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Peng Zhan,Xinyong Liu,Liu Wang,Hong Liu,Xuwang Chen,Xiao Li,Xin Jiang,Qiangqiang Zhang,Christophe Pannecouque,Lieve Naesens,Erik De Clercq,Ailin Liu,Guanhua Du 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.6
In continuation of our endeavor to develop new, potent, selective and less toxic antiviral agents, a novel series of 2-(2-amino/chloro-4-(2,4-dibromophenyl) thiazol-5-ylthio)acetamide derivatives was synthesized via an expeditious route and evaluated for their anti-HIV activities against wild-type virus and clinically relevant mutant strains, and for their anti-influenza virus activities against influenza A (H1N1 and H3N2) and influenza B in cellular assays. The selected active compounds were also assayed for their enzymic inhibitory activities. The results showed that some 2-chloro substituted thiazolylthioacetamide derivatives possessed potent activity against wild type HIV-1 and several key mutant strains (E138K, K103N, L100I) of HIV-1 in MT-4 cells with EC50 values in micromolar range. Two 2-amino substituted thiazole derivatives 8a7 and 8a8 displayed significant potency against influenza A/H1N1 in MDCK cells with EC50 values much lower than that of oseltamivir carboxylate, ribavirin, amantadine and rimantadine. Though the mechanism of actions is still unclear, these novel thiazolylthioacetamides might serve as original leads for further pharmacological investigations as potential therapeutic agents against HIV-1 or influenza virus.
An Improved Model of General Data Publish/Subscribe Based on Data Distribution Service
Shufen Liu,Xuejun Ma,Xinyong Wang 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.11
Most existing data publish/subscribe systems applied in a particular field, the lack of generality. In order to satisfy the general support for interdisciplinary model, proposed an improved model of general data publish/subscribe. The model supports the configuration and modification of the underlying data types. In order to avoid the impact on the application layer while changing the underlying DDS product, proposed an encapsulation on DDS based on the abstract factory pattern. Finally, through simulation experiments to verify the feasibility of the proposed model, the simulation results show that the improved model can be well applied to various types of data publish/subscribe occasions, with high performance.
Xuemin Zhong,Hongqi Liu,Xinyong Mao,Bin Li 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.10
This paper proposes a new method to identify the squareness errors of machine tools and gives an optimal method to improve the volumetric compensation accuracy based on the identified squareness errors. The volumetric error model based on screw theory is proposed and the effects of the squareness errors on the volumetric errors have been analyzed to clarify the possibility of improving volumetric error compensation by proper and accurate squareness errors. Then the identification method of the squareness errors is deduced in theory considering a 3-axis horizontal machine tool. With the identified squareness errors, an optimal method to improve volumetric error compensation in machine tools has been proposed. Experiments have verified that the 3 identified squareness errors are in accordance with the measured squareness errors within the accuracy range. Moreover, compared with the traditional measurement of squareness errors not considering the PDGEs, the proposed method is more effective and shows error compensation improvement in the volumetric error compensation process.
Xin, Yong,Wang, Jia-Yang,Li, Liang,Tang, Tian-You,Liu, Gui-Hong,Wang, Jian-She,Xu, Yu-Mei,Chen, Yong,Zhang, Long-Zhen Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Objective: To make sure the feasibility with $^{18F}FDG$ PET/CT to guided dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma patients, by dosimetric verification before treatment. Methods: Chose 11 patients in III~IVA nasopharyngeal carcinoma treated with functional image-guided IMRT and absolute and relative dosimetric verification by Varian 23EX LA, ionization chamber, 2DICA of I'mRT Matrixx and IBA detachable phantom. Drawing outline and making treatment plan were by different imaging techniques (CT and $^{18F}FDG$ PET/CT). The dose distributions of the various regional were realized by SMART. Results: The absolute mean errors of interest area were $2.39%{\pm}0.66$ using 0.6cc ice chamber. Results using DTA method, the average relative dose measurements within our protocol (3%, 3 mm) were 87.64% at 300 MU/min in all filed. Conclusions: Dosimetric verification before IMRT is obligatory and necessary. Ionization chamber and 2DICA of I'mRT Matrixx was the effective dosimetric verification tool for primary focal hyper metabolism in functional image-guided dynamic IMRT for nasopharyngeal carcinoma. Our preliminary evidence indicates that functional image-guided dynamic IMRT is feasible.