The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer

Pei Xu,Haibo Xiao,Qi Yang,Rui Hu,Lianyong Jiang,Rui Bi,Xueyan Jiang,Lei Wang,Ju Mei,Fangbao Ding,Jianbing Huang 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set and bioinformatics analyses and identified USP21, a DUB, as a potential contributor to oncogenesis in nonsmall-cell lung cancer (NSCLC). We further demonstrated that USP21 was highly expressed in NSCLCs. We then conducted a series of in vitro and in vivo assays to explore the effect of USP21 on NSCLC progression and the underlying mechanism involved. USP21 promoted NSCLC cell proliferation, migration, and invasion and in vivo tumor growth by stabilizing a well-known oncogene, Yin Yang-1 (YY1), via mediating its deubiquitination. Furthermore, YY1 transcriptionally regulates the expression of SNHG16. Moreover, StarBase bioinformatics analyses predicted that miR4500 targets SNHG16 and USP21. A series of in vitro experiments indicated that SNHG16 increased the expression of USP21 through miR-4500. In summary, the USP21/YY1/SNHG16 axis plays a role in promoting the progression of NSCLC. Therefore, the USP21/YY1/SNHG16/miR-4500 axis may be a potential therapeutic target in NSCLC treatment.

The Development of Tea Culture in China

You-Ying Tu,Jiang-Fan Yang2 한국차학회 2015 한국차학회지 Vol.- No.S

Since the discovery and first consumption of tea by Shen-Nong has been 5000 years when he tasted various herbs. About 3000 years ago human started to plant tea trees in China. Now, tea is spread from China into many countries around the world. Tea is the second most popular soft drink in the world, and more people are getting to know its health functions. This review introduces three parts: the first part is the history of tea, which is long and complex, spreading across multiple cultures over the span of thousands of years. The second part is the processing and classification of six kinds of Chinese teas, including green tea, black tea, Oolong tea, yellow tea, white tea and dark tea. The third part is the different tea customs in different places according to different social culture and natural environment.

Who Uses Travel Websites? A Comparison of Demand Across Websites

Yang, Yang,Jiang, Lan Smart Tourism Research Center 2022 Journal of smart tourism Vol.2 No.3

Understanding demand for travel websites can help hoteliers better evaluate their own multi-channel distribution and reputation management strategies. In this study, we estimated demand for eight major travel websites based on the user percentage in 3,120 U.S. counties. Results highlighted the importance of four types of factors: sociodemographic, economic, Internet use-related, and travel-related. Differences between websites were also compared based on estimated coefficients. For example, the demand for Expedia.com appeared to be driven by age, education background, income, and foreign travel history, whereas the demand for Hotels.com was driven by the proportion of the African American population and domestic travel history. Lastly, implications are provided.

Effects of Feeding Purified Zearalenone Contaminated Diets with or without Clay Enterosorbent on Growth, Nutrient Availability, and Genital Organs in Post-weaning Female Pigs

Jiang, S.Z.,Yang, Z.B.,Yang, W.R.,Yao, B.Q.,Zhao, H.,Liu, F.X.,Chen, C.C.,Chi, F. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.1

The effects of different levels of natural clay enterosorbent on the growth, nutrient availability, and genital organs of post-weaning female pigs fed with an addition of zearalenone (ZEA) were investigated in the study. A total of thirty-five post-weaning gilts ($L{\times}Y{\times}D$) with an average body weight of 12.36${\pm}$1.46 kg were used in the test. The gilts were raised individually in metabolism cages and fed a corn-soybean meal-whey basal diet with an addition of 0 or 1 mg/kg of ZEA for 24 d with four levels of natural clay enterosorbent added in the feed. The treatments were: i) control; ii) control+2.5 g/kg clay; iii) control+1 mg/kg ZEA; iv) control+1 mg/kg ZEA+1.25 g/kg clay; v) control+1 mg/kg ZEA+2.5 g/kg clay; vi) control+1 mg/kg ZEA+5.0 g/kg clay; vii) control+1 mg/kg ZEA +10 g/kg clay. Pigs fed diets contaminated with additional purified ZEA had significantly reduced apparent digestibility of crude protein (CP), gross energy (GE) and apparent metabolic rate of GE (ME/GE, p<0.05) without changes of net protein utilization (NPU, p>0.05). Final body weight, average daily gain (ADG), average daily feed intake (ADFI), vulva length, vulva width, vulva area, relative weights of genital organ and proliferative changes of the ovary tissues in gilts fed ZEA-contaminated diet were increased (p<0.05) compared to the gilts fed the control diet. Addition of natural clay enterosorbent in the ZEA-contaminated diet showed a positive protection effect on ZEA feeding, and the protection was increased linearly or quadratically as clay content increased. However, in pigs fed a diet with clay alone at 2.5 g/kg level there was no significant impact (p>0.05) on all the parameters as compared to the control. It is suggested that feeding ZEA at about 1.0 mg/kg for 24 days might result in a deleterious effect in pigs, and addition of 5 or 10 g clay enterosorbent per kg diet can effectively neutralize the detrimental effects of the ZEA feeding.

