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Xie Guohua,Dong ping,Chen Hui,Xu Ling,Liu Yi,Ma Yanhui,Zheng Yingxia,Yang Junyao,Zhou Yunlan,Chen Lei,Shen Lisong 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
ATF3 has been reported to be dysregulated in various cancers and involved in various steps of tumorigenesis. However, the mechanisms underlying the abnormal expression of ATF3 and its biological function in gastric cancer (GC) have not been well investigated. Here, we report ATF3 as one of the key regulators of GC development and progression. Patients with low ATF3 expression had shorter survival and a poorer prognosis. In vitro and in vivo assays investigating ATF3 alterations revealed a complex integrated phenotype that affects cell growth and migration. Strikingly, high-throughput sequencing and microarray analysis of cells with ATF3 silencing or of ATF3-low GC tissues indicated alterations in the Wnt signaling pathway, focal adhesions and adherens junctions. Mechanistically, the expression of β-catenin and cell migration inducing hyaluronidase 1 (CEMIP) was significantly upregulated in GC cells with downregulated ATF3, which was synergistically repressed by the β-catenin/TCF3 signaling axis and noncoding RNA miR-17-5p and HOXA11-AS. In addition, we found that WDR5 expression was promoted by TCF3 and is involved in miR-17-5p and HOXA11-AS activation in GC cells. Taken together, our findings revealed the mechanism of ATF3 downregulation and its biological role in regulating the expression of Wnt signaling-related genes during GC progression, suggesting new informative biomarkers of malignancy and therapeutic directions for GC patients.
( Jun Yao ),( Qing Na Kong ),( Hua Yue Zhu ),( Zhen Zhang ),( Yu Yang Long ),( Dong Sheng Shen ) 한국화학공학회 2015 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.53 No.4
The adsorption characteristics of ammonia on MSWI bottom ash were investigated. The effect of the variation of the landfill environmental parameters including pH, anions and organic matter on the adsorption process was discussed. Results showed that the adsorption could be well described by pseudo-second-order kinetics and Langmuir model, with a maximum adsorption capacity of 156.2 mg/g. The optimum adsorption of ammonia was observed when the pH was 6.0. High level of ion and organic matter could restrict the adsorption to a low level. The above results suggested that MSWI bottom ash could affect the migration of ammonia in the landfill, which is related to the variation of the landfill circumstance.
Jun Yao,Linlin Su,Qiaoping Wang,Lin Gao,Jiarui Xie,Yuwen He,Xianghua Shu,Chunlian Song,Jun Chai,Yifang Zhang,Shibiao Yang 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.4
Background: Classical swine fever virus (CSFV), the causative agent of classical swine fever (CFS), is a highly contagious disease that poses a serious threat to Chinese pig populations. Objectives: Many provinces of China, such as Shandong, Henan, Hebei, Heilongjiang, and Liaoning provinces, have reported epidemics of CSFV, while the references to the epidemic of CSFV in Yunnan province are rare. This study examined the epidemic characteristics of the CSFV in Yunnan province. Methods: In this study, 326 tissue samples were collected from different regions in Yunnan province from 2015 to 2021. A reverse transcription-polymerase chain reaction (RT-PCR), sequences analysis, and phylogenetic analysis were performed for the pathogenic detection and analysis of these 326 clinical specimens. Results: Approximately 3.37% (11/326) of specimens tested positive for the CSFV by RT-PCR, which is lower than that of other regions of China. Sequence analysis of the partial E2 sequences of eleven CSFV strains showed that they shared 89.0–100.0% nucleotide (nt) and 95.0–100.0% amino acid (aa) homology, respectively. Phylogenetic analysis showed that these novel isolates belonged to the subgenotypes 2.1c and 2.1d, with subgenotype 2.1c being predominant. Conclusions: The CSFV was sporadic in China’s Yunnan province from 2015 to 2021. Both 2.1c and 2.1d subgenotypes were found in this region, but 2.1c was dominant.