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      • 现代人的生存困境——弗洛姆异化理论下《疯癫亚当三部曲》中的异化主题探究

        郭紫茜(Ziqian Guo),伍艳京(Yanjing Wu) YIXIN 출판사 2024 教育教学研究论丛 Vol.2 No.3

        玛格丽特·阿特伍德是当代加拿大最具影响力、最多产的女作家之一,被誉为“加拿大文学女王”。她的作品话题涉及性别、民族、生态、政治等多领域,通过揭露社会的本质不断反思人类的生存问题。阿特伍德在《疯癫亚当三部曲》中,通过分析主人公们与自我、他人与社会之间的异化关系,探究了现代人所面临的生存困境,体现了阿特伍德的人文关怀。本文以弗洛姆异化理论为支撑,解读“三部曲”中的异化主题,探讨其成因及解决措施,以期解决现代人的生存困境,并促进其人格的健康发展。 Margaret Atwood is one of the most influential and prolific female writers in contemporary Canada and she is also known as the “Queen of Canadian Literature”. Her works involve gender, ethnicity, ecology, politics and other fields, and constantly reflect on human survival through revealing the nature of society. In The MaddAddam Trilogy, Atwood explores the plight faced by modern people by analyzing the alienated relations between the protagonists and themselves, others and society, and embodies Atwood’s humanistic concern. Therefore, based on Fromm’s theory of alienation, this paper interprets the theme of alienation in the trilogy, discusses its causes and solutions, in order to solve the dilemma of modern people’s existence and promote the healthy development of their personality.

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        Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study

        Xin Liu,Chengcheng Gong,Jieyun Zhang,Wanjing Feng,Yanjing Guo,Youzhou Sang,Chunmeng Wang,Yong Chen,Jian Wang,Lin Yu,Xiaowei Zhang,Zhiguo Luo 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

        Purpose Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal malignancy that occurs primarily in children and adolescents. The clinical and pathological features of IMT in adult patients are not well understood.Materials and Methods We retrospectively searched for records of adult patients with IMT at Fudan University Shanghai Cancer Center from 2006 to 2021. Clinicopathological data, treatments, and outcomes were collected and analyzed.Results Thirty adult patients with IMT, mostly women (60.0%), were included. The median age of the patients was 38 (21-77). The most common primary site was abdominopelvic region (53.3%), followed by lungs (20.0%). Seven patients had an abdominal epithelioid inflammatory myofibroblast sarcoma (EIMS). The positivity rate of anaplastic lymphoma kinase (ALK) was 81.5% (22/27). Sixteen patients with advanced ALK-positive disease received crizotinib, with an objective response rate (ORR) of 81.3% and a disease control rate of 87.5%. The median progression-free survival was 20.8 months. EIMS was associated with more aggressive behavior; however, the prognosis was similar to that of non-EIMS patients after treatment with an ALK inhibitor. At a median follow-up time of 30 months (95% confidence interval [CI], 13.6 to 46.4), the 5-year overall survival was 77% (95% CI, 66 to 88) in all patients.Conclusion Adult IMTs appeared more aggressive, with a higher incidence of recurrence and metastases, and patients with EIMS had more aggressive cases. Treatment with ALK inhibitors resulted in a high ORR and a durable response, which suggested that ALK inhibitors could be used as a first-line treatment option in adult patients with ALK-positive advanced IMT.

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