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Min Wang,Xiaoming He,Biao Jiang,Wenrui Liu,Yu’e Lin,Dasen Xie,Zhaojun Liang,Lihui Chen,Qingwu Peng 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.6
Drought, one of the crucial environmental constraints, seriously threats the quality and yield in chieh-qua. Therefore, cultivat-ing drought-tolerant variety is greatly necessary for its normal growth under water deficiency. However, at present, molecular knowledge on drought resistance is mostly unclear in chieh-qua. In the study, characteristics of two diverse genetic chieh-qua variety, A39 (drought-resistance) and H5 (drought-sensitivity), were analyzed. Under drought stress, H5 exerted high water loss rate, increased malonaldehyde (MDA) content, and decreased enzyme activity of glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) compared with A39. In addition, based on the transcriptome results, we obtained a total of 1821 (511 up-regulated and 1310 down-regulated) and 2114 (1282 up-regulated and 832 down- regulated) differentially expressed genes (DEGs) in the A39 versus H5 under normal and water-deficiency stress, respectively. Several DEGs involved in the cuticle synthesis (cytochrome P450 genes: CYP94A2, CYP86B1, CYP86A7), carbohydrate metabolism, and plant hormone signal transduction (small auxin-up RNA genes: SAUR32, SAUR72; JA-induced genes: TIFY 10A, TIFY 10C; ABA related genes: PYL2, PYL4) were explored and related to drought resistance. These expression patterns observed in the RNA-seq data were further confirmed with quantitative real-time PCR (qRT-PCR). In all, these results not only provided a new insight into analyzing genes of drought response, but also laid a foundation for isolating crucial genes involved in drought stress in chieh-qua.
Taotao Ai,Ning Yu,Xiaoming Feng,Niansuo Xie,Wenhu Li,Pengju Xia 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.1
Ti2AlC/TiAl in situ composites were fabricated via a reaction Hot-Pressing Process using Ti3AlC2, Ti, and Alpowders as initial materials. The effect of Ti2AlC content on the phases and microstructure of the as-sinteredcomposites was investigated by XRD and SEM. The mechanical properties such as Vickers hardness, flexuralstrength and fracture toughness of the as-sintered composites were also tested. The products consisted ofTi2AlC, γ-TiAl and α2-Ti3Al as the major phases. Ti2AlC reinforcements were mainly distributed in the grainboundaries, resulting in obvious γ+α2 grain refinement. With increasing Ti3AlC2 content (up to 5 wt%), theVickers hardness, flexural strength and fracture toughness of the as-sintered composite reached the maximumvalues of 3.7 GPa, 651.5 MPa, and 10.89 MPa·m1/2, respectively. Analysis of fracture surface and crackpropagation paths indicated that crack deflection and crack bridging of the in situ precipitated Ti2AlC phasesobtained by decomposing Ti3AlC2 were the main reasons for the observed composite toughening.
Detection and Isolation of Dendritic Cells Using Lewis X-functionalized Magnetic Nanoparticles
Sara H. Rouhanifard,Ran Xie,Guoxin Zhang,Xiaoming Sun,Xing Chen,Peng Wu 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Dendritic cells (DCs) are professional antigen-presenting cells that serve as messengers between innate and adaptive immunity. Due to their unique roles, DCs are under active investigations as the target for antigen delivery in vaccination against human immunodeficiency virus (HIV), cancer and autoimmune diseases. However, there’s yet no perfect strategy for a cost-effective, high-selective and time-saving detection and isolation of DCs from a complex cell population. Adhesion molecules such as DC-specific intracellular adhesion molecule-3 grabbing non-integrin (DC- SIGN) on the surface of DCs play a critical role in establishing contact between the activated DCs and the naïve T cells through interactions with intercellular adhesion molecule-3 on T cells. DC-SIGN is a member of the C-type lectin receptors and can recognize antigens bearing mannose-rich or fucosylated glycans, as well as Lewis X (LeX). Here, we present the fabrication of magnetic nanoparticles coated with multivalent LeX glycans using the Cu (I)-catalyzed azide-alkyne cycloaddition. The resulting nanoparticles are selective and biocompatible, serving as a highly efficient tool for DC capture detection and enrichment.
