Based on Multi-Thread Dynamic Self-Healing Technology Application Research in Big Data Image Processing

Guangyu Xu,Xiaohua Qiao 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.6

With the rapid development of information technology, the data scale expands unceasingly, produce a large amount of image data, a massive image data processing has also is an important technology. Traditional processing techniques, in dealing with such a large scale of image data, have been unable to meet the requirements. One of the important reason is that whether the c ++ or Java, there is memory leak problem, when the data is the relatively small size, these problems may be insignificant, but when the data is very large, will highlight these shortcomings, will lead to serious program crashes, the system outage, ultimately unable to achieve expected goal. In considering the data processing efficiency, stability, is proposed in this paper, based on multithreading, a dynamic self-healing capacity of mass image data processing technology, compared with the traditional technology can improve the efficiency and improve the stability. Finally, after the experimental results verify that the method is effective.

Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms

Jing Xu,Hairong Liu,Guangyue Su,Meng Ding,Wei Wang,Jincai Lu,Xiuli Bi,Yuqing Zhao 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.1

Background: Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on a-glucosidase and protein tyrosine phosphatase 1B, and protected cardiocytes (H9c2) through PI3K/Akt pathway. Methods: In the research, in order to optimize the 25-OH-PPT enrichment process, optimal macroporous resins and optimal purification conditions were studied. Meanwhile, the hypoglycemic effect and mechanism of 25-OH-PPT were evaluated by using STZ to establish insulin-dependent diabetic mice and the spontaneous type 2 diabetes DB/DB mice. Results and Conclusion: Research found that 25-OH-PPT can reduce blood glucose and enhance glucose tolerance in STZ model mice. It increases insulin sensitivity by upregulating GLUT4 and AMPK in skeletal muscle, and activating insulin signaling pathways. In DB/DB mice, 25-OH-PPT achieves hypoglycemic effects mainly by activating the insulin signaling pathway. Meanwhile, through the influence of liver inflammatory factors and lipids in serum, it can be seen that 25-OH-PPT has obvious anti-inflammatory and lipid-lowering effects. These results provide new insights into the study of ginseng as a functional food.

Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis

Lu Xiao,Xu Guangyu,Lin Zhidi,Zou Fei,Liu Siyang,Zhang Yuxuan,Fu Wei,Jiang Jianyuan,Ma Xiaosheng,Song Jian 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Spinal cord injury (SCI) brings a heavy burden to individuals and society, and there is no effective treatment at present. Exosomes (EX) are cell secreted vesicles containing molecules such as nucleic acids and proteins, which hold promise for the treatment of SCI. Netrin-1 is an axon guidance factor that regulates neuronal growth. We investigated the effects of engineered EX enriched in netrin-1 chemically synthetic modified message RNA (modRNA) in treating SCI in an attempt to find a novel therapeutic approach for SCI.Netrin-1 modRNA was transfected into bone marrow mesenchymal stem cells to obtain EX enriched with netrin-1 (EX-netrin1). We built an inflammatory model in vitro with lipopolysaccharide (LPS) in vitro to study the therapeutic effect of EX-netrin1 on SCI. For experiments in vitro, ELISA, CCK-8 assay, immunofluorescence staining, lactate dehydrogenase release experiments test, real-time quantitative polymerase chain reaction, and western blot were conducted. At the same time, we constructed a rat model of SCI. MRI, hematoxylin-eosin and Nissl staining were used to assess the extent of SCI in rats.In vitro experiments showed that EX had no effect on the viability of oligodendrocytes and PC12 cells. EX-netrin1 could attenuate LPS-induced inflammation and pyroptosis and accelerate axonal/dentritic growth in PC12 cells/oligodendrocytes. In addition, netrin-1 could activate the PI3K/AKT/mTOR signalling pathway upon binding to its receptor unc5b. When Unc5b and PI3K were inhibited, the effect of EX-netrin1 was weakened, which could be reversed by PI3K or mTOR activator. Our in vivo experiments indicated that EX-netrin1 could promote recovery in rats with SCI.We found that EX-netrin1 regulated inflammation, pyroptosis and axon growth in SCI via the Unc5b/PI3K/AKT/mTOR pathway, which provides a new strategy for the treatment of SCI.

