upon visible light excitations. The microbicidal efficiency of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> was evident within 30 min of visible light exposure via direct interaction, while other microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB> demonstrated only slight antimicrobial effects after 120 min, with insufficient ROS generation. The antimicrobial and ROS-generating effects of 2D g-C<SUB>3</SUB>N<SUB>4</SUB> depended on the type and surface area of the synthesized 2D g-C<SUB>3</SUB>N<SUB>4</SUB> material. Considering its availability and excellent disinfection activity, 2D g-C<SUB>3</SUB>N<SUB>4</SUB> obtained from simple and convenient facile synthesis is a promising solar-driven photocatalyst for clearing microbial contamination from water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Waterborne pathogenic bacteria pose significant health risks to the public. </LI> <LI> We synthesized different morphologies of graphitic carbon nitride (g-C<SUB>3</SUB>N<SUB>4</SUB>) polymer. </LI> <LI> Synthesized microstructures of g-C<SUB>3</SUB>N<SUB>4</SUB> had potential effect on ROS generation. </LI> <LI> 2D hexagonal g-C<SUB>3</SUB>N<SUB>4</SUB> exhibited significant antimicrobial potential. </LI> <LI> 2D g-C<SUB>3</SUB>N<SUB>4</SUB> had photocatalytic inactivation efficiency in a water purifying system. </LI> </UL> </P>