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- 저자 : Yeona Cho (검색결과 18 건)
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Cho, Yeona,Cho, Yoon Jin,Chang, Won Suk,Kim, Jun Won,Choi, Won Hoon,Lee, Ik Jae BioMed Central 2019 Radiation oncology Vol.14 No.1
<P><B>Background</B></P><P>We evaluated the optimal radiotherapy (RT) plan for synchronous bilateral breast cancer (SBBC), especially treatment plans including the regional lymph node (LN) area.</P><P><B>Methods</B></P><P>This study was conducted using 15 patients with SBBC (5 with small breasts, 5 with large breasts, and 5 who underwent a left total mastectomy). The clinical target volume (CTV) was defined as the volume enveloping the bilateral whole breasts/chest wall and left regional LN area. We established the following plans: 1) volumetric-modulated arc therapy (VMAT)-the only plan using two pairs of partial arcs for the whole target volume, 2) VMAT using one partial arc for the left CTV followed by a 3D tangential technique for the right breast (primary hybrid plan), and 3) VMAT for the left CTV followed by a tangential technique using an automatically calculated prescription dose for the right breast, considering the background dose from the left breast VMAT plan (modified hybrid plan). The Tukey test and one-way analysis of variance were used to compare the target coverage and doses to organs at risk (OARs) of the three techniques.</P><P><B>Results</B></P><P>For target coverage, the VMAT-only and modified hybrid plans showed comparable target coverage in terms of D<SUB>mean</SUB> (50.33 Gy vs. 50.53 Gy, <I>p</I> = 0.106). The primary hybrid plan showed the largest distribution of the high-dose volume, with V<SUB>105%</SUB> of 25.69% and V<SUB>110%</SUB> of 6.37% for the planning target volume (PTV) (<I>p</I> < 0.001). For OARs including the lungs, heart, and left anterior descending artery, the percentages of volume at various doses (V<SUB>5Gy</SUB>, V<SUB>10Gy</SUB>, V<SUB>20Gy</SUB>, V<SUB>30Gy</SUB>) and D<SUB>mean</SUB> were significantly lower in both the primary and modified hybrid plans compared to those of the VMAT-only plan. These results were consistent in subgroup analyses of breast size and morphological variation.</P><P><B>Conclusions</B></P><P>The modified hybrid plan, using an automatically calculated prescription dose for the right breast and taking into consideration the background dose from the left breast VMAT plan, showed comparable target coverage to that of the VMAT-only plan, and was superior for saving OARs. However, considering that VMAT can be adjusted according to the physician’s intention, further evaluation is needed for developing a better plan.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s13014-019-1257-5) contains supplementary material, which is available to authorized users.</P>
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Morphologic change of rectosigmoid colon using belly board and distended bladder protocol
Cho, Yeona,Chang, Jee Suk,Kim, Mi Sun,Lee, Jaehwan,Byun, Hwakyung,Kim, Nalee,Park, Sang Joon,Keum, Ki Chnag,Koom, Woong Sub The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.2
Purpose: This study investigates morphologic change of the rectosigmoid colon using a belly board in prone position and distended bladder in patients with rectal cancer. We evaluate the possibility of excluding the proximal margin of anastomosis from the radiation field by straightening the rectosigmoid colon. Materials and Methods: Nineteen patients who received preoperative radiotherapy between 2006 and 2009 underwent simulation in a prone position (group A). These patients were compared to 19 patients treated using a belly board in prone position and a distended bladder protocol (group B). Rectosigmoid colon in the pelvic cavity was delineated on planning computed tomography (CT) images. A total dose of 45 Gy was planned for the whole pelvic field with superior margin of the sacral promontory. The volume and redundancy of rectosigmoid colon was assessed. Results: Patients in group B had straighter rectosigmoid colons than those in group A (no redundancy; group A vs. group B, 10% vs. 42%; p = 0.03). The volume of rectosigmoid colon in the radiation field was significantly larger in group A (56.7 vs. 49.1 mL; p = 0.009). In dose volume histogram analysis, the mean irradiated volume was lower in patients in group B (V45 27.2 vs. 18.2 mL; p = 0.004). In Pearson correlation coefficient analysis, the in-field volume of rectosigmoid colon was significantly correlated with the bladder volume (R = 0.86, p = 0.003). Conclusion: Use of a belly board and distended bladder protocol could contribute to exclusion of the proximal margin of anastomosis from the radiation field.
