Nucleos(t)ide Analogues for Reducing Hepatocellular Carcinoma in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis

( Xinhui Wang ),( Xiaoli Liu ),( Zhibo Dang ),( Lihua Yu ),( Yuyong Jiang ),( Xianbo Wang ),( Zhiyun Yang ) 대한간학회 2020 Gut and Liver Vol.14 No.2

Background/Aims: Studies have shown that nucleos(t)ide analogue (NA) treatment can reduce the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients, but it is unclear which NA is most effective. We performed a meta-analysis and systematic review comparing the efficacies of NAs in CHB patients. Methods: We searched literature databases for randomized controlled trials (RCTs) and observational studies that analyzed the hepatic biochemical response, virological response, seroconversion rate, drug resistance rate, and HCC incidence rate in CHB patients treated with NAs. Meta-analyses were performed with RevMan and Stata/SE software. Results: Twelve cohort studies and one RCT were selected, in which entecavir (ETV), lamivudine (LAM), telbivudine (LdT), and/or tenofovir disoproxil fumarate (TDF) were evaluated in CHB patients. The meta-analysis showed that ETV was superior to LAM with regard to the HCC incidence (p<0.001), biochemical response (p=0.001), virological response (p=0.02), and drug resistance (p<0.001), and ETV was superior to LdT with regard to the virological response (p<0.001) and drug resistance (p<0.001). We found no significant difference between ETV and TDF with regard to the HCC incidence (p=0.08), biochemical response (p=0.39), virological response (p=0.31), serological conversion (p=0.38), or drug resistance (p=0.95). NA-treated patients with pre-existing cirrhosis had a 5.49 times greater incidence of HCC than those without cirrhosis (p<0.001). Conclusions: ETV or TDF should be used for long-term first-line monotherapy in CHB patients according to the current guidelines. Standardized protocols are needed for future studies of ETV and TDF to facilitate conclusive comparisons. Patients with cirrhosis are at significantly elevated risk for HCC, despite the benefits of NA treatment. (Gut Liver 2020;14:232-247)

On Some Key Technologies of ATM Switching

Liu Zengji,Yang Xinhui,Zhou Daiqi,Qiu Zhiliang 한국통신학회 1998 한국통신학회 기타 간행물 Vol.- No.-

Analysis of Clostridium Cluster I Community Diversity in Pit Mud Used in Manufacture of Chinese Luzhou-flavor Liquor

Maoke Liu,Ke Zhao,Yuming Tang,Daoqun Ren,Wanchun Yao,Xinhui Tian,Xinyu Zhang,Bin Yi,Bo Deng 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.3

Chinese Luzhou-flavor liquor is prepared using distillation of mixed, fermented grains, such as sorghum and rice. Fermentation occurs in cellars lined with pit mud containing microbes. The identity and community diversity of bacteria in pit mud of fermentation cellars contributes to the aromatic compounds of the liquor. In order to determine the contribution of genus Clostridium to this fermentation, the community diversity of Clostridium cluster I in pit mud of different cellar ages (1, 50, 100, and 400 years) was investigated based on denaturing gradient gel electrophoresis followed by 16S rRNA sequencing. Differences in the community structure within pit mud depended on wall and bottom layer cellar locations. A better understanding of the role of Clostridium in Luzhou-flavor liquor manufacture will be useful.

Electroconvulsive Therapy on Severe Obsessive-Compulsive Disorder Comorbid Depressive Symptoms

Xiaohui Liu,Hong Cui,Qiang Wei,Ying Wang,Keyong Wang,Chen Wang,Chunyan Zhu,Xinhui Xie 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.2

Electroconvulsive therapy (ECT) is not currently used as a first-line treatment for obsessive-compulsive disorder (OCD). However, several related case reports have demonstrated that ECT seems to be effective for severe OCD, especially when first-line therapies have failed. In this study, we describe the courses, detailed parameters, effects, and follow-up information relating to three patients with severe OCD who were treated by modified bifrontal ECT after their first-line anti-OCD treatments pharmacotherapy, behavioral therapy, and cognitive behavioral therapy failed. The number of ECT procedures administered in each case is as follows: Case 1, eight; Case 2, three; and Case 3, four. In all three cases, the patients’ depressive symptoms improved considerably after the ECT procedures. In addition, the condition of all three patients’ OCD significantly improved and remained stable at regular follow-ups. ECT may play an effective role in treating severe OCD.

Electroconvulsive Therapy on Severe Obsessive-Compulsive Disorder Comorbid Depressive Symptoms

Xiaohui Liu,Xinhui Xie,Hong Cui,Qiang Wei,Ying Wang,Keyong Wang,Chen Wang,Chunyan Zhu 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.2

Electroconvulsive therapy (ECT) is not currently used as a first-line treatment for obsessive-compulsive disorder (OCD). However, several related case reports have demonstrated that ECT seems to be effective for severe OCD, especially when first-line therapies have failed. In this study, we describe the courses, detailed parameters, effects, and follow-up information relating to three patients with severe OCD who were treated by modified bifrontal ECT after their first-line anti-OCD treatments pharmacotherapy, behavioral therapy, and cognitive behavioral therapy failed. The number of ECT procedures administered in each case is as follows: Case 1, eight; Case 2, three; and Case 3, four. In all three cases, the patients’ depressive symptoms improved considerably after the ECT procedures. In addition, the condition of all three patients’ OCD significantly improved and remained stable at regular follow-ups. ECT may play an effective role in treating severe OCD.