Xiao, Xiang-Sheng,Tang, Hai-Lin,Xie, Xin-Hua,Li, Lai-Sheng,Kong, Ya-Nan,Wu, Min-Qing,Yang, Lu,Gao, Jie,Wei, Wei-Dong,Xie, Xiaoming Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
The number of axillary lymph nodes involved and retrieved are important prognostic factors in breast cancer. The purpose of our study was to investigate whether the lymph node ratio (LNR) is a better prognostic factor in predicting disease-free survival (DFS) for breast cancer patients as compared with pN staging. The analysis was based on 804 breast cancer patients who had underwent axillary lymph node dissection between 1999 and 2008 in Sun Yat-Sen University Cancer Center. Optimal cutoff points of LNR were calculated using X-tile software and validated by bootstrapping. Patients were then divided into three groups (low-, intermediate-, and high-risk) according to the cutoff points. Predicting risk factors for relapse were performed according to Cox proportional hazards analysis. DFS was estimated using the Kaplan-Meier method and compared by the log-rank test. The 5-year DFS rate decreased significantly with increasing LNRs and pN. Univariate analysis found that the pT, pN, LNR, molecule type, HER2, pTNM stage and radiotherapy well classified patients with significantly different prognosis. By multivariate analysis, only LNR classification was retained as an independent prognostic factor. Furthermore, there was a significant prognostic difference among different LNR categories for pN2 category, but no apparent prognostic difference was seen between different pN categories in any LNR category. Therefore, LNR rather than pN staging is preferable in predicting DFS in node positive breast cancer patients, and routine clinical decision-making should take the LNR into consideration.
Improving Test Efficiency through Prioritization Based On Testing Dependency
Na Zhang,Yangqiu Liu,Xiaoan Bao,Xiaoming Xie,Zhongtao Ren,Hui Lin 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.6
During the various iterations of software development, test case prioritization generally schedules test cases in order to increase test efficiency as soon as possible without reducing the scale of the test. It is noted that currently, many prioritization techniques are usually based on the assumption that the test cases are independent so as to reduce testing effort. However in the actual test, the dependencies and relations exist between the test cases. In this paper, we propose a new type of prioritization technique based on the relationship of dependencies between test cases. We gather the dependency information of a test suite and then put forward a weighted depth-first search algorithm to determine the most effective order. To assess our approach, an academic feasibility study and three industrial experiments are conducted. Evaluation results indicate that our proposed method can be used to improve the fault detection effectiveness when compared with random ordering and some existed prioritization techniques which are based on function coverage.
Yang, Lu,Li, Ning,Wang, Siyu,Kong, Yanan,Tang, Hailin,Xie, Xinhua,Xie, Xiaoming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Background: Since inconsistent results have been reported regarding the relation between the matrix metalloproteinase-2 (MMP-2) -1306C>T polymorphism and susceptibility for breast cancer, we performed a meta-analysis to investigate the issue. Materials and Methods: An internet search of PubMed and EMBASE was performed to identify eligible studies. Pooled odds ratios (ORs) with their corresponding confidence intervals (CIs) were calculated to evaluate any association between MMP-2 -1306C>T polymorphism and breast cancer susceptibility. Results: Nine case-control studies were included in the meta-analysis, involving 9,858 cases and 10,871 controls. Overall, there was no evidence of any association between the MMP-2 -1306C>T polymorphism and breast cancer susceptibility in different genetic models (T-allele vs C-allele: OR=0.95, 95%CI, 0.82-1.10, p=0.49; TT vs CC: OR=1.03, 95%CI, 0.90-1.19, p=0.66; TT+TC vs CC: OR=0.93, 95%CI, 0.78-1.10, p=0.38; TT vs TC+CC: OR=1.02, 95%CI, 0.89-1.17, p=0.77). In the subgroup analysis by ethnicity, CC was associated with a significant increase in breast susceptibility among Latin-Americans in the dominant model (OR=0.61, 95%CI, 0.40-0.93, p=0.02), but the association disappeared in other models. No significant association was observed among Europeans, East Asians and others in different genetic models. In the subgroup analysis by their source of controls, no significant association between MMP-2 -1306C>T polymorphism and breast cancer susceptibility was noted among population-based studies and hospital-based studies in different genetic models. Conclusions: The results of this meta-analysis suggest that MMP-2 -1306C>T polymorphism is not associated with breast cancer susceptibility, although the association among Latin-Americans in the dominant model was significant.