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The role of system Xc<sup>-</sup> in methamphetamine-induced dopaminergic neurotoxicity in mice
Dang, D.K.,Shin, E.J.,Tran, H.Q.,Kim, D.J.,Jeong, J.H.,Jang, C.G.,Nah, S.Y.,Sato, H.,Nabeshima, T.,Yoneda, Y.,Kim, H.C. Pergamon Press 2017 Neurochemistry International Vol.108 No.-
The cystine/glutamate antiporter (system Xc<SUP>-</SUP>, Sxc) transports cystine into cell in exchange for glutamate. Since xCT is a specific subunit of Sxc, we employed xCT knockout mice and investigated whether this antiporter affected methamphetamine (MA)-induced dopaminergic neurotoxicity. MA treatment significantly increased striatal oxidative burdens in wild type mice. xCT inhibitor [i.e., S-4-carboxy-phenylglycine (CPG), sulfasalazine] or an xCT knockout significantly protected against these oxidative burdens. MA-induced increases in Iba-1 expression and Iba-1-labeled microglial immunoreactivity (Iba-1-IR) were significantly attenuated by CPG or sulfasalazine administration or xCT knockout. CPG or sulfasalazine significantly attenuated MA-induced TUNEL-positive cell populations in the striatum of Taconic ICR mice. The decrease in excitatory amino acid transporter-2 (or glutamate transporter-1) expression and increase in glutamate release were attenuated by CPG, sulfasalazine or xCT knockout. In addition, CPG, sulfasalazine or xCT knockout significantly protected against dopaminergic loss (i.e., decreases in tyrosine hydroxylase expression and immunoreactivity, and an increase in dopamine turnover rate) induced by MA. However, CPG, sulfasalazine or xCT knockout did not significantly affect the impaired glutathione system [i.e., decrease in reduced glutathione (GSH) and increase in oxidized glutathione (GSSG)] induced by MA. Our results suggest that Sxc mediates MA-induced neurotoxicity via facilitating oxidative stress, microgliosis, proapoptosis, and glutamate-related toxicity.
Y. Yuan,Z. H. Zhong,Z.S. Yu,H. F. Yin,Y. Y. Dang,X. B. Zhao,Z. Yang,J. T. Lu,J. B. Yan,Y. Gu 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.4
A new Ni-Fe-based superalloy, HT-X, has been developed for applications in 700 °C advanced ultra-supercritical (A-USC) boilers. The HT-X alloy is subjected to various heat treatments. Tensile tests are conducted at room temperature (RT), 700 °C and 750 °C. Creep tests are carried out under conditions of 700 °C/300 MPa and 750 °C/150 MPa. After aging treatment, the yield strength of the HT-X alloy at RT and 750 °C is 787 MPa and 624 MPa, respectively. When additional thermal exposure at 750 °C for 5400 h is applied, the yield strength is decreased to 656 MPa at RT and 480 MPa at 700 °C. For an aged specimen, the a/2<110> dislocation shearing process occurs when tensile testing is conducted at RT and 750 °C. As the γ' precipitate size increases in the specimen that is thermally exposed at 750 °C for 5400 h, Orowan bowing is the dominant dislocation process, and stacking faults develop in the γ' precipitates at both RT and 700 °C. Dislocation slip combined with climb is the dominant mechanism under the creep testing conditions. The factors that affect the mechanical properties and deformation mechanisms are discussed.
Ferromagnetism-to-Paramagnetism Transition in the ZnMnO System
V. S. Dang,Y. Y. Song,N. Q. Hoa,유성초,Y. G. Yoo 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
The magnetic properties of Mn- and P-doped ZnO prepared by using the solid state reaction and pulsed laser deposition (PLD) were investigated by measuring the magnetization and the absorption derivative of the electron paramagnetic resonance (EPR). The film's thickness was about 0.3 μm. The X-ray diraction pattern indicated a single-phase polycrystalline ZnO structure without any MnO₂ phase in both the polycrystalline samples and the thin lms. The magnetic behaviors of the samples were determined by using an alternating gradient magnetometer (AGM) at room tempera- ture. All the bulk samples showed ferromagnetism at room temperature. Mn-doped ZnO films with Zn₃P₂ added also showed ferromagnetism at room temperature. A transition from ferromagnetism to paramagnetism with increasing in sintering temperature was detected in the EPR experiments. The absorption derivative of the EPR signal showed hyperne splitting for the samples sintered at 800 and 900℃ due to a spin degeneracy of Mn²+, the hyperfine splitting disappeared for the samples sintered at 1000℃ due to a superposition of the six lines of hyperfine splitting.
Dang, C.G.,Cho, S.H.,Sharma, A.,Kim, H.C.,Jeon, G.J.,Yeon, S.H.,Hong, S.K.,Park, B.Y.,Kang, H.S.,Lee, S.H. Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.9
Significant SNPs associated with Warner-Bratzler (WB) shear force and sensory traits were confirmed for Hanwoo beef (Korean cattle). A Bonferroni-corrected genome-wide significant association (p< $1.3{\times}10^{-6}$) was detected with only one single nucleotide polymorphism (SNP) on chromosome 5 for WB shear force. A slightly higher number of SNPs was significantly (p<0.001) associated with WB shear force than with other sensory traits. Further, 50, 25, 29, and 34 SNPs were significantly associated with WB shear force, tenderness, juiciness, and flavor likeness, respectively. The SNPs between p = 0.001 and p = 0.0001 thresholds explained 3% to 9% of the phenotypic variance, while the most significant SNPs accounted for 7% to 12% of the phenotypic variance. In conclusion, because WB shear force and sensory evaluation were moderately affected by a few loci and minimally affected by other loci, further studies are required by using a large sample size and high marker density.