An experimental study on positioning conformance control of starch gelant in the heterogeneous porous media by using CT technology

Lei Zhang,Hongming Xu,Chunsheng Pu,Guangyu Yuan,Guangyao Leng,Chunlei Zhang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-

In order to increase the economic efficiency of conformance control in the time of low oil price, a gelant should be injected into the specified location (positioning conformance control) to improve the swept volume in the maximum extent in the heterogeneous oil reservoir. For this purpose, an in-situ crosslinking polymer gelant (it is consisting of modified starch, acrylamide, N, N'- methylene diacrylamide, and potassium persulfate) is taken as the object of study by CT scan. Based on the dynamic and visible images of fluids distribution in the porous media, the gelant can be used to achieve the positioning conformance control because it can almost maintain a whole slug during transportation in porous media. According to the relationship of transportation distance and injection volume of the gelant in porous media, the gelant can be displaced to the specified location in porous media. In addition, the characteristics of water flooding of heterogeneous porous media before and after positioning conformance control are studied by CT scan, which can investigate the function of positioning conformance control and the extent of improving the swept volume in the heterogeneous reservoirs. The experimental results in this paper can provide theoretical guidance for the practical application of positioning conformance control in the heterogeneous oil reservoirs.

Wavelet Noise Elimination & Its Application in Acoustic Leak Detection of Fast Reactor Steam Generator

Liu Zhanhui,Niu Xiaodong,Mu Guangyu,Shang Deyi,Xu Zhiwen,Guo Xiaoxin,Pang Yunjie 대한전자공학회 2005 ITC-CSCC :International Technical Conference on Ci Vol.2005 No.4

Comparison of Monoexponential, Biexponential, Stretched-Exponential, and Kurtosis Models of Diffusion-Weighted Imaging in Differentiation of Renal Solid Masses

Jianjian Zhang,Shiteng Suo,Guiqin Liu,Shan Zhang,Zizhou Zhao,Jianrong Xu,Guangyu Wu 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.5

Objective: To compare various models of diffusion-weighted imaging including monoexponential apparent diffusion coefficient (ADC), biexponential (fast diffusion coefficient [Df], slow diffusion coefficient [Ds], and fraction of fast diffusion), stretched-exponential (distributed diffusion coefficient and anomalous exponent term [α]), and kurtosis (mean diffusivity and mean kurtosis [MK]) models in the differentiation of renal solid masses. Materials and Methods: A total of 81 patients (56 men and 25 women; mean age, 57 years; age range, 30–69 years) with 18 benign and 63 malignant lesions were imaged using 3T diffusion-weighted MRI. Diffusion model selection was investigated in each lesion using the Akaike information criteria. Mann–Whitney U test and receiver operating characteristic (ROC) analysis were used for statistical evaluations. Results: Goodness-of-fit analysis showed that the stretched-exponential model had the highest voxel percentages in benign and malignant lesions (90.7% and 51.4%, respectively). ADC, Ds, and MK showed significant differences between benign and malignant lesions (p < 0.05) and between low- and high-grade clear cell renal cell carcinoma (ccRCC) (p < 0.05). α was significantly lower in the benign group than in the malignant group (p < 0.05). All diffusion measures showed significant differences between ccRCC and non-ccRCC (p < 0.05) except Df and α (p = 0.143 and 0.112, respectively). α showed the highest diagnostic accuracy in differentiating benign and malignant lesions with an area under the ROC curve of 0.923, but none of the parameters from these advanced models revealed significantly better performance over ADC in discriminating subtypes or grades of renal cell carcinoma (RCC) (p > 0.05). Conclusion: Compared with conventional diffusion parameters, α may provide additional information for differentiating benign and malignant renal masses, while ADC remains the most valuable parameter for differentiation of RCC subtypes and for ccRCC grading.

Surfactant-free synthesis of CuBr NPs decorated by Pt for glucose and nitrite sensors

Xinmei Liu,Xue Zhou,Chunyang Yang,Wenlong Yang,Gang Liu,Yuhang Li,Guangyu Zhang,Xu Zhao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-

The high cost and narrow detection range of electrocatalyst are the two major challenges for the electrochemicalbiosensors. This work provided a surfactant-free synthesis of CuBr@Pt nanoparticles (CuBr@PtNPs) with controllable Pt loading rates. The introduction of chloroplatinic acid (H2PtCl6) and an elevatedsynthesis temperature resulted in a high surface area for CuBr@Pt NPs. The abundant active sites enabledthe CuBr@Pt NPs a superior performance as applied in glucose and nitrite detection. Moreover, an optimalPt loading would be conducive to optimize sensor performances of CuBr@Pt NPs. In the glucose detection,the sensor by CuBr@Pt-15% could reach the detection concentration up to 68.0 mM, which was 1.9 timeshigher than that by pure CuBr. And the corresponding sensitivity by CuBr@Pt-15% was calculated to be382.73 lA/mMcm2. In the detection of sodium nitrite, CuBr@Pt-15% also revealed a superior behaviorthan previous work. And the detection concentration (by the linear sweep voltammetry) was form 0 to80.0 mM. This work demonstrated the superior biosensor performance of CuBr@Pt-15%, which offereda promising material for sensor with wider detection range and rationalized cost.