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Morphologic change of rectosigmoid colon using belly board and distended bladder protocol
Yeona Cho,MD,Jee Suk Chang,MD,Mi Sun Kim,MD,Jaehwan Lee,MD,Hwakyung Byun,MD,Nalee Kim,MD,Sang Joon Park,MD,Ki Chnag Keum,MD,Woong Sub Koom,MD 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.2
Purpose: This study investigates morphologic change of the rectosigmoid colon using a belly board in prone position and distended bladder in patients with rectal cancer. We evaluate the possibility of excluding the proximal margin of anastomosis from the radiation field by straightening the rectosigmoid colon. Materials and Methods: Nineteen patients who received preoperative radiotherapy between 2006 and 2009 underwent simulation in a prone position (group A). These patients were compared to 19 patients treated using a belly board in prone position and a distended bladder protocol (group B). Rectosigmoid colon in the pelvic cavity was delineated on planning computed tomography (CT) images. A total dose of 45 Gy was planned for the whole pelvic field with superior margin of the sacral promontory. The volume and redundancy of rectosigmoid colon was assessed. Results: Patients in group B had straighter rectosigmoid colons than those in group A (no redundancy; group A vs. group B, 10% vs. 42%; p = 0.03). The volume of rectosigmoid colon in the radiation field was significantly larger in group A (56.7 vs. 49.1 mL; p = 0.009). In dose volume histogram analysis, the mean irradiated volume was lower in patients in group B (V45 27.2 vs. 18.2 mL; p = 0.004). In Pearson correlation coefficient analysis, the in-field volume of rectosigmoid colon was significantly correlated with the bladder volume (R = 0.86, p = 0.003). Conclusion: Use of a belly board and distended bladder protocol could contribute to exclusion of the proximal margin of anastomosis from the radiation field.
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인슐린 결핍 당뇨 마우스에서 식용곤충 쌍별귀뚜라미 추출물의 항당뇨 활성
조형택(Hyung Taek Cho),심규상(Kyu Sang Sim),김예나(Yeona Kim),장문한(Moon Han Chang),김태완(Taewan Kim),이승환(Seung Hwan Lee),이동희(Dong-Hee Lee),김준호(Jun Ho Kim) 한국식품영양과학회 2019 한국식품영양과학회지 Vol.48 No.10
본 연구에서는 STZ 저용량 반복투여에 의한 인슐린결핍 당뇨 마우스 모델에서 GBE의 항당뇨 활성 및 가능한 작용기전을 검증하였다. 실험기간 동안 GBE 급여는 STZ에 의한 glucose 항상성의 저해를 유의적으로 개선시키며 당뇨 유발을 억제하였으며, 췌장 islet의 형태 및 인슐린분비 기능에 대한 보호 작용을 나타내었다. 또한 GBE의 이러한 보호 효과는 MAPK와 NF-κB 신호전달과정 활성화의 억제와 이로 인한 β-cell apoptosis 저해작용과 연관이 있음을 확인하였다. 이러한 결과는 항당뇨 기능성 식품 소재로써 쌍별귀뚜라미의 활용 가능성에 대한 중요한 학술정보를 제공하며, 향후 식·약용 곤충 소재들의 고부가가치 산업화를 위한 다양한 생리활성 탐색 연구가 지속해서 필요할 것으로 판단된다. The benefits of edible insects as an alternative animal protein source in the future has recently drawn significant attention. This study examined the anti-diabetic potential of edible insect Gryllus bimaculatus in streptozotocin(STZ)-induced insulin-deficient diabetic mice. Diabetes was induced by a multiple-low-dose STZ treatment after two weeks of the oral administration of G. bimaculatus water extracts (GBE) at 150 mg/kg. The administration of GBE reduced the hyperglycemia, delayed the cumulative incidence of diabetes, and improved glucose tolerance in the STZ-treated mice. Moreover, GBE protected the pancreatic islet against STZ-induced disruption of the islet architecture and function by inhibiting β-cell apoptosis in mice. Importantly, these protective effects were associated with the suppression of the mitogen-activated protein kinase- and nuclear factor-kappa B-mediated signaling pathways in the pancreas. These findings provide novel mechanistic insight into the protective effects of GBE against pancreatic islet dysfunction in insulin-deficient diabetes mellitus.