ZnS-modified carbon nitride nanosheet with enhanced performance of elemental Hg removal: An experimental and density functional theory study

Yang Ling,Jiang Wu,Lingtao Yang,Dongjing Liu 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.6

The emission of mercury from anthropogenic activities is a serious concern in both developed and developingcountries due to its high toxicity and persistence. Here, carbon nitride nanosheets (CNNS) were attained via atwo-step thermal etching method and applied for Hg0 removal. Proper deposition of ZnS can markedly reinforce the Hg0capture ability of CNNS. 10ZnS/CNNS notably outperforms ZnS and CNNS at 100 oC, which is primarily attributed tosurface chemisorbed oxygen species and polysulfide active sites. Besides, Hg0 adsorption and thermal catalytic oxidationpathways are further disclosed using quantum chemistry calculations based on density functional theory (DFT). The calculation results show that the presence of zinc species is beneficial to the decomposition of adsorbed oxygen,which plays a key role in the catalytic oxidation of Hg0, thereby contributing to the enhancement of mercury removalperformance.

Study on the neutron imaging detector with high spatial resolution at China spallation neutron source

Jiang, Xingfen,Xiu, Qinglei,Zhou, Jianrong,Yang, Jianqing,Tan, Jinhao,Yang, Wenqin,Zhang, Lianjun,Xia, Yuanguang,Zhou, Xiaojuan,Zhou, Jianjin,Zhu, Lin,Teng, Haiyun,Yang, Gui-an,Song, Yushou,Sun, Zhiji Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.6

Gadolinium oxysulfide (GOS) is regarded as a novel scintillator for the realization of ultra-high spatial resolution in neutron imaging. Monte Carlo simulations of GOS scintillator show that the capability of its spatial resolution is towards the micron level. Through the time-of-flight method, the light output of a GOS scintillator was measured to be 217 photons per captured neutron, ~100 times lower than that of a ZnS/LiF:Ag scintillator. A detector prototype has been developed to evaluate the imaging solution with the GOS scintillator by neutron beam tests. The measured spatial resolution is ~36 ㎛ (28 line pairs/mm) at the modulation transfer function (MTF) of 10%, mainly limited by the low experimental collimation ratio of the beamline. The weak light output of the GOS scintillator requires an enormous increase in the neutron flux to reduce the exposure time for practical applications.

Synthesis and Selective Sorption Behavior of Pt(IV) Ion-Imprinted Polymer Particles

Jiang, Yang,Kim, Dukjoon American Chemical Society 2014 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.53 No.34

<P>Pt(IV) ion-imprinted polymer (Pt(IV)-IIP) was synthesized in the form of porous particles with dimensions of 100–400 μm by the copolymerization of divinylbenzene and styrene in the presence of self-assembled chelates of 4-vinylpyridine and dimethylglyoxime functional monomers along with Pt(IV) ions. The chemical structure of Pt(IV)-IIP was identified by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and energy dispersive X-ray spectroscopy. The pore size and structure of Pt(IV)-IIP was characterized by Brunauer–Emmett–Teller analysis and scanning electron microscope. The effects of pH and the initial concentration of Pt(IV) on the selective adsorption behavior for the template ion was investigated using flame atomic absorption spectroscopy. Compared to nonimprinted polymer particles, the Pt(IV)-IIPs illustrated excellent selectivity toward the template ion, Pt(IV), over other competitive ions such as Ni(II), Cu(II), and Pd(II). The selectivity coefficients (α) of Pt(IV)/Ni(II), Pt(IV)/Cu(II), Pt(IV)/Zn(II), and Pt(IV)/Pd(II) were 330.27, 359.89, 463.91, and 4.85, respectively. The study on the selective separation of Pt(IV) from the spent catalyst solution revealed the potential application of Pt(IV)-IIP particles in the practical industry.</P>

Design and Implementation of Transfusion Auxiliary Device by Patient Manual Control Dressing Change

Jiang Jin-gang,Shen Rui-chao,Wang Bao-fu,Gu Bo-yang,Tang Hai-bo,Jiang Ze-hao 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.11

Transfusion auxiliary device by patient manual control dressing is proposed. It is realized by one-way rotation ratchet mechanism, which is consistent of slider-crank mechanism and double pawl ratchet mechanism. Dressing change is automatically realized by patient manual control rope. This reduces the labor intensity of the medical staff, shortens the waiting time of the patients. This device has the advantage of low cost, large market space.