Simulation of travelling performance and experimental research on heavy double crawlers on a soft ground

Guanyu Zhang,Xinhui Liu,Shuai Wang,Guoqiang Wang 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.2

This study analyzes resistances to sinking, steering bulldozer, steering friction, running, climbing, inertia, and wind and considered the offsetting effects of instantaneous center of speed and center of mass based on the sinkage method proposed by Bekker. The purpose of the analysis is to show the calculation method for the driving power of crawlers under different working conditions. The influence of several performance factors were analyzed to calculate the steering performance of a dumping machine with heavy double crawler. The performance factors include steering radius, offset mass, width-to-length ratio, crawler width wider than the interior and lateral, caterpillar gauge in crawler drive, drive power, and steering torque friction. These factors are involved in driving wheels at a crawler speed of 3.33 RPM. The law of operation for heavy crawlers under different working conditions is obtained by performing a real vehicle test. The results of this test are compared with the theoretical calculations to verify correctness. Such a test provides important theoretical basis for theoretical modeling and for analyzing the performance of large crawlers running on soft ground.

Carbon-coated Mg–Al layered double oxide nanosheets with enhanced removal of hexavalent chromium

Xiaogang Zheng,Fuyan Kang,Xinhui Liu,Hao Peng,JinYang Zhang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-

Carbon-coated Mg–Al layered double oxide (MgAl@C LDO) nanosheets were synthesized for the removalof hexavalent chromium (Cr(VI)) ions. Carbon coating could enhance the sorption capacity of Mg5Al1 LDOfor the Cr(VI) removal. The sorption capacity of Mg5Al1@C LDO increased and then decreased with anincrease in carbon-coated content, of which the Mg5Al1@C-2 with a carbon thickness of around 5.0 nmexhibited the best sorption capacity. The sorption behaviors of Mg5Al1@C-2 was explained by Langmuirsorption model, pseudo-second-order model, Weber–Morris model, and Boyd kinetic model. Mg5Al1@C-2 for Cr(VI) removal was a spontaneous, endothermic, and chemisorption process.

Mechanism analysis of pressure fluctuation in wheel loader articulated steering hydraulic system

Bing-wei Cao,Xinhui Liu,Wei Chen,Chen Zhou,Fei-xiang Xu 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.10

This paper studies the influence of hinge point positioning of a steering cylinder on the pressure fluctuation of the steering system of a wheel loader. Affected by the hinge point position of the steering cylinder, the main causes of the pressure fluctuation are found to be the stroke difference and the force arm difference. Based on theoretical analysis, the hinge point positioning of the steering cylinder was optimized by using genetic algorithm (GA). The AMEsim simulation model of the steering system was built to verify the accuracy of the GA. The wheel loader was reformed according to the optimized articulated points position. Steering tests showed a significant drop in system pressure fluctuation, the energy consumed is also reduced. Further, the analysis shows that the force arm difference is the main factor causing the pressure fluctuation, providing the theoretical and experimental basis for the design of a steering system of wheel loaders.

Intelligent energy-saving operation of wheel loader based on identifiable materials

Bing-wei Cao,Xinhui Liu,Wei Chen,Kuo Yang,Dan Liu 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.3

This study applies image recognition technology to the shovel loading operation of a wheel loader for the first time. In the proposed method, the wheel loader can automatically select the corresponding engine power curve according to different identifiable materials, thus achieving intelligent energy saving. This study first analyzed the working resistance of the wheel loader, and the analysis results provided theoretical support to the energy-saving operation of the wheel loader. The shovel loading test was carried out for different materials. The test results validated the feasibility of intelligent energy-saving operation of the wheel loader based on identifiable materials. A neural network algorithm based on material identification model was then built and verified, whose material identification rate was 92 %. The model was used as the carrier, and the wheel loader-operating characteristics were considered in view of the existing engine energy-saving mode. Finally, the boom cylinder pressure and bucket angle were used as feedback to future discussion about the intelligent energy-saving operation of the wheel loader. The basic conditions for subsequent designs of wheel loaders are provided.

Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression

Gang Li,Keyu Liu,Xinhui Du 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.2

Purpose: Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles and molecular mechanisms of TUG1 in osteosarcoma (OS) development. Materials and Methods: Real-time quantitative PCR was applied to detect the expressions of TUG1 and microRNA-132-3p (miR-132-3p) in OS tissues and cells. Western blot was performed to measure protein levels of sex determining region Y-box 4 (SOX4). Cell viability was assessed using XTT assay. Cell apoptosis was evaluated using flow cytometry and caspase-3 activity detection assays. Bioinformatics analysis and luciferase reporter experiments were employed to confirm relationships among TUG1, miR-132-3p, and SOX4. Results: TUG1 was highly expressed in human OS tissues, OS cell lines, and primary OS cells. TUG1 knockdown hindered proliferationand induced apoptosis in human OS cell lines and primary OS cells. Moreover, TUG1 inhibited miR-132-3p expression by direct interaction, and introduction of miR-132-3p inhibitor partly abrogated the effect of TUG1 knockdown on the proliferation and apoptosis of OS cells. Furthermore, SOX4 was validated as a target of miR-132-3p. Further functional analyses revealed that miR-132-3p inhibited proliferation and induced apoptosis of OS cells, while this effect was greatly abated following SOX4 overexpression. Moreover, TUG1 knockdown suppressed proliferation and promoted apoptosis by upregulating miR-132-3p and downregulatingSOX4 in primary OS cells. Conclusion: TUG1 facilitated proliferation and suppressed apoptosis by regulating the miR-132-3p/SOX4 axis in human OS cell lines and primary OS cells. This finding provides a potential target for OS therapy.