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RISS 인기검색어
- 검색키워드
- 저자 : Y. K. Kima (검색결과 6 건)
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Components-dependent magnetic switching of CoFeB and CoFeSiB magnetic tunnel junction
T. X. Wang,D. K. Kim,B. S. Chuna,Y. K. Kima 한국자기학회 2007 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-
Two kinds of amorphous Co-rich magnetic amorphous films of CoFeB and CoFeSiB of different compositions were prepared by magnetron sputtering and applied as ferromagnetic electrodes in magnetic tunnel junctions (MTJs). The spin polarization of CoFeB is rather sensitive to its composition, but not necessarily to magnetic switching behavior. The switching fields were around 30 Oe for Co contents ranging from 60 to 85 at. %). On the contrary, the switching behavior of CoFeSiB was very sensitive to its Co content (5 to 20 Oe as Co content increased from 71 to 81 at. %), with tunneling magneto-resistance (TMR) ratio saturated when Co surpass 74 at. %. Comparatively, CoFeSiB can be a good candidate for future high density spin memory devices to reduce the switching field or critical current with its excellent adjustable soft magnetic behavior and high spin polarization by properly adjust the contents of metalloid elements Si and B. The Landau-Lifshitz-Gilbert micromagnetics simulation was employed to investigate the size dependenceof MTJs with magnetically soft CoFeSiB free layer with ellipsoidal cells with sizes from 1 μm to 60 nm, using the magnetic parameters extracted from the experiment. The switching field needed was smaller compared to that of the Co [1] and CoFe [2] junctions but slightly larger than that of the NiFe [3] junction at corresponding sizes reported. Above-mentioned features associated with amorphous CoFeSiB junction appear attractive for MRAM applications.
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신발굽 높이와 Wedge 위치 변화가 하지 근활성도에 미치는 영향
이현주(H. J. Lee),김소정(S. J. Kima),김순종(S. J. Kimb),김혜지(H. J. Kim),박보람(B. R. Park),박소영(S. Y. Park),유정화(J. H. Yu),태기식(K. S. Tae) 한국재활복지공학회 2014 재활복지공학회논문지 Vol.8 No.4
본 연구는 30명의 여성에게 내·외측 wedge 삽입과 함께 flated heel 또는 5㎝ heel을 착용하도록 한 후, 넙다리네갈래근 중 쪽빗넓은근(VMO)과 가쪽넓은근(VL)의 근활성도를 측정하여 비교하였다. 연구 결과 내외측 wedge 모두에서 flated heel 군에서는 가쪽넓은근이, 5 ㎝ heel 군에서는 안쪽빗넓은근의 근활성도가 높게 나타났으며 가쪽넓은근에 대한 안쪽빗넓은근의 근활성도비(% VMO/VL) 또한 5㎝ heel 군에서 유의하게 높게 나타났다. 이는 안쪽빗넓은근과 가쪽넓은근의 근활성도에 영향을 미치는 외적 변수가 wedge의 내외측 위치보다는 힐의 높이에 의함을 알 수 있었다. 차후 무릎통증이나 무릎 불안정성으로 인한 하지 재활훈련 또는 하지보조기 제작 시에 하지 근육의 선택적 활성화를 유도하기 위한 변수로써 heel 높이를 고려할 수 있을 것이다. The purpose of this study was to investigate the change of the electromyographic activity in vastus medialis oblique (VMO) and vastus lateralis (VL), also vastus medialis oblique/vastus lateralis ratios after wearing wedged flated or 5㎝ heel shoes. The subjects were 30 healthy women who randomly assigned to two group, divided by flated or 5㎝ heel group. They were asked to perform squat exercise in two postures using medial and lateral wedged shoes. In two groups, EMG activity of VMO and VL was significant difference between the flated heel and 5㎝ heel (p<.01). This study showed that 5㎝ heel could selectively more active VMO than flated heel. It should be considered the heel height as the parameter when the patient with lower extremity problem undergo rehabilitation exercise or design of orthoses for the selective muscle activity of knee pain or knee instability.
