중국 모바일 게임의 소비자 체험이 사용자 만족도와 인앱 구매 의도에 미치는 영향: 몰입의 조절효과 중심으로

Xin-Zhi Chen,김문홍 한국유통경영학회 2022 유통경영학회지 Vol.25 No.5

Purpose: China ‘s mobile game market has been expanding. The purpose of this study is to explore the impact of mobile game users’ consumption experiences on their satisfaction and willingness to purchase game props. Among them, whether the degree of commitment has a moderating effect on user consumption experience and satisfaction is examined. Research design, data, and methodology: Mobile gamers were surveyed online, and 379 valid samples were returned. Technical statistical frequency analysis, factor analysis, and reliability analysis were carried out using the SPSS 26.0 statistical package program. To test these hypotheses, regression analysis, and moderate efficacy analysis were performed using the SPSS PROCESS Marco plug-in. Results: The study showed that consumers’ experience of mobile game users positively (+) affects user satisfaction, all three consumer experience variables have a positive (+) effect on immersion, and among them, entertainment experience has the highest impact on immersion. Then, user satisfaction (+) affects the willingness of users to purchase game props. Lastly, regarding the immersion experience, the results show that immersion plays a positive moderating role in the experience of mobile gaming users and satisfaction. Implications: This paper introduced In theory, most existing research analysis on mobile games lacks research related to user satisfaction and intention to purchase in-app by adding consumer experience and immersion of control variables based on mobile game characteristics, loyalty, and satisfaction. As a result, a new "consumer experience" model that enhances user immersion suggested the potential to improve game user satisfaction using immersion.

Isolation and Characterization of Bacillus sp. Producing Broad-Spectrum Antibiotics Against Human and Plant Pathogenic Fungi

( Na Chen ),( Min Jin ),( Hong Mei Qu ),( Zhi Qiang Chen ),( Zhao Li Chen ),( Zhi Gang Qiu ),( Xin Wei Wang ),( Jun Wen Li ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.2

A strain of bacterium producing antifungal antibiotic was isolated and identification of the strain was attempted. We could identify the bacterium as being a Bacillus sp., based on morphological observation, physiological characteristics, and 16S rDNA sequence analysis, thus leading us to designate the strain as Bacillus sp. AH-E-1. The strain showed potent antibiotic activity against phytopathogenic and human pathogenic fungi by inducing mycelial distortion and swelling and inhibiting spore germination. The antibiotic metabolite produced by the strain demonstrated excellent thermal and pH (2-11) stability, but was labile to autoclaving. From these results, we could find a broader antifungal activity of Bacillus genus. Isolation and characterization of the active agent produced by the strain are under progress.

Risk Factors for Anxiety in Major Depressive Disorder Patients

Li-Min Xin,Lin Chen,Zhen-Peng Ji,Suo-Yuan Zhang,Jun Wang,Yan-Hong Liu,Da-Fang Chen,Fu-De Yang,Gang Wang,Yi-Ru Fang,Zheng Lu,Hai-Chen Yang,Jian Hu,Zhi-Yu Chen,Yi Huang,Jing Sun,Xiao-Ping Wang,Hui-Chun 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3

Objective: To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD). Methods: This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively. Results: Compared with the non-anxious group, the anxious-depression group had an older age at onset (t=−4.39, p<0.001), were older (t=−4.69, p<0.001), reported more lifetime depressive episodes (z=−3.24, p=0.001), were more likely to experience seasonal depressive episodes (χ2=6.896, p=0.009) and depressive episodes following stressful life events (χ2=59.350, p <0.001), and were more likely to have a family history of psychiatric disorders (χ2=6.091, p=0.014). Their positive and total scores on the Mood Disorder Questionnaire (MDQ) and the 32-item Hypomania Checklist (HCL-32) (p<0.05) were also lower. The logistic regression analysis indicated that age (odds ratio [OR]=1.03, p<0.001), a lower total MDQ score (OR=0.94, p=0.011), depressive episodes following stressful life events (OR=3.04, p<0.001), and seasonal depressive episodes (OR=1.75, p=0.039) were significantly associated with anxious depression. Conclusion: These findings indicate that older age, fewer subclinical bipolar features, an increased number of depressive episodes following stressful life events, and seasonal depressive episodes may be risk factors for anxiety-related characteristics in patients with MDD.