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Kim, Kangpyo,Lee, Jeongshim,Cho, Yeona,Chung, Seung Yeun,Lee, Jason Joon Bock,Lee, Chang Geol,Cho, Jaeho The Korean Society for Radiation Oncology 2017 Radiation Oncology Journal Vol.35 No.2
Purpose: Although stereotactic ablative body radiotherapy (SABR) is widely used therapeutic technique, predictive factors of radiation pneumonitis (RP) after SABR remain undefined. We aimed to investigate the predictive factors affecting RP in patients with primary or metastatic lung tumors who received SABR. Materials and Methods: From 2012 to 2015, we reviewed 59 patients with 72 primary or metastatic lung tumors treated with SABR, and performed analyses of clinical and dosimetric variables related to symptomatic RP. SABR was delivered as 45-60 Gy in 3-4 fractions, which were over 100 Gy in BED when the ${\alpha}/{\beta}$ value was assumed to be 10. Tumor volume and other various dose volume factors were analyzed using median value as a cutoff value. RP was graded per the Common Terminology Criteria for Adverse Events v4.03. Results: At the median follow-up period of 11 months, symptomatic RP was observed in 13 lesions (12 patients, 18.1%), including grade 2 RP in 11 lesions and grade 3 in 2 lesions. Patients with planning target volume (PTV) of ${\leq}14.35mL$ had significantly lower rates of symptomatic RP when compared to others (8.6% vs. 27%; p = 0.048). Rates of symptomatic RP in patients with internal gross tumor volume (iGTV) >4.21 mL were higher than with ${\leq}4.21mL$ (29.7% vs. 6.1%; p = 0.017). Conclusions: The incidence of symptomatic RP following treatment with SABR was acceptable with grade 2 RP being observed in most patients. iGTV over 4.21 mL and PTV of over 14.35 mL were significant predictive factors related to symptomatic RP.
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Kangpyo Kim,Jeongshim Lee,Yeona Cho,Seung Yeun Chung,Jason Joon Bock Lee,Chang Geol Lee,Jaeho Cho 대한방사선종양학회 2017 Radiation Oncology Journal Vol.35 No.2
Purpose: Although stereotactic ablative body radiotherapy (SABR) is widely used therapeutic technique, predictive factors of radiation pneumonitis (RP) after SABR remain undefined. We aimed to investigate the predictive factors affecting RP in patients with primary or metastatic lung tumors who received SABR. Materials and Methods: From 2012 to 2015, we reviewed 59 patients with 72 primary or metastatic lung tumors treated with SABR, and performed analyses of clinical and dosimetric variables related to symptomatic RP. SABR was delivered as 45–60 Gy in 3–4 fractions, which were over 100 Gy in BED when the α/β value was assumed to be 10. Tumor volume and other various dose volume factors were analyzed using median value as a cutoff value. RP was graded per the Common Terminology Criteria for Adverse Events v4.03. Results: At the median follow-up period of 11 months, symptomatic RP was observed in 13 lesions (12 patients, 18.1%), including grade 2 RP in 11 lesions and grade 3 in 2 lesions. Patients with planning target volume (PTV) of ≤14.35 mL had significantly lower rates of symptomatic RP when compared to others (8.6% vs. 27%; p = 0.048). Rates of symptomatic RP in patients with internal gross tumor volume (iGTV) >4.21 mL were higher than with ≤4.21 mL (29.7% vs. 6.1%; p = 0.017). Conclusions: The incidence of symptomatic RP following treatment with SABR was acceptable with grade 2 RP being observed in most patients. iGTV over 4.21 mL and PTV of over 14.35 mL were significant predictive factors related to symptomatic RP.
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흑염소의 건락성 림프절염 제어를 위한 소독제 효능 비교
조현우,김연아,장범순,김찬란,박건택,Cho, Hyeunwoo,Kim, Yeona,Jang, Beomsoon,Kim, Chan-Lan,Park, Kun Taek 한국식품위생안전성학회 2022 한국식품위생안전성학회지 Vol.37 No.5
Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA), a chronic contagious disease in small ruminants. The prevalence of CLA has been reported to be >50% in Korean black goats. CLA is difficult to control due to a lack of efficient vaccines and treatment methods. Effective disinfection of the farm environment may be an alternative strategy for reducing the spread of C. pseudotuberculosis. The objective of this study was to evaluate the efficacy of commercial disinfectants against CLA. The six commercial disinfectants, largely composed of sodium dichloroisocyanurate, sodium hypochlorite, potassium monopersulfate triple salt, quaternary ammonium, citric acid, and copper sulfate, were tested against five different genotypes of C. pseudotuberculosis isolated from goat farms in Korea. Efficacy tests were performed in accordance with the disinfectant efficacy test guidelines recommended by the Animal and Plant Quarantine Agency of Korea with slight modifications. All disinfectants except for copper sulfate exhibited >99.99% killing efficacy under hard water conditions following 30 min of incubation, which is the recommended standard treatment time according to guidelines. The minimum bactericidal treatment time was evaluated by employing treatments for durations of 1, 5, and 15 min. The most effective compounds under hard water conditions were sodium dichloroisocyanurate, potassium monopersulfate triple salt, and sodium hypochlorite, exhibiting >99.99% killing efficacy after 1 min of treatment. In the aqueous solution forms, citric acid and the quaternary ammonium compound were the most effective, but required at least 5 min to kill >99.99% of the bacteria. The current study characterizes the killing efficacy of six commercial disinfectant active compounds against C. pseudotuberculosis. Thus, this study provides essential information regarding the efficacy of the disinfectants used to control CLA in goat farms.
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