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Kim, A.,Nam, Y. J.,Lee, M. S.,Shin, Y. K.,Sohn, D. S.,Lee, C. S. Springer Science + Business Media 2016 Neurochem Res Vol.41 No.11
<P>Impairment of proteasomal function has been shown to be implicated in neuronal cell degeneration. The compounds which have antioxidant and anti-inflammatory abilities appear to provide a neuroprotective effect. Flavone apigenin is known to exhibits antioxidant and anti-inflammatory effects. Nevertheless, the effect of apigenin on the proteasome inhibition-induced neuronal apoptosis has not been studied. Therefore, we assessed the effect of apigenin on the proteasome inhibition-induced apoptotic neuronal cell death using differentiated PC12 cells and human neuroblastoma SH-SY5Y cells. Apigenin attenuated the proteasome inhibitors (MG132 and MG115)-induced decrease in the levels of Bid and Bcl-2, increase in the levels of Bax and p53, loss of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases (-8, -9 and -3), cleavage of PARP-1 and cell death in both cell lines. Apigenin attenuated the production of reactive oxygen species, the depletion and oxidation of glutathione, the formations of malondialdehyde and carbonyls in cell lines treated with proteasome inhibitors. The results show that apigenin appears to attenuate the proteasome inhibitor-induced apoptosis in differentiated PC12 cells and SH-SY5Y cells by suppressing the activation of the mitochondrial pathway, and of the caspase-8- and Bid-dependent pathways. The inhibitory effect of apigenin on the proteasome inhibitor-induced apoptosis appears to be attributed to the suppressive effect on the production of reactive oxygen species, the depletion and oxidation of glutathione and the formations of malondialdehyde and carbonyls.</P>
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Caspase-3 activation as a key factor for HBx-transformed cell death
Kim, A.,Kwon, O. S.,Kim, S. O.,He, L.,Bae, E. Y.,Lee, M. S.,Jeong, S. J.,Shim, J. H.,Yoon, D. Y.,Kim, C. H.,Moon, A.,Kim, K. E.,Ahn, J. S.,Kim, B. Y. Blackwell Publishing Ltd 2008 Cell proliferation Vol.41 No.5
<P>Abstract. </P><P><I>Objectives</I>: Nuclear factor-kappa B (NF-&kgr;B) activation has been associated with the tumorigenic growth of hepatitis B virus X protein (HBx)-transformed cells. This study was aimed to find a key target for treatment of HBx-mediated cancers. <I>Materials and methods</I>: NF-&kgr;B activation, endoplasmic reticulum-stress (ER-stress), caspase-3 activation, and cell proliferation were evaluated after Chang/HBx cells permanently expressing HBx viral protein were treated with inhibitors of NF-&kgr;B, proteasome and DNA topoisomerase. <I>Results</I>: Inhibition of NF-&kgr;B transcriptional activity by transient transfection with mutant plasmids encoding Akt1 and glycogen synthase kinase-3&bgr; (GSK-3&bgr;), or by treatment with chemical inhibitors, wortmannin and LY294002, showed little effect on the survival of Chang/HBx cells. Furthermore, I&kgr;Bα (S32/36A) mutant plasmid or other NF-&kgr;B inhibitors, 1-pyrrolidinecarbonidithioic acid and sulphasalazine, were also shown to have little effect on the cell proliferation. By contrast, proteasome inhibitor-1 (Pro1) and MG132 enhanced the HBx-induced ER-stress response and the subsequent activation of caspase-12, -9 and -3 and reduced cell proliferation. Camptothecin (CPT), however, triggered activation of caspase-3 without induction of caspase-12, and reduced cell proliferation. In addition, CPT-induced cell death was reversed by pre-treatment with z-DEVD, a caspase-3-specific inhibitor. <I>Conclusions</I>: Detailed exploitation of the regulators of caspase-3 activation could open the gate for finding an efficient target for development of anticancer therapeutics against HBx-transformed hepatocellular carcinoma.</P>
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