A New Adaptive Region of Interest Extraction Method for Two-Lane Detection

Chen Yingfo,Wong Pak Kin,Yang Zhi-Xin 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.6

As a key environment perception technology of autonomous driving or driver assistance systems, lane detection is to ensure vehicles to drive safely in corresponding lane. However, existing lane detection algorithms for two-lane detection focus on using various filtering methods to reduce the impact of useless information, resulting in low accuracy and low efficiency. In this paper, a novel Adaptive Region of Interest (A-ROI) extraction method is proposed to improve the accuracy and real-time performance of the two-lane detection algorithm. Three key technologies are introduced to solve the problems. First, A-ROI, which only focuses on the lane where the vehicle is located, is applied to the Bird’s-Eye-View image obtained by using Inverse Perspective Mapping (IPM). Next, based on Bayesian framework and Likelihood models, a lane feature extraction method with a lane-like feature filter is used for edge detection. Finally, an improved Random Sample Consensus (RANSAC) algorithm is introduced by using a filter that can remove noisy lane data. The performance of the proposed A-ROI method together with the improved lane detection method is evaluated via simulation of various scenarios. Experimental results show the proposed method has better accuracy and real-time performance than the traditional lane detection methods.

Hsa-miR-181a-5p Expression and Effects on Cell Proliferation in Gastric Cancer

Chen, Gang,Shen, Zhi-Li,Wang, Ling,Lv, Chun-Ye,Huang, Xin-En,Zhou, Rong-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Purpose: MicroRNAs (miRNAs) are small endogenous, non-coding, single-stranded RNAs (approximately 22 nt). Accumulating evidence has shown that aberrant miRNA expression is pronounced and correlated with gastric cancer genesis and progression. Materials and Methods: Expression levels of miR-181a-5p in GC tissues and cell lines were assessed by qRT-PCR and tested for correlation with clinical features. In addition, effects of miR-181a-5p on GC cell growth were investigated. Results: Our findings indicate that miR-181a-5p is upregulated in GC, in correlation with lymph node invasion, nerve invasion and vascular invasion (P<0.05). Enforced expression of miR-181a -5p promoted cell proliferation ability. Conclusions: This study suggested that increased miR-181a-5p is related to GC progression. MiR-181a-5p may represent a potential therapeutic target for GC.

Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism and Folate Intake in Esophageal Squamous Cell Carcinoma

Chen, Jing,Huang, Zhi-Jie,Duan, Yu-Qin,Xiao, Xin-Rong,Jiang, Jian-Qing,Zhang, Ru Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

Aim: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake. Methods: A total of 257 cases of esophageal squamous cell carcinoma confirmed by histopathological examination were collected. Genotyping of P16, MGMT and HMLH1 was accomplished by methylation-specific polymerase chain reaction (PCR) after sodium bisulfate modification of DNA and the MTHFR C677T genetic polymorphism was detected by PCR-restriction fragment-length polymorphism (PCR-RFLP). Results: The proportions of DNA hypermethylation in P16, MGMT and hMLH1 in cancer tissues were significantly higher than in paracancerous normal tissue. The proportion of hypermethylation in at least one gene was 88.5% in cancer tissue, and was also significantly higher than that in paracancerous normal tissue. Our finding showed individuals with homozygotes (TT) of MTHFR C677T had significant risk of DNA hypermethylation of MGMT in cancer tissues, with an OR (95% CI) of 3.15 (1.12-6.87). Similarly, patients with high intake of folate also showed a slight high risk of DNA methylation of MGMT, with OR (95% CI) of 2.03 (1.05-4.57). Conclusion: Our study found the P16, MGMT and hMLH1 demonstrate a high proportion of hypermethylation in esophageal squamous cell cancer cancer tissues, which might be used as biomarkers for cancer detection.

Analysis of longissimus muscle quality characteristics and associations with DNA methylation status in cattle

Zhi Chen,Shuangfeng Chu,Xin Xu,Jingyi Jiang,Wenqiang Wang,Hongliang Shen,Mingxun Li,Huimin Zhang,Yongjiang Mao,Zhangping Yang 한국유전학회 2019 Genes & Genomics Vol.41 No.10

