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- 저자 : Xinliu Lin (검색결과 5 건)
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Xinliu Lin,Xia Ren,Xiaojun Xiao,Zhaowei Yang,Siyang Yao,Gary WK Wong,Zhigang Liu,Charles Wang,Zhong Su,Jing Li 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.6
Allergic asthma is a public health problem that affects human health and socioeconomic development. Studies have found that the prevalence of asthma has significantly increased in recent years, which has become particularly pronounced in developed countries. With rapid urbanization in China in the last 3 decades, the prevalence of asthma has increased significantly in urban areas. As changes in genetic backgrounds of human populations are limited, environmental exposure may be a major factor that is responsible for the increased prevalence of asthma. This review focuses on environmental components of farms and rural areas that may have protective effects in reducing the development of asthma. Farm and rural related microorganism- and pathogen-associated molecular patterns are considered to be important environmental factors that modulate host's innate and adaptive immune system to induce protection effects later in life. Environmental microbial-related immunotherapy will also be discussed as the future research direction for the prevention of allergic asthma.
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Experimental Study on the Monotonic and Cyclic Behavior of Carbonate Sand in the South China Sea
Xin Liu,Sa Li,Lan Lin,Tingting Li,Jiangsong Yin 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.9
Carbonate soils have specific properties that differ from those of siliceous sand. The monotonic and cyclic behavior of carbonate sand from Jinqing Island in the South China Sea was examined by undrained monotonic and cyclic simple shear tests in this paper. The monotonic test results show that the phase transformation state friction angle is 25.7o, and the critical state friction angle decreases from 38.7o to 37.3o due to particle crushing. By comparing the experimental data from the monotonic and cyclic tests, we found that the trend of the peak shear stress ratio with shear strain in each cycle of cyclic tests was close to that of monotonic tests. If the cyclic stress ratio of symmetrical cyclic tests is normalized with the phase transformation strengths obtained by the corresponding monotonic tests, it has a good relationship with the number of cycles at failure and is not affected by the relative density and vertical consolidation stress. The effects of the relative density, vertical consolidation stress and initial static shear stress on the undrained cyclic strength are discussed. Finally, a comparison of the undrained cyclic strength of carbonate sand from different regions shows that different carbonate sands have almost identical undrained cyclic strength under the medium dense state, but significant quantitative differences are observed between these carbonate sands under the dense state.
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Research on the Attenuation of Blast Wave by Groups of Filled Cracks in Surrounding Rock of Cavern
Xin Liu,Hong-fa Xu,Peng-xian Fan,Jian-nan Zhou,Han-sheng Geng,Jia-quan Mo,Tao-lin Zhang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.7
This study introduces an approach for constructing groups of filled cracks in the surroundingrock to achieve anti-blasting and wave elimination protection for underground caverns. Toverify the attenuation effect of the explosion wave by the filled cracks, two models, a no-crackmodel, and a filled-crack model, were constructed using a certain proportion of analoguematerials based on the similarity theory. With the implementation of small equivalentexplosion conditions, the peak pressure of the surrounding rock of the cavern and thevibration acceleration of the cavern wall under different explosion conditions were measured. To accurately judge the attenuation efficiency of the filled cracks, the peak pressure attenuationpercentages between different measuring points were calculated. Furthermore, thecorresponding numerical simulation analysis process was performed according to the testconditions. The results show that not only the peak pressure attenuation percentages, but alsothe value of vibration acceleration, were significantly reduced due to the existence of filledcracks in the model. This indicates that filled cracks in the surrounding rock of the cavern caneffectively attenuate the peak pressure and vibration acceleration caused by the explosionwave, thereby achieving the protection engineering goal of anti-explosion and wave elimination.
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Xin Liu,Zi-Yu Liu,Yang-Hai Zheng,Yong-De Yan,Wen-Da Xu,Yun Xue,Yue-Lin Wang,Fu-Qiu Ma,Kai Zhu,Yu-Sheng Yang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
The disposal of spent radioactive ion exchange resin generated during the operation of nuclear facilitieshas always been a conundrum. The molten salt oxidation (MSO) for the treatment of mixed resin (MR)shows obvious superiority. In this work, ternary carbonate (Li2CO3-Na2CO3-K2CO3) and MR was usedas the molten salt system and the oxidation target, respectively. The oxidation behavior of MR was analyzedby varying the temperature and oxygen equivalent during the MSO process. By studying the effectof different oxygen equivalents on the oxidation efficiency, the oxygen equivalent of 125% could make theoxidation efficiency of MR reach 99.99% at 800 C. The composition of C, N and S containing exhaust gasproduced through MSO process of MR with temperature were almost consistent with the simulationresults. The exhaust gas was successfully adsorbed by molten carbonate to produce nitrate and sulfurcompounds. The carbonate has good absorption to harmful gases such as SO2, CO, NO, etc. The contentof SO2 from the highest 0.32% to 0, and 71.23% of sulfur in MR was trapped by molten carbonate asthe form of sulfate. This work has important implications for reducing the potential harm of radioactivewaste resin to the environment.
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Xin Liu,Chengcheng Gong,Jieyun Zhang,Wanjing Feng,Yanjing Guo,Youzhou Sang,Chunmeng Wang,Yong Chen,Jian Wang,Lin Yu,Xiaowei Zhang,Zhiguo Luo 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Purpose Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal malignancy that occurs primarily in children and adolescents. The clinical and pathological features of IMT in adult patients are not well understood.Materials and Methods We retrospectively searched for records of adult patients with IMT at Fudan University Shanghai Cancer Center from 2006 to 2021. Clinicopathological data, treatments, and outcomes were collected and analyzed.Results Thirty adult patients with IMT, mostly women (60.0%), were included. The median age of the patients was 38 (21-77). The most common primary site was abdominopelvic region (53.3%), followed by lungs (20.0%). Seven patients had an abdominal epithelioid inflammatory myofibroblast sarcoma (EIMS). The positivity rate of anaplastic lymphoma kinase (ALK) was 81.5% (22/27). Sixteen patients with advanced ALK-positive disease received crizotinib, with an objective response rate (ORR) of 81.3% and a disease control rate of 87.5%. The median progression-free survival was 20.8 months. EIMS was associated with more aggressive behavior; however, the prognosis was similar to that of non-EIMS patients after treatment with an ALK inhibitor. At a median follow-up time of 30 months (95% confidence interval [CI], 13.6 to 46.4), the 5-year overall survival was 77% (95% CI, 66 to 88) in all patients.Conclusion Adult IMTs appeared more aggressive, with a higher incidence of recurrence and metastases, and patients with EIMS had more aggressive cases. Treatment with ALK inhibitors resulted in a high ORR and a durable response, which suggested that ALK inhibitors could be used as a first-line treatment option in adult patients with ALK-positive advanced IMT.
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