Sun-induced chlorophyll fluorescence is more strongly related to absorbed light than to photosynthesis at half-hourly resolution in a rice paddy

Yang, Kaige,Ryu, Youngryel,Dechant, Benjamin,Berry, Joseph A.,Hwang, Yorum,Jiang, Chongya,Kang, Minseok,Kim, Jongmin,Kimm, Hyungsuk,Kornfeld, Ari,Yang, Xi Elsevier 2018 Remote sensing of environment Vol.216 No.-

<P><B>Abstract</B></P> <P>Sun-induced chlorophyll fluorescence (SiF) is increasingly used as a proxy for vegetation canopy photosynthesis. While ground-based, airborne, and satellite observations have demonstrated a strong linear relationship between SiF and gross primary production (GPP) at seasonal scales, their relationships at high temporal resolution across diurnal to seasonal scales remain unclear. In this study, far-red canopy SiF, GPP, and absorbed photosynthetically active radiation (APAR) were continuously monitored using automated spectral systems and an eddy flux tower over an entire growing season in a rice paddy. At half-hourly resolution, strong linear relationships between SiF and GPP (R<SUP>2</SUP> = 0.76) and APAR and GPP (R<SUP>2</SUP> = 0.76) for the whole growing season were observed. We found that relative humidity, diffuse PAR fraction, and growth stage influenced the relationships between SiF and GPP, and APAR and GPP, and incorporating those factors into multiple regression analysis led to improvements up to R<SUP>2</SUP> = 0.83 and R<SUP>2</SUP> = 0.88, respectively. Relationships between LUE<SUB>p</SUB> (=GPP/APAR) and LUE<SUB>f</SUB> (=SiF/APAR) were inconsistent at half-hourly and weak at daily resolutions (R<SUP>2</SUP> = 0.24). Both at diurnal and seasonal time scales with half-hourly resolution, we found considerably stronger linear relationships between SiF and APAR than between either SiF and GPP or APAR and GPP. Overall, our results indicate that for subdiurnal temporal resolution, canopy SiF in the rice paddy is above all a very good proxy for APAR at diurnal and seasonal time scales and that therefore SiF-based GPP estimation needs to take into account relevant environmental information to model LUE<SUB>p</SUB>. These findings can help develop mechanistic links between canopy SiF and GPP across multiple temporal scales.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Observed SiF is a better proxy of APAR than GPP. </LI> <LI> Found considerable environmental effects on the SiF-GPP relationships </LI> <LI> Improved GPP estimation by combining SiF or APAR with environmental variables </LI> <LI> Contribute to canopy SiF-GPP mechanistic links across multiple temporal scales </LI> </UL> </P>

Use of software-defined radio receivers in two-way satellite time and frequency transfers for UTC computation

Jiang, Zhiheng,Zhang, Victor,Huang, Yi-Jiun,Achkar, Joseph,Piester, Dirk,Lin, Shinn-Yan,Wu, Wenjun,Naumov, Andrey,Yang, Sung-hoon,Nawrocki, Jerzy,Sesia, Ilaria,Schlunegger, Christian,Yang, Zhiqiang,Fu BUREAU INTERNATIONAL DES POIDS ET MESURES 2018 METROLOGIA -BERLIN- Vol.55 No.5

<P>Two-way satellite time and frequency transfer (TWSTFT) is a primary technique for the generation of coordinated universal time (UTC). About 20 timing laboratories around the world continuously operate TWSTFT using satellite time and ranging equipment (SATRE<SUP>19</SUP>) modems for remote time and frequency comparisons in this context. The precision of the SATRE TWSTFT as observed today is limited by an apparent daily variation pattern (diurnal) in the TWSTFT results. The observed peak-to-peak variation have been found as high as 2 ns in some cases. Investigations into the origins of the diurnals have so far provided no complete understanding about the cause of the diurnals. One major contributor to the diurnals, however, could be related to properties of the receive part in the modem. In 2014 and 2015, it was demonstrated that bypassing the receive part and the use of software-defined radio (SDR) receivers in TWSTFT ground stations (SDR TWSTFT) instead could considerably reduce both the diurnals and the measurement noise.</P> <P>In 2016, the International Bureau of Weights and Measures (BIPM) and the Consultative Committee for Time and Frequency (CCTF) working group (WG) on TWSTFT launched a pilot study on the application of SDR receivers in the TWSTFT network for UTC computation.</P> <P>The first results of the pilot study were reported to the CCTF WG on TWSTFT annual meeting in May 2017, demonstrating that SDR TWSTFT shows superior performance compared to that of SATRE TWSTFT for practically all links between participating stations. In particular, for continental TWSTFT links, in which the strongest diurnals appear, the use of SDR TWSTFT results in a significant suppression of the diurnals by a factor of between two and three. For the very long inter-continental links, e.g. the Europe-to-USA links where the diurnals are less pronounced, SDR TWSTFT achieved a smaller but still significant gain of 30%. These findings are supported by an evaluation of some of the links with an alternate technique based on GPS signals (GPS IPPP) as reported in this paper.</P> <P>Stimulated by these results, the WG on TWSTFT prepared a recommendation for the 21st CCTF meeting, which proposed the introduction of SDR TWSTFT in UTC generation. With CCTF approval of the recommendation, a roadmap was developed for the implementation of SDR TWSTFT in UTC generation. In accordance with the roadmap, most of the stations that participated in the pilot study have updated the SDR TWSTFT settings to facilitate the use of SDR TWSTFT data in UTC generation. In addition, the BIPM conducted a final evaluation to validate the long-term stability of SDR TWSTFT links, made test runs using the BIPM standard software for the calculation of UTC, now including SDR TWSTFT data, and started to calculate SDR TWSTFT time links as backup from October 2017. The use of SDR TWSTFT in UTC generation will begin in 2018.</P>