Background As cattle represent one of the most important livestock species for meat production, control of muscle development in regards to quality is an important research focus. Objectives In this study, the phenotypic quality traits and its associations with DNA methylation levels of the longissimus muscle in two cattle breeds were studied. Methods The pH value, water loss rate, fat and protein and fatty acid content were measured in three beef cattle breeds of longissimus mucle; The longissimus mucle was analyzed by MethylRAD-seq and RNA-seq. The differentially methylated and differentially expressed related genes were subjected to BSP. Results Methylation status of longissimus mucle was analyzed by MethylRAD-seq. Compared with Simmental, there were 39 differentially methylated and expressed genes in muscle of Yunling cattle, and 123 differentially methylated and expressed genes in Wenshan muscle. A combined analysis of MethylRAD-seq and RNA-seq results revealed differential methylation and expression level of 18 genes between Simmental and Wenshan cattle, and 14 genes between Simmental and Yunling cattle. In addition, 28 genes were differentially methylated between Wenshan and Yunling cattle. Results of promoter methylation analysis of ACAD11, FADS6 and FASN showed that the overall degree of DNA methylation of FADS6 and FASN was negatively correlated with their expression levels. Methylation level of FASN in Simmental was greater than Yunling and Wenshan. The degree of methylation at the FADS6 CpG4 site was significantly higher in Simmental than that in Yunling. The levels of methylation at the CpG7 locus of the Simmental and Yunling breeds were greater than Wenshan cattle. A negative correlation was detected between the methylation levels and the expression of FASN CpG1, CpG2, CpG3, CpG5, CpG7, and CpG10. Conclusion The functional and molecular regulatory mechanism of the genes related to meat quality can be revealed systematically from aspects of the genetic and epigenetic regulation. These studies will help to further explore the molecular mechanisms and phenotypic differences that regulate growth and quality of different breeds of cattle.

A topological optimization method for flexible multi-body dynamic system using epsilon algorithm

Zhi-Jun Yang,Xin Chen,Robert Kelly 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.5

In a flexible multi-body dynamic system the typical topological optimization method for structures cannot be directly applied, as the stiffness varies with position. In this paper, the topological optimization of the flexible multi-body dynamic system is converted into structural optimization using the equivalent static load method. First, the actual boundary conditions of the control system and the approximate stiffness curve of the mechanism are obtained from a flexible multi-body dynamical simulation. Second, the finite element models are built using the absolute nodal coordination for different positions according to the stiffness curve. For efficiency, the static reanalysis method is utilized to solve these finite element equilibrium equations. Specifically, the finite element equilibrium equations of key points in the stiffness curve are fully solved as the initia solution, and the following equilibrium equations are solved using a reanalysis method with an error controlled epsilon algorithm. In order to identify the efficiency of the elements, a non-dimensional measurement is introduced. Finally, an improved evolutional structural optimization (ESO) method is used to solve the optimization problem. The presented method is applied to the optimal design of a die bonder. The numerical results show that the presented method is practical and efficient when optimizing the design of the mechanism.

Sources, Components, Structure, Catalytic Mechanism and Applications: a Critical Review on Nicotinate Dehydrogenase

Chen Zhi,Xu Xiangjing,Ju Xin,Yan Lishi,Li Liangzhi,Yang Lin 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.6

Plant-derived insecticide-neonicotinoid insecticides (NIs) played a crucial role in the development of agriculture and food industry in recent years. Nevertheless, synthesis of these nitrogen-containing heterocyclic compounds with an effective and greener routing remains challenging especially to the notion raise of “green chemistry” and “atom economy”. While bio-catalyzed methods mediated by nicotinate dehydrogenase (NDHase) then provide an alternative. The current review mainly focuses on the introduction of sources, components, structure, catalytic mechanism and applications of NDHase. Specifically, NDHase is known as nicotinic acid hydroxylase and the sources principally derived from phylum Proteobacteria. In addition, NDHase requires the participation of the electron respiratory chain system on the cell membrane. And the most important components of the electron respiratory chain are hydrogen carrier, which is mainly composed of iron-sulfur proteins (Fe-S), flavin dehydrogenase (FAD), molybdenum binding protein and cytochromes. Heterologous expression studies were hampered by the plasmid and host with high efficiency and currently only Pseudomonas entomophila L48 as well as Comamonas testosterone was successfully utilized for the expression of NDHase. Furthermore, it is speculated that the conjugate and inductive effects of the substituent group at position 3 of the substrate pyridine ring exerts a critical role in the hydroxylation reactions at position 6 concerning about the substrate molecular recognition mechanism. Finally, applications of NDHase are addressed in terms of pesticide industry and wastewater treatment. On conclusion, this critical review would not only deepen our understanding of the theory about NDHase, but also provides the guideline for future investigation of NDHase.

N-Heterocyclic Carbene-Tricyclohexylphosphine Palladium(II) Complex: Synthesis, Crystal Structure and Application in Suzuki Reaction of Aryl Chlorides

Chen Xu,Xin-Qi Hao,Zhen Li,Lu-Meng Duan,Zhi-Qiang Wang,Bao-Ming Ji,Mao-Ping Song 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.10